Amino acid dipepetide frequency for Vulcaniibacterium tengchongense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.203AlaAla: 24.203 ± 0.272	1.316AlaCys: 1.316 ± 0.039	7.566AlaAsp: 7.566 ± 0.09	8.565AlaGlu: 8.565 ± 0.131	4.337AlaPhe: 4.337 ± 0.074	13.28AlaGly: 13.28 ± 0.163	2.89AlaHis: 2.89 ± 0.054	5.268AlaIle: 5.268 ± 0.091	3.201AlaLys: 3.201 ± 0.081	18.039AlaLeu: 18.039 ± 0.197	3.064AlaMet: 3.064 ± 0.053	2.537AlaAsn: 2.537 ± 0.059	8.507AlaPro: 8.507 ± 0.157	5.664AlaGln: 5.664 ± 0.085	12.956AlaArg: 12.956 ± 0.17	5.89AlaSer: 5.89 ± 0.105	5.804AlaThr: 5.804 ± 0.109	9.497AlaVal: 9.497 ± 0.132	2.372AlaTrp: 2.372 ± 0.059	2.744AlaTyr: 2.744 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.182CysAla: 1.182 ± 0.041	0.085CysCys: 0.085 ± 0.008	0.451CysAsp: 0.451 ± 0.019	0.471CysGlu: 0.471 ± 0.02	0.258CysPhe: 0.258 ± 0.015	0.885CysGly: 0.885 ± 0.027	0.207CysHis: 0.207 ± 0.013	0.265CysIle: 0.265 ± 0.017	0.153CysLys: 0.153 ± 0.014	0.742CysLeu: 0.742 ± 0.028	0.115CysMet: 0.115 ± 0.011	0.178CysAsn: 0.178 ± 0.013	0.441CysPro: 0.441 ± 0.024	0.188CysGln: 0.188 ± 0.014	0.675CysArg: 0.675 ± 0.027	0.36CysSer: 0.36 ± 0.018	0.375CysThr: 0.375 ± 0.02	0.629CysVal: 0.629 ± 0.023	0.117CysTrp: 0.117 ± 0.012	0.191CysTyr: 0.191 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.31AspAla: 9.31 ± 0.115	0.394AspCys: 0.394 ± 0.022	3.091AspAsp: 3.091 ± 0.062	3.515AspGlu: 3.515 ± 0.061	1.939AspPhe: 1.939 ± 0.043	6.043AspGly: 6.043 ± 0.088	1.006AspHis: 1.006 ± 0.029	1.797AspIle: 1.797 ± 0.049	1.247AspLys: 1.247 ± 0.039	5.565AspLeu: 5.565 ± 0.08	0.889AspMet: 0.889 ± 0.03	1.08AspAsn: 1.08 ± 0.042	4.004AspPro: 4.004 ± 0.064	1.304AspGln: 1.304 ± 0.037	4.396AspArg: 4.396 ± 0.077	1.986AspSer: 1.986 ± 0.045	2.213AspThr: 2.213 ± 0.054	3.974AspVal: 3.974 ± 0.064	1.137AspTrp: 1.137 ± 0.035	1.721AspTyr: 1.721 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	8.509GluAla: 8.509 ± 0.133	0.344GluCys: 0.344 ± 0.019	2.697GluAsp: 2.697 ± 0.061	2.607GluGlu: 2.607 ± 0.064	1.898GluPhe: 1.898 ± 0.049	4.264GluGly: 4.264 ± 0.067	1.422GluHis: 1.422 ± 0.039	2.452GluIle: 2.452 ± 0.055	1.315GluLys: 1.315 ± 0.038	6.546GluLeu: 6.546 ± 0.092	0.96GluMet: 0.96 ± 0.032	1.125GluAsn: 1.125 ± 0.035	3.167GluPro: 3.167 ± 0.058	2.348GluGln: 2.348 ± 0.059	6.586GluArg: 6.586 ± 0.103	2.249GluSer: 2.249 ± 0.045	2.55GluThr: 2.55 ± 0.049	4.044GluVal: 4.044 ± 0.063	0.793GluTrp: 0.793 ± 0.029	1.249GluTyr: 1.249 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	4.84PheAla: 4.84 ± 0.077	0.297PheCys: 0.297 ± 0.019	2.734PheAsp: 2.734 ± 0.063	2.112PheGlu: 2.112 ± 0.042	1.085PhePhe: 1.085 ± 0.036	3.444PheGly: 3.444 ± 0.062	0.706PheHis: 0.706 ± 0.027	0.858PheIle: 0.858 ± 0.032	0.724PheLys: 0.724 ± 0.029	2.95PheLeu: 2.95 ± 0.062	0.503PheMet: 0.503 ± 0.019	0.859PheAsn: 0.859 ± 0.03	1.422PhePro: 1.422 ± 0.039	0.778PheGln: 0.778 ± 0.028	2.352PheArg: 2.352 ± 0.047	1.541PheSer: 1.541 ± 0.038	1.313PheThr: 1.313 ± 0.037	2.759PheVal: 2.759 ± 0.058	0.465PheTrp: 0.465 ± 0.023	0.779PheTyr: 0.779 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	11.449GlyAla: 11.449 ± 0.163	0.797GlyCys: 0.797 ± 0.028	5.092GlyAsp: 5.092 ± 0.073	5.833GlyGlu: 5.833 ± 0.075	3.462GlyPhe: 3.462 ± 0.067	8.193GlyGly: 8.193 ± 0.119	1.992GlyHis: 1.992 ± 0.042	3.488GlyIle: 3.488 ± 0.062	2.648GlyLys: 2.648 ± 0.063	9.288GlyLeu: 9.288 ± 0.11	1.95GlyMet: 1.95 ± 0.047	2.105GlyAsn: 2.105 ± 0.069	3.617GlyPro: 3.617 ± 0.067	2.897GlyGln: 2.897 ± 0.058	7.796GlyArg: 7.796 ± 0.1	4.323GlySer: 4.323 ± 0.093	4.146GlyThr: 4.146 ± 0.087	6.531GlyVal: 6.531 ± 0.087	1.748GlyTrp: 1.748 ± 0.04	2.567GlyTyr: 2.567 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	3.165HisAla: 3.165 ± 0.063	0.233HisCys: 0.233 ± 0.015	1.208HisAsp: 1.208 ± 0.038	1.128HisGlu: 1.128 ± 0.033	0.747HisPhe: 0.747 ± 0.029	2.398HisGly: 2.398 ± 0.05	0.525HisHis: 0.525 ± 0.026	0.591HisIle: 0.591 ± 0.026	0.431HisLys: 0.431 ± 0.02	2.07HisLeu: 2.07 ± 0.042	0.311HisMet: 0.311 ± 0.017	0.409HisAsn: 0.409 ± 0.02	1.567HisPro: 1.567 ± 0.041	0.479HisGln: 0.479 ± 0.023	1.844HisArg: 1.844 ± 0.037	0.8HisSer: 0.8 ± 0.03	0.792HisThr: 0.792 ± 0.026	1.487HisVal: 1.487 ± 0.034	0.415HisTrp: 0.415 ± 0.019	0.636HisTyr: 0.636 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.115IleAla: 6.115 ± 0.081	0.276IleCys: 0.276 ± 0.02	2.858IleAsp: 2.858 ± 0.057	2.955IleGlu: 2.955 ± 0.052	0.843IlePhe: 0.843 ± 0.031	3.997IleGly: 3.997 ± 0.087	0.664IleHis: 0.664 ± 0.024	0.772IleIle: 0.772 ± 0.038	0.91IleLys: 0.91 ± 0.033	2.634IleLeu: 2.634 ± 0.053	0.388IleMet: 0.388 ± 0.022	0.952IleAsn: 0.952 ± 0.039	1.82IlePro: 1.82 ± 0.044	0.898IleGln: 0.898 ± 0.033	2.624IleArg: 2.624 ± 0.049	1.46IleSer: 1.46 ± 0.043	1.572IleThr: 1.572 ± 0.048	3.112IleVal: 3.112 ± 0.063	0.363IleTrp: 0.363 ± 0.02	0.703IleTyr: 0.703 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.013LysAla: 3.013 ± 0.076	0.131LysCys: 0.131 ± 0.011	1.185LysAsp: 1.185 ± 0.037	1.019LysGlu: 1.019 ± 0.037	0.659LysPhe: 0.659 ± 0.023	1.711LysGly: 1.711 ± 0.048	0.488LysHis: 0.488 ± 0.021	1.025LysIle: 1.025 ± 0.035	0.886LysLys: 0.886 ± 0.053	2.627LysLeu: 2.627 ± 0.061	0.479LysMet: 0.479 ± 0.021	0.565LysAsn: 0.565 ± 0.021	1.787LysPro: 1.787 ± 0.047	0.937LysGln: 0.937 ± 0.032	2.133LysArg: 2.133 ± 0.05	1.109LysSer: 1.109 ± 0.033	1.271LysThr: 1.271 ± 0.042	1.778LysVal: 1.778 ± 0.052	0.294LysTrp: 0.294 ± 0.017	0.564LysTyr: 0.564 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	17.416LeuAla: 17.416 ± 0.183	0.897LeuCys: 0.897 ± 0.03	6.969LeuAsp: 6.969 ± 0.091	5.559LeuGlu: 5.559 ± 0.094	3.419LeuPhe: 3.419 ± 0.067	9.339LeuGly: 9.339 ± 0.104	2.41LeuHis: 2.41 ± 0.052	3.486LeuIle: 3.486 ± 0.077	2.534LeuLys: 2.534 ± 0.055	11.869LeuLeu: 11.869 ± 0.159	1.818LeuMet: 1.818 ± 0.05	2.139LeuAsn: 2.139 ± 0.046	6.696LeuPro: 6.696 ± 0.089	3.797LeuGln: 3.797 ± 0.066	10.579LeuArg: 10.579 ± 0.129	5.111LeuSer: 5.111 ± 0.089	4.241LeuThr: 4.241 ± 0.07	7.299LeuVal: 7.299 ± 0.098	1.454LeuTrp: 1.454 ± 0.046	2.273LeuTyr: 2.273 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.259MetAla: 2.259 ± 0.051	0.117MetCys: 0.117 ± 0.01	0.891MetAsp: 0.891 ± 0.031	0.736MetGlu: 0.736 ± 0.025	0.53MetPhe: 0.53 ± 0.026	1.254MetGly: 1.254 ± 0.036	0.386MetHis: 0.386 ± 0.019	0.713MetIle: 0.713 ± 0.029	0.659MetLys: 0.659 ± 0.028	2.043MetLeu: 2.043 ± 0.049	0.327MetMet: 0.327 ± 0.019	0.606MetAsn: 0.606 ± 0.022	1.299MetPro: 1.299 ± 0.037	0.728MetGln: 0.728 ± 0.025	1.736MetArg: 1.736 ± 0.046	1.294MetSer: 1.294 ± 0.036	1.081MetThr: 1.081 ± 0.034	1.094MetVal: 1.094 ± 0.035	0.177MetTrp: 0.177 ± 0.015	0.302MetTyr: 0.302 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.034AsnAla: 3.034 ± 0.069	0.175AsnCys: 0.175 ± 0.014	1.148AsnAsp: 1.148 ± 0.037	1.076AsnGlu: 1.076 ± 0.029	0.768AsnPhe: 0.768 ± 0.033	2.137AsnGly: 2.137 ± 0.058	0.405AsnHis: 0.405 ± 0.02	0.816AsnIle: 0.816 ± 0.033	0.501AsnLys: 0.501 ± 0.024	2.28AsnLeu: 2.28 ± 0.047	0.328AsnMet: 0.328 ± 0.024	0.529AsnAsn: 0.529 ± 0.03	1.645AsnPro: 1.645 ± 0.038	0.617AsnGln: 0.617 ± 0.029	1.64AsnArg: 1.64 ± 0.038	0.913AsnSer: 0.913 ± 0.044	0.99AsnThr: 0.99 ± 0.036	1.623AsnVal: 1.623 ± 0.047	0.346AsnTrp: 0.346 ± 0.019	0.562AsnTyr: 0.562 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	9.205ProAla: 9.205 ± 0.144	