Amino acid dipepetide frequency for Marmoricola mangrovicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.45AlaAla: 19.45 ± 0.196	1.015AlaCys: 1.015 ± 0.034	8.546AlaAsp: 8.546 ± 0.088	8.175AlaGlu: 8.175 ± 0.098	3.572AlaPhe: 3.572 ± 0.063	12.752AlaGly: 12.752 ± 0.119	2.746AlaHis: 2.746 ± 0.05	3.956AlaIle: 3.956 ± 0.073	2.564AlaLys: 2.564 ± 0.064	13.55AlaLeu: 13.55 ± 0.136	2.849AlaMet: 2.849 ± 0.051	1.977AlaAsn: 1.977 ± 0.044	5.79AlaPro: 5.79 ± 0.081	3.891AlaGln: 3.891 ± 0.059	9.493AlaArg: 9.493 ± 0.092	6.617AlaSer: 6.617 ± 0.076	7.572AlaThr: 7.572 ± 0.087	12.215AlaVal: 12.215 ± 0.116	1.981AlaTrp: 1.981 ± 0.043	2.643AlaTyr: 2.643 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.833CysAla: 0.833 ± 0.026	0.107CysCys: 0.107 ± 0.009	0.468CysAsp: 0.468 ± 0.019	0.426CysGlu: 0.426 ± 0.02	0.239CysPhe: 0.239 ± 0.013	0.916CysGly: 0.916 ± 0.032	0.201CysHis: 0.201 ± 0.014	0.171CysIle: 0.171 ± 0.012	0.099CysLys: 0.099 ± 0.009	0.704CysLeu: 0.704 ± 0.025	0.1CysMet: 0.1 ± 0.009	0.132CysAsn: 0.132 ± 0.009	0.403CysPro: 0.403 ± 0.018	0.171CysGln: 0.171 ± 0.012	0.565CysArg: 0.565 ± 0.023	0.436CysSer: 0.436 ± 0.019	0.439CysThr: 0.439 ± 0.022	0.648CysVal: 0.648 ± 0.023	0.125CysTrp: 0.125 ± 0.012	0.166CysTyr: 0.166 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.01AspAla: 8.01 ± 0.08	0.372AspCys: 0.372 ± 0.019	4.541AspAsp: 4.541 ± 0.075	3.845AspGlu: 3.845 ± 0.066	1.531AspPhe: 1.531 ± 0.038	5.853AspGly: 5.853 ± 0.073	1.638AspHis: 1.638 ± 0.042	1.622AspIle: 1.622 ± 0.041	1.054AspLys: 1.054 ± 0.038	7.447AspLeu: 7.447 ± 0.083	0.735AspMet: 0.735 ± 0.026	0.884AspAsn: 0.884 ± 0.03	4.577AspPro: 4.577 ± 0.062	1.885AspGln: 1.885 ± 0.04	4.824AspArg: 4.824 ± 0.074	2.483AspSer: 2.483 ± 0.052	2.708AspThr: 2.708 ± 0.051	6.554AspVal: 6.554 ± 0.076	0.955AspTrp: 0.955 ± 0.027	1.19AspTyr: 1.19 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.888GluAla: 6.888 ± 0.102	0.29GluCys: 0.29 ± 0.016	2.939GluAsp: 2.939 ± 0.057	3.413GluGlu: 3.413 ± 0.071	1.25GluPhe: 1.25 ± 0.037	4.032GluGly: 4.032 ± 0.065	1.803GluHis: 1.803 ± 0.039	2.151GluIle: 2.151 ± 0.05	1.157GluLys: 1.157 ± 0.036	6.479GluLeu: 6.479 ± 0.089	0.977GluMet: 0.977 ± 0.032	0.876GluAsn: 0.876 ± 0.029	3.234GluPro: 3.234 ± 0.063	2.591GluGln: 2.591 ± 0.055	5.363GluArg: 5.363 ± 0.082	2.503GluSer: 2.503 ± 0.055	2.827GluThr: 2.827 ± 0.049	5.56GluVal: 5.56 ± 0.076	0.739GluTrp: 0.739 ± 0.026	0.936GluTyr: 0.936 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.753PheAla: 3.753 ± 0.064	0.281PheCys: 0.281 ± 0.016	2.029PheAsp: 2.029 ± 0.041	1.538PheGlu: 1.538 ± 0.037	0.883PhePhe: 0.883 ± 0.03	3.135PheGly: 3.135 ± 0.056	0.589PheHis: 0.589 ± 0.025	0.709PheIle: 0.709 ± 0.023	0.479PheLys: 0.479 ± 0.018	2.591PheLeu: 2.591 ± 0.05	0.408PheMet: 0.408 ± 0.021	0.56PheAsn: 0.56 ± 0.024	1.24PhePro: 1.24 ± 0.027	0.553PheGln: 0.553 ± 0.022	1.679PheArg: 1.679 ± 0.037	1.524PheSer: 1.524 ± 0.032	1.78PheThr: 1.78 ± 0.038	2.76PheVal: 2.76 ± 0.05	0.471PheTrp: 0.471 ± 0.017	0.621PheTyr: 0.621 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.218GlyAla: 10.218 ± 0.095	0.829GlyCys: 0.829 ± 0.023	5.199GlyAsp: 5.199 ± 0.061	5.073GlyGlu: 5.073 ± 0.07	3.224GlyPhe: 3.224 ± 0.054	8.151GlyGly: 8.151 ± 0.101	2.183GlyHis: 2.183 ± 0.04	3.422GlyIle: 3.422 ± 0.054	1.967GlyLys: 1.967 ± 0.039	9.884GlyLeu: 9.884 ± 0.099	1.881GlyMet: 1.881 ± 0.04	1.578GlyAsn: 1.578 ± 0.041	4.376GlyPro: 4.376 ± 0.065	2.692GlyGln: 2.692 ± 0.054	7.466GlyArg: 7.466 ± 0.083	5.628GlySer: 5.628 ± 0.08	5.754GlyThr: 5.754 ± 0.083	8.684GlyVal: 8.684 ± 0.088	1.783GlyTrp: 1.783 ± 0.044	2.344GlyTyr: 2.344 ± 0.042	0.001GlyXaa: 0.001 ± 0.001
His	2.738HisAla: 2.738 ± 0.05	0.164HisCys: 0.164 ± 0.013	1.622HisAsp: 1.622 ± 0.032	1.316HisGlu: 1.316 ± 0.036	0.596HisPhe: 0.596 ± 0.021	2.33HisGly: 2.33 ± 0.04	0.789HisHis: 0.789 ± 0.026	0.499HisIle: 0.499 ± 0.019	0.282HisLys: 0.282 ± 0.016	2.528HisLeu: 2.528 ± 0.044	0.276HisMet: 0.276 ± 0.016	0.353HisAsn: 0.353 ± 0.019	1.704HisPro: 1.704 ± 0.04	0.759HisGln: 0.759 ± 0.027	2.131HisArg: 2.131 ± 0.045	0.895HisSer: 0.895 ± 0.027	1.106HisThr: 1.106 ± 0.029	2.189HisVal: 2.189 ± 0.042	0.373HisTrp: 0.373 ± 0.018	0.479HisTyr: 0.479 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.679IleAla: 4.679 ± 0.07	0.262IleCys: 0.262 ± 0.017	2.26IleAsp: 2.26 ± 0.047	1.992IleGlu: 1.992 ± 0.047	0.753IlePhe: 0.753 ± 0.027	3.665IleGly: 3.665 ± 0.061	0.592IleHis: 0.592 ± 0.019	0.878IleIle: 0.878 ± 0.031	0.673IleLys: 0.673 ± 0.027	2.301IleLeu: 2.301 ± 0.047	0.404IleMet: 0.404 ± 0.019	0.652IleAsn: 0.652 ± 0.026	1.58IlePro: 1.58 ± 0.038	0.671IleGln: 0.671 ± 0.023	2.003IleArg: 2.003 ± 0.049	1.736IleSer: 1.736 ± 0.039	2.106IleThr: 2.106 ± 0.046	3.002IleVal: 3.002 ± 0.06	0.385IleTrp: 0.385 ± 0.019	0.573IleTyr: 0.573 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.453LysAla: 2.453 ± 0.057	0.076LysCys: 0.076 ± 0.009	1.041LysAsp: 1.041 ± 0.034	0.851LysGlu: 0.851 ± 0.031	0.386LysPhe: 0.386 ± 0.018	1.542LysGly: 1.542 ± 0.042	0.38LysHis: 0.38 ± 0.019	0.762LysIle: 0.762 ± 0.028	0.786LysLys: 0.786 ± 0.039	1.704LysLeu: 1.704 ± 0.046	0.345LysMet: 0.345 ± 0.016	0.418LysAsn: 0.418 ± 0.022	1.166LysPro: 1.166 ± 0.036	0.755LysGln: 0.755 ± 0.026	1.332LysArg: 1.332 ± 0.039	1.022LysSer: 1.022 ± 0.03	1.152LysThr: 1.152 ± 0.036	1.844LysVal: 1.844 ± 0.047	0.191LysTrp: 0.191 ± 0.011	0.392LysTyr: 0.392 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.687LeuAla: 15.687 ± 0.151	0.745LeuCys: 0.745 ± 0.025	7.149LeuAsp: 7.149 ± 0.084	5.379LeuGlu: 5.379 ± 0.079	2.51LeuPhe: 2.51 ± 0.045	10.081LeuGly: 10.081 ± 0.094	2.156LeuHis: 2.156 ± 0.04	2.763LeuIle: 2.763 ± 0.052	1.623LeuLys: 1.623 ± 0.04	11.388LeuLeu: 11.388 ± 0.146	1.58LeuMet: 1.58 ± 0.039	1.642LeuAsn: 1.642 ± 0.042	5.892LeuPro: 5.892 ± 0.071	2.606LeuGln: 2.606 ± 0.044	8.162LeuArg: 8.162 ± 0.093	5.467LeuSer: 5.467 ± 0.073	6.311LeuThr: 6.311 ± 0.072	11.318LeuVal: 11.318 ± 0.125	1.239LeuTrp: 1.239 ± 0.036	1.624LeuTyr: 1.624 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.19MetAla: 2.19 ± 0.042	0.152MetCys: 0.152 ± 0.009	0.817MetAsp: 0.817 ± 0.025	0.719MetGlu: 0.719 ± 0.025	0.478MetPhe: 0.478 ± 0.017	1.381MetGly: 1.381 ± 0.029	0.364MetHis: 0.364 ± 0.015	0.629MetIle: 0.629 ± 0.025	0.385MetLys: 0.385 ± 0.02	1.887MetLeu: 1.887 ± 0.04	0.32MetMet: 0.32 ± 0.018	0.396MetAsn: 0.396 ± 0.018	1.105MetPro: 1.105 ± 0.031	0.452MetGln: 0.452 ± 0.018	1.542MetArg: 1.542 ± 0.037	1.42MetSer: 1.42 ± 0.034	1.529MetThr: 1.529 ± 0.032	1.561MetVal: 1.561 ± 0.043	0.208MetTrp: 0.208 ± 0.012	0.283MetTyr: 0.283 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.181AsnAla: 2.181 ± 0.046	0.12AsnCys: 0.12 ± 0.009	1.017AsnAsp: 1.017 ± 0.03	0.724AsnGlu: 0.724 ± 0.026	0.457AsnPhe: 0.457 ± 0.021	1.688AsnGly: 1.688 ± 0.043	0.376AsnHis: 0.376 ± 0.017	0.622AsnIle: 0.622 ± 0.024	0.353AsnLys: 0.353 ± 0.023	1.85AsnLeu: 1.85 ± 0.048	0.249AsnMet: 0.249 ± 0.014	0.394AsnAsn: 0.394 ± 0.022	1.266AsnPro: 1.266 ± 0.035	0.561AsnGln: 0.561 ± 0.026	1.205AsnArg: 1.205 ± 0.033	0.798AsnSer: 0.798 ± 0.029	0.957AsnThr: 0.957 ± 0.029	1.499AsnVal: 1.499 ± 0.046	0.245AsnTrp: 0.245 ± 0.016	0.371AsnTyr: 0.371 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.325ProAla: 7.325 ± 0.09	0.298ProCys: 0.298 ± 0.015	4.25ProAsp: 4.25 ± 0.068	3.658ProGlu: 3.658 ± 0.061	1.538ProPhe: 1.538 ± 0.036	5.508ProGly: 5.508 ± 0.077	1.279ProHis: 1.279 ± 0.032	1.501ProIle: 1.501 ± 0.033	0.921ProLys: 0.921 ± 0.031	4.876ProLeu: 4.876 ± 0.069	0.962ProMet: 0.962 ± 0.027	0.825ProAsn: 0.825 ± 0.022	2.587ProPro: 2.587 ± 0.054	1.627ProGln: 1.627 ± 0.035	3.597ProArg: 3.597 ± 0.056	3.041ProSer: 3.041 ± 0.068	3.634ProThr: 3.634 ± 0.057	5.167ProVal: 5.167 ± 0.069	0.929ProTrp: 0.929 ± 0.029	1.148ProTyr: 1.148 ± 0.034	0.002ProXaa: 0.002 ± 0.001
Gln	4.013GlnAla: 4.013 ± 0.06	0.17GlnCys: 0.17 ± 0.013	1.303GlnAsp: 1.303 ± 0.035	1.331GlnGlu: 1.331 ± 0.037	0.675GlnPhe: 0.675 ± 0.025	2.229GlnGly: 2.229 ± 0.051	0.764GlnHis: 0.764 ± 0.024	1.151GlnIle: 1.151 ± 0.032	0.554GlnLys: 0.554 ± 0.023	3.304GlnLeu: 3.304 ± 0.055	0.557GlnMet: 0.557 ± 0.02	0.526GlnAsn: 0.526 ± 0.019	1.669GlnPro: 1.669 ± 0.036	1.455GlnGln: 1.455 ± 0.035	2.753GlnArg: 2.753 ± 0.051	1.293GlnSer: 1.293 ± 0.04	1.57GlnThr: 1.57 ± 0.036	3.139GlnVal: 3.139 ± 0.049	0.439GlnTrp: 0.439 ± 0.019	0.528GlnTyr: 0.528 ± 0.022	0.001GlnXaa: 0.001 ± 0.001
Arg	9.032ArgAla: 9.032 ± 0.111	0.53ArgCys: 0.53 ± 0.022	4.403ArgAsp: 4.403 ± 0.058	4.815ArgGlu: 4.815 ± 0.077	2.356ArgPhe: 2.356 ± 0.04	5.693ArgGly: 5.693 ± 0.072	2.058ArgHis: 2.058 ± 0.042	2.821ArgIle: 2.821 ± 0.057	1.207ArgLys: 1.207 ± 0.039	8.906ArgLeu: 8.906 ± 0.099	1.729ArgMet: 1.729 ± 0.038	1.19ArgAsn: 1.19 ± 0.032	4.351ArgPro: 4.351 ± 0.069	2.234ArgGln: 2.234 ± 0.046	7.827ArgArg: 7.827 ± 0.109	4.392ArgSer: 4.392 ± 0.063	4.797ArgThr: 4.797 ± 0.067	6.604ArgVal: 6.604 ± 0.081	1.39ArgTrp: 1.39 ± 0.035	1.699ArgTyr: 1.699 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.684SerAla: 6.684 ± 0.084	0.4SerCys: 0.4 ± 0.02	2.922SerAsp: 2.922 ± 0.045	2.352SerGlu: 2.352 ± 0.053	1.689SerPhe: 1.689 ± 0.034	5.788SerGly: 5.788 ± 0.088	1.13SerHis: 1.13 ± 0.033	1.783SerIle: 1.783 ± 0.044	0.976SerLys: 0.976 ± 0.03	5.326SerLeu: 5.326 ± 0.065	1.226SerMet: 1.226 ± 0.035	0.952SerAsn: 0.952 ± 0.031	2.954SerPro: 2.954 ± 0.052	1.559SerGln: 1.559 ± 0.04	3.878SerArg: 3.878 ± 0.059	3.751SerSer: 3.751 ± 0.085	3.549SerThr: 3.549 ± 0.065	4.765SerVal: 4.765 ± 0.064	0.962SerTrp: 0.962 ± 0.025	1.325SerTyr: 1.325 ± 0.034	0.001SerXaa: 0.001 ± 0.001
Thr	7.47ThrAla: 7.47 ± 0.092	0.45ThrCys: 0.45 ± 0.021	3.576ThrAsp: 3.576 ± 0.056	2.75ThrGlu: 2.75 ± 0.048	1.743ThrPhe: 1.743 ± 0.039	6.027ThrGly: 6.027 ± 0.079	1.184ThrHis: 1.184 ± 0.034	2.014ThrIle: 2.014 ± 0.044	1.221ThrLys: 1.221 ± 0.038	5.759ThrLeu: 5.759 ± 0.073	1.119ThrMet: 1.119 ± 0.03	1.114ThrAsn: 1.114 ± 0.035	3.766ThrPro: 3.766 ± 0.058	1.617ThrGln: 1.617 ± 0.039	3.941ThrArg: 3.941 ± 0.055	3.843ThrSer: 3.843 ± 0.072	4.303ThrThr: 4.303 ± 0.077	5.55ThrVal: 5.55 ± 0.07	0.991ThrTrp: 0.991 ± 0.026	1.426ThrTyr: 1.426 ± 0.034	0.001ThrXaa: 0.001 ± 0.001
Val	13.402ValAla: 13.402 ± 0.123	0.77ValCys: 0.77 ± 0.024	6.236ValAsp: 6.236 ± 0.071	5.844ValGlu: 5.844 ± 0.079	2.524ValPhe: 2.524 ± 0.051	8.545ValGly: 8.545 ± 0.096	2.141ValHis: 2.141 ± 0.037	2.807ValIle: 2.807 ± 0.06	1.7ValLys: 1.7 ± 0.044	10.769ValLeu: 10.769 ± 0.109	1.624ValMet: 1.624 ± 0.034	1.72ValAsn: 1.72 ± 0.043	5.178ValPro: 5.178 ± 0.067	2.17ValGln: 2.17 ± 0.043	7.329ValArg: 7.329 ± 0.082	5.075ValSer: 5.075 ± 0.074	5.722ValThr: 5.722 ± 0.084	11.945ValVal: 11.945 ± 0.123	1.235ValTrp: 1.235 ± 0.032	1.569ValTyr: 1.569 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.598TrpAla: 1.598 ± 0.037	0.15TrpCys: 0.15 ± 0.01	0.806TrpAsp: 0.806 ± 0.025	0.688TrpGlu: 0.688 ± 0.025	0.558TrpPhe: 0.558 ± 0.022	1.054TrpGly: 1.054 ± 0.034	0.393TrpHis: 0.393 ± 0.02	0.472TrpIle: 0.472 ± 0.019	0.272TrpLys: 0.272 ± 0.014	1.936TrpLeu: 1.936 ± 0.042	0.256TrpMet: 0.256 ± 0.014	0.36TrpAsn: 0.36 ± 0.018	0.793TrpPro: 0.793 ± 0.029	0.606TrpGln: 0.606 ± 0.02	1.353TrpArg: 1.353 ± 0.036	1.041TrpSer: 1.041 ± 0.034	0.997TrpThr: 0.997 ± 0.027	1.308TrpVal: 1.308 ± 0.035	0.381TrpTrp: 0.381 ± 0.018	0.302TrpTyr: 0.302 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.751TyrAla: 2.751 ± 0.049	0.168TyrCys: 0.168 ± 0.012	1.583TyrAsp: 1.583 ± 0.037	1.117TyrGlu: 1.117 ± 0.03	0.621TyrPhe: 0.621 ± 0.026	1.969TyrGly: 1.969 ± 0.041	0.361TyrHis: 0.361 ± 0.017	0.431TyrIle: 0.431 ± 0.019	0.325TyrLys: 0.325 ± 0.018	2.13TyrLeu: 2.13 ± 0.051	0.221TyrMet: 0.221 ± 0.014	0.384TyrAsn: 0.384 ± 0.018	1.043TyrPro: 1.043 ± 0.03	0.569TyrGln: 0.569 ± 0.021	1.592TyrArg: 1.592 ± 0.038	1.01TyrSer: 1.01 ± 0.03	1.051TyrThr: 1.051 ± 0.031	1.991TyrVal: 1.991 ± 0.039	0.298TyrTrp: 0.298 ± 0.014	0.469TyrTyr: 0.469 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.001XaaGln: 0.001 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 3882 proteins (1253811 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---