Amino acid dipepetide frequency for Streptococcus satellite phage Javan726

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.623AlaAla: 0.623 ± 0.499
0.0AlaCys: 0.0 ± 0.0
2.491AlaAsp: 2.491 ± 0.74
5.293AlaGlu: 5.293 ± 1.733
3.425AlaPhe: 3.425 ± 0.822
2.179AlaGly: 2.179 ± 0.541
0.0AlaHis: 0.0 ± 0.0
2.802AlaIle: 2.802 ± 0.649
6.227AlaLys: 6.227 ± 1.065
2.491AlaLeu: 2.491 ± 0.924
2.491AlaMet: 2.491 ± 0.834
2.802AlaAsn: 2.802 ± 1.062
1.245AlaPro: 1.245 ± 0.464
1.868AlaGln: 1.868 ± 0.738
2.491AlaArg: 2.491 ± 0.618
2.179AlaSer: 2.179 ± 0.98
4.67AlaThr: 4.67 ± 0.926
3.425AlaVal: 3.425 ± 0.861
0.311AlaTrp: 0.311 ± 0.269
2.179AlaTyr: 2.179 ± 0.574
0.0AlaXaa: 0.0 ± 0.0
Cys
1.245CysAla: 1.245 ± 0.474
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.934CysGlu: 0.934 ± 0.411
0.311CysPhe: 0.311 ± 0.269
0.311CysGly: 0.311 ± 0.303
0.311CysHis: 0.311 ± 0.247
0.0CysIle: 0.0 ± 0.0
0.623CysLys: 0.623 ± 0.541
0.934CysLeu: 0.934 ± 0.452
0.311CysMet: 0.311 ± 0.386
0.311CysAsn: 0.311 ± 0.349
0.311CysPro: 0.311 ± 0.247
0.934CysGln: 0.934 ± 0.776
0.311CysArg: 0.311 ± 0.288
0.0CysSer: 0.0 ± 0.0
0.623CysThr: 0.623 ± 0.453
0.311CysVal: 0.311 ± 0.269
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.934AspAla: 0.934 ± 0.424
1.245AspCys: 1.245 ± 0.484
4.67AspAsp: 4.67 ± 1.02
6.849AspGlu: 6.849 ± 1.098
3.736AspPhe: 3.736 ± 0.71
3.113AspGly: 3.113 ± 0.7
0.311AspHis: 0.311 ± 0.269
7.783AspIle: 7.783 ± 1.169
5.293AspLys: 5.293 ± 1.245
9.029AspLeu: 9.029 ± 1.822
0.934AspMet: 0.934 ± 0.474
2.802AspAsn: 2.802 ± 0.815
0.934AspPro: 0.934 ± 0.403
0.623AspGln: 0.623 ± 0.33
3.113AspArg: 3.113 ± 1.261
2.802AspSer: 2.802 ± 0.873
2.802AspThr: 2.802 ± 1.031
2.179AspVal: 2.179 ± 0.796
0.0AspTrp: 0.0 ± 0.0
3.425AspTyr: 3.425 ± 1.269
0.0AspXaa: 0.0 ± 0.0
Glu
3.736GluAla: 3.736 ± 1.434
0.934GluCys: 0.934 ± 0.422
2.802GluAsp: 2.802 ± 1.205
4.67GluGlu: 4.67 ± 1.074
2.491GluPhe: 2.491 ± 0.802
2.179GluGly: 2.179 ± 0.582
2.802GluHis: 2.802 ± 1.005
6.849GluIle: 6.849 ± 1.089
9.029GluLys: 9.029 ± 1.606
12.453GluLeu: 12.453 ± 1.881
3.113GluMet: 3.113 ± 0.911
6.849GluAsn: 6.849 ± 1.435
1.557GluPro: 1.557 ± 0.655
3.425GluGln: 3.425 ± 0.732
4.047GluArg: 4.047 ± 0.956
7.161GluSer: 7.161 ± 1.268
4.359GluThr: 4.359 ± 1.026
5.604GluVal: 5.604 ± 1.664
0.0GluTrp: 0.0 ± 0.0
4.981GluTyr: 4.981 ± 1.335
0.0GluXaa: 0.0 ± 0.0
Phe
0.623PheAla: 0.623 ± 0.383
0.311PheCys: 0.311 ± 0.357
4.359PheAsp: 4.359 ± 1.282
4.047PheGlu: 4.047 ± 1.044
4.047PhePhe: 4.047 ± 0.972
1.868PheGly: 1.868 ± 0.732
0.934PheHis: 0.934 ± 0.49
3.113PheIle: 3.113 ± 0.808
4.047PheLys: 4.047 ± 1.604
4.047PheLeu: 4.047 ± 0.945
0.311PheMet: 0.311 ± 0.337
2.179PheAsn: 2.179 ± 0.966
0.934PhePro: 0.934 ± 0.401
0.623PheGln: 0.623 ± 0.356
2.179PheArg: 2.179 ± 0.656
4.67PheSer: 4.67 ± 1.324
2.179PheThr: 2.179 ± 1.09
3.113PheVal: 3.113 ± 1.094
0.623PheTrp: 0.623 ± 0.369
1.868PheTyr: 1.868 ± 0.625
0.0PheXaa: 0.0 ± 0.0
Gly
3.736GlyAla: 3.736 ± 1.25
0.311GlyCys: 0.311 ± 0.259
3.113GlyAsp: 3.113 ± 1.063
3.425GlyGlu: 3.425 ± 0.826
1.557GlyPhe: 1.557 ± 0.561
2.179GlyGly: 2.179 ± 0.617
0.623GlyHis: 0.623 ± 0.372
3.425GlyIle: 3.425 ± 1.113
4.359GlyLys: 4.359 ± 1.149
4.67GlyLeu: 4.67 ± 1.221
1.245GlyMet: 1.245 ± 0.745
1.557GlyAsn: 1.557 ± 0.742
0.0GlyPro: 0.0 ± 0.0
1.245GlyGln: 1.245 ± 0.533
2.491GlyArg: 2.491 ± 0.818
1.868GlySer: 1.868 ± 0.735
1.868GlyThr: 1.868 ± 0.683
4.359GlyVal: 4.359 ± 0.998
1.245GlyTrp: 1.245 ± 0.792
3.736GlyTyr: 3.736 ± 1.183
0.0GlyXaa: 0.0 ± 0.0
His
2.179HisAla: 2.179 ± 0.844
0.0HisCys: 0.0 ± 0.0
0.623HisAsp: 0.623 ± 0.397
0.0HisGlu: 0.0 ± 0.0
0.311HisPhe: 0.311 ± 0.294
0.311HisGly: 0.311 ± 0.354
0.311HisHis: 0.311 ± 0.259
0.0HisIle: 0.0 ± 0.0
2.179HisLys: 2.179 ± 0.728
2.179HisLeu: 2.179 ± 0.963
0.311HisMet: 0.311 ± 0.306
2.179HisAsn: 2.179 ± 0.79
0.623HisPro: 0.623 ± 0.367
0.311HisGln: 0.311 ± 0.294
1.557HisArg: 1.557 ± 0.658
0.623HisSer: 0.623 ± 0.417
0.934HisThr: 0.934 ± 0.593
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.934HisTyr: 0.934 ± 0.705
0.0HisXaa: 0.0 ± 0.0
Ile
3.736IleAla: 3.736 ± 0.979
0.311IleCys: 0.311 ± 0.349
2.802IleAsp: 2.802 ± 1.048
5.915IleGlu: 5.915 ± 1.52
3.425IlePhe: 3.425 ± 1.034
3.113IleGly: 3.113 ± 1.173
0.934IleHis: 0.934 ± 0.485
6.227IleIle: 6.227 ± 1.221
5.604IleLys: 5.604 ± 1.056
8.095IleLeu: 8.095 ± 1.648
0.623IleMet: 0.623 ± 0.339
2.491IleAsn: 2.491 ± 0.751
2.491IlePro: 2.491 ± 0.8
2.491IleGln: 2.491 ± 0.816
2.491IleArg: 2.491 ± 0.686
3.113IleSer: 3.113 ± 0.926
4.359IleThr: 4.359 ± 0.891
4.67IleVal: 4.67 ± 0.826
0.311IleTrp: 0.311 ± 0.354
4.047IleTyr: 4.047 ± 0.868
0.0IleXaa: 0.0 ± 0.0
Lys
6.849LysAla: 6.849 ± 1.216
0.623LysCys: 0.623 ± 0.361
6.538LysAsp: 6.538 ± 1.197
8.406LysGlu: 8.406 ± 1.72
4.047LysPhe: 4.047 ± 1.228
5.604LysGly: 5.604 ± 1.243
1.868LysHis: 1.868 ± 0.728
7.161LysIle: 7.161 ± 1.306
9.34LysLys: 9.34 ± 1.697
8.095LysLeu: 8.095 ± 1.514
2.179LysMet: 2.179 ± 0.889
4.67LysAsn: 4.67 ± 1.222
2.179LysPro: 2.179 ± 0.81
1.868LysGln: 1.868 ± 1.033
6.227LysArg: 6.227 ± 1.106
6.849LysSer: 6.849 ± 1.075
6.227LysThr: 6.227 ± 1.442
4.67LysVal: 4.67 ± 0.888
1.245LysTrp: 1.245 ± 0.474
3.113LysTyr: 3.113 ± 0.732
0.0LysXaa: 0.0 ± 0.0
Leu
5.604LeuAla: 5.604 ± 1.567
0.934LeuCys: 0.934 ± 0.5
9.029LeuAsp: 9.029 ± 1.595
10.274LeuGlu: 10.274 ± 1.154
4.981LeuPhe: 4.981 ± 1.612
4.981LeuGly: 4.981 ± 1.295
1.245LeuHis: 1.245 ± 0.704
5.915LeuIle: 5.915 ± 1.335
9.34LeuLys: 9.34 ± 1.417
7.161LeuLeu: 7.161 ± 1.872
1.557LeuMet: 1.557 ± 0.627
9.34LeuAsn: 9.34 ± 1.602
2.491LeuPro: 2.491 ± 0.725
2.491LeuGln: 2.491 ± 1.09
5.293LeuArg: 5.293 ± 0.851
5.915LeuSer: 5.915 ± 1.352
7.783LeuThr: 7.783 ± 1.588
4.981LeuVal: 4.981 ± 1.253
0.311LeuTrp: 0.311 ± 0.294
2.491LeuTyr: 2.491 ± 0.989
0.0LeuXaa: 0.0 ± 0.0
Met
0.934MetAla: 0.934 ± 0.544
0.311MetCys: 0.311 ± 0.356
2.491MetAsp: 2.491 ± 0.712
2.802MetGlu: 2.802 ± 0.881
0.934MetPhe: 0.934 ± 0.541
0.934MetGly: 0.934 ± 0.514
0.311MetHis: 0.311 ± 0.294
0.623MetIle: 0.623 ± 0.429
0.934MetLys: 0.934 ± 0.401
0.623MetLeu: 0.623 ± 0.369
0.623MetMet: 0.623 ± 0.422
1.868MetAsn: 1.868 ± 0.72
0.623MetPro: 0.623 ± 0.427
0.934MetGln: 0.934 ± 0.38
2.802MetArg: 2.802 ± 0.717
1.868MetSer: 1.868 ± 0.713
2.179MetThr: 2.179 ± 0.865
0.934MetVal: 0.934 ± 0.808
0.0MetTrp: 0.0 ± 0.0
0.623MetTyr: 0.623 ± 0.404
0.0MetXaa: 0.0 ± 0.0
Asn
2.179AsnAla: 2.179 ± 0.9
0.311AsnCys: 0.311 ± 0.247
3.113AsnAsp: 3.113 ± 0.902
3.425AsnGlu: 3.425 ± 0.854
1.868AsnPhe: 1.868 ± 0.812
3.425AsnGly: 3.425 ± 1.107
1.557AsnHis: 1.557 ± 0.761
2.491AsnIle: 2.491 ± 0.807
8.406AsnLys: 8.406 ± 1.518
4.981AsnLeu: 4.981 ± 0.814
1.868AsnMet: 1.868 ± 0.715
1.557AsnAsn: 1.557 ± 0.523
2.491AsnPro: 2.491 ± 0.848
2.802AsnGln: 2.802 ± 0.888
3.113AsnArg: 3.113 ± 0.801
4.047AsnSer: 4.047 ± 1.081
2.802AsnThr: 2.802 ± 0.732
2.491AsnVal: 2.491 ± 0.971
0.623AsnTrp: 0.623 ± 0.313
2.179AsnTyr: 2.179 ± 0.649
0.0AsnXaa: 0.0 ± 0.0
Pro
1.245ProAla: 1.245 ± 0.642
0.0ProCys: 0.0 ± 0.0
2.802ProAsp: 2.802 ± 0.795
2.802ProGlu: 2.802 ± 0.902
1.245ProPhe: 1.245 ± 0.464
0.623ProGly: 0.623 ± 0.349
0.0ProHis: 0.0 ± 0.0
0.623ProIle: 0.623 ± 0.442
3.113ProLys: 3.113 ± 0.989
1.557ProLeu: 1.557 ± 0.495
0.623ProMet: 0.623 ± 0.539
1.245ProAsn: 1.245 ± 0.691
2.179ProPro: 2.179 ± 0.878
0.934ProGln: 0.934 ± 0.422
1.557ProArg: 1.557 ± 0.525
0.934ProSer: 0.934 ± 0.569
1.245ProThr: 1.245 ± 0.486
0.934ProVal: 0.934 ± 0.422
0.311ProTrp: 0.311 ± 0.357
1.557ProTyr: 1.557 ± 0.556
0.0ProXaa: 0.0 ± 0.0
Gln
3.736GlnAla: 3.736 ± 1.289
0.623GlnCys: 0.623 ± 0.388
1.557GlnAsp: 1.557 ± 0.981
3.425GlnGlu: 3.425 ± 0.79
1.868GlnPhe: 1.868 ± 0.673
2.179GlnGly: 2.179 ± 0.923
0.623GlnHis: 0.623 ± 0.34
1.557GlnIle: 1.557 ± 0.633
1.868GlnLys: 1.868 ± 0.783
3.736GlnLeu: 3.736 ± 1.174
0.934GlnMet: 0.934 ± 0.504
0.934GlnAsn: 0.934 ± 0.371
0.311GlnPro: 0.311 ± 0.354
1.245GlnGln: 1.245 ± 0.503
1.868GlnArg: 1.868 ± 0.683
0.311GlnSer: 0.311 ± 0.288
1.557GlnThr: 1.557 ± 0.722
3.113GlnVal: 3.113 ± 0.819
0.311GlnTrp: 0.311 ± 0.247
0.934GlnTyr: 0.934 ± 0.54
0.0GlnXaa: 0.0 ± 0.0
Arg
2.802ArgAla: 2.802 ± 1.039
0.311ArgCys: 0.311 ± 0.303
3.113ArgAsp: 3.113 ± 0.725
6.227ArgGlu: 6.227 ± 1.122
1.868ArgPhe: 1.868 ± 0.695
1.557ArgGly: 1.557 ± 1.074
1.245ArgHis: 1.245 ± 0.408
4.047ArgIle: 4.047 ± 1.115
5.604ArgLys: 5.604 ± 1.09
4.981ArgLeu: 4.981 ± 1.33
1.868ArgMet: 1.868 ± 1.093
2.491ArgAsn: 2.491 ± 0.835
0.623ArgPro: 0.623 ± 0.539
3.425ArgGln: 3.425 ± 0.963
3.425ArgArg: 3.425 ± 1.066
2.179ArgSer: 2.179 ± 0.64
2.491ArgThr: 2.491 ± 0.643
2.491ArgVal: 2.491 ± 0.797
0.311ArgTrp: 0.311 ± 0.288
4.981ArgTyr: 4.981 ± 1.432
0.0ArgXaa: 0.0 ± 0.0
Ser
1.868SerAla: 1.868 ± 0.821
0.623SerCys: 0.623 ± 0.349
2.802SerAsp: 2.802 ± 0.906
6.849SerGlu: 6.849 ± 1.759
2.491SerPhe: 2.491 ± 0.734
4.359SerGly: 4.359 ± 0.772
1.245SerHis: 1.245 ± 0.472
3.425SerIle: 3.425 ± 1.058
5.604SerLys: 5.604 ± 1.068
6.849SerLeu: 6.849 ± 1.406
1.245SerMet: 1.245 ± 0.622
3.425SerAsn: 3.425 ± 0.81
1.245SerPro: 1.245 ± 0.493
1.557SerGln: 1.557 ± 0.705
3.113SerArg: 3.113 ± 0.872
3.113SerSer: 3.113 ± 0.868
2.179SerThr: 2.179 ± 0.728
1.557SerVal: 1.557 ± 0.448
0.623SerTrp: 0.623 ± 0.502
1.245SerTyr: 1.245 ± 0.61
0.0SerXaa: 0.0 ± 0.0
Thr
0.934ThrAla: 0.934 ± 0.446
0.0ThrCys: 0.0 ± 0.0
3.736ThrAsp: 3.736 ± 1.178
3.425ThrGlu: 3.425 ± 0.7
2.179ThrPhe: 2.179 ± 0.61
3.113ThrGly: 3.113 ± 0.745
0.934ThrHis: 0.934 ± 0.399
3.425ThrIle: 3.425 ± 0.817
4.359ThrLys: 4.359 ± 1.02
7.472ThrLeu: 7.472 ± 1.427
0.623ThrMet: 0.623 ± 0.434
2.179ThrAsn: 2.179 ± 0.776
2.802ThrPro: 2.802 ± 0.699
3.113ThrGln: 3.113 ± 0.83
3.736ThrArg: 3.736 ± 0.905
2.491ThrSer: 2.491 ± 0.798
3.425ThrThr: 3.425 ± 1.086
5.293ThrVal: 5.293 ± 1.468
0.0ThrTrp: 0.0 ± 0.0
4.047ThrTyr: 4.047 ± 1.091
0.0ThrXaa: 0.0 ± 0.0
Val
4.359ValAla: 4.359 ± 1.292
0.0ValCys: 0.0 ± 0.0
4.359ValAsp: 4.359 ± 1.245
6.227ValGlu: 6.227 ± 1.301
2.491ValPhe: 2.491 ± 0.949
3.425ValGly: 3.425 ± 1.137
0.311ValHis: 0.311 ± 0.269
3.736ValIle: 3.736 ± 0.901
5.293ValLys: 5.293 ± 0.983
3.425ValLeu: 3.425 ± 0.924
0.934ValMet: 0.934 ± 0.583
4.047ValAsn: 4.047 ± 0.995
1.868ValPro: 1.868 ± 0.748
1.245ValGln: 1.245 ± 0.598
3.113ValArg: 3.113 ± 0.911
2.491ValSer: 2.491 ± 0.977
3.113ValThr: 3.113 ± 0.984
4.359ValVal: 4.359 ± 1.173
0.311ValTrp: 0.311 ± 0.349
2.179ValTyr: 2.179 ± 0.774
0.0ValXaa: 0.0 ± 0.0
Trp
0.311TrpAla: 0.311 ± 0.247
0.311TrpCys: 0.311 ± 0.269
0.311TrpAsp: 0.311 ± 0.357
1.557TrpGlu: 1.557 ± 0.564
0.0TrpPhe: 0.0 ± 0.0
0.311TrpGly: 0.311 ± 0.269
0.0TrpHis: 0.0 ± 0.0
0.623TrpIle: 0.623 ± 0.475
0.934TrpLys: 0.934 ± 0.648
0.311TrpLeu: 0.311 ± 0.247
0.0TrpMet: 0.0 ± 0.0
0.311TrpAsn: 0.311 ± 0.288
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.311TrpArg: 0.311 ± 0.269
0.311TrpSer: 0.311 ± 0.247
0.311TrpThr: 0.311 ± 0.269
0.623TrpVal: 0.623 ± 0.42
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.557TyrAla: 1.557 ± 0.612
0.623TyrCys: 0.623 ± 0.385
1.868TyrAsp: 1.868 ± 0.5
2.491TyrGlu: 2.491 ± 0.622
2.802TyrPhe: 2.802 ± 1.031
1.245TyrGly: 1.245 ± 0.546
0.0TyrHis: 0.0 ± 0.0
3.425TyrIle: 3.425 ± 0.87
5.604TyrLys: 5.604 ± 1.605
9.34TyrLeu: 9.34 ± 1.33
1.245TyrMet: 1.245 ± 0.546
2.491TyrAsn: 2.491 ± 0.704
0.623TyrPro: 0.623 ± 0.313
1.557TyrGln: 1.557 ± 0.455
2.802TyrArg: 2.802 ± 0.824
2.491TyrSer: 2.491 ± 0.727
2.179TyrThr: 2.179 ± 0.664
2.179TyrVal: 2.179 ± 0.878
0.0TyrTrp: 0.0 ± 0.0
1.245TyrTyr: 1.245 ± 0.811
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (3213 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski