Amino acid dipepetide frequency for Rhizobium etli CNPAF512

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.544AlaAla: 16.544 ± 0.145	1.18AlaCys: 1.18 ± 0.03	6.826AlaAsp: 6.826 ± 0.078	7.5AlaGlu: 7.5 ± 0.072	4.52AlaPhe: 4.52 ± 0.05	10.51AlaGly: 10.51 ± 0.096	2.219AlaHis: 2.219 ± 0.04	6.826AlaIle: 6.826 ± 0.074	4.139AlaLys: 4.139 ± 0.061	11.92AlaLeu: 11.92 ± 0.089	3.309AlaMet: 3.309 ± 0.049	2.932AlaAsn: 2.932 ± 0.044	4.764AlaPro: 4.764 ± 0.063	3.381AlaGln: 3.381 ± 0.046	7.885AlaArg: 7.885 ± 0.072	6.599AlaSer: 6.599 ± 0.067	5.299AlaThr: 5.299 ± 0.056	8.552AlaVal: 8.552 ± 0.07	1.321AlaTrp: 1.321 ± 0.028	2.435AlaTyr: 2.435 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.036CysAla: 1.036 ± 0.024	0.19CysCys: 0.19 ± 0.012	0.556CysAsp: 0.556 ± 0.015	0.474CysGlu: 0.474 ± 0.017	0.406CysPhe: 0.406 ± 0.017	1.034CysGly: 1.034 ± 0.026	0.332CysHis: 0.332 ± 0.015	0.44CysIle: 0.44 ± 0.016	0.233CysLys: 0.233 ± 0.011	0.983CysLeu: 0.983 ± 0.023	0.205CysMet: 0.205 ± 0.011	0.259CysAsn: 0.259 ± 0.012	0.499CysPro: 0.499 ± 0.02	0.314CysGln: 0.314 ± 0.013	0.976CysArg: 0.976 ± 0.033	0.628CysSer: 0.628 ± 0.017	0.405CysThr: 0.405 ± 0.016	0.605CysVal: 0.605 ± 0.016	0.131CysTrp: 0.131 ± 0.008	0.204CysTyr: 0.204 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.416AspAla: 6.416 ± 0.068	0.535AspCys: 0.535 ± 0.019	3.358AspAsp: 3.358 ± 0.052	3.595AspGlu: 3.595 ± 0.046	2.391AspPhe: 2.391 ± 0.041	5.168AspGly: 5.168 ± 0.06	1.414AspHis: 1.414 ± 0.03	3.499AspIle: 3.499 ± 0.046	1.815AspLys: 1.815 ± 0.037	5.738AspLeu: 5.738 ± 0.065	1.359AspMet: 1.359 ± 0.028	1.422AspAsn: 1.422 ± 0.031	3.124AspPro: 3.124 ± 0.046	1.863AspGln: 1.863 ± 0.038	4.621AspArg: 4.621 ± 0.074	2.158AspSer: 2.158 ± 0.041	2.285AspThr: 2.285 ± 0.034	3.997AspVal: 3.997 ± 0.051	0.873AspTrp: 0.873 ± 0.022	1.44AspTyr: 1.44 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	7.067GluAla: 7.067 ± 0.077	0.409GluCys: 0.409 ± 0.015	2.828GluAsp: 2.828 ± 0.048	3.391GluGlu: 3.391 ± 0.05	1.966GluPhe: 1.966 ± 0.03	4.059GluGly: 4.059 ± 0.053	1.256GluHis: 1.256 ± 0.029	3.954GluIle: 3.954 ± 0.055	2.636GluLys: 2.636 ± 0.039	5.253GluLeu: 5.253 ± 0.058	1.562GluMet: 1.562 ± 0.031	1.835GluAsn: 1.835 ± 0.033	2.563GluPro: 2.563 ± 0.041	2.136GluGln: 2.136 ± 0.039	4.852GluArg: 4.852 ± 0.061	2.438GluSer: 2.438 ± 0.038	3.419GluThr: 3.419 ± 0.041	3.568GluVal: 3.568 ± 0.048	0.649GluTrp: 0.649 ± 0.022	0.996GluTyr: 0.996 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.675PheAla: 4.675 ± 0.054	0.45PheCys: 0.45 ± 0.015	2.734PheAsp: 2.734 ± 0.042	2.216PheGlu: 2.216 ± 0.034	1.623PhePhe: 1.623 ± 0.031	3.729PheGly: 3.729 ± 0.053	0.868PheHis: 0.868 ± 0.023	1.884PheIle: 1.884 ± 0.031	1.123PheLys: 1.123 ± 0.022	3.661PheLeu: 3.661 ± 0.051	0.865PheMet: 0.865 ± 0.022	1.14PheAsn: 1.14 ± 0.027	1.726PhePro: 1.726 ± 0.032	1.176PheGln: 1.176 ± 0.029	2.626PheArg: 2.626 ± 0.044	2.576PheSer: 2.576 ± 0.038	1.877PheThr: 1.877 ± 0.033	2.906PheVal: 2.906 ± 0.036	0.555PheTrp: 0.555 ± 0.018	0.985PheTyr: 0.985 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	8.426GlyAla: 8.426 ± 0.085	0.932GlyCys: 0.932 ± 0.024	4.529GlyAsp: 4.529 ± 0.053	4.834GlyGlu: 4.834 ± 0.051	3.669GlyPhe: 3.669 ± 0.052	6.887GlyGly: 6.887 ± 0.081	1.951GlyHis: 1.951 ± 0.041	5.029GlyIle: 5.029 ± 0.063	3.691GlyLys: 3.691 ± 0.051	8.412GlyLeu: 8.412 ± 0.076	2.257GlyMet: 2.257 ± 0.04	2.538GlyAsn: 2.538 ± 0.042	3.142GlyPro: 3.142 ± 0.043	2.748GlyGln: 2.748 ± 0.045	6.305GlyArg: 6.305 ± 0.071	4.835GlySer: 4.835 ± 0.053	4.194GlyThr: 4.194 ± 0.067	5.544GlyVal: 5.544 ± 0.054	1.235GlyTrp: 1.235 ± 0.027	2.187GlyTyr: 2.187 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.402HisAla: 2.402 ± 0.038	0.311HisCys: 0.311 ± 0.013	1.392HisAsp: 1.392 ± 0.029	1.158HisGlu: 1.158 ± 0.026	1.008HisPhe: 1.008 ± 0.024	2.002HisGly: 2.002 ± 0.036	0.728HisHis: 0.728 ± 0.024	1.052HisIle: 1.052 ± 0.022	0.523HisLys: 0.523 ± 0.015	2.225HisLeu: 2.225 ± 0.038	0.551HisMet: 0.551 ± 0.018	0.49HisAsn: 0.49 ± 0.016	1.362HisPro: 1.362 ± 0.029	0.777HisGln: 0.777 ± 0.023	1.925HisArg: 1.925 ± 0.043	1.057HisSer: 1.057 ± 0.024	0.758HisThr: 0.758 ± 0.021	1.523HisVal: 1.523 ± 0.037	0.305HisTrp: 0.305 ± 0.013	0.541HisTyr: 0.541 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	7.634IleAla: 7.634 ± 0.066	0.613IleCys: 0.613 ± 0.018	3.915IleAsp: 3.915 ± 0.046	3.721IleGlu: 3.721 ± 0.044	2.093IlePhe: 2.093 ± 0.039	5.524IleGly: 5.524 ± 0.054	0.996IleHis: 0.996 ± 0.022	2.748IleIle: 2.748 ± 0.048	1.581IleLys: 1.581 ± 0.03	4.828IleLeu: 4.828 ± 0.056	1.135IleMet: 1.135 ± 0.024	1.499IleAsn: 1.499 ± 0.032	2.496IlePro: 2.496 ± 0.039	1.235IleGln: 1.235 ± 0.029	3.598IleArg: 3.598 ± 0.044	3.642IleSer: 3.642 ± 0.05	2.662IleThr: 2.662 ± 0.04	4.56IleVal: 4.56 ± 0.056	0.646IleTrp: 0.646 ± 0.019	1.194IleTyr: 1.194 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.546LysAla: 4.546 ± 0.06	0.207LysCys: 0.207 ± 0.01	1.895LysAsp: 1.895 ± 0.03	1.72LysGlu: 1.72 ± 0.036	0.997LysPhe: 0.997 ± 0.024	2.745LysGly: 2.745 ± 0.041	0.679LysHis: 0.679 ± 0.018	2.076LysIle: 2.076 ± 0.035	1.475LysLys: 1.475 ± 0.037	3.499LysLeu: 3.499 ± 0.051	0.901LysMet: 0.901 ± 0.024	1.03LysAsn: 1.03 ± 0.024	2.222LysPro: 2.222 ± 0.036	1.186LysGln: 1.186 ± 0.025	2.591LysArg: 2.591 ± 0.045	2.265LysSer: 2.265 ± 0.04	2.115LysThr: 2.115 ± 0.039	2.458LysVal: 2.458 ± 0.042	0.376LysTrp: 0.376 ± 0.013	0.664LysTyr: 0.664 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	12.42LeuAla: 12.42 ± 0.094	0.998LeuCys: 0.998 ± 0.025	5.789LeuAsp: 5.789 ± 0.069	5.021LeuGlu: 5.021 ± 0.047	3.803LeuPhe: 3.803 ± 0.05	7.68LeuGly: 7.68 ± 0.076	2.023LeuHis: 2.023 ± 0.036	5.072LeuIle: 5.072 ± 0.06	3.88LeuLys: 3.88 ± 0.052	9.241LeuLeu: 9.241 ± 0.099	2.294LeuMet: 2.294 ± 0.034	2.541LeuAsn: 2.541 ± 0.039	5.378LeuPro: 5.378 ± 0.059	3.146LeuGln: 3.146 ± 0.045	6.725LeuArg: 6.725 ± 0.061	6.782LeuSer: 6.782 ± 0.07	5.256LeuThr: 5.256 ± 0.066	7.055LeuVal: 7.055 ± 0.073	1.018LeuTrp: 1.018 ± 0.027	1.992LeuTyr: 1.992 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.025MetAla: 3.025 ± 0.041	0.165MetCys: 0.165 ± 0.01	1.103MetAsp: 1.103 ± 0.026	1.165MetGlu: 1.165 ± 0.028	0.712MetPhe: 0.712 ± 0.023	1.67MetGly: 1.67 ± 0.033	0.473MetHis: 0.473 ± 0.014	1.466MetIle: 1.466 ± 0.026	1.11MetLys: 1.11 ± 0.028	2.505MetLeu: 2.505 ± 0.041	0.668MetMet: 0.668 ± 0.022	0.828MetAsn: 0.828 ± 0.022	1.53MetPro: 1.53 ± 0.029	0.907MetGln: 0.907 ± 0.022	1.939MetArg: 1.939 ± 0.034	1.765MetSer: 1.765 ± 0.029	1.912MetThr: 1.912 ± 0.037	1.674MetVal: 1.674 ± 0.032	0.185MetTrp: 0.185 ± 0.01	0.296MetTyr: 0.296 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.197AsnAla: 3.197 ± 0.045	0.266AsnCys: 0.266 ± 0.012	1.564AsnAsp: 1.564 ± 0.035	1.352AsnGlu: 1.352 ± 0.031	1.122AsnPhe: 1.122 ± 0.03	2.564AsnGly: 2.564 ± 0.041	0.602AsnHis: 0.602 ± 0.02	1.548AsnIle: 1.548 ± 0.028	0.788AsnLys: 0.788 ± 0.023	2.738AsnLeu: 2.738 ± 0.04	0.664AsnMet: 0.664 ± 0.02	0.826AsnAsn: 0.826 ± 0.022	1.81AsnPro: 1.81 ± 0.032	0.836AsnGln: 0.836 ± 0.022	2.04AsnArg: 2.04 ± 0.036	1.517AsnSer: 1.517 ± 0.032	1.247AsnThr: 1.247 ± 0.026	2.008AsnVal: 2.008 ± 0.035	0.452AsnTrp: 0.452 ± 0.017	0.664AsnTyr: 0.664 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	5.897ProAla: 5.897 ± 0.073	0.436ProCys: 0.436 ± 0.016	3.376ProAsp: 3.376 ± 0.045	3.443ProGlu: 3.443 ± 0.051	2.061ProPhe: 2.061 ± 0.036	4.087ProGly: 4.087 ± 0.052	1.132ProHis: 1.132 ± 0.027	2.398ProIle: 2.398 ± 0.038	1.698ProLys: 1.698 ± 0.036	4.653ProLeu: 4.653 ± 0.053	1.145ProMet: 1.145 ± 0.022	1.341ProAsn: 1.341 ± 0.027	2.368ProPro: 2.368 ± 0.045	1.619ProGln: 1.619 ± 0.031	2.954ProArg: 2.954 ± 0.041	2.974ProSer: 2.974 ± 0.037	2.253ProThr: 2.253 ± 0.035	3.985ProVal: 3.985 ± 0.047	0.64ProTrp: 0.64 ± 0.02	1.153ProTyr: 1.153 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.959GlnAla: 3.959 ± 0.05	0.284GlnCys: 0.284 ± 0.014	1.461GlnAsp: 1.461 ± 0.028	1.575GlnGlu: 1.575 ± 0.034	1.134GlnPhe: 1.134 ± 0.025	2.208GlnGly: 2.208 ± 0.037	0.837GlnHis: 0.837 ± 0.023	1.877GlnIle: 1.877 ± 0.033	1.218GlnLys: 1.218 ± 0.025	2.909GlnLeu: 2.909 ± 0.043	0.929GlnMet: 0.929 ± 0.022	0.931GlnAsn: 0.931 ± 0.023	1.87GlnPro: 1.87 ± 0.039	1.484GlnGln: 1.484 ± 0.037	2.728GlnArg: 2.728 ± 0.049	2.016GlnSer: 2.016 ± 0.035	1.732GlnThr: 1.732 ± 0.034	2.043GlnVal: 2.043 ± 0.037	0.392GlnTrp: 0.392 ± 0.015	0.614GlnTyr: 0.614 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	7.202ArgAla: 7.202 ± 0.066	0.789ArgCys: 0.789 ± 0.027	3.935ArgAsp: 3.935 ± 0.049	3.936ArgGlu: 3.936 ± 0.051	2.998ArgPhe: 2.998 ± 0.04	4.672ArgGly: 4.672 ± 0.056	2.215ArgHis: 2.215 ± 0.047	4.256ArgIle: 4.256 ± 0.049	2.662ArgLys: 2.662 ± 0.041	8.089ArgLeu: 8.089 ± 0.08	2.016ArgMet: 2.016 ± 0.033	2.196ArgAsn: 2.196 ± 0.034	3.798ArgPro: 3.798 ± 0.059	3.176ArgGln: 3.176 ± 0.043	6.893ArgArg: 6.893 ± 0.097	4.494ArgSer: 4.494 ± 0.062	3.295ArgThr: 3.295 ± 0.04	4.191ArgVal: 4.191 ± 0.051	0.934ArgTrp: 0.934 ± 0.025	1.733ArgTyr: 1.733 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.651SerAla: 6.651 ± 0.069	0.622SerCys: 0.622 ± 0.02	3.167SerAsp: 3.167 ± 0.048	3.052SerGlu: 3.052 ± 0.044	2.554SerPhe: 2.554 ± 0.039	5.97SerGly: 5.97 ± 0.063	1.226SerHis: 1.226 ± 0.031	3.272SerIle: 3.272 ± 0.041	1.879SerLys: 1.879 ± 0.027	5.783SerLeu: 5.783 ± 0.063	1.509SerMet: 1.509 ± 0.027	1.614SerAsn: 1.614 ± 0.031	3.02SerPro: 3.02 ± 0.04	1.73SerGln: 1.73 ± 0.033	4.25SerArg: 4.25 ± 0.051	3.882SerSer: 3.882 ± 0.059	2.863SerThr: 2.863 ± 0.047	4.202SerVal: 4.202 ± 0.051	0.842SerTrp: 0.842 ± 0.025	1.361SerTyr: 1.361 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.818ThrAla: 5.818 ± 0.049	0.466ThrCys: 0.466 ± 0.019	2.613ThrAsp: 2.613 ± 0.041	2.572ThrGlu: 2.572 ± 0.042	1.959ThrPhe: 1.959 ± 0.037	4.708ThrGly: 4.708 ± 0.055	0.969ThrHis: 0.969 ± 0.02	3.026ThrIle: 3.026 ± 0.045	1.573ThrLys: 1.573 ± 0.029	5.185ThrLeu: 5.185 ± 0.062	1.22ThrMet: 1.22 ± 0.029	1.339ThrAsn: 1.339 ± 0.031	2.845ThrPro: 2.845 ± 0.039	1.292ThrGln: 1.292 ± 0.028	3.009ThrArg: 3.009 ± 0.041	3.062ThrSer: 3.062 ± 0.044	2.577ThrThr: 2.577 ± 0.048	4.057ThrVal: 4.057 ± 0.052	0.571ThrTrp: 0.571 ± 0.02	1.135ThrTyr: 1.135 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.292ValAla: 8.292 ± 0.068	0.655ValCys: 0.655 ± 0.022	4.061ValAsp: 4.061 ± 0.052	4.418ValGlu: 4.418 ± 0.054	2.864ValPhe: 2.864 ± 0.045	5.319ValGly: 5.319 ± 0.062	1.383ValHis: 1.383 ± 0.03	4.216ValIle: 4.216 ± 0.049	2.422ValLys: 2.422 ± 0.039	6.819ValLeu: 6.819 ± 0.073	1.754ValMet: 1.754 ± 0.029	1.955ValAsn: 1.955 ± 0.034	3.369ValPro: 3.369 ± 0.042	1.939ValGln: 1.939 ± 0.037	4.64ValArg: 4.64 ± 0.048	4.688ValSer: 4.688 ± 0.056	4.208ValThr: 4.208 ± 0.049	5.453ValVal: 5.453 ± 0.06	0.775ValTrp: 0.775 ± 0.02	1.403ValTyr: 1.403 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.125TrpAla: 1.125 ± 0.026	0.137TrpCys: 0.137 ± 0.009	0.565TrpAsp: 0.565 ± 0.018	0.515TrpGlu: 0.515 ± 0.018	0.52TrpPhe: 0.52 ± 0.019	0.791TrpGly: 0.791 ± 0.023	0.298TrpHis: 0.298 ± 0.013	0.691TrpIle: 0.691 ± 0.018	0.551TrpLys: 0.551 ± 0.019	1.49TrpLeu: 1.49 ± 0.032	0.326TrpMet: 0.326 ± 0.014	0.482TrpAsn: 0.482 ± 0.017	0.657TrpPro: 0.657 ± 0.02	0.529TrpGln: 0.529 ± 0.019	1.101TrpArg: 1.101 ± 0.028	0.817TrpSer: 0.817 ± 0.022	0.689TrpThr: 0.689 ± 0.02	0.709TrpVal: 0.709 ± 0.022	0.217TrpTrp: 0.217 ± 0.012	0.257TrpTyr: 0.257 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.329TyrAla: 2.329 ± 0.038	0.265TyrCys: 0.265 ± 0.012	1.404TyrAsp: 1.404 ± 0.028	1.181TyrGlu: 1.181 ± 0.027	0.994TyrPhe: 0.994 ± 0.022	2.019TyrGly: 2.019 ± 0.033	0.49TyrHis: 0.49 ± 0.015	0.988TyrIle: 0.988 ± 0.028	0.65TyrLys: 0.65 ± 0.021	2.182TyrLeu: 2.182 ± 0.039	0.429TyrMet: 0.429 ± 0.014	0.606TyrAsn: 0.606 ± 0.018	1.072TyrPro: 1.072 ± 0.024	0.725TyrGln: 0.725 ± 0.019	1.821TyrArg: 1.821 ± 0.033	1.252TyrSer: 1.252 ± 0.028	0.95TyrThr: 0.95 ± 0.022	1.542TyrVal: 1.542 ± 0.03	0.353TyrTrp: 0.353 ± 0.015	0.615TyrTyr: 0.615 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6543 proteins (1785383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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