Amino acid dipepetide frequency for Alkalihalobacillus nanhaiisediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.829AlaAla: 5.829 ± 0.094	0.639AlaCys: 0.639 ± 0.025	3.489AlaAsp: 3.489 ± 0.058	4.976AlaGlu: 4.976 ± 0.083	3.323AlaPhe: 3.323 ± 0.065	5.326AlaGly: 5.326 ± 0.085	1.417AlaHis: 1.417 ± 0.039	6.136AlaIle: 6.136 ± 0.095	4.765AlaLys: 4.765 ± 0.08	7.637AlaLeu: 7.637 ± 0.096	2.163AlaMet: 2.163 ± 0.051	2.906AlaAsn: 2.906 ± 0.053	2.082AlaPro: 2.082 ± 0.043	2.314AlaGln: 2.314 ± 0.057	2.888AlaArg: 2.888 ± 0.053	4.122AlaSer: 4.122 ± 0.07	4.097AlaThr: 4.097 ± 0.063	5.371AlaVal: 5.371 ± 0.083	0.599AlaTrp: 0.599 ± 0.024	2.314AlaTyr: 2.314 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.437CysAla: 0.437 ± 0.021	0.097CysCys: 0.097 ± 0.011	0.373CysAsp: 0.373 ± 0.021	0.489CysGlu: 0.489 ± 0.023	0.269CysPhe: 0.269 ± 0.015	0.708CysGly: 0.708 ± 0.029	0.227CysHis: 0.227 ± 0.014	0.43CysIle: 0.43 ± 0.021	0.332CysLys: 0.332 ± 0.02	0.682CysLeu: 0.682 ± 0.028	0.18CysMet: 0.18 ± 0.011	0.262CysAsn: 0.262 ± 0.018	0.37CysPro: 0.37 ± 0.022	0.289CysGln: 0.289 ± 0.018	0.288CysArg: 0.288 ± 0.017	0.446CysSer: 0.446 ± 0.022	0.383CysThr: 0.383 ± 0.018	0.429CysVal: 0.429 ± 0.02	0.067CysTrp: 0.067 ± 0.008	0.246CysTyr: 0.246 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.222AspAla: 3.222 ± 0.059	0.351AspCys: 0.351 ± 0.021	2.499AspAsp: 2.499 ± 0.059	4.568AspGlu: 4.568 ± 0.081	2.235AspPhe: 2.235 ± 0.045	3.348AspGly: 3.348 ± 0.074	1.297AspHis: 1.297 ± 0.04	4.058AspIle: 4.058 ± 0.061	2.696AspLys: 2.696 ± 0.056	5.077AspLeu: 5.077 ± 0.069	1.369AspMet: 1.369 ± 0.032	1.494AspAsn: 1.494 ± 0.045	1.926AspPro: 1.926 ± 0.043	2.283AspGln: 2.283 ± 0.048	2.399AspArg: 2.399 ± 0.051	2.51AspSer: 2.51 ± 0.051	2.414AspThr: 2.414 ± 0.051	4.22AspVal: 4.22 ± 0.077	0.554AspTrp: 0.554 ± 0.027	2.005AspTyr: 2.005 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.926GluAla: 5.926 ± 0.084	0.371GluCys: 0.371 ± 0.018	3.849GluAsp: 3.849 ± 0.069	7.733GluGlu: 7.733 ± 0.114	2.398GluPhe: 2.398 ± 0.047	4.703GluGly: 4.703 ± 0.073	1.703GluHis: 1.703 ± 0.045	5.505GluIle: 5.505 ± 0.085	6.14GluLys: 6.14 ± 0.079	7.784GluLeu: 7.784 ± 0.104	2.46GluMet: 2.46 ± 0.054	3.309GluAsn: 3.309 ± 0.061	2.213GluPro: 2.213 ± 0.047	4.313GluGln: 4.313 ± 0.08	4.342GluArg: 4.342 ± 0.078	3.677GluSer: 3.677 ± 0.057	3.973GluThr: 3.973 ± 0.066	5.53GluVal: 5.53 ± 0.08	0.872GluTrp: 0.872 ± 0.029	2.146GluTyr: 2.146 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.174PheAla: 3.174 ± 0.068	0.318PheCys: 0.318 ± 0.015	2.295PheAsp: 2.295 ± 0.049	3.035PheGlu: 3.035 ± 0.062	2.288PhePhe: 2.288 ± 0.063	3.171PheGly: 3.171 ± 0.059	1.023PheHis: 1.023 ± 0.034	3.655PheIle: 3.655 ± 0.072	2.09PheLys: 2.09 ± 0.045	4.44PheLeu: 4.44 ± 0.095	1.104PheMet: 1.104 ± 0.035	1.653PheAsn: 1.653 ± 0.046	1.598PhePro: 1.598 ± 0.041	1.617PheGln: 1.617 ± 0.039	1.541PheArg: 1.541 ± 0.037	3.121PheSer: 3.121 ± 0.065	2.435PheThr: 2.435 ± 0.06	3.147PheVal: 3.147 ± 0.062	0.429PheTrp: 0.429 ± 0.023	1.464PheTyr: 1.464 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	5.148GlyAla: 5.148 ± 0.087	0.607GlyCys: 0.607 ± 0.028	3.213GlyAsp: 3.213 ± 0.062	4.837GlyGlu: 4.837 ± 0.076	3.412GlyPhe: 3.412 ± 0.066	4.893GlyGly: 4.893 ± 0.08	1.477GlyHis: 1.477 ± 0.035	5.664GlyIle: 5.664 ± 0.082	4.397GlyLys: 4.397 ± 0.068	6.75GlyLeu: 6.75 ± 0.103	2.208GlyMet: 2.208 ± 0.051	2.403GlyAsn: 2.403 ± 0.05	1.826GlyPro: 1.826 ± 0.05	2.394GlyGln: 2.394 ± 0.053	2.836GlyArg: 2.836 ± 0.063	3.823GlySer: 3.823 ± 0.058	4.047GlyThr: 4.047 ± 0.073	5.295GlyVal: 5.295 ± 0.073	0.722GlyTrp: 0.722 ± 0.033	2.71GlyTyr: 2.71 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.474HisAla: 1.474 ± 0.044	0.197HisCys: 0.197 ± 0.013	1.108HisAsp: 1.108 ± 0.039	1.585HisGlu: 1.585 ± 0.037	1.108HisPhe: 1.108 ± 0.032	1.396HisGly: 1.396 ± 0.04	0.751HisHis: 0.751 ± 0.028	1.623HisIle: 1.623 ± 0.041	0.998HisLys: 0.998 ± 0.03	2.317HisLeu: 2.317 ± 0.052	0.537HisMet: 0.537 ± 0.023	0.721HisAsn: 0.721 ± 0.03	1.147HisPro: 1.147 ± 0.036	0.962HisGln: 0.962 ± 0.028	0.952HisArg: 0.952 ± 0.028	1.346HisSer: 1.346 ± 0.034	1.116HisThr: 1.116 ± 0.037	1.636HisVal: 1.636 ± 0.043	0.216HisTrp: 0.216 ± 0.014	0.937HisTyr: 0.937 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.999IleAla: 5.999 ± 0.089	0.597IleCys: 0.597 ± 0.026	4.45IleAsp: 4.45 ± 0.08	6.248IleGlu: 6.248 ± 0.093	3.009IlePhe: 3.009 ± 0.07	6.157IleGly: 6.157 ± 0.094	1.743IleHis: 1.743 ± 0.043	5.835IleIle: 5.835 ± 0.091	4.052IleLys: 4.052 ± 0.065	6.742IleLeu: 6.742 ± 0.097	1.78IleMet: 1.78 ± 0.047	3.127IleAsn: 3.127 ± 0.057	3.367IlePro: 3.367 ± 0.067	2.916IleGln: 2.916 ± 0.054	3.324IleArg: 3.324 ± 0.064	4.882IleSer: 4.882 ± 0.076	4.095IleThr: 4.095 ± 0.066	5.829IleVal: 5.829 ± 0.072	0.62IleTrp: 0.62 ± 0.027	2.232IleTyr: 2.232 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.451LysAla: 4.451 ± 0.073	0.289LysCys: 0.289 ± 0.017	3.21LysAsp: 3.21 ± 0.06	6.625LysGlu: 6.625 ± 0.09	1.48LysPhe: 1.48 ± 0.042	4.217LysGly: 4.217 ± 0.079	1.35LysHis: 1.35 ± 0.037	3.886LysIle: 3.886 ± 0.07	5.233LysLys: 5.233 ± 0.074	5.257LysLeu: 5.257 ± 0.07	2.101LysMet: 2.101 ± 0.044	2.69LysAsn: 2.69 ± 0.055	2.13LysPro: 2.13 ± 0.049	3.353LysGln: 3.353 ± 0.061	3.566LysArg: 3.566 ± 0.062	3.108LysSer: 3.108 ± 0.053	3.131LysThr: 3.131 ± 0.051	4.541LysVal: 4.541 ± 0.08	0.743LysTrp: 0.743 ± 0.03	1.675LysTyr: 1.675 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	7.875LeuAla: 7.875 ± 0.097	0.641LeuCys: 0.641 ± 0.026	4.911LeuAsp: 4.911 ± 0.073	7.008LeuGlu: 7.008 ± 0.095	4.753LeuPhe: 4.753 ± 0.098	6.573LeuGly: 6.573 ± 0.092	2.074LeuHis: 2.074 ± 0.049	7.24LeuIle: 7.24 ± 0.098	6.028LeuLys: 6.028 ± 0.064	10.132LeuLeu: 10.132 ± 0.146	2.574LeuMet: 2.574 ± 0.048	4.023LeuAsn: 4.023 ± 0.066	3.894LeuPro: 3.894 ± 0.065	3.71LeuGln: 3.71 ± 0.074	4.033LeuArg: 4.033 ± 0.076	6.546LeuSer: 6.546 ± 0.079	5.871LeuThr: 5.871 ± 0.077	6.622LeuVal: 6.622 ± 0.086	0.761LeuTrp: 0.761 ± 0.029	2.935LeuTyr: 2.935 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.158MetAla: 2.158 ± 0.05	0.153MetCys: 0.153 ± 0.013	1.348MetAsp: 1.348 ± 0.04	2.003MetGlu: 2.003 ± 0.04	1.051MetPhe: 1.051 ± 0.033	1.705MetGly: 1.705 ± 0.04	0.41MetHis: 0.41 ± 0.02	2.361MetIle: 2.361 ± 0.058	2.51MetLys: 2.51 ± 0.054	2.607MetLeu: 2.607 ± 0.054	0.955MetMet: 0.955 ± 0.028	1.623MetAsn: 1.623 ± 0.034	1.008MetPro: 1.008 ± 0.035	0.959MetGln: 0.959 ± 0.032	1.182MetArg: 1.182 ± 0.034	1.759MetSer: 1.759 ± 0.04	1.94MetThr: 1.94 ± 0.051	1.83MetVal: 1.83 ± 0.046	0.176MetTrp: 0.176 ± 0.014	0.748MetTyr: 0.748 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.574AsnAla: 2.574 ± 0.057	0.287AsnCys: 0.287 ± 0.017	2.17AsnAsp: 2.17 ± 0.048	3.629AsnGlu: 3.629 ± 0.069	1.32AsnPhe: 1.32 ± 0.036	3.164AsnGly: 3.164 ± 0.065	1.063AsnHis: 1.063 ± 0.033	2.962AsnIle: 2.962 ± 0.058	2.415AsnLys: 2.415 ± 0.054	3.341AsnLeu: 3.341 ± 0.065	1.161AsnMet: 1.161 ± 0.033	1.702AsnAsn: 1.702 ± 0.057	1.928AsnPro: 1.928 ± 0.045	2.103AsnGln: 2.103 ± 0.051	2.003AsnArg: 2.003 ± 0.047	1.99AsnSer: 1.99 ± 0.051	1.901AsnThr: 1.901 ± 0.046	3.148AsnVal: 3.148 ± 0.067	0.446AsnTrp: 0.446 ± 0.019	1.261AsnTyr: 1.261 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	2.265ProAla: 2.265 ± 0.051	0.216ProCys: 0.216 ± 0.015	1.983ProAsp: 1.983 ± 0.046	2.928ProGlu: 2.928 ± 0.053	1.97ProPhe: 1.97 ± 0.045	2.193ProGly: 2.193 ± 0.053	0.833ProHis: 0.833 ± 0.029	2.955ProIle: 2.955 ± 0.06	2.036ProLys: 2.036 ± 0.051	3.675ProLeu: 3.675 ± 0.068	0.898ProMet: 0.898 ± 0.031	1.712ProAsn: 1.712 ± 0.044	1.039ProPro: 1.039 ± 0.035	1.079ProGln: 1.079 ± 0.042	1.235ProArg: 1.235 ± 0.036	2.223ProSer: 2.223 ± 0.055	2.213ProThr: 2.213 ± 0.056	2.798ProVal: 2.798 ± 0.052	0.359ProTrp: 0.359 ± 0.022	1.399ProTyr: 1.399 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.267GlnAla: 3.267 ± 0.061	0.221GlnCys: 0.221 ± 0.014	1.729GlnAsp: 1.729 ± 0.048	3.154GlnGlu: 3.154 ± 0.06	1.696GlnPhe: 1.696 ± 0.038	2.342GlnGly: 2.342 ± 0.045	0.837GlnHis: 0.837 ± 0.03	2.818GlnIle: 2.818 ± 0.053	2.616GlnLys: 2.616 ± 0.056	4.576GlnLeu: 4.576 ± 0.074	1.313GlnMet: 1.313 ± 0.043	1.506GlnAsn: 1.506 ± 0.042	1.373GlnPro: 1.373 ± 0.048	2.054GlnGln: 2.054 ± 0.069	1.772GlnArg: 1.772 ± 0.041	2.306GlnSer: 2.306 ± 0.048	2.31GlnThr: 2.31 ± 0.052	2.979GlnVal: 2.979 ± 0.061	0.427GlnTrp: 0.427 ± 0.021	1.179GlnTyr: 1.179 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.871ArgAla: 2.871 ± 0.059	0.287ArgCys: 0.287 ± 0.017	2.241ArgAsp: 2.241 ± 0.044	3.483ArgGlu: 3.483 ± 0.06	2.062ArgPhe: 2.062 ± 0.05	2.517ArgGly: 2.517 ± 0.053	0.943ArgHis: 0.943 ± 0.032	3.326ArgIle: 3.326 ± 0.061	3.138ArgLys: 3.138 ± 0.061	4.366ArgLeu: 4.366 ± 0.075	1.383ArgMet: 1.383 ± 0.037	1.86ArgAsn: 1.86 ± 0.047	1.482ArgPro: 1.482 ± 0.041	1.852ArgGln: 1.852 ± 0.048	1.972ArgArg: 1.972 ± 0.047	2.412ArgSer: 2.412 ± 0.046	2.316ArgThr: 2.316 ± 0.044	3.019ArgVal: 3.019 ± 0.051	0.454ArgTrp: 0.454 ± 0.023	1.675ArgTyr: 1.675 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.746SerAla: 3.746 ± 0.074	0.389SerCys: 0.389 ± 0.018	2.778SerAsp: 2.778 ± 0.056	4.096SerGlu: 4.096 ± 0.073	3.237SerPhe: 3.237 ± 0.062	4.192SerGly: 4.192 ± 0.068	1.21SerHis: 1.21 ± 0.035	4.917SerIle: 4.917 ± 0.069	3.428SerLys: 3.428 ± 0.057	6.14SerLeu: 6.14 ± 0.079	1.719SerMet: 1.719 ± 0.036	2.291SerAsn: 2.291 ± 0.045	2.13SerPro: 2.13 ± 0.049	2.099SerGln: 2.099 ± 0.046	2.326SerArg: 2.326 ± 0.045	3.749SerSer: 3.749 ± 0.076	3.152SerThr: 3.152 ± 0.054	4.043SerVal: 4.043 ± 0.064	0.62SerTrp: 0.62 ± 0.025	2.166SerTyr: 2.166 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	3.831ThrAla: 3.831 ± 0.073	0.401ThrCys: 0.401 ± 0.019	2.7ThrAsp: 2.7 ± 0.055	3.771ThrGlu: 3.771 ± 0.061	2.763ThrPhe: 2.763 ± 0.061	4.026ThrGly: 4.026 ± 0.069	1.168ThrHis: 1.168 ± 0.039	4.748ThrIle: 4.748 ± 0.073	3.237ThrLys: 3.237 ± 0.058	5.423ThrLeu: 5.423 ± 0.083	1.405ThrMet: 1.405 ± 0.037	2.451ThrAsn: 2.451 ± 0.044	2.22ThrPro: 2.22 ± 0.042	1.552ThrGln: 1.552 ± 0.041	2.026ThrArg: 2.026 ± 0.046	3.316ThrSer: 3.316 ± 0.062	3.159ThrThr: 3.159 ± 0.061	4.318ThrVal: 4.318 ± 0.066	0.526ThrTrp: 0.526 ± 0.023	2.061ThrTyr: 2.061 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.551ValAla: 5.551 ± 0.085	0.574ValCys: 0.574 ± 0.027	3.874ValAsp: 3.874 ± 0.072	5.589ValGlu: 5.589 ± 0.08	3.042ValPhe: 3.042 ± 0.054	5.021ValGly: 5.021 ± 0.071	1.519ValHis: 1.519 ± 0.038	5.921ValIle: 5.921 ± 0.076	4.489ValLys: 4.489 ± 0.064	6.809ValLeu: 6.809 ± 0.102	2.044ValMet: 2.044 ± 0.048	3.099ValAsn: 3.099 ± 0.059	2.665ValPro: 2.665 ± 0.054	2.543ValGln: 2.543 ± 0.059	2.978ValArg: 2.978 ± 0.063	4.59ValSer: 4.59 ± 0.073	4.5ValThr: 4.5 ± 0.075	5.488ValVal: 5.488 ± 0.091	0.614ValTrp: 0.614 ± 0.023	2.234ValTyr: 2.234 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.605TrpAla: 0.605 ± 0.029	0.069TrpCys: 0.069 ± 0.008	0.448TrpAsp: 0.448 ± 0.018	0.64TrpGlu: 0.64 ± 0.023	0.49TrpPhe: 0.49 ± 0.028	0.621TrpGly: 0.621 ± 0.029	0.21TrpHis: 0.21 ± 0.014	0.75TrpIle: 0.75 ± 0.03	0.668TrpLys: 0.668 ± 0.028	1.135TrpLeu: 1.135 ± 0.039	0.336TrpMet: 0.336 ± 0.02	0.491TrpAsn: 0.491 ± 0.024	0.243TrpPro: 0.243 ± 0.015	0.425TrpGln: 0.425 ± 0.024	0.409TrpArg: 0.409 ± 0.019	0.613TrpSer: 0.613 ± 0.024	0.469TrpThr: 0.469 ± 0.023	0.608TrpVal: 0.608 ± 0.023	0.137TrpTrp: 0.137 ± 0.012	0.308TrpTyr: 0.308 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.991TyrAla: 1.991 ± 0.047	0.298TyrCys: 0.298 ± 0.017	1.86TyrAsp: 1.86 ± 0.049	2.552TyrGlu: 2.552 ± 0.054	1.694TyrPhe: 1.694 ± 0.043	2.388TyrGly: 2.388 ± 0.052	0.873TyrHis: 0.873 ± 0.033	2.211TyrIle: 2.211 ± 0.047	1.765TyrLys: 1.765 ± 0.045	3.317TyrLeu: 3.317 ± 0.068	0.794TyrMet: 0.794 ± 0.031	1.244TyrAsn: 1.244 ± 0.038	1.367TyrPro: 1.367 ± 0.037	1.658TyrGln: 1.658 ± 0.049	1.587TyrArg: 1.587 ± 0.039	1.889TyrSer: 1.889 ± 0.042	1.581TyrThr: 1.581 ± 0.041	2.296TyrVal: 2.296 ± 0.053	0.33TyrTrp: 0.33 ± 0.018	1.257TyrTyr: 1.257 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3479 proteins (1004815 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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