Amino acid dipepetide frequency for Brevibacterium mcbrellneri ATCC 49030

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.501AlaAla: 11.501 ± 0.14	0.902AlaCys: 0.902 ± 0.034	6.063AlaAsp: 6.063 ± 0.094	6.551AlaGlu: 6.551 ± 0.106	3.479AlaPhe: 3.479 ± 0.063	10.146AlaGly: 10.146 ± 0.128	2.881AlaHis: 2.881 ± 0.067	5.067AlaIle: 5.067 ± 0.091	3.907AlaLys: 3.907 ± 0.093	11.229AlaLeu: 11.229 ± 0.151	2.464AlaMet: 2.464 ± 0.065	2.776AlaAsn: 2.776 ± 0.063	4.742AlaPro: 4.742 ± 0.09	4.915AlaGln: 4.915 ± 0.073	7.11AlaArg: 7.11 ± 0.108	6.469AlaSer: 6.469 ± 0.092	7.061AlaThr: 7.061 ± 0.107	9.492AlaVal: 9.492 ± 0.14	1.432AlaTrp: 1.432 ± 0.042	2.173AlaTyr: 2.173 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.845CysAla: 0.845 ± 0.033	0.094CysCys: 0.094 ± 0.012	0.426CysAsp: 0.426 ± 0.023	0.48CysGlu: 0.48 ± 0.028	0.233CysPhe: 0.233 ± 0.018	0.663CysGly: 0.663 ± 0.028	0.153CysHis: 0.153 ± 0.014	0.294CysIle: 0.294 ± 0.016	0.177CysLys: 0.177 ± 0.018	0.576CysLeu: 0.576 ± 0.03	0.141CysMet: 0.141 ± 0.014	0.167CysAsn: 0.167 ± 0.015	0.354CysPro: 0.354 ± 0.025	0.168CysGln: 0.168 ± 0.013	0.35CysArg: 0.35 ± 0.02	0.489CysSer: 0.489 ± 0.025	0.436CysThr: 0.436 ± 0.025	0.727CysVal: 0.727 ± 0.033	0.089CysTrp: 0.089 ± 0.01	0.145CysTyr: 0.145 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.447AspAla: 6.447 ± 0.099	0.358AspCys: 0.358 ± 0.02	3.604AspAsp: 3.604 ± 0.081	4.261AspGlu: 4.261 ± 0.092	2.109AspPhe: 2.109 ± 0.062	4.87AspGly: 4.87 ± 0.097	1.346AspHis: 1.346 ± 0.041	2.966AspIle: 2.966 ± 0.066	2.014AspLys: 2.014 ± 0.065	5.59AspLeu: 5.59 ± 0.1	1.233AspMet: 1.233 ± 0.042	1.546AspAsn: 1.546 ± 0.058	3.652AspPro: 3.652 ± 0.077	1.916AspGln: 1.916 ± 0.049	3.565AspArg: 3.565 ± 0.081	3.392AspSer: 3.392 ± 0.07	3.62AspThr: 3.62 ± 0.078	5.099AspVal: 5.099 ± 0.097	0.804AspTrp: 0.804 ± 0.033	1.412AspTyr: 1.412 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.659GluAla: 6.659 ± 0.111	0.385GluCys: 0.385 ± 0.025	3.47GluAsp: 3.47 ± 0.072	4.12GluGlu: 4.12 ± 0.096	2.07GluPhe: 2.07 ± 0.051	3.993GluGly: 3.993 ± 0.084	1.666GluHis: 1.666 ± 0.05	2.919GluIle: 2.919 ± 0.067	2.467GluLys: 2.467 ± 0.068	6.662GluLeu: 6.662 ± 0.106	1.116GluMet: 1.116 ± 0.035	1.997GluAsn: 1.997 ± 0.048	3.259GluPro: 3.259 ± 0.082	2.513GluGln: 2.513 ± 0.064	4.238GluArg: 4.238 ± 0.081	3.522GluSer: 3.522 ± 0.079	3.533GluThr: 3.533 ± 0.076	5.04GluVal: 5.04 ± 0.085	0.89GluTrp: 0.89 ± 0.031	1.426GluTyr: 1.426 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	4.005PheAla: 4.005 ± 0.078	0.269PheCys: 0.269 ± 0.02	2.558PheAsp: 2.558 ± 0.053	1.986PheGlu: 1.986 ± 0.045	1.248PhePhe: 1.248 ± 0.044	3.218PheGly: 3.218 ± 0.074	0.645PheHis: 0.645 ± 0.025	1.692PheIle: 1.692 ± 0.055	0.981PheLys: 0.981 ± 0.04	2.823PheLeu: 2.823 ± 0.073	0.688PheMet: 0.688 ± 0.037	1.083PheAsn: 1.083 ± 0.041	1.416PhePro: 1.416 ± 0.043	0.818PheGln: 0.818 ± 0.034	1.526PheArg: 1.526 ± 0.055	2.192PheSer: 2.192 ± 0.056	2.386PheThr: 2.386 ± 0.057	2.955PheVal: 2.955 ± 0.071	0.453PheTrp: 0.453 ± 0.028	0.709PheTyr: 0.709 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.498GlyAla: 8.498 ± 0.127	0.641GlyCys: 0.641 ± 0.03	4.663GlyAsp: 4.663 ± 0.09	4.899GlyGlu: 4.899 ± 0.086	3.216GlyPhe: 3.216 ± 0.072	6.73GlyGly: 6.73 ± 0.113	1.892GlyHis: 1.892 ± 0.053	4.396GlyIle: 4.396 ± 0.076	3.444GlyLys: 3.444 ± 0.08	7.795GlyLeu: 7.795 ± 0.133	2.052GlyMet: 2.052 ± 0.047	2.295GlyAsn: 2.295 ± 0.055	3.456GlyPro: 3.456 ± 0.077	2.828GlyGln: 2.828 ± 0.067	4.806GlyArg: 4.806 ± 0.088	5.286GlySer: 5.286 ± 0.097	5.42GlyThr: 5.42 ± 0.083	7.396GlyVal: 7.396 ± 0.104	1.317GlyTrp: 1.317 ± 0.044	2.174GlyTyr: 2.174 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.539HisAla: 2.539 ± 0.064	0.149HisCys: 0.149 ± 0.014	1.397HisAsp: 1.397 ± 0.039	1.411HisGlu: 1.411 ± 0.047	0.7HisPhe: 0.7 ± 0.03	1.918HisGly: 1.918 ± 0.051	0.58HisHis: 0.58 ± 0.028	1.111HisIle: 1.111 ± 0.039	0.605HisLys: 0.605 ± 0.027	1.972HisLeu: 1.972 ± 0.05	0.507HisMet: 0.507 ± 0.022	0.608HisAsn: 0.608 ± 0.028	1.487HisPro: 1.487 ± 0.049	0.713HisGln: 0.713 ± 0.033	1.482HisArg: 1.482 ± 0.045	1.308HisSer: 1.308 ± 0.044	1.585HisThr: 1.585 ± 0.049	2.122HisVal: 2.122 ± 0.059	0.264HisTrp: 0.264 ± 0.019	0.467HisTyr: 0.467 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.113IleAla: 6.113 ± 0.104	0.331IleCys: 0.331 ± 0.021	3.542IleAsp: 3.542 ± 0.065	3.154IleGlu: 3.154 ± 0.068	1.444IlePhe: 1.444 ± 0.05	3.964IleGly: 3.964 ± 0.084	1.02IleHis: 1.02 ± 0.037	2.105IleIle: 2.105 ± 0.058	1.34IleLys: 1.34 ± 0.051	4.007IleLeu: 4.007 ± 0.077	0.989IleMet: 0.989 ± 0.037	1.428IleAsn: 1.428 ± 0.049	2.497IlePro: 2.497 ± 0.057	1.158IleGln: 1.158 ± 0.036	2.753IleArg: 2.753 ± 0.06	2.872IleSer: 2.872 ± 0.061	3.245IleThr: 3.245 ± 0.067	4.558IleVal: 4.558 ± 0.082	0.412IleTrp: 0.412 ± 0.022	0.888IleTyr: 0.888 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.666LysAla: 3.666 ± 0.083	0.155LysCys: 0.155 ± 0.014	2.301LysAsp: 2.301 ± 0.063	2.174LysGlu: 2.174 ± 0.066	1.036LysPhe: 1.036 ± 0.039	2.399LysGly: 2.399 ± 0.068	0.825LysHis: 0.825 ± 0.032	1.547LysIle: 1.547 ± 0.05	2.013LysLys: 2.013 ± 0.067	3.17LysLeu: 3.17 ± 0.074	0.808LysMet: 0.808 ± 0.033	1.211LysAsn: 1.211 ± 0.042	2.077LysPro: 2.077 ± 0.067	1.289LysGln: 1.289 ± 0.045	2.491LysArg: 2.491 ± 0.072	2.065LysSer: 2.065 ± 0.057	2.096LysThr: 2.096 ± 0.061	2.807LysVal: 2.807 ± 0.088	0.426LysTrp: 0.426 ± 0.025	0.888LysTyr: 0.888 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	11.258LeuAla: 11.258 ± 0.151	0.667LeuCys: 0.667 ± 0.028	5.793LeuAsp: 5.793 ± 0.094	5.25LeuGlu: 5.25 ± 0.092	2.967LeuPhe: 2.967 ± 0.074	8.012LeuGly: 8.012 ± 0.113	1.848LeuHis: 1.848 ± 0.05	4.615LeuIle: 4.615 ± 0.094	3.15LeuLys: 3.15 ± 0.073	8.349LeuLeu: 8.349 ± 0.154	2.209LeuMet: 2.209 ± 0.062	2.728LeuAsn: 2.728 ± 0.059	4.837LeuPro: 4.837 ± 0.085	2.406LeuGln: 2.406 ± 0.059	5.571LeuArg: 5.571 ± 0.098	6.001LeuSer: 6.001 ± 0.092	6.671LeuThr: 6.671 ± 0.092	8.05LeuVal: 8.05 ± 0.145	1.017LeuTrp: 1.017 ± 0.038	1.623LeuTyr: 1.623 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.159MetAla: 2.159 ± 0.066	0.207MetCys: 0.207 ± 0.014	1.092MetAsp: 1.092 ± 0.035	0.992MetGlu: 0.992 ± 0.034	0.817MetPhe: 0.817 ± 0.037	1.793MetGly: 1.793 ± 0.055	0.478MetHis: 0.478 ± 0.026	0.989MetIle: 0.989 ± 0.037	0.854MetLys: 0.854 ± 0.037	2.056MetLeu: 2.056 ± 0.055	0.413MetMet: 0.413 ± 0.028	0.705MetAsn: 0.705 ± 0.026	1.115MetPro: 1.115 ± 0.038	0.626MetGln: 0.626 ± 0.026	1.511MetArg: 1.511 ± 0.043	1.8MetSer: 1.8 ± 0.05	1.664MetThr: 1.664 ± 0.046	1.685MetVal: 1.685 ± 0.05	0.31MetTrp: 0.31 ± 0.019	0.444MetTyr: 0.444 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.193AsnAla: 3.193 ± 0.063	0.168AsnCys: 0.168 ± 0.016	1.683AsnAsp: 1.683 ± 0.045	1.687AsnGlu: 1.687 ± 0.053	0.88AsnPhe: 0.88 ± 0.036	2.341AsnGly: 2.341 ± 0.066	0.579AsnHis: 0.579 ± 0.029	1.251AsnIle: 1.251 ± 0.041	0.966AsnLys: 0.966 ± 0.04	2.53AsnLeu: 2.53 ± 0.061	0.622AsnMet: 0.622 ± 0.029	0.944AsnAsn: 0.944 ± 0.039	2.102AsnPro: 2.102 ± 0.052	0.963AsnGln: 0.963 ± 0.036	1.806AsnArg: 1.806 ± 0.055	1.578AsnSer: 1.578 ± 0.044	1.859AsnThr: 1.859 ± 0.055	2.386AsnVal: 2.386 ± 0.053	0.38AsnTrp: 0.38 ± 0.024	0.685AsnTyr: 0.685 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.463ProAla: 5.463 ± 0.091	0.236ProCys: 0.236 ± 0.02	3.254ProAsp: 3.254 ± 0.068	4.17ProGlu: 4.17 ± 0.081	1.596ProPhe: 1.596 ± 0.052	4.801ProGly: 4.801 ± 0.101	1.34ProHis: 1.34 ± 0.042	2.064ProIle: 2.064 ± 0.061	1.768ProLys: 1.768 ± 0.049	4.059ProLeu: 4.059 ± 0.066	0.938ProMet: 0.938 ± 0.035	1.476ProAsn: 1.476 ± 0.042	1.929ProPro: 1.929 ± 0.058	2.136ProGln: 2.136 ± 0.06	2.792ProArg: 2.792 ± 0.062	2.996ProSer: 2.996 ± 0.071	3.399ProThr: 3.399 ± 0.087	4.599ProVal: 4.599 ± 0.082	0.716ProTrp: 0.716 ± 0.033	1.057ProTyr: 1.057 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.164GlnAla: 4.164 ± 0.076	0.183GlnCys: 0.183 ± 0.015	1.616GlnAsp: 1.616 ± 0.048	1.901GlnGlu: 1.901 ± 0.053	1.079GlnPhe: 1.079 ± 0.038	2.431GlnGly: 2.431 ± 0.059	0.794GlnHis: 0.794 ± 0.033	1.73GlnIle: 1.73 ± 0.05	1.312GlnLys: 1.312 ± 0.046	3.404GlnLeu: 3.404 ± 0.071	0.713GlnMet: 0.713 ± 0.026	0.977GlnAsn: 0.977 ± 0.035	1.945GlnPro: 1.945 ± 0.064	1.447GlnGln: 1.447 ± 0.055	2.326GlnArg: 2.326 ± 0.052	1.869GlnSer: 1.869 ± 0.044	1.827GlnThr: 1.827 ± 0.048	2.807GlnVal: 2.807 ± 0.066	0.499GlnTrp: 0.499 ± 0.027	0.732GlnTyr: 0.732 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.455ArgAla: 6.455 ± 0.104	0.345ArgCys: 0.345 ± 0.022	3.583ArgAsp: 3.583 ± 0.073	4.215ArgGlu: 4.215 ± 0.078	2.056ArgPhe: 2.056 ± 0.061	4.495ArgGly: 4.495 ± 0.088	1.33ArgHis: 1.33 ± 0.045	3.326ArgIle: 3.326 ± 0.064	2.381ArgLys: 2.381 ± 0.066	5.631ArgLeu: 5.631 ± 0.112	1.564ArgMet: 1.564 ± 0.044	1.823ArgAsn: 1.823 ± 0.049	2.745ArgPro: 2.745 ± 0.062	2.023ArgGln: 2.023 ± 0.054	4.035ArgArg: 4.035 ± 0.095	3.721ArgSer: 3.721 ± 0.082	3.961ArgThr: 3.961 ± 0.081	5.33ArgVal: 5.33 ± 0.083	0.806ArgTrp: 0.806 ± 0.029	1.416ArgTyr: 1.416 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.791SerAla: 6.791 ± 0.104	0.39SerCys: 0.39 ± 0.025	3.662SerAsp: 3.662 ± 0.073	3.696SerGlu: 3.696 ± 0.083	2.088SerPhe: 2.088 ± 0.053	5.904SerGly: 5.904 ± 0.092	1.456SerHis: 1.456 ± 0.048	2.685SerIle: 2.685 ± 0.057	2.05SerLys: 2.05 ± 0.059	5.355SerLeu: 5.355 ± 0.094	1.457SerMet: 1.457 ± 0.044	1.685SerAsn: 1.685 ± 0.055	2.996SerPro: 2.996 ± 0.06	2.156SerGln: 2.156 ± 0.055	3.705SerArg: 3.705 ± 0.082	3.789SerSer: 3.789 ± 0.082	3.948SerThr: 3.948 ± 0.072	5.222SerVal: 5.222 ± 0.086	0.811SerTrp: 0.811 ± 0.034	1.365SerTyr: 1.365 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.745ThrAla: 6.745 ± 0.112	0.444ThrCys: 0.444 ± 0.026	3.67ThrAsp: 3.67 ± 0.073	3.602ThrGlu: 3.602 ± 0.084	2.223ThrPhe: 2.223 ± 0.055	5.8ThrGly: 5.8 ± 0.085	1.685ThrHis: 1.685 ± 0.049	2.944ThrIle: 2.944 ± 0.06	1.948ThrLys: 1.948 ± 0.065	5.977ThrLeu: 5.977 ± 0.094	1.16ThrMet: 1.16 ± 0.042	1.66ThrAsn: 1.66 ± 0.044	4.156ThrPro: 4.156 ± 0.091	2.282ThrGln: 2.282 ± 0.059	3.729ThrArg: 3.729 ± 0.073	4.209ThrSer: 4.209 ± 0.08	3.989ThrThr: 3.989 ± 0.07	6.351ThrVal: 6.351 ± 0.099	0.844ThrTrp: 0.844 ± 0.036	1.493ThrTyr: 1.493 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	10.145ValAla: 10.145 ± 0.162	0.803ValCys: 0.803 ± 0.031	5.366ValAsp: 5.366 ± 0.1	5.435ValGlu: 5.435 ± 0.088	3.04ValPhe: 3.04 ± 0.076	6.956ValGly: 6.956 ± 0.105	1.751ValHis: 1.751 ± 0.049	4.555ValIle: 4.555 ± 0.078	2.963ValLys: 2.963 ± 0.077	8.372ValLeu: 8.372 ± 0.127	1.863ValMet: 1.863 ± 0.054	2.445ValAsn: 2.445 ± 0.06	4.36ValPro: 4.36 ± 0.079	2.215ValGln: 2.215 ± 0.052	5.168ValArg: 5.168 ± 0.084	5.523ValSer: 5.523 ± 0.093	6.094ValThr: 6.094 ± 0.098	8.286ValVal: 8.286 ± 0.124	1.054ValTrp: 1.054 ± 0.042	1.598ValTyr: 1.598 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.357TrpAla: 1.357 ± 0.043	0.132TrpCys: 0.132 ± 0.013	0.685TrpAsp: 0.685 ± 0.029	0.691TrpGlu: 0.691 ± 0.034	0.575TrpPhe: 0.575 ± 0.026	0.897TrpGly: 0.897 ± 0.036	0.289TrpHis: 0.289 ± 0.021	0.718TrpIle: 0.718 ± 0.035	0.478TrpLys: 0.478 ± 0.027	1.426TrpLeu: 1.426 ± 0.046	0.341TrpMet: 0.341 ± 0.022	0.485TrpAsn: 0.485 ± 0.026	0.576TrpPro: 0.576 ± 0.031	0.473TrpGln: 0.473 ± 0.024	0.777TrpArg: 0.777 ± 0.034	0.772TrpSer: 0.772 ± 0.035	0.731TrpThr: 0.731 ± 0.033	1.142TrpVal: 1.142 ± 0.038	0.307TrpTrp: 0.307 ± 0.022	0.282TrpTyr: 0.282 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.359TyrAla: 2.359 ± 0.053	0.148TyrCys: 0.148 ± 0.013	1.376TyrAsp: 1.376 ± 0.045	1.272TyrGlu: 1.272 ± 0.045	0.795TyrPhe: 0.795 ± 0.031	1.873TyrGly: 1.873 ± 0.06	0.366TyrHis: 0.366 ± 0.022	0.847TyrIle: 0.847 ± 0.037	0.623TyrLys: 0.623 ± 0.029	2.04TyrLeu: 2.04 ± 0.049	0.432TyrMet: 0.432 ± 0.02	0.562TyrAsn: 0.562 ± 0.029	1.088TyrPro: 1.088 ± 0.039	0.708TyrGln: 0.708 ± 0.03	1.498TyrArg: 1.498 ± 0.052	1.358TyrSer: 1.358 ± 0.039	1.385TyrThr: 1.385 ± 0.042	1.942TyrVal: 1.942 ± 0.051	0.305TyrTrp: 0.305 ± 0.019	0.491TyrTyr: 0.491 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2432 proteins (779593 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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