Amino acid dipepetide frequency for Trichuris suis (pig whipworm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.998AlaAla: 5.998 ± 0.104	1.685AlaCys: 1.685 ± 0.043	3.801AlaAsp: 3.801 ± 0.061	4.558AlaGlu: 4.558 ± 0.068	3.013AlaPhe: 3.013 ± 0.059	3.84AlaGly: 3.84 ± 0.07	1.51AlaHis: 1.51 ± 0.037	3.554AlaIle: 3.554 ± 0.06	4.177AlaLys: 4.177 ± 0.068	6.761AlaLeu: 6.761 ± 0.088	1.815AlaMet: 1.815 ± 0.041	3.045AlaAsn: 3.045 ± 0.055	2.905AlaPro: 2.905 ± 0.058	2.475AlaGln: 2.475 ± 0.047	3.545AlaArg: 3.545 ± 0.061	5.746AlaSer: 5.746 ± 0.072	3.858AlaThr: 3.858 ± 0.063	5.334AlaVal: 5.334 ± 0.066	0.751AlaTrp: 0.751 ± 0.026	2.073AlaTyr: 2.073 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.669CysAla: 1.669 ± 0.042	0.857CysCys: 0.857 ± 0.04	1.424CysAsp: 1.424 ± 0.048	1.489CysGlu: 1.489 ± 0.065	1.244CysPhe: 1.244 ± 0.036	1.592CysGly: 1.592 ± 0.049	0.708CysHis: 0.708 ± 0.026	1.292CysIle: 1.292 ± 0.041	1.464CysLys: 1.464 ± 0.046	2.653CysLeu: 2.653 ± 0.056	0.554CysMet: 0.554 ± 0.02	1.159CysAsn: 1.159 ± 0.037	1.472CysPro: 1.472 ± 0.068	1.204CysGln: 1.204 ± 0.043	1.735CysArg: 1.735 ± 0.044	2.409CysSer: 2.409 ± 0.053	1.32CysThr: 1.32 ± 0.034	1.61CysVal: 1.61 ± 0.044	0.339CysTrp: 0.339 ± 0.02	0.766CysTyr: 0.766 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.445AspAla: 3.445 ± 0.051	1.372AspCys: 1.372 ± 0.043	3.296AspAsp: 3.296 ± 0.061	4.02AspGlu: 4.02 ± 0.068	2.326AspPhe: 2.326 ± 0.042	3.389AspGly: 3.389 ± 0.061	1.215AspHis: 1.215 ± 0.03	2.732AspIle: 2.732 ± 0.049	2.471AspLys: 2.471 ± 0.046	4.73AspLeu: 4.73 ± 0.059	1.177AspMet: 1.177 ± 0.034	1.958AspAsn: 1.958 ± 0.04	2.317AspPro: 2.317 ± 0.044	1.966AspGln: 1.966 ± 0.038	3.0AspArg: 3.0 ± 0.053	4.208AspSer: 4.208 ± 0.064	2.222AspThr: 2.222 ± 0.041	3.915AspVal: 3.915 ± 0.059	0.721AspTrp: 0.721 ± 0.024	1.675AspTyr: 1.675 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	4.606GluAla: 4.606 ± 0.071	1.44GluCys: 1.44 ± 0.048	3.354GluAsp: 3.354 ± 0.057	5.282GluGlu: 5.282 ± 0.092	2.282GluPhe: 2.282 ± 0.048	2.95GluGly: 2.95 ± 0.054	1.435GluHis: 1.435 ± 0.033	3.128GluIle: 3.128 ± 0.053	4.31GluLys: 4.31 ± 0.065	5.965GluLeu: 5.965 ± 0.082	1.794GluMet: 1.794 ± 0.038	2.913GluAsn: 2.913 ± 0.05	2.52GluPro: 2.52 ± 0.055	2.983GluGln: 2.983 ± 0.051	4.064GluArg: 4.064 ± 0.067	4.431GluSer: 4.431 ± 0.067	3.151GluThr: 3.151 ± 0.048	4.037GluVal: 4.037 ± 0.071	0.757GluTrp: 0.757 ± 0.027	1.695GluTyr: 1.695 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.138PheAla: 3.138 ± 0.055	1.308PheCys: 1.308 ± 0.037	2.476PheAsp: 2.476 ± 0.042	2.478PheGlu: 2.478 ± 0.043	1.84PhePhe: 1.84 ± 0.046	2.772PheGly: 2.772 ± 0.053	1.151PheHis: 1.151 ± 0.031	2.117PheIle: 2.117 ± 0.044	2.034PheLys: 2.034 ± 0.041	4.053PheLeu: 4.053 ± 0.066	0.921PheMet: 0.921 ± 0.028	1.822PheAsn: 1.822 ± 0.043	1.937PhePro: 1.937 ± 0.038	1.602PheGln: 1.602 ± 0.034	2.447PheArg: 2.447 ± 0.043	3.431PheSer: 3.431 ± 0.057	2.229PheThr: 2.229 ± 0.052	3.191PheVal: 3.191 ± 0.054	0.548PheTrp: 0.548 ± 0.021	1.458PheTyr: 1.458 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	3.527GlyAla: 3.527 ± 0.074	1.396GlyCys: 1.396 ± 0.049	2.877GlyAsp: 2.877 ± 0.052	3.181GlyGlu: 3.181 ± 0.073	2.361GlyPhe: 2.361 ± 0.052	3.731GlyGly: 3.731 ± 0.092	1.413GlyHis: 1.413 ± 0.044	3.02GlyIle: 3.02 ± 0.055	3.513GlyLys: 3.513 ± 0.071	4.539GlyLeu: 4.539 ± 0.079	1.333GlyMet: 1.333 ± 0.039	2.519GlyAsn: 2.519 ± 0.051	2.313GlyPro: 2.313 ± 0.092	2.23GlyGln: 2.23 ± 0.053	3.772GlyArg: 3.772 ± 0.069	4.842GlySer: 4.842 ± 0.07	3.106GlyThr: 3.106 ± 0.05	3.38GlyVal: 3.38 ± 0.056	0.723GlyTrp: 0.723 ± 0.023	1.935GlyTyr: 1.935 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.467HisAla: 1.467 ± 0.037	0.864HisCys: 0.864 ± 0.034	1.041HisAsp: 1.041 ± 0.029	1.256HisGlu: 1.256 ± 0.036	1.299HisPhe: 1.299 ± 0.033	1.471HisGly: 1.471 ± 0.032	0.654HisHis: 0.654 ± 0.027	1.13HisIle: 1.13 ± 0.026	0.979HisLys: 0.979 ± 0.03	2.442HisLeu: 2.442 ± 0.047	0.58HisMet: 0.58 ± 0.02	0.809HisAsn: 0.809 ± 0.024	1.318HisPro: 1.318 ± 0.036	0.937HisGln: 0.937 ± 0.027	1.557HisArg: 1.557 ± 0.037	1.873HisSer: 1.873 ± 0.037	1.073HisThr: 1.073 ± 0.03	1.677HisVal: 1.677 ± 0.035	0.371HisTrp: 0.371 ± 0.016	0.813HisTyr: 0.813 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	3.665IleAla: 3.665 ± 0.057	1.427IleCys: 1.427 ± 0.039	2.87IleAsp: 2.87 ± 0.053	3.061IleGlu: 3.061 ± 0.054	2.114IlePhe: 2.114 ± 0.045	2.943IleGly: 2.943 ± 0.057	1.138IleHis: 1.138 ± 0.033	2.299IleIle: 2.299 ± 0.051	2.26IleLys: 2.26 ± 0.045	4.452IleLeu: 4.452 ± 0.06	1.075IleMet: 1.075 ± 0.026	1.997IleAsn: 1.997 ± 0.045	2.467IlePro: 2.467 ± 0.046	1.724IleGln: 1.724 ± 0.04	3.195IleArg: 3.195 ± 0.052	4.022IleSer: 4.022 ± 0.057	2.45IleThr: 2.45 ± 0.049	3.614IleVal: 3.614 ± 0.057	0.531IleTrp: 0.531 ± 0.024	1.458IleTyr: 1.458 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.075LysAla: 4.075 ± 0.069	1.47LysCys: 1.47 ± 0.043	2.629LysAsp: 2.629 ± 0.055	4.038LysGlu: 4.038 ± 0.065	2.017LysPhe: 2.017 ± 0.043	2.809LysGly: 2.809 ± 0.075	1.335LysHis: 1.335 ± 0.036	2.625LysIle: 2.625 ± 0.044	3.624LysLys: 3.624 ± 0.077	5.481LysLeu: 5.481 ± 0.068	1.459LysMet: 1.459 ± 0.035	2.236LysAsn: 2.236 ± 0.047	2.574LysPro: 2.574 ± 0.052	2.593LysGln: 2.593 ± 0.053	4.139LysArg: 4.139 ± 0.065	3.957LysSer: 3.957 ± 0.055	2.877LysThr: 2.877 ± 0.057	3.65LysVal: 3.65 ± 0.054	0.736LysTrp: 0.736 ± 0.025	1.708LysTyr: 1.708 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	6.577LeuAla: 6.577 ± 0.083	2.596LeuCys: 2.596 ± 0.054	4.39LeuAsp: 4.39 ± 0.058	5.689LeuGlu: 5.689 ± 0.081	4.135LeuPhe: 4.135 ± 0.059	4.336LeuGly: 4.336 ± 0.06	2.443LeuHis: 2.443 ± 0.042	4.653LeuIle: 4.653 ± 0.056	5.781LeuLys: 5.781 ± 0.071	10.627LeuLeu: 10.627 ± 0.123	2.218LeuMet: 2.218 ± 0.042	4.271LeuAsn: 4.271 ± 0.063	5.274LeuPro: 5.274 ± 0.083	4.309LeuGln: 4.309 ± 0.068	6.484LeuArg: 6.484 ± 0.074	8.116LeuSer: 8.116 ± 0.108	4.974LeuThr: 4.974 ± 0.067	5.77LeuVal: 5.77 ± 0.08	1.123LeuTrp: 1.123 ± 0.034	2.838LeuTyr: 2.838 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	1.904MetAla: 1.904 ± 0.038	0.469MetCys: 0.469 ± 0.02	1.313MetAsp: 1.313 ± 0.034	1.765MetGlu: 1.765 ± 0.037	0.936MetPhe: 0.936 ± 0.027	1.113MetGly: 1.113 ± 0.031	0.612MetHis: 0.612 ± 0.021	1.067MetIle: 1.067 ± 0.028	1.511MetLys: 1.511 ± 0.038	2.384MetLeu: 2.384 ± 0.048	0.581MetMet: 0.581 ± 0.021	1.142MetAsn: 1.142 ± 0.03	1.285MetPro: 1.285 ± 0.033	1.086MetGln: 1.086 ± 0.031	1.386MetArg: 1.386 ± 0.033	1.799MetSer: 1.799 ± 0.037	1.265MetThr: 1.265 ± 0.034	1.581MetVal: 1.581 ± 0.037	0.22MetTrp: 0.22 ± 0.012	0.648MetTyr: 0.648 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.195AsnAla: 3.195 ± 0.061	1.186AsnCys: 1.186 ± 0.034	2.301AsnAsp: 2.301 ± 0.044	2.763AsnGlu: 2.763 ± 0.051	1.942AsnPhe: 1.942 ± 0.047	3.2AsnGly: 3.2 ± 0.062	0.852AsnHis: 0.852 ± 0.024	1.93AsnIle: 1.93 ± 0.034	1.97AsnLys: 1.97 ± 0.042	3.852AsnLeu: 3.852 ± 0.061	1.024AsnMet: 1.024 ± 0.028	1.71AsnAsn: 1.71 ± 0.039	1.879AsnPro: 1.879 ± 0.041	1.418AsnGln: 1.418 ± 0.036	2.556AsnArg: 2.556 ± 0.046	3.373AsnSer: 3.373 ± 0.06	1.695AsnThr: 1.695 ± 0.036	3.393AsnVal: 3.393 ± 0.054	0.586AsnTrp: 0.586 ± 0.021	1.368AsnTyr: 1.368 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	3.14ProAla: 3.14 ± 0.067	1.139ProCys: 1.139 ± 0.052	2.51ProAsp: 2.51 ± 0.05	2.983ProGlu: 2.983 ± 0.056	2.218ProPhe: 2.218 ± 0.046	2.737ProGly: 2.737 ± 0.178	0.932ProHis: 0.932 ± 0.029	2.259ProIle: 2.259 ± 0.042	2.467ProLys: 2.467 ± 0.048	4.46ProLeu: 4.46 ± 0.065	1.062ProMet: 1.062 ± 0.035	2.019ProAsn: 2.019 ± 0.051	3.225ProPro: 3.225 ± 0.086	1.533ProGln: 1.533 ± 0.043	2.338ProArg: 2.338 ± 0.047	4.589ProSer: 4.589 ± 0.075	3.015ProThr: 3.015 ± 0.052	3.386ProVal: 3.386 ± 0.052	0.585ProTrp: 0.585 ± 0.022	1.623ProTyr: 1.623 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.652GlnAla: 2.652 ± 0.048	1.191GlnCys: 1.191 ± 0.037	1.534GlnAsp: 1.534 ± 0.043	2.331GlnGlu: 2.331 ± 0.049	1.722GlnPhe: 1.722 ± 0.036	1.745GlnGly: 1.745 ± 0.039	0.982GlnHis: 0.982 ± 0.03	1.839GlnIle: 1.839 ± 0.042	2.275GlnLys: 2.275 ± 0.043	4.483GlnLeu: 4.483 ± 0.076	1.132GlnMet: 1.132 ± 0.028	1.62GlnAsn: 1.62 ± 0.037	2.017GlnPro: 2.017 ± 0.049	2.326GlnGln: 2.326 ± 0.067	2.953GlnArg: 2.953 ± 0.059	3.18GlnSer: 3.18 ± 0.054	2.085GlnThr: 2.085 ± 0.041	2.422GlnVal: 2.422 ± 0.046	0.599GlnTrp: 0.599 ± 0.023	1.142GlnTyr: 1.142 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.524ArgAla: 3.524 ± 0.06	1.838ArgCys: 1.838 ± 0.045	2.66ArgAsp: 2.66 ± 0.054	3.387ArgGlu: 3.387 ± 0.056	2.859ArgPhe: 2.859 ± 0.054	2.907ArgGly: 2.907 ± 0.058	1.722ArgHis: 1.722 ± 0.038	3.112ArgIle: 3.112 ± 0.053	3.997ArgLys: 3.997 ± 0.07	6.593ArgLeu: 6.593 ± 0.085	1.593ArgMet: 1.593 ± 0.037	2.766ArgAsn: 2.766 ± 0.046	2.783ArgPro: 2.783 ± 0.061	2.843ArgGln: 2.843 ± 0.052	5.28ArgArg: 5.28 ± 0.085	5.096ArgSer: 5.096 ± 0.077	3.219ArgThr: 3.219 ± 0.047	3.473ArgVal: 3.473 ± 0.058	0.941ArgTrp: 0.941 ± 0.028	2.038ArgTyr: 2.038 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.939SerAla: 5.939 ± 0.073	2.193SerCys: 2.193 ± 0.056	4.434SerAsp: 4.434 ± 0.067	4.784SerGlu: 4.784 ± 0.076	3.532SerPhe: 3.532 ± 0.06	4.775SerGly: 4.775 ± 0.065	1.709SerHis: 1.709 ± 0.04	3.978SerIle: 3.978 ± 0.061	4.21SerLys: 4.21 ± 0.057	7.818SerLeu: 7.818 ± 0.085	1.862SerMet: 1.862 ± 0.041	3.456SerAsn: 3.456 ± 0.065	4.088SerPro: 4.088 ± 0.083	2.922SerGln: 2.922 ± 0.047	4.75SerArg: 4.75 ± 0.061	8.958SerSer: 8.958 ± 0.138	4.663SerThr: 4.663 ± 0.08	5.644SerVal: 5.644 ± 0.07	0.991SerTrp: 0.991 ± 0.03	2.328SerTyr: 2.328 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.082ThrAla: 4.082 ± 0.06	1.479ThrCys: 1.479 ± 0.053	2.797ThrAsp: 2.797 ± 0.049	3.295ThrGlu: 3.295 ± 0.053	2.409ThrPhe: 2.409 ± 0.046	3.114ThrGly: 3.114 ± 0.056	0.897ThrHis: 0.897 ± 0.025	2.672ThrIle: 2.672 ± 0.044	2.787ThrLys: 2.787 ± 0.049	4.967ThrLeu: 4.967 ± 0.068	1.259ThrMet: 1.259 ± 0.033	1.986ThrAsn: 1.986 ± 0.039	2.487ThrPro: 2.487 ± 0.05	1.576ThrGln: 1.576 ± 0.038	2.498ThrArg: 2.498 ± 0.047	4.449ThrSer: 4.449 ± 0.061	3.168ThrThr: 3.168 ± 0.067	4.218ThrVal: 4.218 ± 0.062	0.609ThrTrp: 0.609 ± 0.026	1.533ThrTyr: 1.533 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	5.038ValAla: 5.038 ± 0.064	1.791ValCys: 1.791 ± 0.043	4.085ValAsp: 4.085 ± 0.058	4.316ValGlu: 4.316 ± 0.064	2.641ValPhe: 2.641 ± 0.053	3.652ValGly: 3.652 ± 0.062	1.802ValHis: 1.802 ± 0.042	3.363ValIle: 3.363 ± 0.055	3.773ValLys: 3.773 ± 0.065	6.06ValLeu: 6.06 ± 0.077	1.536ValMet: 1.536 ± 0.035	2.917ValAsn: 2.917 ± 0.048	3.328ValPro: 3.328 ± 0.048	2.782ValGln: 2.782 ± 0.051	4.098ValArg: 4.098 ± 0.074	5.307ValSer: 5.307 ± 0.065	3.779ValThr: 3.779 ± 0.064	4.791ValVal: 4.791 ± 0.076	0.774ValTrp: 0.774 ± 0.027	2.004ValTyr: 2.004 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.699TrpAla: 0.699 ± 0.025	0.314TrpCys: 0.314 ± 0.018	0.599TrpAsp: 0.599 ± 0.025	0.614TrpGlu: 0.614 ± 0.025	0.551TrpPhe: 0.551 ± 0.025	0.417TrpGly: 0.417 ± 0.021	0.352TrpHis: 0.352 ± 0.017	0.693TrpIle: 0.693 ± 0.025	0.923TrpLys: 0.923 ± 0.032	1.368TrpLeu: 1.368 ± 0.036	0.366TrpMet: 0.366 ± 0.017	0.664TrpAsn: 0.664 ± 0.025	0.595TrpPro: 0.595 ± 0.024	0.606TrpGln: 0.606 ± 0.026	0.802TrpArg: 0.802 ± 0.028	0.972TrpSer: 0.972 ± 0.035	0.761TrpThr: 0.761 ± 0.027	0.632TrpVal: 0.632 ± 0.022	0.183TrpTrp: 0.183 ± 0.013	0.419TrpTyr: 0.419 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.107TyrAla: 2.107 ± 0.047	0.946TyrCys: 0.946 ± 0.032	1.763TyrAsp: 1.763 ± 0.042	1.808TyrGlu: 1.808 ± 0.04	1.513TyrPhe: 1.513 ± 0.039	2.219TyrGly: 2.219 ± 0.053	0.749TyrHis: 0.749 ± 0.028	1.296TyrIle: 1.296 ± 0.032	1.507TyrLys: 1.507 ± 0.033	2.917TyrLeu: 2.917 ± 0.054	0.724TyrMet: 0.724 ± 0.024	1.183TyrAsn: 1.183 ± 0.033	1.437TyrPro: 1.437 ± 0.039	1.115TyrGln: 1.115 ± 0.034	2.03TyrArg: 2.03 ± 0.043	2.274TyrSer: 2.274 ± 0.052	1.377TyrThr: 1.377 ± 0.034	2.117TyrVal: 2.117 ± 0.042	0.441TyrTrp: 0.441 ± 0.019	1.113TyrTyr: 1.113 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3288 proteins (1291231 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---