Amino acid dipepetide frequency for Pontibacter diazotrophicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.793AlaAla: 7.793 ± 0.098
0.692AlaCys: 0.692 ± 0.022
4.299AlaAsp: 4.299 ± 0.051
5.162AlaGlu: 5.162 ± 0.055
3.698AlaPhe: 3.698 ± 0.051
6.375AlaGly: 6.375 ± 0.076
1.404AlaHis: 1.404 ± 0.029
4.911AlaIle: 4.911 ± 0.054
4.037AlaLys: 4.037 ± 0.052
7.935AlaLeu: 7.935 ± 0.074
2.025AlaMet: 2.025 ± 0.039
3.338AlaAsn: 3.338 ± 0.041
3.127AlaPro: 3.127 ± 0.054
3.32AlaGln: 3.32 ± 0.049
3.367AlaArg: 3.367 ± 0.043
4.909AlaSer: 4.909 ± 0.06
4.664AlaThr: 4.664 ± 0.061
5.742AlaVal: 5.742 ± 0.065
0.848AlaTrp: 0.848 ± 0.021
3.027AlaTyr: 3.027 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.541CysAla: 0.541 ± 0.02
0.135CysCys: 0.135 ± 0.01
0.348CysAsp: 0.348 ± 0.015
0.41CysGlu: 0.41 ± 0.017
0.363CysPhe: 0.363 ± 0.015
0.606CysGly: 0.606 ± 0.027
0.212CysHis: 0.212 ± 0.011
0.473CysIle: 0.473 ± 0.016
0.312CysLys: 0.312 ± 0.012
0.74CysLeu: 0.74 ± 0.024
0.155CysMet: 0.155 ± 0.011
0.298CysAsn: 0.298 ± 0.014
0.317CysPro: 0.317 ± 0.014
0.292CysGln: 0.292 ± 0.015
0.34CysArg: 0.34 ± 0.016
0.536CysSer: 0.536 ± 0.016
0.428CysThr: 0.428 ± 0.019
0.447CysVal: 0.447 ± 0.018
0.077CysTrp: 0.077 ± 0.007
0.274CysTyr: 0.274 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.129AspAla: 4.129 ± 0.047
0.34AspCys: 0.34 ± 0.016
2.337AspAsp: 2.337 ± 0.043
3.557AspGlu: 3.557 ± 0.045
2.861AspPhe: 2.861 ± 0.038
3.634AspGly: 3.634 ± 0.063
0.868AspHis: 0.868 ± 0.025
3.502AspIle: 3.502 ± 0.05
3.406AspLys: 3.406 ± 0.049
4.899AspLeu: 4.899 ± 0.061
1.291AspMet: 1.291 ± 0.027
2.488AspAsn: 2.488 ± 0.042
2.181AspPro: 2.181 ± 0.034
1.691AspGln: 1.691 ± 0.031
2.459AspArg: 2.459 ± 0.04
2.717AspSer: 2.717 ± 0.045
2.737AspThr: 2.737 ± 0.047
3.57AspVal: 3.57 ± 0.049
0.761AspTrp: 0.761 ± 0.019
2.475AspTyr: 2.475 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.861GluAla: 5.861 ± 0.069
0.284GluCys: 0.284 ± 0.014
3.37GluAsp: 3.37 ± 0.048
5.67GluGlu: 5.67 ± 0.075
2.352GluPhe: 2.352 ± 0.041
4.49GluGly: 4.49 ± 0.061
1.388GluHis: 1.388 ± 0.03
3.738GluIle: 3.738 ± 0.056
4.484GluLys: 4.484 ± 0.063
6.593GluLeu: 6.593 ± 0.068
1.69GluMet: 1.69 ± 0.034
3.365GluAsn: 3.365 ± 0.047
2.217GluPro: 2.217 ± 0.037
3.509GluGln: 3.509 ± 0.056
3.43GluArg: 3.43 ± 0.051
3.163GluSer: 3.163 ± 0.048
3.262GluThr: 3.262 ± 0.042
5.083GluVal: 5.083 ± 0.058
0.781GluTrp: 0.781 ± 0.021
2.273GluTyr: 2.273 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.312PheAla: 3.312 ± 0.046
0.395PheCys: 0.395 ± 0.014
2.612PheAsp: 2.612 ± 0.038
2.704PheGlu: 2.704 ± 0.044
2.297PhePhe: 2.297 ± 0.042
3.25PheGly: 3.25 ± 0.045
0.87PheHis: 0.87 ± 0.024
2.745PheIle: 2.745 ± 0.044
2.28PheLys: 2.28 ± 0.035
4.26PheLeu: 4.26 ± 0.057
1.108PheMet: 1.108 ± 0.024
2.252PheAsn: 2.252 ± 0.039
1.678PhePro: 1.678 ± 0.03
1.475PheGln: 1.475 ± 0.036
2.199PheArg: 2.199 ± 0.037
3.467PheSer: 3.467 ± 0.051
2.894PheThr: 2.894 ± 0.053
2.965PheVal: 2.965 ± 0.041
0.607PheTrp: 0.607 ± 0.018
1.915PheTyr: 1.915 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.262GlyAla: 5.262 ± 0.066
0.633GlyCys: 0.633 ± 0.028
3.467GlyAsp: 3.467 ± 0.052
4.283GlyGlu: 4.283 ± 0.053
3.427GlyPhe: 3.427 ± 0.046
5.354GlyGly: 5.354 ± 0.087
1.355GlyHis: 1.355 ± 0.031
4.847GlyIle: 4.847 ± 0.057
4.537GlyLys: 4.537 ± 0.06
6.443GlyLeu: 6.443 ± 0.068
1.888GlyMet: 1.888 ± 0.04
3.429GlyAsn: 3.429 ± 0.052
1.952GlyPro: 1.952 ± 0.034
2.562GlyGln: 2.562 ± 0.043
3.079GlyArg: 3.079 ± 0.042
4.392GlySer: 4.392 ± 0.069
4.435GlyThr: 4.435 ± 0.085
4.93GlyVal: 4.93 ± 0.058
0.965GlyTrp: 0.965 ± 0.026
3.058GlyTyr: 3.058 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.354HisAla: 1.354 ± 0.031
0.172HisCys: 0.172 ± 0.011
0.955HisAsp: 0.955 ± 0.025
1.2HisGlu: 1.2 ± 0.025
1.083HisPhe: 1.083 ± 0.027
1.367HisGly: 1.367 ± 0.03
0.608HisHis: 0.608 ± 0.019
1.242HisIle: 1.242 ± 0.026
1.0HisLys: 1.0 ± 0.025
2.093HisLeu: 2.093 ± 0.041
0.462HisMet: 0.462 ± 0.015
0.952HisAsn: 0.952 ± 0.025
1.149HisPro: 1.149 ± 0.025
0.909HisGln: 0.909 ± 0.025
0.968HisArg: 0.968 ± 0.023
1.173HisSer: 1.173 ± 0.029
1.217HisThr: 1.217 ± 0.026
1.273HisVal: 1.273 ± 0.026
0.26HisTrp: 0.26 ± 0.014
0.927HisTyr: 0.927 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.093IleAla: 5.093 ± 0.062
0.535IleCys: 0.535 ± 0.021
3.37IleAsp: 3.37 ± 0.046
3.787IleGlu: 3.787 ± 0.052
2.493IlePhe: 2.493 ± 0.048
4.485IleGly: 4.485 ± 0.053
1.111IleHis: 1.111 ± 0.027
3.76IleIle: 3.76 ± 0.054
3.364IleLys: 3.364 ± 0.052
5.384IleLeu: 5.384 ± 0.072
1.24IleMet: 1.24 ± 0.027
2.938IleAsn: 2.938 ± 0.045
2.717IlePro: 2.717 ± 0.039
2.126IleGln: 2.126 ± 0.038
3.008IleArg: 3.008 ± 0.045
4.095IleSer: 4.095 ± 0.053
3.815IleThr: 3.815 ± 0.066
3.88IleVal: 3.88 ± 0.05
0.642IleTrp: 0.642 ± 0.018
2.173IleTyr: 2.173 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.848LysAla: 4.848 ± 0.065
0.235LysCys: 0.235 ± 0.012
3.112LysAsp: 3.112 ± 0.049
4.603LysGlu: 4.603 ± 0.063
1.877LysPhe: 1.877 ± 0.032
3.932LysGly: 3.932 ± 0.045
1.214LysHis: 1.214 ± 0.027
3.227LysIle: 3.227 ± 0.052
3.87LysLys: 3.87 ± 0.063
5.327LysLeu: 5.327 ± 0.066
1.439LysMet: 1.439 ± 0.03
2.635LysAsn: 2.635 ± 0.042
2.542LysPro: 2.542 ± 0.037
2.582LysGln: 2.582 ± 0.038
2.757LysArg: 2.757 ± 0.041
3.155LysSer: 3.155 ± 0.044
2.973LysThr: 2.973 ± 0.044
4.184LysVal: 4.184 ± 0.054
0.617LysTrp: 0.617 ± 0.018
2.232LysTyr: 2.232 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
7.582LeuAla: 7.582 ± 0.078
0.79LeuCys: 0.79 ± 0.023
4.759LeuAsp: 4.759 ± 0.063
6.126LeuGlu: 6.126 ± 0.075
4.561LeuPhe: 4.561 ± 0.062
6.074LeuGly: 6.074 ± 0.072
2.199LeuHis: 2.199 ± 0.038
5.438LeuIle: 5.438 ± 0.063
5.709LeuLys: 5.709 ± 0.07
11.048LeuLeu: 11.048 ± 0.119
2.308LeuMet: 2.308 ± 0.035
4.656LeuAsn: 4.656 ± 0.06
4.597LeuPro: 4.597 ± 0.064
5.118LeuGln: 5.118 ± 0.073
4.619LeuArg: 4.619 ± 0.061
6.678LeuSer: 6.678 ± 0.072
5.62LeuThr: 5.62 ± 0.059
6.312LeuVal: 6.312 ± 0.071
1.021LeuTrp: 1.021 ± 0.026
3.574LeuTyr: 3.574 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.23MetAla: 2.23 ± 0.038
0.136MetCys: 0.136 ± 0.009
1.162MetAsp: 1.162 ± 0.03
1.576MetGlu: 1.576 ± 0.031
0.839MetPhe: 0.839 ± 0.024
1.651MetGly: 1.651 ± 0.032
0.528MetHis: 0.528 ± 0.019
1.255MetIle: 1.255 ± 0.027
1.727MetLys: 1.727 ± 0.027
2.516MetLeu: 2.516 ± 0.039
0.673MetMet: 0.673 ± 0.026
1.177MetAsn: 1.177 ± 0.027
1.167MetPro: 1.167 ± 0.026
1.22MetGln: 1.22 ± 0.027
1.189MetArg: 1.189 ± 0.027
1.393MetSer: 1.393 ± 0.027
1.115MetThr: 1.115 ± 0.026
1.621MetVal: 1.621 ± 0.035
0.206MetTrp: 0.206 ± 0.011
0.695MetTyr: 0.695 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.345AsnAla: 3.345 ± 0.046
0.305AsnCys: 0.305 ± 0.014
2.222AsnAsp: 2.222 ± 0.044
2.735AsnGlu: 2.735 ± 0.042
2.169AsnPhe: 2.169 ± 0.038
3.369AsnGly: 3.369 ± 0.062
0.871AsnHis: 0.871 ± 0.022
3.262AsnIle: 3.262 ± 0.043
2.621AsnLys: 2.621 ± 0.041
4.574AsnLeu: 4.574 ± 0.058
1.132AsnMet: 1.132 ± 0.024
2.503AsnAsn: 2.503 ± 0.048
2.535AsnPro: 2.535 ± 0.039
1.817AsnGln: 1.817 ± 0.034
2.421AsnArg: 2.421 ± 0.041
2.883AsnSer: 2.883 ± 0.046
2.894AsnThr: 2.894 ± 0.047
2.906AsnVal: 2.906 ± 0.045
0.683AsnTrp: 0.683 ± 0.021
2.271AsnTyr: 2.271 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
3.902ProAla: 3.902 ± 0.056
0.233ProCys: 0.233 ± 0.009
2.907ProAsp: 2.907 ± 0.041
3.792ProGlu: 3.792 ± 0.046
1.907ProPhe: 1.907 ± 0.03
2.863ProGly: 2.863 ± 0.045
0.848ProHis: 0.848 ± 0.022
2.164ProIle: 2.164 ± 0.033
1.954ProLys: 1.954 ± 0.034
3.775ProLeu: 3.775 ± 0.048
0.871ProMet: 0.871 ± 0.025
1.881ProAsn: 1.881 ± 0.03
1.286ProPro: 1.286 ± 0.038
1.723ProGln: 1.723 ± 0.035
1.426ProArg: 1.426 ± 0.03
2.261ProSer: 2.261 ± 0.035
2.196ProThr: 2.196 ± 0.039
3.494ProVal: 3.494 ± 0.048
0.471ProTrp: 0.471 ± 0.018
1.652ProTyr: 1.652 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.53GlnAla: 3.53 ± 0.05
0.209GlnCys: 0.209 ± 0.012
2.087GlnAsp: 2.087 ± 0.032
3.52GlnGlu: 3.52 ± 0.05
1.528GlnPhe: 1.528 ± 0.029
2.489GlnGly: 2.489 ± 0.047
1.141GlnHis: 1.141 ± 0.028
2.113GlnIle: 2.113 ± 0.039
2.493GlnLys: 2.493 ± 0.044
4.537GlnLeu: 4.537 ± 0.056
1.003GlnMet: 1.003 ± 0.024
2.031GlnAsn: 2.031 ± 0.036
1.862GlnPro: 1.862 ± 0.036
2.885GlnGln: 2.885 ± 0.058
2.041GlnArg: 2.041 ± 0.035
2.045GlnSer: 2.045 ± 0.029
2.015GlnThr: 2.015 ± 0.036
3.131GlnVal: 3.131 ± 0.043
0.474GlnTrp: 0.474 ± 0.02
1.546GlnTyr: 1.546 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.054ArgAla: 3.054 ± 0.045
0.277ArgCys: 0.277 ± 0.012
2.319ArgAsp: 2.319 ± 0.038
3.265ArgGlu: 3.265 ± 0.049
2.332ArgPhe: 2.332 ± 0.039
2.788ArgGly: 2.788 ± 0.046
1.058ArgHis: 1.058 ± 0.026
3.081ArgIle: 3.081 ± 0.044
2.891ArgLys: 2.891 ± 0.048
4.724ArgLeu: 4.724 ± 0.056
1.357ArgMet: 1.357 ± 0.031
2.513ArgAsn: 2.513 ± 0.045
1.727ArgPro: 1.727 ± 0.037
2.208ArgGln: 2.208 ± 0.04
2.31ArgArg: 2.31 ± 0.045
2.581ArgSer: 2.581 ± 0.038
2.434ArgThr: 2.434 ± 0.035
3.18ArgVal: 3.18 ± 0.046
0.608ArgTrp: 0.608 ± 0.02
2.035ArgTyr: 2.035 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.451SerAla: 4.451 ± 0.056
0.597SerCys: 0.597 ± 0.019
3.115SerAsp: 3.115 ± 0.041
3.623SerGlu: 3.623 ± 0.051
3.223SerPhe: 3.223 ± 0.047
4.827SerGly: 4.827 ± 0.065
1.131SerHis: 1.131 ± 0.026
3.872SerIle: 3.872 ± 0.049
3.217SerLys: 3.217 ± 0.048
6.02SerLeu: 6.02 ± 0.058
1.46SerMet: 1.46 ± 0.029
2.765SerAsn: 2.765 ± 0.045
2.586SerPro: 2.586 ± 0.04
2.138SerGln: 2.138 ± 0.034
2.851SerArg: 2.851 ± 0.041
3.986SerSer: 3.986 ± 0.06
3.423SerThr: 3.423 ± 0.05
4.006SerVal: 4.006 ± 0.046
0.757SerTrp: 0.757 ± 0.022
2.511SerTyr: 2.511 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
4.887ThrAla: 4.887 ± 0.071
0.367ThrCys: 0.367 ± 0.02
3.132ThrAsp: 3.132 ± 0.046
3.433ThrGlu: 3.433 ± 0.047
2.693ThrPhe: 2.693 ± 0.044
4.728ThrGly: 4.728 ± 0.077
1.071ThrHis: 1.071 ± 0.03
3.573ThrIle: 3.573 ± 0.054
2.626ThrLys: 2.626 ± 0.043
5.516ThrLeu: 5.516 ± 0.059
1.093ThrMet: 1.093 ± 0.024
2.369ThrAsn: 2.369 ± 0.046
2.868ThrPro: 2.868 ± 0.039
1.938ThrGln: 1.938 ± 0.033
2.209ThrArg: 2.209 ± 0.034
3.482ThrSer: 3.482 ± 0.054
3.455ThrThr: 3.455 ± 0.08
4.175ThrVal: 4.175 ± 0.064
0.685ThrTrp: 0.685 ± 0.022
2.383ThrTyr: 2.383 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
5.786ValAla: 5.786 ± 0.063
0.563ValCys: 0.563 ± 0.021
3.49ValAsp: 3.49 ± 0.045
4.522ValGlu: 4.522 ± 0.06
3.068ValPhe: 3.068 ± 0.046
4.416ValGly: 4.416 ± 0.055
1.284ValHis: 1.284 ± 0.029
3.988ValIle: 3.988 ± 0.055
3.9ValLys: 3.9 ± 0.056
7.223ValLeu: 7.223 ± 0.069
1.661ValMet: 1.661 ± 0.036
3.163ValAsn: 3.163 ± 0.047
3.09ValPro: 3.09 ± 0.041
2.894ValGln: 2.894 ± 0.048
3.177ValArg: 3.177 ± 0.041
4.421ValSer: 4.421 ± 0.054
4.001ValThr: 4.001 ± 0.074
5.259ValVal: 5.259 ± 0.06
0.8ValTrp: 0.8 ± 0.024
2.637ValTyr: 2.637 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.864TrpAla: 0.864 ± 0.021
0.095TrpCys: 0.095 ± 0.008
0.633TrpAsp: 0.633 ± 0.023
0.74TrpGlu: 0.74 ± 0.026
0.544TrpPhe: 0.544 ± 0.019
0.838TrpGly: 0.838 ± 0.023
0.301TrpHis: 0.301 ± 0.014
0.597TrpIle: 0.597 ± 0.021
0.658TrpLys: 0.658 ± 0.02
1.276TrpLeu: 1.276 ± 0.032
0.347TrpMet: 0.347 ± 0.015
0.578TrpAsn: 0.578 ± 0.02
0.401TrpPro: 0.401 ± 0.015
0.677TrpGln: 0.677 ± 0.022
0.633TrpArg: 0.633 ± 0.021
0.684TrpSer: 0.684 ± 0.02
0.612TrpThr: 0.612 ± 0.024
0.829TrpVal: 0.829 ± 0.026
0.18TrpTrp: 0.18 ± 0.011
0.446TrpTyr: 0.446 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.849TyrAla: 2.849 ± 0.043
0.309TyrCys: 0.309 ± 0.014
2.208TyrAsp: 2.208 ± 0.042
2.294TyrGlu: 2.294 ± 0.041
1.971TyrPhe: 1.971 ± 0.04
2.762TyrGly: 2.762 ± 0.05
0.9TyrHis: 0.9 ± 0.027
2.228TyrIle: 2.228 ± 0.043
2.275TyrLys: 2.275 ± 0.038
3.907TyrLeu: 3.907 ± 0.051
0.872TyrMet: 0.872 ± 0.021
2.187TyrAsn: 2.187 ± 0.04
1.609TyrPro: 1.609 ± 0.028
1.6TyrGln: 1.6 ± 0.033
2.26TyrArg: 2.26 ± 0.04
2.537TyrSer: 2.537 ± 0.045
2.494TyrThr: 2.494 ± 0.049
2.356TyrVal: 2.356 ± 0.037
0.486TyrTrp: 0.486 ± 0.017
1.757TyrTyr: 1.757 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5237 proteins (1775216 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski