Amino acid dipepetide frequency for Chryseobacterium piperi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.206AlaAla: 4.206 ± 0.085	0.517AlaCys: 0.517 ± 0.025	3.346AlaAsp: 3.346 ± 0.057	4.102AlaGlu: 4.102 ± 0.067	3.117AlaPhe: 3.117 ± 0.056	4.354AlaGly: 4.354 ± 0.08	1.045AlaHis: 1.045 ± 0.033	4.715AlaIle: 4.715 ± 0.071	4.655AlaLys: 4.655 ± 0.069	5.799AlaLeu: 5.799 ± 0.081	1.532AlaMet: 1.532 ± 0.04	3.227AlaAsn: 3.227 ± 0.058	1.839AlaPro: 1.839 ± 0.039	2.574AlaGln: 2.574 ± 0.055	1.955AlaArg: 1.955 ± 0.046	4.0AlaSer: 4.0 ± 0.07	3.359AlaThr: 3.359 ± 0.067	4.083AlaVal: 4.083 ± 0.074	0.616AlaTrp: 0.616 ± 0.022	2.479AlaTyr: 2.479 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.395CysAla: 0.395 ± 0.02	0.086CysCys: 0.086 ± 0.009	0.346CysAsp: 0.346 ± 0.017	0.382CysGlu: 0.382 ± 0.016	0.389CysPhe: 0.389 ± 0.019	0.6CysGly: 0.6 ± 0.026	0.178CysHis: 0.178 ± 0.012	0.597CysIle: 0.597 ± 0.026	0.452CysLys: 0.452 ± 0.021	0.605CysLeu: 0.605 ± 0.024	0.173CysMet: 0.173 ± 0.013	0.362CysAsn: 0.362 ± 0.016	0.318CysPro: 0.318 ± 0.021	0.156CysGln: 0.156 ± 0.012	0.213CysArg: 0.213 ± 0.013	0.528CysSer: 0.528 ± 0.021	0.418CysThr: 0.418 ± 0.023	0.428CysVal: 0.428 ± 0.019	0.052CysTrp: 0.052 ± 0.006	0.277CysTyr: 0.277 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.267AspAla: 3.267 ± 0.054	0.335AspCys: 0.335 ± 0.018	2.611AspAsp: 2.611 ± 0.047	3.798AspGlu: 3.798 ± 0.068	3.723AspPhe: 3.723 ± 0.064	3.387AspGly: 3.387 ± 0.056	1.104AspHis: 1.104 ± 0.029	4.258AspIle: 4.258 ± 0.064	4.183AspLys: 4.183 ± 0.073	5.127AspLeu: 5.127 ± 0.07	1.136AspMet: 1.136 ± 0.034	2.847AspAsn: 2.847 ± 0.055	1.827AspPro: 1.827 ± 0.044	1.95AspGln: 1.95 ± 0.046	1.91AspArg: 1.91 ± 0.04	2.892AspSer: 2.892 ± 0.053	2.401AspThr: 2.401 ± 0.047	3.233AspVal: 3.233 ± 0.05	0.785AspTrp: 0.785 ± 0.027	2.81AspTyr: 2.81 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	3.94GluAla: 3.94 ± 0.058	0.347GluCys: 0.347 ± 0.019	3.337GluAsp: 3.337 ± 0.071	4.844GluGlu: 4.844 ± 0.093	3.007GluPhe: 3.007 ± 0.05	3.556GluGly: 3.556 ± 0.063	1.037GluHis: 1.037 ± 0.031	5.651GluIle: 5.651 ± 0.085	6.724GluLys: 6.724 ± 0.091	5.704GluLeu: 5.704 ± 0.072	1.692GluMet: 1.692 ± 0.038	4.976GluAsn: 4.976 ± 0.076	1.445GluPro: 1.445 ± 0.036	2.23GluGln: 2.23 ± 0.037	2.411GluArg: 2.411 ± 0.052	3.352GluSer: 3.352 ± 0.055	3.329GluThr: 3.329 ± 0.048	4.112GluVal: 4.112 ± 0.066	0.728GluTrp: 0.728 ± 0.028	2.554GluTyr: 2.554 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.078PheAla: 3.078 ± 0.059	0.433PheCys: 0.433 ± 0.018	3.0PheAsp: 3.0 ± 0.047	3.169PheGlu: 3.169 ± 0.058	2.882PhePhe: 2.882 ± 0.068	3.698PheGly: 3.698 ± 0.062	0.909PheHis: 0.909 ± 0.027	4.15PheIle: 4.15 ± 0.072	3.664PheLys: 3.664 ± 0.059	4.916PheLeu: 4.916 ± 0.08	1.204PheMet: 1.204 ± 0.031	3.389PheAsn: 3.389 ± 0.06	1.95PhePro: 1.95 ± 0.044	1.681PheGln: 1.681 ± 0.044	1.798PheArg: 1.798 ± 0.038	4.163PheSer: 4.163 ± 0.062	3.107PheThr: 3.107 ± 0.055	2.984PheVal: 2.984 ± 0.058	0.628PheTrp: 0.628 ± 0.028	2.345PheTyr: 2.345 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.078GlyAla: 4.078 ± 0.082	0.502GlyCys: 0.502 ± 0.022	3.096GlyAsp: 3.096 ± 0.053	3.463GlyGlu: 3.463 ± 0.053	3.665GlyPhe: 3.665 ± 0.062	4.795GlyGly: 4.795 ± 0.099	1.053GlyHis: 1.053 ± 0.033	5.588GlyIle: 5.588 ± 0.074	5.483GlyLys: 5.483 ± 0.076	5.608GlyLeu: 5.608 ± 0.082	1.675GlyMet: 1.675 ± 0.042	4.11GlyAsn: 4.11 ± 0.075	1.272GlyPro: 1.272 ± 0.037	2.04GlyGln: 2.04 ± 0.047	2.165GlyArg: 2.165 ± 0.047	4.216GlySer: 4.216 ± 0.066	3.97GlyThr: 3.97 ± 0.075	4.228GlyVal: 4.228 ± 0.057	0.818GlyTrp: 0.818 ± 0.03	3.066GlyTyr: 3.066 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.919HisAla: 0.919 ± 0.03	0.173HisCys: 0.173 ± 0.012	0.849HisAsp: 0.849 ± 0.027	1.021HisGlu: 1.021 ± 0.031	1.13HisPhe: 1.13 ± 0.037	1.011HisGly: 1.011 ± 0.034	0.501HisHis: 0.501 ± 0.025	1.36HisIle: 1.36 ± 0.035	1.131HisLys: 1.131 ± 0.027	1.712HisLeu: 1.712 ± 0.038	0.352HisMet: 0.352 ± 0.018	0.892HisAsn: 0.892 ± 0.026	0.93HisPro: 0.93 ± 0.028	0.751HisGln: 0.751 ± 0.028	0.61HisArg: 0.61 ± 0.024	1.158HisSer: 1.158 ± 0.029	0.866HisThr: 0.866 ± 0.027	0.796HisVal: 0.796 ± 0.024	0.225HisTrp: 0.225 ± 0.015	0.854HisTyr: 0.854 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.199IleAla: 5.199 ± 0.074	0.661IleCys: 0.661 ± 0.028	4.573IleAsp: 4.573 ± 0.065	5.129IleGlu: 5.129 ± 0.074	3.974IlePhe: 3.974 ± 0.072	5.042IleGly: 5.042 ± 0.079	1.425IleHis: 1.425 ± 0.035	6.315IleIle: 6.315 ± 0.106	5.922IleLys: 5.922 ± 0.078	7.428IleLeu: 7.428 ± 0.109	1.502IleMet: 1.502 ± 0.035	4.836IleAsn: 4.836 ± 0.072	3.492IlePro: 3.492 ± 0.052	2.826IleGln: 2.826 ± 0.05	2.574IleArg: 2.574 ± 0.054	6.145IleSer: 6.145 ± 0.073	4.622IleThr: 4.622 ± 0.07	4.417IleVal: 4.417 ± 0.058	0.733IleTrp: 0.733 ± 0.027	2.992IleTyr: 2.992 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.868LysAla: 4.868 ± 0.079	0.309LysCys: 0.309 ± 0.016	4.984LysAsp: 4.984 ± 0.068	6.364LysGlu: 6.364 ± 0.092	3.301LysPhe: 3.301 ± 0.058	4.582LysGly: 4.582 ± 0.068	1.206LysHis: 1.206 ± 0.031	6.976LysIle: 6.976 ± 0.088	7.343LysLys: 7.343 ± 0.11	6.45LysLeu: 6.45 ± 0.081	2.341LysMet: 2.341 ± 0.051	6.118LysAsn: 6.118 ± 0.081	2.476LysPro: 2.476 ± 0.046	2.597LysGln: 2.597 ± 0.049	2.661LysArg: 2.661 ± 0.044	4.687LysSer: 4.687 ± 0.065	4.815LysThr: 4.815 ± 0.069	4.881LysVal: 4.881 ± 0.063	0.736LysTrp: 0.736 ± 0.026	3.164LysTyr: 3.164 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.574LeuAla: 5.574 ± 0.072	0.672LeuCys: 0.672 ± 0.023	4.694LeuAsp: 4.694 ± 0.067	5.728LeuGlu: 5.728 ± 0.077	4.749LeuPhe: 4.749 ± 0.078	6.044LeuGly: 6.044 ± 0.074	1.523LeuHis: 1.523 ± 0.036	6.922LeuIle: 6.922 ± 0.087	7.856LeuLys: 7.856 ± 0.084	8.315LeuLeu: 8.315 ± 0.112	2.23LeuMet: 2.23 ± 0.047	5.591LeuAsn: 5.591 ± 0.08	3.662LeuPro: 3.662 ± 0.056	3.36LeuGln: 3.36 ± 0.06	3.033LeuArg: 3.033 ± 0.051	6.737LeuSer: 6.737 ± 0.08	4.801LeuThr: 4.801 ± 0.07	4.967LeuVal: 4.967 ± 0.082	0.833LeuTrp: 0.833 ± 0.029	3.272LeuTyr: 3.272 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.504MetAla: 1.504 ± 0.038	0.125MetCys: 0.125 ± 0.01	1.222MetAsp: 1.222 ± 0.033	1.546MetGlu: 1.546 ± 0.041	0.908MetPhe: 0.908 ± 0.031	1.526MetGly: 1.526 ± 0.038	0.371MetHis: 0.371 ± 0.016	1.78MetIle: 1.78 ± 0.042	2.659MetLys: 2.659 ± 0.055	2.034MetLeu: 2.034 ± 0.045	0.737MetMet: 0.737 ± 0.032	1.554MetAsn: 1.554 ± 0.041	0.869MetPro: 0.869 ± 0.025	0.811MetGln: 0.811 ± 0.025	0.871MetArg: 0.871 ± 0.027	1.486MetSer: 1.486 ± 0.037	1.175MetThr: 1.175 ± 0.034	1.451MetVal: 1.451 ± 0.039	0.16MetTrp: 0.16 ± 0.011	0.766MetTyr: 0.766 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.733AsnAla: 3.733 ± 0.069	0.394AsnCys: 0.394 ± 0.02	3.087AsnAsp: 3.087 ± 0.063	3.685AsnGlu: 3.685 ± 0.049	3.517AsnPhe: 3.517 ± 0.059	4.28AsnGly: 4.28 ± 0.076	1.134AsnHis: 1.134 ± 0.031	5.319AsnIle: 5.319 ± 0.072	4.397AsnLys: 4.397 ± 0.075	5.614AsnLeu: 5.614 ± 0.073	1.303AsnMet: 1.303 ± 0.034	4.233AsnAsn: 4.233 ± 0.084	2.939AsnPro: 2.939 ± 0.055	2.385AsnGln: 2.385 ± 0.054	2.125AsnArg: 2.125 ± 0.041	4.024AsnSer: 4.024 ± 0.077	3.648AsnThr: 3.648 ± 0.059	3.513AsnVal: 3.513 ± 0.054	0.752AsnTrp: 0.752 ± 0.027	3.065AsnTyr: 3.065 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	2.196ProAla: 2.196 ± 0.047	0.202ProCys: 0.202 ± 0.014	2.178ProAsp: 2.178 ± 0.047	2.973ProGlu: 2.973 ± 0.056	1.955ProPhe: 1.955 ± 0.042	2.14ProGly: 2.14 ± 0.044	0.559ProHis: 0.559 ± 0.023	2.482ProIle: 2.482 ± 0.048	2.621ProLys: 2.621 ± 0.054	2.925ProLeu: 2.925 ± 0.049	0.782ProMet: 0.782 ± 0.029	2.26ProAsn: 2.26 ± 0.048	0.776ProPro: 0.776 ± 0.034	1.354ProGln: 1.354 ± 0.035	0.947ProArg: 0.947 ± 0.029	2.291ProSer: 2.291 ± 0.046	1.98ProThr: 1.98 ± 0.044	2.677ProVal: 2.677 ± 0.049	0.328ProTrp: 0.328 ± 0.018	1.455ProTyr: 1.455 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.971GlnAla: 1.971 ± 0.049	0.167GlnCys: 0.167 ± 0.013	1.734GlnAsp: 1.734 ± 0.038	2.339GlnGlu: 2.339 ± 0.049	1.786GlnPhe: 1.786 ± 0.037	1.91GlnGly: 1.91 ± 0.04	0.613GlnHis: 0.613 ± 0.021	2.762GlnIle: 2.762 ± 0.045	3.434GlnLys: 3.434 ± 0.06	3.495GlnLeu: 3.495 ± 0.058	0.887GlnMet: 0.887 ± 0.024	2.643GlnAsn: 2.643 ± 0.051	1.229GlnPro: 1.229 ± 0.034	1.585GlnGln: 1.585 ± 0.043	1.306GlnArg: 1.306 ± 0.038	2.244GlnSer: 2.244 ± 0.048	1.967GlnThr: 1.967 ± 0.046	1.997GlnVal: 1.997 ± 0.05	0.45GlnTrp: 0.45 ± 0.02	1.675GlnTyr: 1.675 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.899ArgAla: 1.899 ± 0.045	0.184ArgCys: 0.184 ± 0.014	1.713ArgAsp: 1.713 ± 0.044	2.178ArgGlu: 2.178 ± 0.042	1.895ArgPhe: 1.895 ± 0.037	1.828ArgGly: 1.828 ± 0.04	0.535ArgHis: 0.535 ± 0.023	2.891ArgIle: 2.891 ± 0.051	3.006ArgLys: 3.006 ± 0.054	3.063ArgLeu: 3.063 ± 0.06	0.948ArgMet: 0.948 ± 0.027	2.335ArgAsn: 2.335 ± 0.052	1.096ArgPro: 1.096 ± 0.034	1.148ArgGln: 1.148 ± 0.033	1.272ArgArg: 1.272 ± 0.038	1.944ArgSer: 1.944 ± 0.043	1.86ArgThr: 1.86 ± 0.043	2.034ArgVal: 2.034 ± 0.044	0.372ArgTrp: 0.372 ± 0.017	1.451ArgTyr: 1.451 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.028SerAla: 4.028 ± 0.059	0.587SerCys: 0.587 ± 0.022	3.495SerAsp: 3.495 ± 0.054	4.073SerGlu: 4.073 ± 0.073	3.782SerPhe: 3.782 ± 0.06	4.901SerGly: 4.901 ± 0.071	1.109SerHis: 1.109 ± 0.031	5.177SerIle: 5.177 ± 0.07	4.801SerLys: 4.801 ± 0.062	6.196SerLeu: 6.196 ± 0.082	1.444SerMet: 1.444 ± 0.038	3.671SerAsn: 3.671 ± 0.06	2.309SerPro: 2.309 ± 0.043	2.49SerGln: 2.49 ± 0.045	2.135SerArg: 2.135 ± 0.047	4.41SerSer: 4.41 ± 0.075	3.622SerThr: 3.622 ± 0.063	4.17SerVal: 4.17 ± 0.061	0.764SerTrp: 0.764 ± 0.029	2.848SerTyr: 2.848 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.76ThrAla: 3.76 ± 0.065	0.332ThrCys: 0.332 ± 0.02	3.106ThrAsp: 3.106 ± 0.053	3.461ThrGlu: 3.461 ± 0.054	2.903ThrPhe: 2.903 ± 0.054	4.048ThrGly: 4.048 ± 0.067	0.953ThrHis: 0.953 ± 0.025	4.332ThrIle: 4.332 ± 0.059	3.774ThrLys: 3.774 ± 0.057	5.096ThrLeu: 5.096 ± 0.069	1.029ThrMet: 1.029 ± 0.028	3.042ThrAsn: 3.042 ± 0.062	2.526ThrPro: 2.526 ± 0.05	2.087ThrGln: 2.087 ± 0.044	1.67ThrArg: 1.67 ± 0.041	3.713ThrSer: 3.713 ± 0.067	3.364ThrThr: 3.364 ± 0.071	3.559ThrVal: 3.559 ± 0.067	0.554ThrTrp: 0.554 ± 0.021	2.316ThrTyr: 2.316 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	3.851ValAla: 3.851 ± 0.068	0.493ValCys: 0.493 ± 0.021	3.161ValAsp: 3.161 ± 0.053	3.69ValGlu: 3.69 ± 0.068	3.211ValPhe: 3.211 ± 0.057	3.789ValGly: 3.789 ± 0.061	0.9ValHis: 0.9 ± 0.029	4.739ValIle: 4.739 ± 0.064	4.734ValLys: 4.734 ± 0.066	5.628ValLeu: 5.628 ± 0.09	1.413ValMet: 1.413 ± 0.037	3.595ValAsn: 3.595 ± 0.058	2.232ValPro: 2.232 ± 0.045	1.91ValGln: 1.91 ± 0.044	1.954ValArg: 1.954 ± 0.047	4.47ValSer: 4.47 ± 0.061	3.329ValThr: 3.329 ± 0.06	3.782ValVal: 3.782 ± 0.078	0.625ValTrp: 0.625 ± 0.023	2.516ValTyr: 2.516 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.628TrpAla: 0.628 ± 0.026	0.088TrpCys: 0.088 ± 0.009	0.619TrpAsp: 0.619 ± 0.022	0.666TrpGlu: 0.666 ± 0.023	0.547TrpPhe: 0.547 ± 0.02	0.77TrpGly: 0.77 ± 0.036	0.186TrpHis: 0.186 ± 0.013	0.793TrpIle: 0.793 ± 0.027	0.967TrpLys: 0.967 ± 0.034	0.963TrpLeu: 0.963 ± 0.032	0.363TrpMet: 0.363 ± 0.017	0.78TrpAsn: 0.78 ± 0.027	0.226TrpPro: 0.226 ± 0.015	0.438TrpGln: 0.438 ± 0.02	0.397TrpArg: 0.397 ± 0.02	0.645TrpSer: 0.645 ± 0.025	0.553TrpThr: 0.553 ± 0.023	0.621TrpVal: 0.621 ± 0.023	0.157TrpTrp: 0.157 ± 0.012	0.411TrpTyr: 0.411 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.427TyrAla: 2.427 ± 0.043	0.346TyrCys: 0.346 ± 0.018	2.432TyrAsp: 2.432 ± 0.051	2.367TyrGlu: 2.367 ± 0.044	2.707TyrPhe: 2.707 ± 0.058	2.63TyrGly: 2.63 ± 0.05	0.896TyrHis: 0.896 ± 0.032	3.0TyrIle: 3.0 ± 0.05	3.054TyrLys: 3.054 ± 0.058	3.883TyrLeu: 3.883 ± 0.066	0.815TyrMet: 0.815 ± 0.025	2.686TyrAsn: 2.686 ± 0.057	1.669TyrPro: 1.669 ± 0.042	1.821TyrGln: 1.821 ± 0.05	1.646TyrArg: 1.646 ± 0.046	2.904TyrSer: 2.904 ± 0.049	2.441TyrThr: 2.441 ± 0.056	2.09TyrVal: 2.09 ± 0.043	0.503TyrTrp: 0.503 ± 0.022	2.041TyrTyr: 2.041 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3502 proteins (1174652 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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