Amino acid dipepetide frequency for Devosia sp. YR412

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.406AlaAla: 16.406 ± 0.187
0.733AlaCys: 0.733 ± 0.025
6.898AlaAsp: 6.898 ± 0.083
7.802AlaGlu: 7.802 ± 0.117
4.38AlaPhe: 4.38 ± 0.072
10.347AlaGly: 10.347 ± 0.106
2.022AlaHis: 2.022 ± 0.043
6.896AlaIle: 6.896 ± 0.091
4.096AlaLys: 4.096 ± 0.071
13.714AlaLeu: 13.714 ± 0.127
3.796AlaMet: 3.796 ± 0.06
3.404AlaAsn: 3.404 ± 0.058
5.46AlaPro: 5.46 ± 0.091
4.331AlaGln: 4.331 ± 0.078
7.286AlaArg: 7.286 ± 0.102
6.401AlaSer: 6.401 ± 0.089
6.468AlaThr: 6.468 ± 0.105
9.036AlaVal: 9.036 ± 0.095
1.349AlaTrp: 1.349 ± 0.034
2.635AlaTyr: 2.635 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.718CysAla: 0.718 ± 0.024
0.08CysCys: 0.08 ± 0.008
0.411CysAsp: 0.411 ± 0.022
0.355CysGlu: 0.355 ± 0.016
0.233CysPhe: 0.233 ± 0.016
0.678CysGly: 0.678 ± 0.024
0.192CysHis: 0.192 ± 0.013
0.336CysIle: 0.336 ± 0.018
0.161CysLys: 0.161 ± 0.011
0.612CysLeu: 0.612 ± 0.025
0.117CysMet: 0.117 ± 0.01
0.164CysAsn: 0.164 ± 0.011
0.296CysPro: 0.296 ± 0.016
0.2CysGln: 0.2 ± 0.015
0.376CysArg: 0.376 ± 0.022
0.333CysSer: 0.333 ± 0.017
0.323CysThr: 0.323 ± 0.017
0.456CysVal: 0.456 ± 0.019
0.087CysTrp: 0.087 ± 0.009
0.147CysTyr: 0.147 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.943AspAla: 6.943 ± 0.078
0.383AspCys: 0.383 ± 0.018
3.114AspAsp: 3.114 ± 0.061
3.504AspGlu: 3.504 ± 0.061
2.318AspPhe: 2.318 ± 0.056
5.079AspGly: 5.079 ± 0.078
1.217AspHis: 1.217 ± 0.033
3.441AspIle: 3.441 ± 0.058
1.853AspLys: 1.853 ± 0.044
5.969AspLeu: 5.969 ± 0.081
1.456AspMet: 1.456 ± 0.036
1.57AspAsn: 1.57 ± 0.043
3.23AspPro: 3.23 ± 0.061
1.821AspGln: 1.821 ± 0.044
3.754AspArg: 3.754 ± 0.061
2.387AspSer: 2.387 ± 0.047
2.734AspThr: 2.734 ± 0.047
4.32AspVal: 4.32 ± 0.064
1.009AspTrp: 1.009 ± 0.031
1.617AspTyr: 1.617 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
7.482GluAla: 7.482 ± 0.11
0.267GluCys: 0.267 ± 0.015
2.763GluAsp: 2.763 ± 0.059
2.844GluGlu: 2.844 ± 0.063
1.866GluPhe: 1.866 ± 0.04
4.162GluGly: 4.162 ± 0.063
1.22GluHis: 1.22 ± 0.034
3.325GluIle: 3.325 ± 0.06
2.068GluLys: 2.068 ± 0.046
5.536GluLeu: 5.536 ± 0.075
1.502GluMet: 1.502 ± 0.039
1.587GluAsn: 1.587 ± 0.033
2.575GluPro: 2.575 ± 0.049
2.348GluGln: 2.348 ± 0.051
4.155GluArg: 4.155 ± 0.063
2.349GluSer: 2.349 ± 0.047
3.468GluThr: 3.468 ± 0.057
3.997GluVal: 3.997 ± 0.061
0.675GluTrp: 0.675 ± 0.026
0.986GluTyr: 0.986 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.879PheAla: 4.879 ± 0.061
0.329PheCys: 0.329 ± 0.018
2.707PheAsp: 2.707 ± 0.05
2.176PheGlu: 2.176 ± 0.043
1.521PhePhe: 1.521 ± 0.043
3.857PheGly: 3.857 ± 0.067
0.714PheHis: 0.714 ± 0.025
1.895PheIle: 1.895 ± 0.046
1.098PheLys: 1.098 ± 0.03
3.278PheLeu: 3.278 ± 0.059
0.855PheMet: 0.855 ± 0.026
1.26PheAsn: 1.26 ± 0.032
1.55PhePro: 1.55 ± 0.036
1.046PheGln: 1.046 ± 0.033
1.878PheArg: 1.878 ± 0.045
2.338PheSer: 2.338 ± 0.047
2.181PheThr: 2.181 ± 0.049
2.942PheVal: 2.942 ± 0.063
0.568PheTrp: 0.568 ± 0.025
0.985PheTyr: 0.985 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
8.88GlyAla: 8.88 ± 0.099
0.632GlyCys: 0.632 ± 0.023
4.56GlyAsp: 4.56 ± 0.068
4.673GlyGlu: 4.673 ± 0.073
3.723GlyPhe: 3.723 ± 0.06
6.89GlyGly: 6.89 ± 0.095
1.829GlyHis: 1.829 ± 0.046
4.748GlyIle: 4.748 ± 0.073
3.594GlyLys: 3.594 ± 0.062
9.028GlyLeu: 9.028 ± 0.093
2.413GlyMet: 2.413 ± 0.042
2.428GlyAsn: 2.428 ± 0.05
3.293GlyPro: 3.293 ± 0.058
3.145GlyGln: 3.145 ± 0.057
5.086GlyArg: 5.086 ± 0.064
4.731GlySer: 4.731 ± 0.075
5.015GlyThr: 5.015 ± 0.087
6.377GlyVal: 6.377 ± 0.074
1.334GlyTrp: 1.334 ± 0.042
2.321GlyTyr: 2.321 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.215HisAla: 2.215 ± 0.046
0.163HisCys: 0.163 ± 0.013
1.221HisAsp: 1.221 ± 0.035
1.012HisGlu: 1.012 ± 0.032
0.86HisPhe: 0.86 ± 0.03
1.837HisGly: 1.837 ± 0.037
0.562HisHis: 0.562 ± 0.025
1.035HisIle: 1.035 ± 0.032
0.543HisLys: 0.543 ± 0.023
1.918HisLeu: 1.918 ± 0.044
0.542HisMet: 0.542 ± 0.023
0.526HisAsn: 0.526 ± 0.021
1.157HisPro: 1.157 ± 0.029
0.625HisGln: 0.625 ± 0.026
1.243HisArg: 1.243 ± 0.034
0.887HisSer: 0.887 ± 0.029
0.856HisThr: 0.856 ± 0.03
1.438HisVal: 1.438 ± 0.039
0.334HisTrp: 0.334 ± 0.018
0.547HisTyr: 0.547 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
8.033IleAla: 8.033 ± 0.088
0.436IleCys: 0.436 ± 0.019
3.703IleAsp: 3.703 ± 0.05
3.508IleGlu: 3.508 ± 0.063
1.935IlePhe: 1.935 ± 0.048
5.315IleGly: 5.315 ± 0.074
0.878IleHis: 0.878 ± 0.026
2.798IleIle: 2.798 ± 0.056
1.715IleLys: 1.715 ± 0.037
4.805IleLeu: 4.805 ± 0.071
1.112IleMet: 1.112 ± 0.033
1.68IleAsn: 1.68 ± 0.041
2.358IlePro: 2.358 ± 0.051
1.32IleGln: 1.32 ± 0.038
3.003IleArg: 3.003 ± 0.056
3.146IleSer: 3.146 ± 0.058
3.221IleThr: 3.221 ± 0.057
4.31IleVal: 4.31 ± 0.071
0.691IleTrp: 0.691 ± 0.027
1.231IleTyr: 1.231 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.229LysAla: 4.229 ± 0.07
0.124LysCys: 0.124 ± 0.01
1.716LysAsp: 1.716 ± 0.045
1.432LysGlu: 1.432 ± 0.036
1.011LysPhe: 1.011 ± 0.031
2.623LysGly: 2.623 ± 0.048
0.665LysHis: 0.665 ± 0.02
1.691LysIle: 1.691 ± 0.043
1.175LysLys: 1.175 ± 0.039
3.578LysLeu: 3.578 ± 0.058
0.762LysMet: 0.762 ± 0.024
0.8LysAsn: 0.8 ± 0.027
2.141LysPro: 2.141 ± 0.042
1.053LysGln: 1.053 ± 0.035
2.242LysArg: 2.242 ± 0.039
2.03LysSer: 2.03 ± 0.047
2.017LysThr: 2.017 ± 0.041
2.591LysVal: 2.591 ± 0.056
0.368LysTrp: 0.368 ± 0.021
0.631LysTyr: 0.631 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
13.604LeuAla: 13.604 ± 0.129
0.686LeuCys: 0.686 ± 0.031
6.414LeuAsp: 6.414 ± 0.086
5.241LeuGlu: 5.241 ± 0.075
3.677LeuPhe: 3.677 ± 0.063
8.803LeuGly: 8.803 ± 0.096
1.752LeuHis: 1.752 ± 0.044
5.35LeuIle: 5.35 ± 0.074
3.503LeuLys: 3.503 ± 0.057
10.024LeuLeu: 10.024 ± 0.121
2.359LeuMet: 2.359 ± 0.047
2.894LeuAsn: 2.894 ± 0.05
5.513LeuPro: 5.513 ± 0.086
2.865LeuGln: 2.865 ± 0.047
6.139LeuArg: 6.139 ± 0.069
6.665LeuSer: 6.665 ± 0.088
6.233LeuThr: 6.233 ± 0.083
8.233LeuVal: 8.233 ± 0.111
1.145LeuTrp: 1.145 ± 0.036
2.131LeuTyr: 2.131 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.397MetAla: 3.397 ± 0.06
0.111MetCys: 0.111 ± 0.01
1.261MetAsp: 1.261 ± 0.032
1.058MetGlu: 1.058 ± 0.035
0.784MetPhe: 0.784 ± 0.029
1.918MetGly: 1.918 ± 0.041
0.422MetHis: 0.422 ± 0.018
1.421MetIle: 1.421 ± 0.037
0.815MetLys: 0.815 ± 0.029
2.744MetLeu: 2.744 ± 0.048
0.647MetMet: 0.647 ± 0.026
0.747MetAsn: 0.747 ± 0.023
1.423MetPro: 1.423 ± 0.039
0.918MetGln: 0.918 ± 0.026
1.641MetArg: 1.641 ± 0.041
1.854MetSer: 1.854 ± 0.037
2.014MetThr: 2.014 ± 0.04
1.982MetVal: 1.982 ± 0.047
0.211MetTrp: 0.211 ± 0.014
0.309MetTyr: 0.309 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.485AsnAla: 3.485 ± 0.06
0.203AsnCys: 0.203 ± 0.013
1.482AsnAsp: 1.482 ± 0.039
1.33AsnGlu: 1.33 ± 0.037
1.102AsnPhe: 1.102 ± 0.032
2.636AsnGly: 2.636 ± 0.049
0.554AsnHis: 0.554 ± 0.022
1.581AsnIle: 1.581 ± 0.04
0.806AsnLys: 0.806 ± 0.025
2.908AsnLeu: 2.908 ± 0.06
0.679AsnMet: 0.679 ± 0.024
0.834AsnAsn: 0.834 ± 0.031
1.943AsnPro: 1.943 ± 0.043
0.958AsnGln: 0.958 ± 0.036
1.783AsnArg: 1.783 ± 0.042
1.462AsnSer: 1.462 ± 0.04
1.417AsnThr: 1.417 ± 0.037
2.157AsnVal: 2.157 ± 0.051
0.489AsnTrp: 0.489 ± 0.022
0.808AsnTyr: 0.808 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
6.039ProAla: 6.039 ± 0.097
0.227ProCys: 0.227 ± 0.015
3.344ProAsp: 3.344 ± 0.062
3.513ProGlu: 3.513 ± 0.061
1.9ProPhe: 1.9 ± 0.043
4.15ProGly: 4.15 ± 0.059
1.029ProHis: 1.029 ± 0.031
2.512ProIle: 2.512 ± 0.051
1.69ProLys: 1.69 ± 0.04
4.637ProLeu: 4.637 ± 0.07
1.252ProMet: 1.252 ± 0.031
1.517ProAsn: 1.517 ± 0.04
2.056ProPro: 2.056 ± 0.054
1.583ProGln: 1.583 ± 0.038
2.488ProArg: 2.488 ± 0.052
2.703ProSer: 2.703 ± 0.058
2.749ProThr: 2.749 ± 0.059
4.212ProVal: 4.212 ± 0.066
0.627ProTrp: 0.627 ± 0.023
1.186ProTyr: 1.186 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
4.158GlnAla: 4.158 ± 0.055
0.166GlnCys: 0.166 ± 0.011
1.613GlnAsp: 1.613 ± 0.037
1.326GlnGlu: 1.326 ± 0.038
1.301GlnPhe: 1.301 ± 0.036
2.408GlnGly: 2.408 ± 0.045
0.688GlnHis: 0.688 ± 0.024
1.912GlnIle: 1.912 ± 0.04
1.058GlnLys: 1.058 ± 0.031
3.334GlnLeu: 3.334 ± 0.056
0.994GlnMet: 0.994 ± 0.029
0.912GlnAsn: 0.912 ± 0.03
1.863GlnPro: 1.863 ± 0.047
1.416GlnGln: 1.416 ± 0.043
2.503GlnArg: 2.503 ± 0.056
2.083GlnSer: 2.083 ± 0.047
1.92GlnThr: 1.92 ± 0.045
2.521GlnVal: 2.521 ± 0.046
0.395GlnTrp: 0.395 ± 0.019
0.698GlnTyr: 0.698 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
6.617ArgAla: 6.617 ± 0.076
0.337ArgCys: 0.337 ± 0.02
3.693ArgAsp: 3.693 ± 0.057
3.327ArgGlu: 3.327 ± 0.055
2.548ArgPhe: 2.548 ± 0.047
4.102ArgGly: 4.102 ± 0.065
1.429ArgHis: 1.429 ± 0.036
3.533ArgIle: 3.533 ± 0.053
2.139ArgLys: 2.139 ± 0.049
7.013ArgLeu: 7.013 ± 0.099
1.641ArgMet: 1.641 ± 0.04
1.847ArgAsn: 1.847 ± 0.041
3.022ArgPro: 3.022 ± 0.058
2.547ArgGln: 2.547 ± 0.057
4.263ArgArg: 4.263 ± 0.065
3.349ArgSer: 3.349 ± 0.053
3.079ArgThr: 3.079 ± 0.059
4.356ArgVal: 4.356 ± 0.073
0.815ArgTrp: 0.815 ± 0.027
1.559ArgTyr: 1.559 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.338SerAla: 6.338 ± 0.088
0.299SerCys: 0.299 ± 0.017
3.039SerAsp: 3.039 ± 0.053
2.875SerGlu: 2.875 ± 0.054
2.5SerPhe: 2.5 ± 0.043
5.612SerGly: 5.612 ± 0.082
1.161SerHis: 1.161 ± 0.031
3.185SerIle: 3.185 ± 0.061
1.712SerLys: 1.712 ± 0.041
5.682SerLeu: 5.682 ± 0.079
1.411SerMet: 1.411 ± 0.035
1.617SerAsn: 1.617 ± 0.04
2.583SerPro: 2.583 ± 0.048
1.829SerGln: 1.829 ± 0.04
3.301SerArg: 3.301 ± 0.055
3.101SerSer: 3.101 ± 0.063
2.996SerThr: 2.996 ± 0.059
4.315SerVal: 4.315 ± 0.074
0.765SerTrp: 0.765 ± 0.027
1.34SerTyr: 1.34 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.629ThrAla: 6.629 ± 0.104
0.314ThrCys: 0.314 ± 0.016
3.039ThrAsp: 3.039 ± 0.051
2.755ThrGlu: 2.755 ± 0.049
2.051ThrPhe: 2.051 ± 0.041
5.296ThrGly: 5.296 ± 0.074
1.053ThrHis: 1.053 ± 0.028
3.397ThrIle: 3.397 ± 0.057
1.617ThrLys: 1.617 ± 0.044
6.569ThrLeu: 6.569 ± 0.091
1.321ThrMet: 1.321 ± 0.035
1.589ThrAsn: 1.589 ± 0.038
3.473ThrPro: 3.473 ± 0.066
1.743ThrGln: 1.743 ± 0.042
3.265ThrArg: 3.265 ± 0.053
3.116ThrSer: 3.116 ± 0.062
3.359ThrThr: 3.359 ± 0.061
4.609ThrVal: 4.609 ± 0.09
0.616ThrTrp: 0.616 ± 0.025
1.277ThrTyr: 1.277 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
9.561ValAla: 9.561 ± 0.104
0.463ValCys: 0.463 ± 0.018
4.55ValAsp: 4.55 ± 0.072
4.637ValGlu: 4.637 ± 0.07
2.794ValPhe: 2.794 ± 0.049
5.898ValGly: 5.898 ± 0.09
1.365ValHis: 1.365 ± 0.037
4.512ValIle: 4.512 ± 0.07
2.229ValLys: 2.229 ± 0.044
7.988ValLeu: 7.988 ± 0.098
1.997ValMet: 1.997 ± 0.047
2.099ValAsn: 2.099 ± 0.039
3.722ValPro: 3.722 ± 0.058
2.136ValGln: 2.136 ± 0.048
4.277ValArg: 4.277 ± 0.065
4.627ValSer: 4.627 ± 0.063
5.092ValThr: 5.092 ± 0.093
6.535ValVal: 6.535 ± 0.084
0.924ValTrp: 0.924 ± 0.029
1.547ValTyr: 1.547 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.244TrpAla: 1.244 ± 0.037
0.118TrpCys: 0.118 ± 0.009
0.67TrpAsp: 0.67 ± 0.028
0.539TrpGlu: 0.539 ± 0.023
0.541TrpPhe: 0.541 ± 0.023
0.908TrpGly: 0.908 ± 0.029
0.296TrpHis: 0.296 ± 0.018
0.663TrpIle: 0.663 ± 0.024
0.39TrpLys: 0.39 ± 0.018
1.566TrpLeu: 1.566 ± 0.038
0.345TrpMet: 0.345 ± 0.018
0.459TrpAsn: 0.459 ± 0.02
0.67TrpPro: 0.67 ± 0.025
0.617TrpGln: 0.617 ± 0.022
0.951TrpArg: 0.951 ± 0.031
0.868TrpSer: 0.868 ± 0.029
0.798TrpThr: 0.798 ± 0.028
0.864TrpVal: 0.864 ± 0.028
0.242TrpTrp: 0.242 ± 0.014
0.283TrpTyr: 0.283 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.607TyrAla: 2.607 ± 0.051
0.203TyrCys: 0.203 ± 0.012
1.523TyrAsp: 1.523 ± 0.034
1.267TyrGlu: 1.267 ± 0.031
1.008TyrPhe: 1.008 ± 0.029
2.184TyrGly: 2.184 ± 0.043
0.471TyrHis: 0.471 ± 0.017
0.968TyrIle: 0.968 ± 0.029
0.613TyrLys: 0.613 ± 0.025
2.324TyrLeu: 2.324 ± 0.054
0.473TyrMet: 0.473 ± 0.021
0.683TyrAsn: 0.683 ± 0.025
1.092TyrPro: 1.092 ± 0.03
0.771TyrGln: 0.771 ± 0.027
1.584TyrArg: 1.584 ± 0.039
1.231TyrSer: 1.231 ± 0.036
1.145TyrThr: 1.145 ± 0.038
1.703TyrVal: 1.703 ± 0.038
0.386TyrTrp: 0.386 ± 0.02
0.62TyrTyr: 0.62 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3685 proteins (1143512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski