Amino acid dipepetide frequency for Rhodococcus sp. S2-17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.27AlaAla: 18.27 ± 0.127	0.963AlaCys: 0.963 ± 0.022	7.971AlaAsp: 7.971 ± 0.061	7.877AlaGlu: 7.877 ± 0.074	3.468AlaPhe: 3.468 ± 0.043	11.253AlaGly: 11.253 ± 0.09	2.682AlaHis: 2.682 ± 0.036	4.883AlaIle: 4.883 ± 0.049	2.877AlaLys: 2.877 ± 0.045	13.008AlaLeu: 13.008 ± 0.098	2.592AlaMet: 2.592 ± 0.034	2.269AlaAsn: 2.269 ± 0.033	5.968AlaPro: 5.968 ± 0.07	3.718AlaGln: 3.718 ± 0.043	8.428AlaArg: 8.428 ± 0.086	6.323AlaSer: 6.323 ± 0.061	7.06AlaThr: 7.06 ± 0.064	11.59AlaVal: 11.59 ± 0.092	1.485AlaTrp: 1.485 ± 0.027	2.23AlaTyr: 2.23 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.042CysAla: 1.042 ± 0.024	0.104CysCys: 0.104 ± 0.007	0.5CysAsp: 0.5 ± 0.017	0.464CysGlu: 0.464 ± 0.014	0.222CysPhe: 0.222 ± 0.01	0.961CysGly: 0.961 ± 0.022	0.198CysHis: 0.198 ± 0.01	0.295CysIle: 0.295 ± 0.012	0.127CysLys: 0.127 ± 0.008	0.685CysLeu: 0.685 ± 0.018	0.13CysMet: 0.13 ± 0.007	0.165CysAsn: 0.165 ± 0.009	0.481CysPro: 0.481 ± 0.017	0.18CysGln: 0.18 ± 0.01	0.643CysArg: 0.643 ± 0.022	0.516CysSer: 0.516 ± 0.015	0.54CysThr: 0.54 ± 0.017	0.646CysVal: 0.646 ± 0.017	0.114CysTrp: 0.114 ± 0.007	0.151CysTyr: 0.151 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.654AspAla: 7.654 ± 0.064	0.45AspCys: 0.45 ± 0.014	3.861AspAsp: 3.861 ± 0.044	4.077AspGlu: 4.077 ± 0.047	1.763AspPhe: 1.763 ± 0.03	5.737AspGly: 5.737 ± 0.052	1.455AspHis: 1.455 ± 0.028	2.654AspIle: 2.654 ± 0.036	1.285AspLys: 1.285 ± 0.027	6.506AspLeu: 6.506 ± 0.061	0.963AspMet: 0.963 ± 0.023	1.232AspAsn: 1.232 ± 0.026	4.368AspPro: 4.368 ± 0.049	1.684AspGln: 1.684 ± 0.029	4.747AspArg: 4.747 ± 0.055	3.204AspSer: 3.204 ± 0.042	3.583AspThr: 3.583 ± 0.044	5.339AspVal: 5.339 ± 0.056	0.894AspTrp: 0.894 ± 0.021	1.315AspTyr: 1.315 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	6.193GluAla: 6.193 ± 0.056	0.401GluCys: 0.401 ± 0.012	2.775GluAsp: 2.775 ± 0.037	3.023GluGlu: 3.023 ± 0.042	1.908GluPhe: 1.908 ± 0.03	3.857GluGly: 3.857 ± 0.045	1.675GluHis: 1.675 ± 0.031	2.733GluIle: 2.733 ± 0.037	1.579GluLys: 1.579 ± 0.031	6.72GluLeu: 6.72 ± 0.072	1.11GluMet: 1.11 ± 0.023	1.366GluAsn: 1.366 ± 0.026	2.945GluPro: 2.945 ± 0.045	2.456GluGln: 2.456 ± 0.037	4.822GluArg: 4.822 ± 0.056	3.3GluSer: 3.3 ± 0.041	2.849GluThr: 2.849 ± 0.034	4.774GluVal: 4.774 ± 0.05	0.858GluTrp: 0.858 ± 0.022	1.198GluTyr: 1.198 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	4.008PheAla: 4.008 ± 0.043	0.326PheCys: 0.326 ± 0.013	2.472PheAsp: 2.472 ± 0.037	1.719PheGlu: 1.719 ± 0.029	1.018PhePhe: 1.018 ± 0.026	3.433PheGly: 3.433 ± 0.051	0.665PheHis: 0.665 ± 0.019	0.995PheIle: 0.995 ± 0.021	0.478PheLys: 0.478 ± 0.016	2.679PheLeu: 2.679 ± 0.046	0.461PheMet: 0.461 ± 0.016	0.585PheAsn: 0.585 ± 0.018	1.42PhePro: 1.42 ± 0.026	0.678PheGln: 0.678 ± 0.018	1.817PheArg: 1.817 ± 0.031	1.681PheSer: 1.681 ± 0.03	2.106PheThr: 2.106 ± 0.038	2.701PheVal: 2.701 ± 0.035	0.409PheTrp: 0.409 ± 0.014	0.674PheTyr: 0.674 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	9.902GlyAla: 9.902 ± 0.095	0.779GlyCys: 0.779 ± 0.022	4.998GlyAsp: 4.998 ± 0.052	4.548GlyGlu: 4.548 ± 0.052	3.133GlyPhe: 3.133 ± 0.046	7.93GlyGly: 7.93 ± 0.11	2.064GlyHis: 2.064 ± 0.034	4.412GlyIle: 4.412 ± 0.046	2.445GlyLys: 2.445 ± 0.035	8.506GlyLeu: 8.506 ± 0.076	2.106GlyMet: 2.106 ± 0.03	2.036GlyAsn: 2.036 ± 0.036	4.274GlyPro: 4.274 ± 0.042	2.572GlyGln: 2.572 ± 0.042	6.494GlyArg: 6.494 ± 0.06	5.58GlySer: 5.58 ± 0.052	5.682GlyThr: 5.682 ± 0.056	7.683GlyVal: 7.683 ± 0.061	1.524GlyTrp: 1.524 ± 0.026	2.25GlyTyr: 2.25 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.474HisAla: 2.474 ± 0.036	0.243HisCys: 0.243 ± 0.012	1.342HisAsp: 1.342 ± 0.025	1.194HisGlu: 1.194 ± 0.024	0.729HisPhe: 0.729 ± 0.019	2.077HisGly: 2.077 ± 0.029	0.759HisHis: 0.759 ± 0.024	0.904HisIle: 0.904 ± 0.022	0.35HisLys: 0.35 ± 0.013	2.298HisLeu: 2.298 ± 0.038	0.395HisMet: 0.395 ± 0.014	0.467HisAsn: 0.467 ± 0.016	1.637HisPro: 1.637 ± 0.03	0.652HisGln: 0.652 ± 0.017	1.974HisArg: 1.974 ± 0.034	1.236HisSer: 1.236 ± 0.028	1.291HisThr: 1.291 ± 0.024	1.742HisVal: 1.742 ± 0.032	0.368HisTrp: 0.368 ± 0.014	0.525HisTyr: 0.525 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	6.217IleAla: 6.217 ± 0.059	0.368IleCys: 0.368 ± 0.013	3.465IleAsp: 3.465 ± 0.041	2.721IleGlu: 2.721 ± 0.04	1.094IlePhe: 1.094 ± 0.023	4.562IleGly: 4.562 ± 0.054	0.782IleHis: 0.782 ± 0.019	1.423IleIle: 1.423 ± 0.032	0.808IleLys: 0.808 ± 0.019	3.498IleLeu: 3.498 ± 0.045	0.615IleMet: 0.615 ± 0.017	1.001IleAsn: 1.001 ± 0.023	2.411IlePro: 2.411 ± 0.037	0.882IleGln: 0.882 ± 0.02	2.716IleArg: 2.716 ± 0.035	2.358IleSer: 2.358 ± 0.035	2.857IleThr: 2.857 ± 0.034	3.797IleVal: 3.797 ± 0.041	0.43IleTrp: 0.43 ± 0.013	0.766IleTyr: 0.766 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.678LysAla: 2.678 ± 0.044	0.122LysCys: 0.122 ± 0.008	1.123LysAsp: 1.123 ± 0.026	1.086LysGlu: 1.086 ± 0.021	0.668LysPhe: 0.668 ± 0.019	1.603LysGly: 1.603 ± 0.033	0.489LysHis: 0.489 ± 0.016	1.142LysIle: 1.142 ± 0.024	0.749LysLys: 0.749 ± 0.024	2.094LysLeu: 2.094 ± 0.03	0.5LysMet: 0.5 ± 0.015	0.575LysAsn: 0.575 ± 0.017	1.265LysPro: 1.265 ± 0.025	0.723LysGln: 0.723 ± 0.021	1.491LysArg: 1.491 ± 0.029	1.327LysSer: 1.327 ± 0.026	1.361LysThr: 1.361 ± 0.029	1.991LysVal: 1.991 ± 0.032	0.305LysTrp: 0.305 ± 0.011	0.509LysTyr: 0.509 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	13.5LeuAla: 13.5 ± 0.095	0.859LeuCys: 0.859 ± 0.021	7.035LeuAsp: 7.035 ± 0.062	5.185LeuGlu: 5.185 ± 0.055	2.773LeuPhe: 2.773 ± 0.042	9.201LeuGly: 9.201 ± 0.1	2.122LeuHis: 2.122 ± 0.03	4.074LeuIle: 4.074 ± 0.05	1.627LeuLys: 1.627 ± 0.03	9.635LeuLeu: 9.635 ± 0.09	1.683LeuMet: 1.683 ± 0.027	1.852LeuAsn: 1.852 ± 0.027	5.791LeuPro: 5.791 ± 0.057	2.448LeuGln: 2.448 ± 0.034	7.486LeuArg: 7.486 ± 0.071	5.879LeuSer: 5.879 ± 0.058	6.629LeuThr: 6.629 ± 0.05	8.786LeuVal: 8.786 ± 0.069	1.185LeuTrp: 1.185 ± 0.023	1.622LeuTyr: 1.622 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.324MetAla: 2.324 ± 0.035	0.189MetCys: 0.189 ± 0.01	0.868MetAsp: 0.868 ± 0.022	0.726MetGlu: 0.726 ± 0.019	0.648MetPhe: 0.648 ± 0.021	1.434MetGly: 1.434 ± 0.028	0.425MetHis: 0.425 ± 0.015	0.925MetIle: 0.925 ± 0.021	0.499MetLys: 0.499 ± 0.016	1.947MetLeu: 1.947 ± 0.034	0.417MetMet: 0.417 ± 0.013	0.538MetAsn: 0.538 ± 0.015	1.1MetPro: 1.1 ± 0.022	0.57MetGln: 0.57 ± 0.016	1.424MetArg: 1.424 ± 0.025	1.738MetSer: 1.738 ± 0.026	1.815MetThr: 1.815 ± 0.03	1.551MetVal: 1.551 ± 0.028	0.251MetTrp: 0.251 ± 0.01	0.342MetTyr: 0.342 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.499AsnAla: 2.499 ± 0.036	0.186AsnCys: 0.186 ± 0.01	1.159AsnAsp: 1.159 ± 0.025	1.01AsnGlu: 1.01 ± 0.025	0.647AsnPhe: 0.647 ± 0.017	1.963AsnGly: 1.963 ± 0.033	0.431AsnHis: 0.431 ± 0.013	0.922AsnIle: 0.922 ± 0.018	0.48AsnLys: 0.48 ± 0.014	2.069AsnLeu: 2.069 ± 0.032	0.397AsnMet: 0.397 ± 0.014	0.526AsnAsn: 0.526 ± 0.016	1.632AsnPro: 1.632 ± 0.029	0.593AsnGln: 0.593 ± 0.018	1.45AsnArg: 1.45 ± 0.025	1.261AsnSer: 1.261 ± 0.026	1.301AsnThr: 1.301 ± 0.027	1.719AsnVal: 1.719 ± 0.033	0.352AsnTrp: 0.352 ± 0.014	0.53AsnTyr: 0.53 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.751ProAla: 6.751 ± 0.069	0.31ProCys: 0.31 ± 0.011	4.268ProAsp: 4.268 ± 0.047	3.922ProGlu: 3.922 ± 0.049	1.588ProPhe: 1.588 ± 0.027	5.298ProGly: 5.298 ± 0.054	1.287ProHis: 1.287 ± 0.024	2.143ProIle: 2.143 ± 0.031	1.185ProLys: 1.185 ± 0.025	4.899ProLeu: 4.899 ± 0.049	1.116ProMet: 1.116 ± 0.022	1.125ProAsn: 1.125 ± 0.023	2.948ProPro: 2.948 ± 0.055	1.61ProGln: 1.61 ± 0.026	3.46ProArg: 3.46 ± 0.038	3.278ProSer: 3.278 ± 0.038	3.52ProThr: 3.52 ± 0.045	5.044ProVal: 5.044 ± 0.051	0.754ProTrp: 0.754 ± 0.018	1.087ProTyr: 1.087 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.203GlnAla: 3.203 ± 0.041	0.2GlnCys: 0.2 ± 0.01	1.269GlnAsp: 1.269 ± 0.025	1.225GlnGlu: 1.225 ± 0.024	0.955GlnPhe: 0.955 ± 0.018	1.994GlnGly: 1.994 ± 0.029	0.713GlnHis: 0.713 ± 0.018	1.492GlnIle: 1.492 ± 0.031	0.678GlnLys: 0.678 ± 0.019	3.346GlnLeu: 3.346 ± 0.043	0.663GlnMet: 0.663 ± 0.02	0.642GlnAsn: 0.642 ± 0.02	1.594GlnPro: 1.594 ± 0.031	1.218GlnGln: 1.218 ± 0.031	2.44GlnArg: 2.44 ± 0.035	1.573GlnSer: 1.573 ± 0.028	1.417GlnThr: 1.417 ± 0.025	2.529GlnVal: 2.529 ± 0.037	0.565GlnTrp: 0.565 ± 0.016	0.644GlnTyr: 0.644 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.061ArgAla: 8.061 ± 0.075	0.604ArgCys: 0.604 ± 0.018	4.146ArgAsp: 4.146 ± 0.042	4.338ArgGlu: 4.338 ± 0.055	2.297ArgPhe: 2.297 ± 0.03	5.273ArgGly: 5.273 ± 0.052	1.818ArgHis: 1.818 ± 0.036	3.6ArgIle: 3.6 ± 0.041	1.746ArgLys: 1.746 ± 0.031	7.194ArgLeu: 7.194 ± 0.07	1.793ArgMet: 1.793 ± 0.031	1.653ArgAsn: 1.653 ± 0.027	3.856ArgPro: 3.856 ± 0.044	2.112ArgGln: 2.112 ± 0.031	6.373ArgArg: 6.373 ± 0.068	4.448ArgSer: 4.448 ± 0.054	4.821ArgThr: 4.821 ± 0.053	5.621ArgVal: 5.621 ± 0.053	1.268ArgTrp: 1.268 ± 0.024	1.765ArgTyr: 1.765 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.284SerAla: 7.284 ± 0.062	0.467SerCys: 0.467 ± 0.014	3.52SerAsp: 3.52 ± 0.044	3.081SerGlu: 3.081 ± 0.038	1.786SerPhe: 1.786 ± 0.029	6.034SerGly: 6.034 ± 0.055	1.098SerHis: 1.098 ± 0.025	2.425SerIle: 2.425 ± 0.037	1.231SerLys: 1.231 ± 0.029	5.278SerLeu: 5.278 ± 0.052	1.441SerMet: 1.441 ± 0.025	1.153SerAsn: 1.153 ± 0.023	3.275SerPro: 3.275 ± 0.04	1.44SerGln: 1.44 ± 0.028	4.09SerArg: 4.09 ± 0.048	3.627SerSer: 3.627 ± 0.048	3.908SerThr: 3.908 ± 0.043	4.995SerVal: 4.995 ± 0.051	0.945SerTrp: 0.945 ± 0.023	1.243SerTyr: 1.243 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.015ThrAla: 8.015 ± 0.077	0.452ThrCys: 0.452 ± 0.015	3.883ThrAsp: 3.883 ± 0.047	3.615ThrGlu: 3.615 ± 0.041	1.852ThrPhe: 1.852 ± 0.034	6.015ThrGly: 6.015 ± 0.052	1.29ThrHis: 1.29 ± 0.025	2.563ThrIle: 2.563 ± 0.033	1.271ThrLys: 1.271 ± 0.024	5.906ThrLeu: 5.906 ± 0.057	1.174ThrMet: 1.174 ± 0.027	1.194ThrAsn: 1.194 ± 0.027	3.895ThrPro: 3.895 ± 0.041	1.509ThrGln: 1.509 ± 0.026	3.943ThrArg: 3.943 ± 0.034	3.749ThrSer: 3.749 ± 0.044	4.335ThrThr: 4.335 ± 0.058	6.186ThrVal: 6.186 ± 0.058	0.843ThrTrp: 0.843 ± 0.021	1.271ThrTyr: 1.271 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	11.065ValAla: 11.065 ± 0.077	0.764ValCys: 0.764 ± 0.021	6.062ValAsp: 6.062 ± 0.061	4.96ValGlu: 4.96 ± 0.051	2.55ValPhe: 2.55 ± 0.04	7.258ValGly: 7.258 ± 0.059	1.928ValHis: 1.928 ± 0.034	3.8ValIle: 3.8 ± 0.045	1.644ValLys: 1.644 ± 0.031	9.312ValLeu: 9.312 ± 0.075	1.527ValMet: 1.527 ± 0.027	1.886ValAsn: 1.886 ± 0.034	4.9ValPro: 4.9 ± 0.049	2.182ValGln: 2.182 ± 0.034	6.155ValArg: 6.155 ± 0.056	5.04ValSer: 5.04 ± 0.053	5.789ValThr: 5.789 ± 0.054	8.833ValVal: 8.833 ± 0.076	1.078ValTrp: 1.078 ± 0.027	1.492ValTyr: 1.492 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.528TrpAla: 1.528 ± 0.024	0.162TrpCys: 0.162 ± 0.008	0.731TrpAsp: 0.731 ± 0.024	0.669TrpGlu: 0.669 ± 0.018	0.515TrpPhe: 0.515 ± 0.019	1.027TrpGly: 1.027 ± 0.023	0.351TrpHis: 0.351 ± 0.016	0.704TrpIle: 0.704 ± 0.018	0.376TrpLys: 0.376 ± 0.014	1.547TrpLeu: 1.547 ± 0.029	0.355TrpMet: 0.355 ± 0.012	0.445TrpAsn: 0.445 ± 0.015	0.689TrpPro: 0.689 ± 0.017	0.522TrpGln: 0.522 ± 0.016	1.093TrpArg: 1.093 ± 0.022	0.962TrpSer: 0.962 ± 0.02	0.9TrpThr: 0.9 ± 0.024	1.108TrpVal: 1.108 ± 0.025	0.306TrpTrp: 0.306 ± 0.013	0.298TrpTyr: 0.298 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.248TyrAla: 2.248 ± 0.035	0.215TyrCys: 0.215 ± 0.01	1.321TyrAsp: 1.321 ± 0.03	1.102TyrGlu: 1.102 ± 0.024	0.714TyrPhe: 0.714 ± 0.021	2.007TyrGly: 2.007 ± 0.032	0.422TyrHis: 0.422 ± 0.016	0.68TyrIle: 0.68 ± 0.018	0.368TyrLys: 0.368 ± 0.014	2.245TyrLeu: 2.245 ± 0.033	0.293TyrMet: 0.293 ± 0.012	0.417TyrAsn: 0.417 ± 0.013	1.145TyrPro: 1.145 ± 0.021	0.612TyrGln: 0.612 ± 0.018	1.74TyrArg: 1.74 ± 0.028	1.241TyrSer: 1.241 ± 0.024	1.202TyrThr: 1.202 ± 0.025	1.59TyrVal: 1.59 ± 0.033	0.351TyrTrp: 0.351 ± 0.014	0.453TyrTyr: 0.453 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6874 proteins (2188525 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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