Amino acid dipepetide frequency for Roseicyclus mahoneyensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.222AlaAla: 19.222 ± 0.185	1.203AlaCys: 1.203 ± 0.036	7.57AlaAsp: 7.57 ± 0.086	8.338AlaGlu: 8.338 ± 0.118	4.295AlaPhe: 4.295 ± 0.067	11.664AlaGly: 11.664 ± 0.115	2.637AlaHis: 2.637 ± 0.052	6.154AlaIle: 6.154 ± 0.087	2.884AlaLys: 2.884 ± 0.052	15.193AlaLeu: 15.193 ± 0.137	4.233AlaMet: 4.233 ± 0.068	2.527AlaAsn: 2.527 ± 0.045	6.701AlaPro: 6.701 ± 0.083	4.904AlaGln: 4.904 ± 0.07	10.771AlaArg: 10.771 ± 0.122	5.518AlaSer: 5.518 ± 0.072	6.901AlaThr: 6.901 ± 0.077	9.131AlaVal: 9.131 ± 0.105	1.564AlaTrp: 1.564 ± 0.037	2.431AlaTyr: 2.431 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.118CysAla: 1.118 ± 0.035	0.095CysCys: 0.095 ± 0.009	0.581CysAsp: 0.581 ± 0.02	0.407CysGlu: 0.407 ± 0.021	0.311CysPhe: 0.311 ± 0.015	0.956CysGly: 0.956 ± 0.031	0.255CysHis: 0.255 ± 0.015	0.369CysIle: 0.369 ± 0.016	0.151CysLys: 0.151 ± 0.011	0.831CysLeu: 0.831 ± 0.028	0.168CysMet: 0.168 ± 0.014	0.19CysAsn: 0.19 ± 0.014	0.501CysPro: 0.501 ± 0.022	0.19CysGln: 0.19 ± 0.013	0.577CysArg: 0.577 ± 0.021	0.4CysSer: 0.4 ± 0.021	0.443CysThr: 0.443 ± 0.02	0.635CysVal: 0.635 ± 0.027	0.106CysTrp: 0.106 ± 0.009	0.206CysTyr: 0.206 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.74AspAla: 7.74 ± 0.102	0.465AspCys: 0.465 ± 0.022	3.215AspAsp: 3.215 ± 0.079	2.969AspGlu: 2.969 ± 0.052	2.15AspPhe: 2.15 ± 0.042	5.659AspGly: 5.659 ± 0.085	1.478AspHis: 1.478 ± 0.04	3.03AspIle: 3.03 ± 0.053	1.237AspLys: 1.237 ± 0.034	7.058AspLeu: 7.058 ± 0.09	1.636AspMet: 1.636 ± 0.034	1.078AspAsn: 1.078 ± 0.035	4.159AspPro: 4.159 ± 0.062	1.719AspGln: 1.719 ± 0.039	5.17AspArg: 5.17 ± 0.077	1.971AspSer: 1.971 ± 0.041	3.079AspThr: 3.079 ± 0.071	4.044AspVal: 4.044 ± 0.06	1.336AspTrp: 1.336 ± 0.033	1.402AspTyr: 1.402 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.61GluAla: 8.61 ± 0.111	0.318GluCys: 0.318 ± 0.018	3.107GluAsp: 3.107 ± 0.051	2.829GluGlu: 2.829 ± 0.058	1.639GluPhe: 1.639 ± 0.036	5.074GluGly: 5.074 ± 0.055	1.048GluHis: 1.048 ± 0.029	3.34GluIle: 3.34 ± 0.061	1.429GluLys: 1.429 ± 0.037	4.382GluLeu: 4.382 ± 0.067	1.692GluMet: 1.692 ± 0.041	1.286GluAsn: 1.286 ± 0.035	2.328GluPro: 2.328 ± 0.047	1.646GluGln: 1.646 ± 0.041	4.119GluArg: 4.119 ± 0.079	1.778GluSer: 1.778 ± 0.038	3.701GluThr: 3.701 ± 0.056	4.367GluVal: 4.367 ± 0.066	0.595GluTrp: 0.595 ± 0.023	0.844GluTyr: 0.844 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.58PheAla: 4.58 ± 0.075	0.403PheCys: 0.403 ± 0.018	2.906PheAsp: 2.906 ± 0.049	2.06PheGlu: 2.06 ± 0.044	1.369PhePhe: 1.369 ± 0.04	3.666PheGly: 3.666 ± 0.063	0.746PheHis: 0.746 ± 0.024	1.457PheIle: 1.457 ± 0.041	0.641PheLys: 0.641 ± 0.024	3.442PheLeu: 3.442 ± 0.062	0.753PheMet: 0.753 ± 0.028	0.933PheAsn: 0.933 ± 0.031	1.642PhePro: 1.642 ± 0.038	0.962PheGln: 0.962 ± 0.031	2.252PheArg: 2.252 ± 0.058	1.854PheSer: 1.854 ± 0.04	2.074PheThr: 2.074 ± 0.046	2.766PheVal: 2.766 ± 0.05	0.579PheTrp: 0.579 ± 0.022	0.816PheTyr: 0.816 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.958GlyAla: 10.958 ± 0.108	0.861GlyCys: 0.861 ± 0.027	4.883GlyAsp: 4.883 ± 0.081	4.37GlyGlu: 4.37 ± 0.06	3.88GlyPhe: 3.88 ± 0.061	7.915GlyGly: 7.915 ± 0.115	2.014GlyHis: 2.014 ± 0.044	4.41GlyIle: 4.41 ± 0.061	2.455GlyLys: 2.455 ± 0.049	10.057GlyLeu: 10.057 ± 0.116	2.659GlyMet: 2.659 ± 0.058	2.037GlyAsn: 2.037 ± 0.067	4.317GlyPro: 4.317 ± 0.063	3.341GlyGln: 3.341 ± 0.053	6.421GlyArg: 6.421 ± 0.082	4.07GlySer: 4.07 ± 0.078	4.897GlyThr: 4.897 ± 0.067	6.667GlyVal: 6.667 ± 0.077	1.59GlyTrp: 1.59 ± 0.038	2.19GlyTyr: 2.19 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.619HisAla: 2.619 ± 0.046	0.21HisCys: 0.21 ± 0.012	1.381HisAsp: 1.381 ± 0.042	1.012HisGlu: 1.012 ± 0.031	0.743HisPhe: 0.743 ± 0.025	2.058HisGly: 2.058 ± 0.04	0.602HisHis: 0.602 ± 0.027	0.894HisIle: 0.894 ± 0.027	0.45HisLys: 0.45 ± 0.02	2.273HisLeu: 2.273 ± 0.047	0.534HisMet: 0.534 ± 0.021	0.406HisAsn: 0.406 ± 0.017	1.507HisPro: 1.507 ± 0.034	0.535HisGln: 0.535 ± 0.021	1.46HisArg: 1.46 ± 0.037	0.82HisSer: 0.82 ± 0.027	0.795HisThr: 0.795 ± 0.026	1.66HisVal: 1.66 ± 0.032	0.388HisTrp: 0.388 ± 0.018	0.516HisTyr: 0.516 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.414IleAla: 7.414 ± 0.095	0.555IleCys: 0.555 ± 0.022	3.564IleAsp: 3.564 ± 0.059	3.395IleGlu: 3.395 ± 0.053	1.768IlePhe: 1.768 ± 0.043	4.945IleGly: 4.945 ± 0.067	0.881IleHis: 0.881 ± 0.028	1.969IleIle: 1.969 ± 0.048	1.054IleLys: 1.054 ± 0.033	4.935IleLeu: 4.935 ± 0.083	1.0IleMet: 1.0 ± 0.03	1.192IleAsn: 1.192 ± 0.032	2.375IlePro: 2.375 ± 0.051	0.999IleGln: 0.999 ± 0.026	3.298IleArg: 3.298 ± 0.059	2.439IleSer: 2.439 ± 0.05	2.944IleThr: 2.944 ± 0.056	3.855IleVal: 3.855 ± 0.062	0.71IleTrp: 0.71 ± 0.025	1.038IleTyr: 1.038 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.001LysAla: 3.001 ± 0.062	0.13LysCys: 0.13 ± 0.011	1.23LysAsp: 1.23 ± 0.035	0.98LysGlu: 0.98 ± 0.036	0.604LysPhe: 0.604 ± 0.026	2.18LysGly: 2.18 ± 0.052	0.453LysHis: 0.453 ± 0.019	1.322LysIle: 1.322 ± 0.031	0.795LysLys: 0.795 ± 0.03	2.273LysLeu: 2.273 ± 0.045	0.678LysMet: 0.678 ± 0.025	0.521LysAsn: 0.521 ± 0.022	1.471LysPro: 1.471 ± 0.037	0.63LysGln: 0.63 ± 0.025	1.789LysArg: 1.789 ± 0.046	1.295LysSer: 1.295 ± 0.034	1.527LysThr: 1.527 ± 0.037	1.642LysVal: 1.642 ± 0.04	0.262LysTrp: 0.262 ± 0.015	0.426LysTyr: 0.426 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.442LeuAla: 14.442 ± 0.138	0.941LeuCys: 0.941 ± 0.027	6.24LeuAsp: 6.24 ± 0.09	5.012LeuGlu: 5.012 ± 0.069	3.492LeuPhe: 3.492 ± 0.058	8.739LeuGly: 8.739 ± 0.101	2.005LeuHis: 2.005 ± 0.044	5.382LeuIle: 5.382 ± 0.075	2.507LeuLys: 2.507 ± 0.05	8.552LeuLeu: 8.552 ± 0.103	2.77LeuMet: 2.77 ± 0.054	2.323LeuAsn: 2.323 ± 0.04	6.088LeuPro: 6.088 ± 0.078	2.79LeuGln: 2.79 ± 0.046	7.827LeuArg: 7.827 ± 0.087	6.657LeuSer: 6.657 ± 0.078	6.346LeuThr: 6.346 ± 0.074	7.337LeuVal: 7.337 ± 0.089	1.372LeuTrp: 1.372 ± 0.044	1.937LeuTyr: 1.937 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.913MetAla: 3.913 ± 0.063	0.16MetCys: 0.16 ± 0.012	1.375MetAsp: 1.375 ± 0.031	1.301MetGlu: 1.301 ± 0.033	0.719MetPhe: 0.719 ± 0.025	2.413MetGly: 2.413 ± 0.035	0.441MetHis: 0.441 ± 0.017	1.593MetIle: 1.593 ± 0.036	0.733MetLys: 0.733 ± 0.028	2.554MetLeu: 2.554 ± 0.051	0.767MetMet: 0.767 ± 0.025	0.67MetAsn: 0.67 ± 0.025	1.714MetPro: 1.714 ± 0.043	0.891MetGln: 0.891 ± 0.03	2.075MetArg: 2.075 ± 0.045	1.619MetSer: 1.619 ± 0.039	2.291MetThr: 2.291 ± 0.042	1.942MetVal: 1.942 ± 0.038	0.221MetTrp: 0.221 ± 0.015	0.29MetTyr: 0.29 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.8AsnAla: 2.8 ± 0.046	0.211AsnCys: 0.211 ± 0.012	1.26AsnAsp: 1.26 ± 0.058	0.93AsnGlu: 0.93 ± 0.027	0.824AsnPhe: 0.824 ± 0.027	2.092AsnGly: 2.092 ± 0.049	0.452AsnHis: 0.452 ± 0.018	1.192AsnIle: 1.192 ± 0.033	0.467AsnLys: 0.467 ± 0.021	2.268AsnLeu: 2.268 ± 0.048	0.594AsnMet: 0.594 ± 0.022	0.546AsnAsn: 0.546 ± 0.026	1.771AsnPro: 1.771 ± 0.042	0.591AsnGln: 0.591 ± 0.022	1.602AsnArg: 1.602 ± 0.038	0.973AsnSer: 0.973 ± 0.033	1.186AsnThr: 1.186 ± 0.034	1.522AsnVal: 1.522 ± 0.04	0.353AsnTrp: 0.353 ± 0.018	0.544AsnTyr: 0.544 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.787ProAla: 6.787 ± 0.093	0.401ProCys: 0.401 ± 0.02	4.255ProAsp: 4.255 ± 0.058	4.216ProGlu: 4.216 ± 0.058	1.996ProPhe: 1.996 ± 0.042	5.187ProGly: 5.187 ± 0.063	1.142ProHis: 1.142 ± 0.037	2.284ProIle: 2.284 ± 0.048	1.319ProLys: 1.319 ± 0.041	4.831ProLeu: 4.831 ± 0.074	1.482ProMet: 1.482 ± 0.042	1.202ProAsn: 1.202 ± 0.031	2.892ProPro: 2.892 ± 0.067	1.754ProGln: 1.754 ± 0.038	3.388ProArg: 3.388 ± 0.063	2.487ProSer: 2.487 ± 0.043	2.622ProThr: 2.622 ± 0.05	4.739ProVal: 4.739 ± 0.067	0.746ProTrp: 0.746 ± 0.025	1.114ProTyr: 1.114 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.225GlnAla: 4.225 ± 0.066	0.176GlnCys: 0.176 ± 0.011	1.776GlnAsp: 1.776 ± 0.04	1.281GlnGlu: 1.281 ± 0.036	0.983GlnPhe: 0.983 ± 0.029	2.827GlnGly: 2.827 ± 0.048	0.525GlnHis: 0.525 ± 0.018	2.03GlnIle: 2.03 ± 0.04	0.746GlnLys: 0.746 ± 0.027	2.611GlnLeu: 2.611 ± 0.052	1.041GlnMet: 1.041 ± 0.028	0.746GlnAsn: 0.746 ± 0.024	1.653GlnPro: 1.653 ± 0.038	0.912GlnGln: 0.912 ± 0.029	2.102GlnArg: 2.102 ± 0.047	1.629GlnSer: 1.629 ± 0.038	1.998GlnThr: 1.998 ± 0.042	2.39GlnVal: 2.39 ± 0.045	0.396GlnTrp: 0.396 ± 0.019	0.507GlnTyr: 0.507 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.868ArgAla: 9.868 ± 0.117	0.489ArgCys: 0.489 ± 0.02	4.719ArgAsp: 4.719 ± 0.072	3.611ArgGlu: 3.611 ± 0.064	2.886ArgPhe: 2.886 ± 0.055	5.225ArgGly: 5.225 ± 0.066	1.768ArgHis: 1.768 ± 0.043	4.084ArgIle: 4.084 ± 0.06	1.833ArgLys: 1.833 ± 0.042	8.4ArgLeu: 8.4 ± 0.099	2.119ArgMet: 2.119 ± 0.041	1.629ArgAsn: 1.629 ± 0.038	3.962ArgPro: 3.962 ± 0.062	2.349ArgGln: 2.349 ± 0.048	5.569ArgArg: 5.569 ± 0.073	3.197ArgSer: 3.197 ± 0.054	3.134ArgThr: 3.134 ± 0.06	5.294ArgVal: 5.294 ± 0.061	0.993ArgTrp: 0.993 ± 0.028	1.529ArgTyr: 1.529 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.718SerAla: 5.718 ± 0.079	0.408SerCys: 0.408 ± 0.02	3.049SerAsp: 3.049 ± 0.052	2.404SerGlu: 2.404 ± 0.048	2.124SerPhe: 2.124 ± 0.042	5.089SerGly: 5.089 ± 0.076	1.012SerHis: 1.012 ± 0.031	2.203SerIle: 2.203 ± 0.049	1.016SerLys: 1.016 ± 0.03	4.828SerLeu: 4.828 ± 0.06	1.197SerMet: 1.197 ± 0.031	1.066SerAsn: 1.066 ± 0.03	2.491SerPro: 2.491 ± 0.05	1.364SerGln: 1.364 ± 0.034	3.056SerArg: 3.056 ± 0.055	2.166SerSer: 2.166 ± 0.052	2.367SerThr: 2.367 ± 0.046	3.655SerVal: 3.655 ± 0.059	0.624SerTrp: 0.624 ± 0.024	1.174SerTyr: 1.174 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.864ThrAla: 6.864 ± 0.08	0.49ThrCys: 0.49 ± 0.025	3.304ThrAsp: 3.304 ± 0.049	2.989ThrGlu: 2.989 ± 0.053	1.795ThrPhe: 1.795 ± 0.042	5.853ThrGly: 5.853 ± 0.087	1.2ThrHis: 1.2 ± 0.032	2.829ThrIle: 2.829 ± 0.06	1.121ThrLys: 1.121 ± 0.034	6.552ThrLeu: 6.552 ± 0.084	1.307ThrMet: 1.307 ± 0.035	1.145ThrAsn: 1.145 ± 0.028	3.656ThrPro: 3.656 ± 0.057	1.623ThrGln: 1.623 ± 0.039	3.958ThrArg: 3.958 ± 0.057	2.509ThrSer: 2.509 ± 0.052	2.967ThrThr: 2.967 ± 0.054	4.34ThrVal: 4.34 ± 0.066	0.736ThrTrp: 0.736 ± 0.024	1.181ThrTyr: 1.181 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	9.941ValAla: 9.941 ± 0.105	0.615ValCys: 0.615 ± 0.022	3.988ValAsp: 3.988 ± 0.061	4.349ValGlu: 4.349 ± 0.064	2.941ValPhe: 2.941 ± 0.052	5.356ValGly: 5.356 ± 0.08	1.332ValHis: 1.332 ± 0.031	4.307ValIle: 4.307 ± 0.068	1.619ValLys: 1.619 ± 0.039	7.828ValLeu: 7.828 ± 0.089	2.221ValMet: 2.221 ± 0.043	1.788ValAsn: 1.788 ± 0.038	3.868ValPro: 3.868 ± 0.057	2.116ValGln: 2.116 ± 0.048	4.494ValArg: 4.494 ± 0.063	3.934ValSer: 3.934 ± 0.062	5.206ValThr: 5.206 ± 0.07	5.636ValVal: 5.636 ± 0.077	1.058ValTrp: 1.058 ± 0.033	1.421ValTyr: 1.421 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.521TrpAla: 1.521 ± 0.041	0.136TrpCys: 0.136 ± 0.011	0.791TrpAsp: 0.791 ± 0.027	0.628TrpGlu: 0.628 ± 0.025	0.554TrpPhe: 0.554 ± 0.022	1.058TrpGly: 1.058 ± 0.03	0.381TrpHis: 0.381 ± 0.019	0.646TrpIle: 0.646 ± 0.024	0.318TrpLys: 0.318 ± 0.016	1.734TrpLeu: 1.734 ± 0.04	0.399TrpMet: 0.399 ± 0.016	0.407TrpAsn: 0.407 ± 0.017	0.718TrpPro: 0.718 ± 0.025	0.657TrpGln: 0.657 ± 0.023	1.194TrpArg: 1.194 ± 0.03	0.759TrpSer: 0.759 ± 0.025	0.843TrpThr: 0.843 ± 0.028	0.97TrpVal: 0.97 ± 0.027	0.256TrpTrp: 0.256 ± 0.016	0.251TrpTyr: 0.251 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.502TyrAla: 2.502 ± 0.049	0.221TyrCys: 0.221 ± 0.013	1.4TyrAsp: 1.4 ± 0.038	1.051TyrGlu: 1.051 ± 0.028	0.829TyrPhe: 0.829 ± 0.026	2.036TyrGly: 2.036 ± 0.046	0.491TyrHis: 0.491 ± 0.021	0.831TyrIle: 0.831 ± 0.025	0.435TyrLys: 0.435 ± 0.02	2.158TyrLeu: 2.158 ± 0.045	0.434TyrMet: 0.434 ± 0.019	0.489TyrAsn: 0.489 ± 0.021	1.029TyrPro: 1.029 ± 0.03	0.579TyrGln: 0.579 ± 0.022	1.539TyrArg: 1.539 ± 0.035	0.935TyrSer: 0.935 ± 0.031	1.097TyrThr: 1.097 ± 0.035	1.427TyrVal: 1.427 ± 0.03	0.335TyrTrp: 0.335 ± 0.017	0.492TyrTyr: 0.492 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3941 proteins (1221957 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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