Amino acid dipepetide frequency for Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent) (Peronospora arabidopsidis)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.421AlaAla: 9.421 ± 0.068	1.425AlaCys: 1.425 ± 0.018	4.196AlaAsp: 4.196 ± 0.032	4.892AlaGlu: 4.892 ± 0.039	3.082AlaPhe: 3.082 ± 0.03	5.0AlaGly: 5.0 ± 0.041	1.863AlaHis: 1.863 ± 0.021	3.709AlaIle: 3.709 ± 0.034	4.303AlaLys: 4.303 ± 0.035	8.395AlaLeu: 8.395 ± 0.055	2.275AlaMet: 2.275 ± 0.024	2.675AlaAsn: 2.675 ± 0.025	3.673AlaPro: 3.673 ± 0.033	3.301AlaGln: 3.301 ± 0.033	5.324AlaArg: 5.324 ± 0.043	7.452AlaSer: 7.452 ± 0.049	5.585AlaThr: 5.585 ± 0.039	6.404AlaVal: 6.404 ± 0.037	0.864AlaTrp: 0.864 ± 0.016	1.852AlaTyr: 1.852 ± 0.022	0.002AlaXaa: 0.002 ± 0.001
Cys	1.499CysAla: 1.499 ± 0.019	0.542CysCys: 0.542 ± 0.012	0.987CysAsp: 0.987 ± 0.017	0.966CysGlu: 0.966 ± 0.015	0.754CysPhe: 0.754 ± 0.015	1.397CysGly: 1.397 ± 0.018	0.504CysHis: 0.504 ± 0.012	0.871CysIle: 0.871 ± 0.015	0.841CysLys: 0.841 ± 0.017	1.644CysLeu: 1.644 ± 0.019	0.468CysMet: 0.468 ± 0.01	0.64CysAsn: 0.64 ± 0.011	0.842CysPro: 0.842 ± 0.016	0.635CysGln: 0.635 ± 0.011	1.347CysArg: 1.347 ± 0.018	1.699CysSer: 1.699 ± 0.02	1.108CysThr: 1.108 ± 0.019	1.433CysVal: 1.433 ± 0.022	0.275CysTrp: 0.275 ± 0.007	0.491CysTyr: 0.491 ± 0.011	0.001CysXaa: 0.001 ± 0.0
Asp	5.156AspAla: 5.156 ± 0.037	0.909AspCys: 0.909 ± 0.015	4.489AspAsp: 4.489 ± 0.046	4.815AspGlu: 4.815 ± 0.041	2.067AspPhe: 2.067 ± 0.022	4.006AspGly: 4.006 ± 0.035	1.285AspHis: 1.285 ± 0.018	2.403AspIle: 2.403 ± 0.026	2.565AspLys: 2.565 ± 0.026	4.638AspLeu: 4.638 ± 0.031	1.371AspMet: 1.371 ± 0.016	1.713AspAsn: 1.713 ± 0.02	2.404AspPro: 2.404 ± 0.03	1.884AspGln: 1.884 ± 0.022	3.161AspArg: 3.161 ± 0.027	3.99AspSer: 3.99 ± 0.034	2.989AspThr: 2.989 ± 0.028	4.87AspVal: 4.87 ± 0.034	0.64AspTrp: 0.64 ± 0.011	1.367AspTyr: 1.367 ± 0.016	0.002AspXaa: 0.002 ± 0.001
Glu	5.324GluAla: 5.324 ± 0.045	0.96GluCys: 0.96 ± 0.014	3.956GluAsp: 3.956 ± 0.038	5.528GluGlu: 5.528 ± 0.055	2.002GluPhe: 2.002 ± 0.024	3.237GluGly: 3.237 ± 0.034	1.604GluHis: 1.604 ± 0.018	2.692GluIle: 2.692 ± 0.026	3.853GluLys: 3.853 ± 0.038	6.329GluLeu: 6.329 ± 0.045	1.805GluMet: 1.805 ± 0.02	2.188GluAsn: 2.188 ± 0.026	2.111GluPro: 2.111 ± 0.024	2.903GluGln: 2.903 ± 0.031	4.229GluArg: 4.229 ± 0.038	4.444GluSer: 4.444 ± 0.036	3.601GluThr: 3.601 ± 0.028	4.294GluVal: 4.294 ± 0.029	0.703GluTrp: 0.703 ± 0.014	1.548GluTyr: 1.548 ± 0.022	0.001GluXaa: 0.001 ± 0.001
Phe	3.021PheAla: 3.021 ± 0.029	0.827PheCys: 0.827 ± 0.015	2.227PheAsp: 2.227 ± 0.022	2.165PheGlu: 2.165 ± 0.024	1.535PhePhe: 1.535 ± 0.021	2.596PheGly: 2.596 ± 0.033	0.952PheHis: 0.952 ± 0.016	1.44PheIle: 1.44 ± 0.021	1.442PheLys: 1.442 ± 0.018	3.439PheLeu: 3.439 ± 0.028	0.896PheMet: 0.896 ± 0.014	1.175PheAsn: 1.175 ± 0.018	1.563PhePro: 1.563 ± 0.019	1.411PheGln: 1.411 ± 0.019	2.142PheArg: 2.142 ± 0.025	2.89PheSer: 2.89 ± 0.03	1.94PheThr: 1.94 ± 0.025	2.972PheVal: 2.972 ± 0.029	0.437PheTrp: 0.437 ± 0.012	1.109PheTyr: 1.109 ± 0.016	0.001PheXaa: 0.001 ± 0.0
Gly	4.813GlyAla: 4.813 ± 0.037	1.182GlyCys: 1.182 ± 0.018	3.712GlyAsp: 3.712 ± 0.031	3.43GlyGlu: 3.43 ± 0.028	2.292GlyPhe: 2.292 ± 0.027	4.779GlyGly: 4.779 ± 0.05	1.633GlyHis: 1.633 ± 0.024	2.796GlyIle: 2.796 ± 0.029	3.207GlyLys: 3.207 ± 0.032	4.976GlyLeu: 4.976 ± 0.034	1.532GlyMet: 1.532 ± 0.021	2.251GlyAsn: 2.251 ± 0.024	2.103GlyPro: 2.103 ± 0.022	2.095GlyGln: 2.095 ± 0.019	3.902GlyArg: 3.902 ± 0.037	5.397GlySer: 5.397 ± 0.045	3.583GlyThr: 3.583 ± 0.032	4.514GlyVal: 4.514 ± 0.034	0.719GlyTrp: 0.719 ± 0.013	1.693GlyTyr: 1.693 ± 0.018	0.003GlyXaa: 0.003 ± 0.001
His	2.04HisAla: 2.04 ± 0.02	0.531HisCys: 0.531 ± 0.012	1.419HisAsp: 1.419 ± 0.019	1.664HisGlu: 1.664 ± 0.02	1.049HisPhe: 1.049 ± 0.018	1.735HisGly: 1.735 ± 0.021	0.863HisHis: 0.863 ± 0.016	0.964HisIle: 0.964 ± 0.016	1.081HisLys: 1.081 ± 0.016	2.394HisLeu: 2.394 ± 0.026	0.597HisMet: 0.597 ± 0.013	0.776HisAsn: 0.776 ± 0.014	1.332HisPro: 1.332 ± 0.017	1.109HisGln: 1.109 ± 0.015	1.791HisArg: 1.791 ± 0.022	1.867HisSer: 1.867 ± 0.022	1.251HisThr: 1.251 ± 0.019	2.131HisVal: 2.131 ± 0.019	0.321HisTrp: 0.321 ± 0.009	0.697HisTyr: 0.697 ± 0.013	0.001HisXaa: 0.001 ± 0.0
Ile	3.708IleAla: 3.708 ± 0.032	0.889IleCys: 0.889 ± 0.016	2.574IleAsp: 2.574 ± 0.025	2.646IleGlu: 2.646 ± 0.027	1.5IlePhe: 1.5 ± 0.02	2.622IleGly: 2.622 ± 0.024	0.982IleHis: 0.982 ± 0.015	1.64IleIle: 1.64 ± 0.02	1.998IleLys: 1.998 ± 0.024	3.614IleLeu: 3.614 ± 0.031	0.953IleMet: 0.953 ± 0.018	1.375IleAsn: 1.375 ± 0.021	1.956IlePro: 1.956 ± 0.024	1.608IleGln: 1.608 ± 0.02	2.544IleArg: 2.544 ± 0.028	3.122IleSer: 3.122 ± 0.028	2.22IleThr: 2.22 ± 0.025	3.267IleVal: 3.267 ± 0.03	0.504IleTrp: 0.504 ± 0.012	1.087IleTyr: 1.087 ± 0.016	0.001IleXaa: 0.001 ± 0.0
Lys	3.951LysAla: 3.951 ± 0.037	0.899LysCys: 0.899 ± 0.015	2.491LysAsp: 2.491 ± 0.025	3.398LysGlu: 3.398 ± 0.042	1.57LysPhe: 1.57 ± 0.019	2.45LysGly: 2.45 ± 0.027	1.367LysHis: 1.367 ± 0.02	1.997LysIle: 1.997 ± 0.021	3.947LysLys: 3.947 ± 0.048	4.896LysLeu: 4.896 ± 0.037	1.411LysMet: 1.411 ± 0.018	1.791LysAsn: 1.791 ± 0.021	1.972LysPro: 1.972 ± 0.026	2.382LysGln: 2.382 ± 0.026	4.056LysArg: 4.056 ± 0.04	3.726LysSer: 3.726 ± 0.034	3.113LysThr: 3.113 ± 0.028	3.271LysVal: 3.271 ± 0.032	0.694LysTrp: 0.694 ± 0.012	1.445LysTyr: 1.445 ± 0.02	0.002LysXaa: 0.002 ± 0.001
Leu	7.867LeuAla: 7.867 ± 0.051	1.869LeuCys: 1.869 ± 0.02	5.272LeuAsp: 5.272 ± 0.037	6.068LeuGlu: 6.068 ± 0.048	3.436LeuPhe: 3.436 ± 0.039	4.973LeuGly: 4.973 ± 0.039	2.727LeuHis: 2.727 ± 0.026	3.258LeuIle: 3.258 ± 0.03	4.54LeuLys: 4.54 ± 0.041	10.184LeuLeu: 10.184 ± 0.065	2.24LeuMet: 2.24 ± 0.024	3.046LeuAsn: 3.046 ± 0.028	4.666LeuPro: 4.666 ± 0.035	4.75LeuGln: 4.75 ± 0.04	6.602LeuArg: 6.602 ± 0.048	7.617LeuSer: 7.617 ± 0.045	5.024LeuThr: 5.024 ± 0.036	6.878LeuVal: 6.878 ± 0.047	1.109LeuTrp: 1.109 ± 0.015	2.394LeuTyr: 2.394 ± 0.024	0.004LeuXaa: 0.004 ± 0.001
Met	2.242MetAla: 2.242 ± 0.022	0.435MetCys: 0.435 ± 0.01	1.568MetAsp: 1.568 ± 0.022	1.762MetGlu: 1.762 ± 0.02	0.809MetPhe: 0.809 ± 0.014	1.445MetGly: 1.445 ± 0.018	0.625MetHis: 0.625 ± 0.013	0.974MetIle: 0.974 ± 0.015	1.41MetLys: 1.41 ± 0.018	2.486MetLeu: 2.486 ± 0.026	0.753MetMet: 0.753 ± 0.014	0.95MetAsn: 0.95 ± 0.014	1.141MetPro: 1.141 ± 0.017	1.201MetGln: 1.201 ± 0.02	1.625MetArg: 1.625 ± 0.021	1.968MetSer: 1.968 ± 0.021	1.6MetThr: 1.6 ± 0.02	1.638MetVal: 1.638 ± 0.021	0.317MetTrp: 0.317 ± 0.008	0.676MetTyr: 0.676 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	2.98AsnAla: 2.98 ± 0.03	0.626AsnCys: 0.626 ± 0.013	2.023AsnAsp: 2.023 ± 0.023	2.288AsnGlu: 2.288 ± 0.028	1.181AsnPhe: 1.181 ± 0.017	2.576AsnGly: 2.576 ± 0.024	0.772AsnHis: 0.772 ± 0.013	1.398AsnIle: 1.398 ± 0.016	1.593AsnLys: 1.593 ± 0.023	2.771AsnLeu: 2.771 ± 0.029	0.859AsnMet: 0.859 ± 0.014	1.163AsnAsn: 1.163 ± 0.019	1.566AsnPro: 1.566 ± 0.021	1.163AsnGln: 1.163 ± 0.016	1.992AsnArg: 1.992 ± 0.02	2.515AsnSer: 2.515 ± 0.027	1.747AsnThr: 1.747 ± 0.021	2.801AsnVal: 2.801 ± 0.025	0.421AsnTrp: 0.421 ± 0.01	0.875AsnTyr: 0.875 ± 0.013	0.002AsnXaa: 0.002 ± 0.001
Pro	3.549ProAla: 3.549 ± 0.036	0.673ProCys: 0.673 ± 0.013	2.298ProAsp: 2.298 ± 0.027	2.63ProGlu: 2.63 ± 0.025	1.664ProPhe: 1.664 ± 0.02	2.424ProGly: 2.424 ± 0.029	1.102ProHis: 1.102 ± 0.018	1.803ProIle: 1.803 ± 0.022	1.912ProLys: 1.912 ± 0.028	4.17ProLeu: 4.17 ± 0.033	1.142ProMet: 1.142 ± 0.018	1.411ProAsn: 1.411 ± 0.018	2.824ProPro: 2.824 ± 0.037	1.649ProGln: 1.649 ± 0.021	2.908ProArg: 2.908 ± 0.031	4.488ProSer: 4.488 ± 0.045	2.967ProThr: 2.967 ± 0.028	3.427ProVal: 3.427 ± 0.033	0.475ProTrp: 0.475 ± 0.01	1.011ProTyr: 1.011 ± 0.015	0.002ProXaa: 0.002 ± 0.001
Gln	3.18GlnAla: 3.18 ± 0.031	0.696GlnCys: 0.696 ± 0.012	1.957GlnAsp: 1.957 ± 0.024	2.716GlnGlu: 2.716 ± 0.026	1.367GlnPhe: 1.367 ± 0.017	1.895GlnGly: 1.895 ± 0.024	1.277GlnHis: 1.277 ± 0.019	1.557GlnIle: 1.557 ± 0.02	2.169GlnLys: 2.169 ± 0.025	4.614GlnLeu: 4.614 ± 0.04	1.119GlnMet: 1.119 ± 0.018	1.218GlnAsn: 1.218 ± 0.018	1.688GlnPro: 1.688 ± 0.021	2.986GlnGln: 2.986 ± 0.053	3.181GlnArg: 3.181 ± 0.031	3.04GlnSer: 3.04 ± 0.029	2.232GlnThr: 2.232 ± 0.025	2.887GlnVal: 2.887 ± 0.024	0.573GlnTrp: 0.573 ± 0.012	1.083GlnTyr: 1.083 ± 0.017	0.001GlnXaa: 0.001 ± 0.0
Arg	5.26ArgAla: 5.26 ± 0.04	1.356ArgCys: 1.356 ± 0.021	3.443ArgAsp: 3.443 ± 0.028	3.963ArgGlu: 3.963 ± 0.03	2.347ArgPhe: 2.347 ± 0.026	3.841ArgGly: 3.841 ± 0.03	1.929ArgHis: 1.929 ± 0.026	2.586ArgIle: 2.586 ± 0.024	3.67ArgLys: 3.67 ± 0.037	6.371ArgLeu: 6.371 ± 0.044	1.696ArgMet: 1.696 ± 0.022	2.241ArgAsn: 2.241 ± 0.023	2.711ArgPro: 2.711 ± 0.029	2.996ArgGln: 2.996 ± 0.028	6.034ArgArg: 6.034 ± 0.055	5.654ArgSer: 5.654 ± 0.043	3.54ArgThr: 3.54 ± 0.031	4.669ArgVal: 4.669 ± 0.035	0.92ArgTrp: 0.92 ± 0.014	1.734ArgTyr: 1.734 ± 0.023	0.003ArgXaa: 0.003 ± 0.001
Ser	6.947SerAla: 6.947 ± 0.05	1.682SerCys: 1.682 ± 0.02	4.578SerAsp: 4.578 ± 0.041	4.306SerGlu: 4.306 ± 0.034	3.109SerPhe: 3.109 ± 0.026	5.464SerGly: 5.464 ± 0.041	1.9SerHis: 1.9 ± 0.02	3.547SerIle: 3.547 ± 0.031	3.823SerLys: 3.823 ± 0.031	7.187SerLeu: 7.187 ± 0.048	2.152SerMet: 2.152 ± 0.023	2.791SerAsn: 2.791 ± 0.028	3.899SerPro: 3.899 ± 0.038	2.707SerGln: 2.707 ± 0.028	5.404SerArg: 5.404 ± 0.041	10.07SerSer: 10.07 ± 0.091	5.834SerThr: 5.834 ± 0.045	5.86SerVal: 5.86 ± 0.038	1.029SerTrp: 1.029 ± 0.015	1.866SerTyr: 1.866 ± 0.022	0.004SerXaa: 0.004 ± 0.001
Thr	5.152ThrAla: 5.152 ± 0.036	1.16ThrCys: 1.16 ± 0.018	2.879ThrAsp: 2.879 ± 0.027	3.157ThrGlu: 3.157 ± 0.031	2.193ThrPhe: 2.193 ± 0.025	3.692ThrGly: 3.692 ± 0.03	1.328ThrHis: 1.328 ± 0.019	2.61ThrIle: 2.61 ± 0.029	2.987ThrLys: 2.987 ± 0.029	5.404ThrLeu: 5.404 ± 0.036	1.498ThrMet: 1.498 ± 0.021	1.98ThrAsn: 1.98 ± 0.022	3.164ThrPro: 3.164 ± 0.032	2.039ThrGln: 2.039 ± 0.018	3.735ThrArg: 3.735 ± 0.027	5.698ThrSer: 5.698 ± 0.042	4.293ThrThr: 4.293 ± 0.044	3.975ThrVal: 3.975 ± 0.034	0.717ThrTrp: 0.717 ± 0.014	1.37ThrTyr: 1.37 ± 0.018	0.003ThrXaa: 0.003 ± 0.001
Val	6.79ValAla: 6.79 ± 0.045	1.462ValCys: 1.462 ± 0.018	4.513ValAsp: 4.513 ± 0.033	4.763ValGlu: 4.763 ± 0.039	2.695ValPhe: 2.695 ± 0.026	4.129ValGly: 4.129 ± 0.036	1.897ValHis: 1.897 ± 0.021	2.907ValIle: 2.907 ± 0.028	3.601ValLys: 3.601 ± 0.037	7.338ValLeu: 7.338 ± 0.044	1.781ValMet: 1.781 ± 0.02	2.463ValAsn: 2.463 ± 0.021	3.443ValPro: 3.443 ± 0.03	3.132ValGln: 3.132 ± 0.028	4.367ValArg: 4.367 ± 0.036	5.726ValSer: 5.726 ± 0.034	4.217ValThr: 4.217 ± 0.033	6.134ValVal: 6.134 ± 0.046	0.83ValTrp: 0.83 ± 0.014	1.871ValTyr: 1.871 ± 0.02	0.004ValXaa: 0.004 ± 0.001
Trp	0.713TrpAla: 0.713 ± 0.013	0.253TrpCys: 0.253 ± 0.008	0.632TrpAsp: 0.632 ± 0.012	0.597TrpGlu: 0.597 ± 0.012	0.43TrpPhe: 0.43 ± 0.011	0.613TrpGly: 0.613 ± 0.013	0.311TrpHis: 0.311 ± 0.008	0.609TrpIle: 0.609 ± 0.014	0.788TrpLys: 0.788 ± 0.014	1.273TrpLeu: 1.273 ± 0.021	0.413TrpMet: 0.413 ± 0.01	0.528TrpAsn: 0.528 ± 0.011	0.411TrpPro: 0.411 ± 0.009	0.512TrpGln: 0.512 ± 0.011	0.924TrpArg: 0.924 ± 0.015	0.989TrpSer: 0.989 ± 0.016	0.835TrpThr: 0.835 ± 0.015	0.719TrpVal: 0.719 ± 0.014	0.212TrpTrp: 0.212 ± 0.007	0.346TrpTyr: 0.346 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.078TyrAla: 2.078 ± 0.023	0.566TyrCys: 0.566 ± 0.011	1.507TyrAsp: 1.507 ± 0.018	1.559TyrGlu: 1.559 ± 0.021	1.098TyrPhe: 1.098 ± 0.017	1.735TyrGly: 1.735 ± 0.021	0.688TyrHis: 0.688 ± 0.013	1.045TyrIle: 1.045 ± 0.015	1.096TyrLys: 1.096 ± 0.016	2.397TyrLeu: 2.397 ± 0.026	0.665TyrMet: 0.665 ± 0.012	0.937TyrAsn: 0.937 ± 0.015	1.057TyrPro: 1.057 ± 0.018	0.97TyrGln: 0.97 ± 0.014	1.695TyrArg: 1.695 ± 0.021	1.803TyrSer: 1.803 ± 0.019	1.357TyrThr: 1.357 ± 0.016	1.914TyrVal: 1.914 ± 0.022	0.349TyrTrp: 0.349 ± 0.01	0.777TyrTyr: 0.777 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.002XaaPro: 0.002 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.004XaaSer: 0.004 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.004XaaVal: 0.004 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.209XaaXaa: 0.209 ± 0.032

Statistics based on 13837 proteins (4494721 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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