0.358ProCys: 0.358 ± 0.019	3.531ProAsp: 3.531 ± 0.07	3.643ProGlu: 3.643 ± 0.065	1.708ProPhe: 1.708 ± 0.042	5.663ProGly: 5.663 ± 0.091	1.234ProHis: 1.234 ± 0.038	1.796ProIle: 1.796 ± 0.047	1.336ProLys: 1.336 ± 0.038	5.873ProLeu: 5.873 ± 0.101	1.128ProMet: 1.128 ± 0.036	1.193ProAsn: 1.193 ± 0.037	3.858ProPro: 3.858 ± 0.1	2.197ProGln: 2.197 ± 0.053	4.668ProArg: 4.668 ± 0.082	2.504ProSer: 2.504 ± 0.055	2.243ProThr: 2.243 ± 0.045	4.164ProVal: 4.164 ± 0.06	0.904ProTrp: 0.904 ± 0.034	1.28ProTyr: 1.28 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	5.638GlnAla: 5.638 ± 0.096	0.207GlnCys: 0.207 ± 0.013	1.412GlnAsp: 1.412 ± 0.041	1.265GlnGlu: 1.265 ± 0.042	0.952GlnPhe: 0.952 ± 0.03	2.584GlnGly: 2.584 ± 0.052	0.658GlnHis: 0.658 ± 0.024	1.316GlnIle: 1.316 ± 0.042	0.764GlnLys: 0.764 ± 0.026	3.597GlnLeu: 3.597 ± 0.063	0.624GlnMet: 0.624 ± 0.021	0.599GlnAsn: 0.599 ± 0.026	2.12GlnPro: 2.12 ± 0.046	1.442GlnGln: 1.442 ± 0.042	3.693GlnArg: 3.693 ± 0.067	1.309GlnSer: 1.309 ± 0.038	1.275GlnThr: 1.275 ± 0.036	2.655GlnVal: 2.655 ± 0.057	0.546GlnTrp: 0.546 ± 0.025	0.694GlnTyr: 0.694 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	11.729ArgAla: 11.729 ± 0.142	0.694ArgCys: 0.694 ± 0.029	5.066ArgAsp: 5.066 ± 0.074	5.875ArgGlu: 5.875 ± 0.095	3.268ArgPhe: 3.268 ± 0.063	6.878ArgGly: 6.878 ± 0.085	2.158ArgHis: 2.158 ± 0.05	4.002ArgIle: 4.002 ± 0.067	2.005ArgLys: 2.005 ± 0.048	10.339ArgLeu: 10.339 ± 0.133	1.992ArgMet: 1.992 ± 0.041	1.886ArgAsn: 1.886 ± 0.039	4.616ArgPro: 4.616 ± 0.074	2.989ArgGln: 2.989 ± 0.068	8.409ArgArg: 8.409 ± 0.115	3.521ArgSer: 3.521 ± 0.059	3.504ArgThr: 3.504 ± 0.059	6.0ArgVal: 6.0 ± 0.084	1.628ArgTrp: 1.628 ± 0.046	2.671ArgTyr: 2.671 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	5.849SerAla: 5.849 ± 0.091	0.316SerCys: 0.316 ± 0.017	2.202SerAsp: 2.202 ± 0.056	2.273SerGlu: 2.273 ± 0.052	1.591SerPhe: 1.591 ± 0.046	4.629SerGly: 4.629 ± 0.092	0.89SerHis: 0.89 ± 0.029	1.665SerIle: 1.665 ± 0.049	1.045SerLys: 1.045 ± 0.038	4.573SerLeu: 4.573 ± 0.072	0.754SerMet: 0.754 ± 0.026	1.098SerAsn: 1.098 ± 0.037	2.638SerPro: 2.638 ± 0.059	1.321SerGln: 1.321 ± 0.033	3.502SerArg: 3.502 ± 0.055	2.031SerSer: 2.031 ± 0.051	2.059SerThr: 2.059 ± 0.054	3.156SerVal: 3.156 ± 0.076	0.666SerTrp: 0.666 ± 0.03	1.113SerTyr: 1.113 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.458ThrAla: 5.458 ± 0.106	0.339ThrCys: 0.339 ± 0.02	2.108ThrAsp: 2.108 ± 0.055	2.018ThrGlu: 2.018 ± 0.047	1.323ThrPhe: 1.323 ± 0.045	4.241ThrGly: 4.241 ± 0.075	0.856ThrHis: 0.856 ± 0.033	1.697ThrIle: 1.697 ± 0.048	0.742ThrLys: 0.742 ± 0.03	5.408ThrLeu: 5.408 ± 0.093	0.666ThrMet: 0.666 ± 0.024	0.839ThrAsn: 0.839 ± 0.043	3.17ThrPro: 3.17 ± 0.062	1.212ThrGln: 1.212 ± 0.037	3.34ThrArg: 3.34 ± 0.053	1.674ThrSer: 1.674 ± 0.042	2.038ThrThr: 2.038 ± 0.055	3.832ThrVal: 3.832 ± 0.078	0.596ThrTrp: 0.596 ± 0.023	0.986ThrTyr: 0.986 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	10.469ValAla: 10.469 ± 0.127	0.639ValCys: 0.639 ± 0.024	4.196ValAsp: 4.196 ± 0.067	4.7ValGlu: 4.7 ± 0.078	2.339ValPhe: 2.339 ± 0.051	5.759ValGly: 5.759 ± 0.096	1.474ValHis: 1.474 ± 0.04	2.677ValIle: 2.677 ± 0.057	1.66ValLys: 1.66 ± 0.053	7.939ValLeu: 7.939 ± 0.102	1.227ValMet: 1.227 ± 0.037	1.782ValAsn: 1.782 ± 0.05	4.078ValPro: 4.078 ± 0.059	2.149ValGln: 2.149 ± 0.054	6.077ValArg: 6.077 ± 0.083	3.405ValSer: 3.405 ± 0.062	3.265ValThr: 3.265 ± 0.074	5.707ValVal: 5.707 ± 0.099	0.882ValTrp: 0.882 ± 0.03	1.585ValTyr: 1.585 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.571TrpAla: 1.571 ± 0.045	0.154TrpCys: 0.154 ± 0.011	0.746TrpAsp: 0.746 ± 0.03	0.571TrpGlu: 0.571 ± 0.023	0.558TrpPhe: 0.558 ± 0.024	0.959TrpGly: 0.959 ± 0.034	0.358TrpHis: 0.358 ± 0.02	0.628TrpIle: 0.628 ± 0.024	0.388TrpLys: 0.388 ± 0.022	2.343TrpLeu: 2.343 ± 0.057	0.377TrpMet: 0.377 ± 0.02	0.465TrpAsn: 0.465 ± 0.024	0.846TrpPro: 0.846 ± 0.036	0.696TrpGln: 0.696 ± 0.025	1.803TrpArg: 1.803 ± 0.052	0.843TrpSer: 0.843 ± 0.03	0.724TrpThr: 0.724 ± 0.027	0.894TrpVal: 0.894 ± 0.03	0.326TrpTrp: 0.326 ± 0.019	0.385TrpTyr: 0.385 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.288TyrAla: 3.288 ± 0.065	0.198TyrCys: 0.198 ± 0.013	1.46TyrAsp: 1.46 ± 0.045	1.203TyrGlu: 1.203 ± 0.036	0.838TyrPhe: 0.838 ± 0.03	2.265TyrGly: 2.265 ± 0.061	0.506TyrHis: 0.506 ± 0.023	0.604TyrIle: 0.604 ± 0.025	0.516TyrLys: 0.516 ± 0.027	2.579TyrLeu: 2.579 ± 0.055	0.33TyrMet: 0.33 ± 0.019	0.587TyrAsn: 0.587 ± 0.034	1.186TyrPro: 1.186 ± 0.035	0.706TyrGln: 0.706 ± 0.024	2.421TyrArg: 2.421 ± 0.052	1.05TyrSer: 1.05 ± 0.04	1.088TyrThr: 1.088 ± 0.038	1.777TyrVal: 1.777 ± 0.041	0.405TyrTrp: 0.405 ± 0.022	0.646TyrTyr: 0.646 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3153 proteins (1042108 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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