Amino acid dipepetide frequency for Corynebacterium sp. LMM-1652

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.485AlaAla: 14.485 ± 0.178	0.892AlaCys: 0.892 ± 0.043	6.722AlaAsp: 6.722 ± 0.11	8.392AlaGlu: 8.392 ± 0.157	3.362AlaPhe: 3.362 ± 0.076	10.242AlaGly: 10.242 ± 0.119	2.251AlaHis: 2.251 ± 0.056	5.16AlaIle: 5.16 ± 0.104	4.101AlaLys: 4.101 ± 0.102	10.715AlaLeu: 10.715 ± 0.144	2.826AlaMet: 2.826 ± 0.066	2.982AlaAsn: 2.982 ± 0.058	5.071AlaPro: 5.071 ± 0.142	4.406AlaGln: 4.406 ± 0.081	6.79AlaArg: 6.79 ± 0.122	6.205AlaSer: 6.205 ± 0.089	6.873AlaThr: 6.873 ± 0.108	9.145AlaVal: 9.145 ± 0.136	1.529AlaTrp: 1.529 ± 0.049	2.11AlaTyr: 2.11 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.809CysAla: 0.809 ± 0.038	0.092CysCys: 0.092 ± 0.012	0.38CysAsp: 0.38 ± 0.023	0.451CysGlu: 0.451 ± 0.027	0.228CysPhe: 0.228 ± 0.019	0.758CysGly: 0.758 ± 0.038	0.14CysHis: 0.14 ± 0.016	0.314CysIle: 0.314 ± 0.024	0.141CysLys: 0.141 ± 0.013	0.605CysLeu: 0.605 ± 0.029	0.147CysMet: 0.147 ± 0.015	0.172CysAsn: 0.172 ± 0.017	0.405CysPro: 0.405 ± 0.03	0.224CysGln: 0.224 ± 0.019	0.403CysArg: 0.403 ± 0.027	0.461CysSer: 0.461 ± 0.026	0.455CysThr: 0.455 ± 0.026	0.621CysVal: 0.621 ± 0.031	0.08CysTrp: 0.08 ± 0.01	0.14CysTyr: 0.14 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.765AspAla: 6.765 ± 0.114	0.412AspCys: 0.412 ± 0.027	3.401AspAsp: 3.401 ± 0.091	4.392AspGlu: 4.392 ± 0.094	1.946AspPhe: 1.946 ± 0.052	5.005AspGly: 5.005 ± 0.088	1.32AspHis: 1.32 ± 0.046	2.81AspIle: 2.81 ± 0.068	2.075AspLys: 2.075 ± 0.062	5.316AspLeu: 5.316 ± 0.085	1.307AspMet: 1.307 ± 0.048	1.886AspAsn: 1.886 ± 0.063	3.494AspPro: 3.494 ± 0.074	1.802AspGln: 1.802 ± 0.053	3.471AspArg: 3.471 ± 0.075	3.527AspSer: 3.527 ± 0.076	3.027AspThr: 3.027 ± 0.069	4.866AspVal: 4.866 ± 0.096	0.777AspTrp: 0.777 ± 0.037	1.455AspTyr: 1.455 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.237GluAla: 7.237 ± 0.106	0.361GluCys: 0.361 ± 0.022	4.241GluAsp: 4.241 ± 0.092	5.071GluGlu: 5.071 ± 0.094	2.122GluPhe: 2.122 ± 0.055	5.21GluGly: 5.21 ± 0.08	1.694GluHis: 1.694 ± 0.055	3.29GluIle: 3.29 ± 0.066	2.688GluLys: 2.688 ± 0.066	6.796GluLeu: 6.796 ± 0.12	1.465GluMet: 1.465 ± 0.049	2.014GluAsn: 2.014 ± 0.052	2.82GluPro: 2.82 ± 0.072	3.162GluGln: 3.162 ± 0.073	4.533GluArg: 4.533 ± 0.095	3.413GluSer: 3.413 ± 0.081	3.206GluThr: 3.206 ± 0.066	5.028GluVal: 5.028 ± 0.089	0.933GluTrp: 0.933 ± 0.036	1.452GluTyr: 1.452 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.754PheAla: 3.754 ± 0.078	0.265PheCys: 0.265 ± 0.018	2.077PheAsp: 2.077 ± 0.058	1.74PheGlu: 1.74 ± 0.056	1.286PhePhe: 1.286 ± 0.048	3.398PheGly: 3.398 ± 0.075	0.665PheHis: 0.665 ± 0.031	1.522PheIle: 1.522 ± 0.054	0.802PheLys: 0.802 ± 0.038	2.94PheLeu: 2.94 ± 0.084	0.68PheMet: 0.68 ± 0.031	0.924PheAsn: 0.924 ± 0.038	1.432PhePro: 1.432 ± 0.047	0.841PheGln: 0.841 ± 0.033	1.755PheArg: 1.755 ± 0.057	2.189PheSer: 2.189 ± 0.063	2.112PheThr: 2.112 ± 0.065	2.531PheVal: 2.531 ± 0.057	0.431PheTrp: 0.431 ± 0.025	0.732PheTyr: 0.732 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.229GlyAla: 9.229 ± 0.146	0.662GlyCys: 0.662 ± 0.033	4.58GlyAsp: 4.58 ± 0.09	5.769GlyGlu: 5.769 ± 0.096	2.979GlyPhe: 2.979 ± 0.068	7.299GlyGly: 7.299 ± 0.123	1.994GlyHis: 1.994 ± 0.059	4.309GlyIle: 4.309 ± 0.086	3.213GlyLys: 3.213 ± 0.076	8.018GlyLeu: 8.018 ± 0.11	2.295GlyMet: 2.295 ± 0.063	2.331GlyAsn: 2.331 ± 0.069	3.369GlyPro: 3.369 ± 0.074	3.193GlyGln: 3.193 ± 0.079	5.127GlyArg: 5.127 ± 0.095	5.342GlySer: 5.342 ± 0.089	5.143GlyThr: 5.143 ± 0.089	7.47GlyVal: 7.47 ± 0.114	1.336GlyTrp: 1.336 ± 0.045	2.296GlyTyr: 2.296 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.244HisAla: 2.244 ± 0.063	0.201HisCys: 0.201 ± 0.018	1.215HisAsp: 1.215 ± 0.044	1.259HisGlu: 1.259 ± 0.047	0.669HisPhe: 0.669 ± 0.033	1.97HisGly: 1.97 ± 0.058	0.585HisHis: 0.585 ± 0.033	1.051HisIle: 1.051 ± 0.043	0.576HisLys: 0.576 ± 0.029	1.876HisLeu: 1.876 ± 0.052	0.483HisMet: 0.483 ± 0.027	0.658HisAsn: 0.658 ± 0.029	1.435HisPro: 1.435 ± 0.05	0.664HisGln: 0.664 ± 0.032	1.532HisArg: 1.532 ± 0.048	1.452HisSer: 1.452 ± 0.048	1.332HisThr: 1.332 ± 0.047	1.659HisVal: 1.659 ± 0.057	0.276HisTrp: 0.276 ± 0.022	0.54HisTyr: 0.54 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.326IleAla: 6.326 ± 0.107	0.377IleCys: 0.377 ± 0.023	3.306IleAsp: 3.306 ± 0.07	2.974IleGlu: 2.974 ± 0.082	1.598IlePhe: 1.598 ± 0.052	4.409IleGly: 4.409 ± 0.097	0.998IleHis: 0.998 ± 0.041	2.593IleIle: 2.593 ± 0.071	1.337IleLys: 1.337 ± 0.049	4.016IleLeu: 4.016 ± 0.077	0.975IleMet: 0.975 ± 0.045	1.583IleAsn: 1.583 ± 0.052	2.528IlePro: 2.528 ± 0.069	1.276IleGln: 1.276 ± 0.042	2.557IleArg: 2.557 ± 0.058	2.91IleSer: 2.91 ± 0.066	3.082IleThr: 3.082 ± 0.077	4.144IleVal: 4.144 ± 0.089	0.488IleTrp: 0.488 ± 0.029	0.939IleTyr: 0.939 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.797LysAla: 3.797 ± 0.086	0.118LysCys: 0.118 ± 0.013	2.288LysAsp: 2.288 ± 0.069	2.197LysGlu: 2.197 ± 0.066	0.912LysPhe: 0.912 ± 0.036	2.647LysGly: 2.647 ± 0.069	0.7LysHis: 0.7 ± 0.034	1.647LysIle: 1.647 ± 0.054	1.994LysLys: 1.994 ± 0.079	3.049LysLeu: 3.049 ± 0.073	0.843LysMet: 0.843 ± 0.035	1.218LysAsn: 1.218 ± 0.042	1.825LysPro: 1.825 ± 0.055	1.266LysGln: 1.266 ± 0.04	2.148LysArg: 2.148 ± 0.058	1.912LysSer: 1.912 ± 0.059	1.973LysThr: 1.973 ± 0.061	2.628LysVal: 2.628 ± 0.076	0.405LysTrp: 0.405 ± 0.027	0.739LysTyr: 0.739 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.041LeuAla: 11.041 ± 0.136	0.648LeuCys: 0.648 ± 0.034	5.718LeuAsp: 5.718 ± 0.105	5.397LeuGlu: 5.397 ± 0.098	2.87LeuPhe: 2.87 ± 0.077	8.143LeuGly: 8.143 ± 0.117	1.962LeuHis: 1.962 ± 0.06	4.62LeuIle: 4.62 ± 0.092	3.078LeuLys: 3.078 ± 0.076	8.749LeuLeu: 8.749 ± 0.145	2.043LeuMet: 2.043 ± 0.056	2.593LeuAsn: 2.593 ± 0.061	5.086LeuPro: 5.086 ± 0.087	2.835LeuGln: 2.835 ± 0.069	6.134LeuArg: 6.134 ± 0.09	5.878LeuSer: 5.878 ± 0.097	5.459LeuThr: 5.459 ± 0.09	7.395LeuVal: 7.395 ± 0.123	1.246LeuTrp: 1.246 ± 0.047	1.639LeuTyr: 1.639 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.742MetAla: 2.742 ± 0.06	0.18MetCys: 0.18 ± 0.017	1.292MetAsp: 1.292 ± 0.043	1.23MetGlu: 1.23 ± 0.047	0.758MetPhe: 0.758 ± 0.036	1.855MetGly: 1.855 ± 0.062	0.46MetHis: 0.46 ± 0.026	1.123MetIle: 1.123 ± 0.045	0.806MetLys: 0.806 ± 0.035	2.219MetLeu: 2.219 ± 0.063	0.575MetMet: 0.575 ± 0.032	0.822MetAsn: 0.822 ± 0.032	1.199MetPro: 1.199 ± 0.037	0.681MetGln: 0.681 ± 0.028	1.416MetArg: 1.416 ± 0.049	1.791MetSer: 1.791 ± 0.043	1.853MetThr: 1.853 ± 0.053	1.822MetVal: 1.822 ± 0.052	0.288MetTrp: 0.288 ± 0.02	0.413MetTyr: 0.413 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.116AsnAla: 3.116 ± 0.067	0.198AsnCys: 0.198 ± 0.018	1.556AsnAsp: 1.556 ± 0.048	1.604AsnGlu: 1.604 ± 0.047	0.96AsnPhe: 0.96 ± 0.042	2.481AsnGly: 2.481 ± 0.076	0.616AsnHis: 0.616 ± 0.028	1.442AsnIle: 1.442 ± 0.043	1.093AsnLys: 1.093 ± 0.045	2.683AsnLeu: 2.683 ± 0.062	0.662AsnMet: 0.662 ± 0.035	1.068AsnAsn: 1.068 ± 0.046	2.25AsnPro: 2.25 ± 0.062	1.02AsnGln: 1.02 ± 0.045	1.786AsnArg: 1.786 ± 0.055	1.915AsnSer: 1.915 ± 0.055	1.671AsnThr: 1.671 ± 0.051	2.125AsnVal: 2.125 ± 0.056	0.429AsnTrp: 0.429 ± 0.024	0.786AsnTyr: 0.786 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.681ProAla: 5.681 ± 0.131	0.242ProCys: 0.242 ± 0.021	3.059ProAsp: 3.059 ± 0.063	4.396ProGlu: 4.396 ± 0.091	1.579ProPhe: 1.579 ± 0.047	4.644ProGly: 4.644 ± 0.104	1.163ProHis: 1.163 ± 0.045	1.986ProIle: 1.986 ± 0.056	1.621ProLys: 1.621 ± 0.053	4.355ProLeu: 4.355 ± 0.089	1.081ProMet: 1.081 ± 0.046	1.471ProAsn: 1.471 ± 0.048	1.719ProPro: 1.719 ± 0.058	2.181ProGln: 2.181 ± 0.073	2.828ProArg: 2.828 ± 0.066	3.081ProSer: 3.081 ± 0.071	3.114ProThr: 3.114 ± 0.074	4.264ProVal: 4.264 ± 0.076	0.733ProTrp: 0.733 ± 0.035	1.03ProTyr: 1.03 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.949GlnAla: 3.949 ± 0.071	0.217GlnCys: 0.217 ± 0.019	1.671GlnAsp: 1.671 ± 0.047	2.208GlnGlu: 2.208 ± 0.057	0.982GlnPhe: 0.982 ± 0.034	2.699GlnGly: 2.699 ± 0.078	0.793GlnHis: 0.793 ± 0.033	1.726GlnIle: 1.726 ± 0.052	1.183GlnLys: 1.183 ± 0.043	3.64GlnLeu: 3.64 ± 0.083	0.854GlnMet: 0.854 ± 0.037	0.972GlnAsn: 0.972 ± 0.039	2.021GlnPro: 2.021 ± 0.074	1.825GlnGln: 1.825 ± 0.067	2.915GlnArg: 2.915 ± 0.071	1.797GlnSer: 1.797 ± 0.055	1.624GlnThr: 1.624 ± 0.051	2.584GlnVal: 2.584 ± 0.062	0.661GlnTrp: 0.661 ± 0.032	0.678GlnTyr: 0.678 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	6.474ArgAla: 6.474 ± 0.116	0.389ArgCys: 0.389 ± 0.026	3.465ArgAsp: 3.465 ± 0.08	4.641ArgGlu: 4.641 ± 0.085	1.967ArgPhe: 1.967 ± 0.053	4.75ArgGly: 4.75 ± 0.08	1.432ArgHis: 1.432 ± 0.049	3.241ArgIle: 3.241 ± 0.072	2.328ArgLys: 2.328 ± 0.063	5.339ArgLeu: 5.339 ± 0.103	1.752ArgMet: 1.752 ± 0.053	1.88ArgAsn: 1.88 ± 0.058	2.999ArgPro: 2.999 ± 0.064	2.343ArgGln: 2.343 ± 0.053	4.929ArgArg: 4.929 ± 0.12	3.632ArgSer: 3.632 ± 0.093	3.637ArgThr: 3.637 ± 0.076	4.786ArgVal: 4.786 ± 0.092	1.062ArgTrp: 1.062 ± 0.04	1.489ArgTyr: 1.489 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.917SerAla: 6.917 ± 0.109	0.361SerCys: 0.361 ± 0.024	3.331SerAsp: 3.331 ± 0.064	3.81SerGlu: 3.81 ± 0.076	2.007SerPhe: 2.007 ± 0.057	5.588SerGly: 5.588 ± 0.102	1.217SerHis: 1.217 ± 0.045	2.779SerIle: 2.779 ± 0.072	1.967SerLys: 1.967 ± 0.06	5.351SerLeu: 5.351 ± 0.095	1.559SerMet: 1.559 ± 0.041	1.688SerAsn: 1.688 ± 0.05	3.069SerPro: 3.069 ± 0.071	2.042SerGln: 2.042 ± 0.055	3.589SerArg: 3.589 ± 0.074	4.354SerSer: 4.354 ± 0.097	4.099SerThr: 4.099 ± 0.081	4.827SerVal: 4.827 ± 0.095	0.824SerTrp: 0.824 ± 0.04	1.297SerTyr: 1.297 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	6.57ThrAla: 6.57 ± 0.108	0.429ThrCys: 0.429 ± 0.026	3.354ThrAsp: 3.354 ± 0.066	3.459ThrGlu: 3.459 ± 0.076	1.965ThrPhe: 1.965 ± 0.054	5.282ThrGly: 5.282 ± 0.099	1.278ThrHis: 1.278 ± 0.042	2.924ThrIle: 2.924 ± 0.069	1.786ThrLys: 1.786 ± 0.053	5.409ThrLeu: 5.409 ± 0.09	1.381ThrMet: 1.381 ± 0.048	1.8ThrAsn: 1.8 ± 0.06	3.721ThrPro: 3.721 ± 0.08	1.823ThrGln: 1.823 ± 0.055	3.257ThrArg: 3.257 ± 0.066	3.759ThrSer: 3.759 ± 0.067	3.855ThrThr: 3.855 ± 0.092	5.466ThrVal: 5.466 ± 0.097	0.853ThrTrp: 0.853 ± 0.039	1.348ThrTyr: 1.348 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	9.45ValAla: 9.45 ± 0.135	0.681ValCys: 0.681 ± 0.033	5.338ValAsp: 5.338 ± 0.092	5.578ValGlu: 5.578 ± 0.1	2.57ValPhe: 2.57 ± 0.072	6.527ValGly: 6.527 ± 0.113	1.692ValHis: 1.692 ± 0.047	4.233ValIle: 4.233 ± 0.093	2.429ValLys: 2.429 ± 0.061	7.842ValLeu: 7.842 ± 0.119	1.778ValMet: 1.778 ± 0.056	2.302ValAsn: 2.302 ± 0.057	4.063ValPro: 4.063 ± 0.085	2.241ValGln: 2.241 ± 0.061	4.91ValArg: 4.91 ± 0.09	4.789ValSer: 4.789 ± 0.105	5.211ValThr: 5.211 ± 0.095	7.404ValVal: 7.404 ± 0.113	1.035ValTrp: 1.035 ± 0.046	1.414ValTyr: 1.414 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.426TrpAla: 1.426 ± 0.059	0.118TrpCys: 0.118 ± 0.012	0.728TrpAsp: 0.728 ± 0.034	0.815TrpGlu: 0.815 ± 0.04	0.55TrpPhe: 0.55 ± 0.031	1.008TrpGly: 1.008 ± 0.039	0.336TrpHis: 0.336 ± 0.021	0.741TrpIle: 0.741 ± 0.032	0.479TrpLys: 0.479 ± 0.028	1.538TrpLeu: 1.538 ± 0.05	0.415TrpMet: 0.415 ± 0.025	0.48TrpAsn: 0.48 ± 0.025	0.623TrpPro: 0.623 ± 0.032	0.52TrpGln: 0.52 ± 0.029	0.978TrpArg: 0.978 ± 0.046	0.806TrpSer: 0.806 ± 0.035	0.809TrpThr: 0.809 ± 0.034	1.056TrpVal: 1.056 ± 0.043	0.314TrpTrp: 0.314 ± 0.023	0.294TrpTyr: 0.294 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.247TyrAla: 2.247 ± 0.055	0.186TyrCys: 0.186 ± 0.015	1.334TyrAsp: 1.334 ± 0.047	1.352TyrGlu: 1.352 ± 0.052	0.764TyrPhe: 0.764 ± 0.033	2.037TyrGly: 2.037 ± 0.073	0.383TyrHis: 0.383 ± 0.027	0.905TyrIle: 0.905 ± 0.035	0.608TyrLys: 0.608 ± 0.031	2.075TyrLeu: 2.075 ± 0.057	0.405TyrMet: 0.405 ± 0.026	0.614TyrAsn: 0.614 ± 0.031	1.1TyrPro: 1.1 ± 0.036	0.655TyrGln: 0.655 ± 0.032	1.48TyrArg: 1.48 ± 0.052	1.46TyrSer: 1.46 ± 0.049	1.185TyrThr: 1.185 ± 0.046	1.666TyrVal: 1.666 ± 0.049	0.335TyrTrp: 0.335 ± 0.025	0.508TyrTyr: 0.508 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2031 proteins (687179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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