Amino acid dipepetide frequency for Swingsia sp. F3b2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.789AlaAla: 15.789 ± 0.253
1.397AlaCys: 1.397 ± 0.059
5.34AlaAsp: 5.34 ± 0.112
6.279AlaGlu: 6.279 ± 0.125
3.844AlaPhe: 3.844 ± 0.097
10.803AlaGly: 10.803 ± 0.174
3.128AlaHis: 3.128 ± 0.082
4.751AlaIle: 4.751 ± 0.095
3.718AlaLys: 3.718 ± 0.102
16.319AlaLeu: 16.319 ± 0.236
3.926AlaMet: 3.926 ± 0.092
3.009AlaAsn: 3.009 ± 0.107
8.104AlaPro: 8.104 ± 0.157
6.362AlaGln: 6.362 ± 0.135
8.323AlaArg: 8.323 ± 0.142
6.485AlaSer: 6.485 ± 0.111
6.625AlaThr: 6.625 ± 0.108
7.981AlaVal: 7.981 ± 0.127
2.03AlaTrp: 2.03 ± 0.061
2.086AlaTyr: 2.086 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
1.383CysAla: 1.383 ± 0.051
0.185CysCys: 0.185 ± 0.02
0.518CysAsp: 0.518 ± 0.032
0.379CysGlu: 0.379 ± 0.025
0.317CysPhe: 0.317 ± 0.025
1.088CysGly: 1.088 ± 0.053
0.335CysHis: 0.335 ± 0.023
0.359CysIle: 0.359 ± 0.024
0.261CysLys: 0.261 ± 0.021
1.2CysLeu: 1.2 ± 0.055
0.219CysMet: 0.219 ± 0.021
0.241CysAsn: 0.241 ± 0.019
0.687CysPro: 0.687 ± 0.037
0.451CysGln: 0.451 ± 0.026
0.676CysArg: 0.676 ± 0.038
0.517CysSer: 0.517 ± 0.034
0.58CysThr: 0.58 ± 0.033
0.778CysVal: 0.778 ± 0.032
0.174CysTrp: 0.174 ± 0.019
0.181CysTyr: 0.181 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.867AspAla: 4.867 ± 0.101
0.466AspCys: 0.466 ± 0.026
2.596AspAsp: 2.596 ± 0.087
2.808AspGlu: 2.808 ± 0.092
1.896AspPhe: 1.896 ± 0.064
4.751AspGly: 4.751 ± 0.11
1.231AspHis: 1.231 ± 0.046
2.465AspIle: 2.465 ± 0.067
1.693AspLys: 1.693 ± 0.056
4.412AspLeu: 4.412 ± 0.088
1.367AspMet: 1.367 ± 0.045
1.345AspAsn: 1.345 ± 0.059
2.742AspPro: 2.742 ± 0.071
1.686AspGln: 1.686 ± 0.054
2.543AspArg: 2.543 ± 0.064
2.385AspSer: 2.385 ± 0.079
1.894AspThr: 1.894 ± 0.065
3.906AspVal: 3.906 ± 0.09
0.821AspTrp: 0.821 ± 0.039
1.408AspTyr: 1.408 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
7.163GluAla: 7.163 ± 0.138
0.368GluCys: 0.368 ± 0.027
2.273GluAsp: 2.273 ± 0.084
3.092GluGlu: 3.092 ± 0.103
1.069GluPhe: 1.069 ± 0.051
5.711GluGly: 5.711 ± 0.104
1.16GluHis: 1.16 ± 0.05
2.123GluIle: 2.123 ± 0.065
2.233GluLys: 2.233 ± 0.082
4.212GluLeu: 4.212 ± 0.104
1.209GluMet: 1.209 ± 0.046
1.745GluAsn: 1.745 ± 0.059
2.055GluPro: 2.055 ± 0.059
2.01GluGln: 2.01 ± 0.066
4.633GluArg: 4.633 ± 0.109
2.4GluSer: 2.4 ± 0.063
2.552GluThr: 2.552 ± 0.064
3.433GluVal: 3.433 ± 0.082
0.651GluTrp: 0.651 ± 0.039
0.633GluTyr: 0.633 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.11PheAla: 3.11 ± 0.095
0.451PheCys: 0.451 ± 0.029
1.639PheAsp: 1.639 ± 0.058
1.675PheGlu: 1.675 ± 0.056
1.107PhePhe: 1.107 ± 0.049
2.851PheGly: 2.851 ± 0.076
0.783PheHis: 0.783 ± 0.038
1.43PheIle: 1.43 ± 0.054
1.245PheLys: 1.245 ± 0.05
3.087PheLeu: 3.087 ± 0.088
1.147PheMet: 1.147 ± 0.052
1.236PheAsn: 1.236 ± 0.047
1.657PhePro: 1.657 ± 0.062
1.098PheGln: 1.098 ± 0.042
1.813PheArg: 1.813 ± 0.056
2.168PheSer: 2.168 ± 0.069
2.231PheThr: 2.231 ± 0.072
1.798PheVal: 1.798 ± 0.057
0.613PheTrp: 0.613 ± 0.032
0.841PheTyr: 0.841 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
10.872GlyAla: 10.872 ± 0.157
1.156GlyCys: 1.156 ± 0.055
3.765GlyAsp: 3.765 ± 0.085
4.285GlyGlu: 4.285 ± 0.101
3.185GlyPhe: 3.185 ± 0.092
7.997GlyGly: 7.997 ± 0.187
2.686GlyHis: 2.686 ± 0.07
3.272GlyIle: 3.272 ± 0.085
3.455GlyLys: 3.455 ± 0.08
9.799GlyLeu: 9.799 ± 0.155
2.458GlyMet: 2.458 ± 0.058
2.266GlyAsn: 2.266 ± 0.11
4.444GlyPro: 4.444 ± 0.094
4.803GlyGln: 4.803 ± 0.104
6.429GlyArg: 6.429 ± 0.136
4.41GlySer: 4.41 ± 0.103
5.472GlyThr: 5.472 ± 0.223
6.416GlyVal: 6.416 ± 0.107
1.744GlyTrp: 1.744 ± 0.065
1.834GlyTyr: 1.834 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.8HisAla: 2.8 ± 0.076
0.31HisCys: 0.31 ± 0.024
1.503HisAsp: 1.503 ± 0.056
1.414HisGlu: 1.414 ± 0.054
0.924HisPhe: 0.924 ± 0.04
2.657HisGly: 2.657 ± 0.08
1.167HisHis: 1.167 ± 0.064
1.039HisIle: 1.039 ± 0.045
0.77HisLys: 0.77 ± 0.043
2.532HisLeu: 2.532 ± 0.072
0.6HisMet: 0.6 ± 0.032
0.73HisAsn: 0.73 ± 0.038
1.912HisPro: 1.912 ± 0.063
1.162HisGln: 1.162 ± 0.053
1.376HisArg: 1.376 ± 0.056
1.407HisSer: 1.407 ± 0.045
1.122HisThr: 1.122 ± 0.043
2.084HisVal: 2.084 ± 0.068
0.453HisTrp: 0.453 ± 0.029
0.654HisTyr: 0.654 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
4.305IleAla: 4.305 ± 0.091
0.417IleCys: 0.417 ± 0.035
2.119IleAsp: 2.119 ± 0.063
1.949IleGlu: 1.949 ± 0.073
0.952IlePhe: 0.952 ± 0.043
3.217IleGly: 3.217 ± 0.085
0.959IleHis: 0.959 ± 0.038
1.927IleIle: 1.927 ± 0.074
1.678IleLys: 1.678 ± 0.06
3.852IleLeu: 3.852 ± 0.097
1.147IleMet: 1.147 ± 0.049
1.479IleAsn: 1.479 ± 0.06
1.963IlePro: 1.963 ± 0.059
1.213IleGln: 1.213 ± 0.052
1.903IleArg: 1.903 ± 0.055
2.255IleSer: 2.255 ± 0.077
2.79IleThr: 2.79 ± 0.069
2.73IleVal: 2.73 ± 0.083
0.419IleTrp: 0.419 ± 0.028
0.854IleTyr: 0.854 ± 0.039
0.0IleXaa: 0.0 ± 0.0
Lys
5.652LysAla: 5.652 ± 0.133
0.165LysCys: 0.165 ± 0.016
1.506LysAsp: 1.506 ± 0.056
1.548LysGlu: 1.548 ± 0.058
0.669LysPhe: 0.669 ± 0.037
3.524LysGly: 3.524 ± 0.078
0.714LysHis: 0.714 ± 0.037
1.131LysIle: 1.131 ± 0.052
1.39LysLys: 1.39 ± 0.069
3.388LysLeu: 3.388 ± 0.089
0.75LysMet: 0.75 ± 0.042
0.988LysAsn: 0.988 ± 0.048
2.552LysPro: 2.552 ± 0.078
1.182LysGln: 1.182 ± 0.051
2.887LysArg: 2.887 ± 0.081
1.637LysSer: 1.637 ± 0.06
1.847LysThr: 1.847 ± 0.058
2.278LysVal: 2.278 ± 0.078
0.303LysTrp: 0.303 ± 0.021
0.431LysTyr: 0.431 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
14.588LeuAla: 14.588 ± 0.211
1.359LeuCys: 1.359 ± 0.058
5.398LeuAsp: 5.398 ± 0.112
6.266LeuGlu: 6.266 ± 0.116
3.341LeuPhe: 3.341 ± 0.093
9.404LeuGly: 9.404 ± 0.164
2.713LeuHis: 2.713 ± 0.075
3.244LeuIle: 3.244 ± 0.091
3.892LeuLys: 3.892 ± 0.1
10.333LeuLeu: 10.333 ± 0.203
2.525LeuMet: 2.525 ± 0.085
3.109LeuAsn: 3.109 ± 0.113
7.122LeuPro: 7.122 ± 0.126
3.748LeuGln: 3.748 ± 0.093
6.79LeuArg: 6.79 ± 0.125
5.733LeuSer: 5.733 ± 0.112
5.32LeuThr: 5.32 ± 0.117
7.272LeuVal: 7.272 ± 0.121
1.55LeuTrp: 1.55 ± 0.065
2.219LeuTyr: 2.219 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
4.439MetAla: 4.439 ± 0.109
0.189MetCys: 0.189 ± 0.019
1.231MetAsp: 1.231 ± 0.041
1.231MetGlu: 1.231 ± 0.055
0.605MetPhe: 0.605 ± 0.035
2.539MetGly: 2.539 ± 0.065
0.408MetHis: 0.408 ± 0.026
0.796MetIle: 0.796 ± 0.041
1.102MetLys: 1.102 ± 0.044
2.471MetLeu: 2.471 ± 0.075
0.803MetMet: 0.803 ± 0.047
0.846MetAsn: 0.846 ± 0.045
1.742MetPro: 1.742 ± 0.061
0.812MetGln: 0.812 ± 0.043
1.575MetArg: 1.575 ± 0.056
1.227MetSer: 1.227 ± 0.048
1.86MetThr: 1.86 ± 0.051
2.204MetVal: 2.204 ± 0.075
0.205MetTrp: 0.205 ± 0.017
0.205MetTyr: 0.205 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.524AsnAla: 3.524 ± 0.093
0.259AsnCys: 0.259 ± 0.025
1.262AsnAsp: 1.262 ± 0.052
0.946AsnGlu: 0.946 ± 0.037
0.875AsnPhe: 0.875 ± 0.044
2.621AsnGly: 2.621 ± 0.125
0.883AsnHis: 0.883 ± 0.048
1.298AsnIle: 1.298 ± 0.059
0.89AsnLys: 0.89 ± 0.045
2.762AsnLeu: 2.762 ± 0.076
0.759AsnMet: 0.759 ± 0.04
0.885AsnAsn: 0.885 ± 0.052
2.449AsnPro: 2.449 ± 0.064
1.392AsnGln: 1.392 ± 0.071
1.653AsnArg: 1.653 ± 0.05
1.329AsnSer: 1.329 ± 0.065
1.526AsnThr: 1.526 ± 0.064
2.003AsnVal: 2.003 ± 0.094
0.462AsnTrp: 0.462 ± 0.031
0.643AsnTyr: 0.643 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
8.318ProAla: 8.318 ± 0.151
0.624ProCys: 0.624 ± 0.039
3.371ProAsp: 3.371 ± 0.085
4.105ProGlu: 4.105 ± 0.096
2.123ProPhe: 2.123 ± 0.067
5.762ProGly: 5.762 ± 0.128
1.86ProHis: 1.86 ± 0.061
1.793ProIle: 1.793 ± 0.061
1.869ProLys: 1.869 ± 0.064
6.594ProLeu: 6.594 ± 0.126
1.475ProMet: 1.475 ± 0.047
1.657ProAsn: 1.657 ± 0.052
4.323ProPro: 4.323 ± 0.127
2.916ProGln: 2.916 ± 0.082
2.858ProArg: 2.858 ± 0.076
4.031ProSer: 4.031 ± 0.09
3.888ProThr: 3.888 ± 0.09
4.312ProVal: 4.312 ± 0.096
1.104ProTrp: 1.104 ± 0.049
1.283ProTyr: 1.283 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
7.129GlnAla: 7.129 ± 0.151
0.324GlnCys: 0.324 ± 0.026
1.856GlnAsp: 1.856 ± 0.058
2.025GlnGlu: 2.025 ± 0.064
1.082GlnPhe: 1.082 ± 0.043
4.385GlnGly: 4.385 ± 0.122
0.999GlnHis: 0.999 ± 0.042
1.312GlnIle: 1.312 ± 0.049
1.533GlnLys: 1.533 ± 0.054
3.598GlnLeu: 3.598 ± 0.078
0.828GlnMet: 0.828 ± 0.037
1.35GlnAsn: 1.35 ± 0.053
3.547GlnPro: 3.547 ± 0.088
2.003GlnGln: 2.003 ± 0.071
3.081GlnArg: 3.081 ± 0.078
2.113GlnSer: 2.113 ± 0.07
1.949GlnThr: 1.949 ± 0.069
2.605GlnVal: 2.605 ± 0.077
0.562GlnTrp: 0.562 ± 0.032
0.593GlnTyr: 0.593 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
7.468ArgAla: 7.468 ± 0.135
0.633ArgCys: 0.633 ± 0.033
3.034ArgAsp: 3.034 ± 0.084
3.078ArgGlu: 3.078 ± 0.097
2.722ArgPhe: 2.722 ± 0.067
4.292ArgGly: 4.292 ± 0.102
2.295ArgHis: 2.295 ± 0.077
2.621ArgIle: 2.621 ± 0.074
2.307ArgLys: 2.307 ± 0.072
7.78ArgLeu: 7.78 ± 0.136
1.59ArgMet: 1.59 ± 0.053
1.646ArgAsn: 1.646 ± 0.048
3.939ArgPro: 3.939 ± 0.084
3.524ArgGln: 3.524 ± 0.093
4.448ArgArg: 4.448 ± 0.106
3.157ArgSer: 3.157 ± 0.077
3.13ArgThr: 3.13 ± 0.074
3.716ArgVal: 3.716 ± 0.087
1.001ArgTrp: 1.001 ± 0.039
1.602ArgTyr: 1.602 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
6.511SerAla: 6.511 ± 0.116
0.558SerCys: 0.558 ± 0.034
2.302SerAsp: 2.302 ± 0.064
2.112SerGlu: 2.112 ± 0.073
1.878SerPhe: 1.878 ± 0.062
5.001SerGly: 5.001 ± 0.136
1.499SerHis: 1.499 ± 0.056
1.961SerIle: 1.961 ± 0.072
1.581SerLys: 1.581 ± 0.055
5.579SerLeu: 5.579 ± 0.101
1.359SerMet: 1.359 ± 0.046
1.441SerAsn: 1.441 ± 0.058
3.576SerPro: 3.576 ± 0.092
2.362SerGln: 2.362 ± 0.078
2.9SerArg: 2.9 ± 0.077
2.976SerSer: 2.976 ± 0.08
3.186SerThr: 3.186 ± 0.077
3.455SerVal: 3.455 ± 0.086
1.024SerTrp: 1.024 ± 0.045
1.035SerTyr: 1.035 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
6.469ThrAla: 6.469 ± 0.107
0.504ThrCys: 0.504 ± 0.032
2.369ThrAsp: 2.369 ± 0.068
2.09ThrGlu: 2.09 ± 0.07
1.745ThrPhe: 1.745 ± 0.066
4.99ThrGly: 4.99 ± 0.128
1.289ThrHis: 1.289 ± 0.05
2.525ThrIle: 2.525 ± 0.076
1.591ThrLys: 1.591 ± 0.057
6.799ThrLeu: 6.799 ± 0.132
1.537ThrMet: 1.537 ± 0.052
1.477ThrAsn: 1.477 ± 0.058
4.916ThrPro: 4.916 ± 0.103
1.91ThrGln: 1.91 ± 0.061
2.728ThrArg: 2.728 ± 0.067
2.893ThrSer: 2.893 ± 0.078
3.446ThrThr: 3.446 ± 0.101
3.939ThrVal: 3.939 ± 0.09
0.796ThrTrp: 0.796 ± 0.04
1.049ThrTyr: 1.049 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
8.383ValAla: 8.383 ± 0.147
0.698ValCys: 0.698 ± 0.036
3.433ValAsp: 3.433 ± 0.078
3.921ValGlu: 3.921 ± 0.106
2.369ValPhe: 2.369 ± 0.071
5.592ValGly: 5.592 ± 0.103
1.423ValHis: 1.423 ± 0.051
2.904ValIle: 2.904 ± 0.067
2.246ValLys: 2.246 ± 0.08
7.359ValLeu: 7.359 ± 0.128
1.958ValMet: 1.958 ± 0.06
1.82ValAsn: 1.82 ± 0.099
4.531ValPro: 4.531 ± 0.092
2.603ValGln: 2.603 ± 0.079
4.531ValArg: 4.531 ± 0.097
3.424ValSer: 3.424 ± 0.085
4.163ValThr: 4.163 ± 0.091
5.532ValVal: 5.532 ± 0.104
0.868ValTrp: 0.868 ± 0.039
1.138ValTyr: 1.138 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.437TrpAla: 1.437 ± 0.053
0.236TrpCys: 0.236 ± 0.019
0.614TrpAsp: 0.614 ± 0.031
0.6TrpGlu: 0.6 ± 0.029
0.571TrpPhe: 0.571 ± 0.032
1.368TrpGly: 1.368 ± 0.062
0.538TrpHis: 0.538 ± 0.038
0.415TrpIle: 0.415 ± 0.031
0.473TrpLys: 0.473 ± 0.029
2.146TrpLeu: 2.146 ± 0.078
0.386TrpMet: 0.386 ± 0.025
0.48TrpAsn: 0.48 ± 0.035
0.953TrpPro: 0.953 ± 0.049
0.788TrpGln: 0.788 ± 0.037
1.579TrpArg: 1.579 ± 0.06
0.636TrpSer: 0.636 ± 0.037
0.591TrpThr: 0.591 ± 0.037
0.982TrpVal: 0.982 ± 0.039
0.339TrpTrp: 0.339 ± 0.029
0.303TrpTyr: 0.303 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.094TyrAla: 2.094 ± 0.064
0.23TyrCys: 0.23 ± 0.022
1.153TyrAsp: 1.153 ± 0.051
0.926TyrGlu: 0.926 ± 0.05
0.705TyrPhe: 0.705 ± 0.036
2.195TyrGly: 2.195 ± 0.063
0.547TyrHis: 0.547 ± 0.033
0.761TyrIle: 0.761 ± 0.042
0.614TyrLys: 0.614 ± 0.033
1.704TyrLeu: 1.704 ± 0.055
0.442TyrMet: 0.442 ± 0.028
0.671TyrAsn: 0.671 ± 0.036
1.053TyrPro: 1.053 ± 0.04
0.848TyrGln: 0.848 ± 0.044
1.254TyrArg: 1.254 ± 0.056
1.113TyrSer: 1.113 ± 0.048
0.89TyrThr: 0.89 ± 0.046
1.472TyrVal: 1.472 ± 0.051
0.321TyrTrp: 0.321 ± 0.023
0.509TyrTyr: 0.509 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1664 proteins (551706 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski