Amino acid dipepetide frequency for Helicobacter sanguini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.64AlaAla: 3.64 ± 0.106	0.862AlaCys: 0.862 ± 0.052	2.986AlaAsp: 2.986 ± 0.067	2.776AlaGlu: 2.776 ± 0.067	3.477AlaPhe: 3.477 ± 0.068	3.349AlaGly: 3.349 ± 0.088	1.121AlaHis: 1.121 ± 0.035	5.313AlaIle: 5.313 ± 0.098	5.933AlaLys: 5.933 ± 0.093	7.399AlaLeu: 7.399 ± 0.096	1.607AlaMet: 1.607 ± 0.049	4.409AlaAsn: 4.409 ± 0.08	1.623AlaPro: 1.623 ± 0.055	2.25AlaGln: 2.25 ± 0.056	2.718AlaArg: 2.718 ± 0.078	4.038AlaSer: 4.038 ± 0.095	3.142AlaThr: 3.142 ± 0.063	2.941AlaVal: 2.941 ± 0.071	0.478AlaTrp: 0.478 ± 0.025	2.19AlaTyr: 2.19 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.73CysAla: 0.73 ± 0.039	0.11CysCys: 0.11 ± 0.011	0.792CysAsp: 0.792 ± 0.041	0.903CysGlu: 0.903 ± 0.038	0.592CysPhe: 0.592 ± 0.03	0.927CysGly: 0.927 ± 0.044	0.237CysHis: 0.237 ± 0.018	0.887CysIle: 0.887 ± 0.039	0.958CysLys: 0.958 ± 0.038	0.903CysLeu: 0.903 ± 0.036	0.225CysMet: 0.225 ± 0.017	0.562CysAsn: 0.562 ± 0.027	0.288CysPro: 0.288 ± 0.02	0.2CysGln: 0.2 ± 0.017	0.252CysArg: 0.252 ± 0.018	0.613CysSer: 0.613 ± 0.028	0.328CysThr: 0.328 ± 0.019	1.117CysVal: 1.117 ± 0.041	0.051CysTrp: 0.051 ± 0.009	0.47CysTyr: 0.47 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	2.466AspAla: 2.466 ± 0.063	0.692AspCys: 0.692 ± 0.033	2.11AspAsp: 2.11 ± 0.058	2.767AspGlu: 2.767 ± 0.069	4.418AspPhe: 4.418 ± 0.082	2.399AspGly: 2.399 ± 0.065	0.237AspHis: 0.237 ± 0.02	5.259AspIle: 5.259 ± 0.097	4.661AspLys: 4.661 ± 0.079	4.858AspLeu: 4.858 ± 0.095	1.335AspMet: 1.335 ± 0.038	3.09AspAsn: 3.09 ± 0.077	0.841AspPro: 0.841 ± 0.037	0.374AspGln: 0.374 ± 0.026	1.458AspArg: 1.458 ± 0.049	11.976AspSer: 11.976 ± 0.232	2.373AspThr: 2.373 ± 0.058	2.902AspVal: 2.902 ± 0.064	0.259AspTrp: 0.259 ± 0.018	2.317AspTyr: 2.317 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	3.199GluAla: 3.199 ± 0.072	0.801GluCys: 0.801 ± 0.034	2.075GluAsp: 2.075 ± 0.05	2.316GluGlu: 2.316 ± 0.067	3.165GluPhe: 3.165 ± 0.073	1.94GluGly: 1.94 ± 0.064	0.925GluHis: 0.925 ± 0.035	6.554GluIle: 6.554 ± 0.102	5.118GluLys: 5.118 ± 0.11	5.317GluLeu: 5.317 ± 0.097	1.655GluMet: 1.655 ± 0.04	5.071GluAsn: 5.071 ± 0.094	1.182GluPro: 1.182 ± 0.042	1.999GluGln: 1.999 ± 0.066	2.183GluArg: 2.183 ± 0.06	9.543GluSer: 9.543 ± 0.184	2.095GluThr: 2.095 ± 0.05	2.989GluVal: 2.989 ± 0.067	0.548GluTrp: 0.548 ± 0.029	2.5GluTyr: 2.5 ± 0.074	0.0GluXaa: 0.0 ± 0.0
Phe	3.517PheAla: 3.517 ± 0.083	0.854PheCys: 0.854 ± 0.037	2.987PheAsp: 2.987 ± 0.072	3.004PheGlu: 3.004 ± 0.069	2.982PhePhe: 2.982 ± 0.083	3.446PheGly: 3.446 ± 0.075	0.747PheHis: 0.747 ± 0.032	5.044PheIle: 5.044 ± 0.104	4.311PheLys: 4.311 ± 0.086	5.397PheLeu: 5.397 ± 0.106	1.432PheMet: 1.432 ± 0.042	3.536PheAsn: 3.536 ± 0.085	1.161PhePro: 1.161 ± 0.04	1.044PheGln: 1.044 ± 0.037	1.723PheArg: 1.723 ± 0.05	4.573PheSer: 4.573 ± 0.09	2.19PheThr: 2.19 ± 0.058	3.025PheVal: 3.025 ± 0.07	0.483PheTrp: 0.483 ± 0.026	2.652PheTyr: 2.652 ± 0.071	0.0PheXaa: 0.0 ± 0.0
Gly	3.766GlyAla: 3.766 ± 0.095	0.569GlyCys: 0.569 ± 0.03	2.787GlyAsp: 2.787 ± 0.069	3.372GlyGlu: 3.372 ± 0.07	3.53GlyPhe: 3.53 ± 0.078	4.51GlyGly: 4.51 ± 0.132	0.855GlyHis: 0.855 ± 0.033	4.696GlyIle: 4.696 ± 0.093	3.892GlyLys: 3.892 ± 0.086	5.076GlyLeu: 5.076 ± 0.087	1.316GlyMet: 1.316 ± 0.042	2.985GlyAsn: 2.985 ± 0.086	0.606GlyPro: 0.606 ± 0.031	1.39GlyGln: 1.39 ± 0.05	2.006GlyArg: 2.006 ± 0.063	3.522GlySer: 3.522 ± 0.084	1.906GlyThr: 1.906 ± 0.066	4.283GlyVal: 4.283 ± 0.089	0.464GlyTrp: 0.464 ± 0.024	2.6GlyTyr: 2.6 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.118HisAla: 1.118 ± 0.042	0.194HisCys: 0.194 ± 0.019	0.743HisAsp: 0.743 ± 0.034	0.804HisGlu: 0.804 ± 0.036	1.217HisPhe: 1.217 ± 0.04	0.834HisGly: 0.834 ± 0.042	0.39HisHis: 0.39 ± 0.023	1.798HisIle: 1.798 ± 0.043	1.446HisLys: 1.446 ± 0.048	1.603HisLeu: 1.603 ± 0.049	0.187HisMet: 0.187 ± 0.016	1.314HisAsn: 1.314 ± 0.047	0.644HisPro: 0.644 ± 0.032	0.321HisGln: 0.321 ± 0.018	0.569HisArg: 0.569 ± 0.03	1.037HisSer: 1.037 ± 0.036	0.979HisThr: 0.979 ± 0.037	0.524HisVal: 0.524 ± 0.028	0.077HisTrp: 0.077 ± 0.011	0.715HisTyr: 0.715 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.194IleAla: 6.194 ± 0.124	1.071IleCys: 1.071 ± 0.039	5.485IleAsp: 5.485 ± 0.096	7.828IleGlu: 7.828 ± 0.137	4.908IlePhe: 4.908 ± 0.106	4.08IleGly: 4.08 ± 0.09	1.29IleHis: 1.29 ± 0.043	6.663IleIle: 6.663 ± 0.127	7.404IleLys: 7.404 ± 0.118	9.536IleLeu: 9.536 ± 0.14	1.841IleMet: 1.841 ± 0.053	6.028IleAsn: 6.028 ± 0.107	2.629IlePro: 2.629 ± 0.061	2.144IleGln: 2.144 ± 0.064	2.332IleArg: 2.332 ± 0.057	5.961IleSer: 5.961 ± 0.083	4.518IleThr: 4.518 ± 0.095	4.154IleVal: 4.154 ± 0.083	0.474IleTrp: 0.474 ± 0.027	3.452IleTyr: 3.452 ± 0.073	0.0IleXaa: 0.0 ± 0.0
Lys	5.218LysAla: 5.218 ± 0.095	0.644LysCys: 0.644 ± 0.035	7.215LysAsp: 7.215 ± 0.123	6.97LysGlu: 6.97 ± 0.122	3.149LysPhe: 3.149 ± 0.073	4.277LysGly: 4.277 ± 0.08	1.451LysHis: 1.451 ± 0.049	8.49LysIle: 8.49 ± 0.135	7.934LysLys: 7.934 ± 0.127	6.836LysLeu: 6.836 ± 0.1	2.085LysMet: 2.085 ± 0.051	8.105LysAsn: 8.105 ± 0.14	2.334LysPro: 2.334 ± 0.061	3.002LysGln: 3.002 ± 0.073	2.814LysArg: 2.814 ± 0.065	5.835LysSer: 5.835 ± 0.102	3.913LysThr: 3.913 ± 0.072	4.26LysVal: 4.26 ± 0.074	0.577LysTrp: 0.577 ± 0.029	3.227LysTyr: 3.227 ± 0.074	0.0LysXaa: 0.0 ± 0.0
Leu	6.336LeuAla: 6.336 ± 0.109	1.305LeuCys: 1.305 ± 0.046	7.553LeuAsp: 7.553 ± 0.123	7.467LeuGlu: 7.467 ± 0.12	4.459LeuPhe: 4.459 ± 0.106	5.609LeuGly: 5.609 ± 0.097	1.807LeuHis: 1.807 ± 0.055	6.251LeuIle: 6.251 ± 0.117	8.701LeuLys: 8.701 ± 0.125	8.237LeuLeu: 8.237 ± 0.126	1.898LeuMet: 1.898 ± 0.051	6.864LeuAsn: 6.864 ± 0.127	3.04LeuPro: 3.04 ± 0.072	4.533LeuGln: 4.533 ± 0.091	3.731LeuArg: 3.731 ± 0.068	7.781LeuSer: 7.781 ± 0.126	3.468LeuThr: 3.468 ± 0.063	4.286LeuVal: 4.286 ± 0.08	0.67LeuTrp: 0.67 ± 0.032	3.339LeuTyr: 3.339 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.382MetAla: 1.382 ± 0.043	0.295MetCys: 0.295 ± 0.019	1.179MetAsp: 1.179 ± 0.041	1.346MetGlu: 1.346 ± 0.04	1.072MetPhe: 1.072 ± 0.043	1.324MetGly: 1.324 ± 0.033	0.295MetHis: 0.295 ± 0.017	1.67MetIle: 1.67 ± 0.042	1.722MetLys: 1.722 ± 0.048	2.653MetLeu: 2.653 ± 0.06	0.463MetMet: 0.463 ± 0.027	1.145MetAsn: 1.145 ± 0.039	1.071MetPro: 1.071 ± 0.04	1.62MetGln: 1.62 ± 0.045	1.059MetArg: 1.059 ± 0.038	1.471MetSer: 1.471 ± 0.046	0.788MetThr: 0.788 ± 0.034	0.968MetVal: 0.968 ± 0.042	0.168MetTrp: 0.168 ± 0.015	0.677MetTyr: 0.677 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	5.692AsnAla: 5.692 ± 0.098	0.543AsnCys: 0.543 ± 0.028	3.582AsnAsp: 3.582 ± 0.07	4.153AsnGlu: 4.153 ± 0.1	3.865AsnPhe: 3.865 ± 0.085	3.366AsnGly: 3.366 ± 0.086	1.19AsnHis: 1.19 ± 0.042	7.884AsnIle: 7.884 ± 0.148	5.582AsnLys: 5.582 ± 0.112	8.352AsnLeu: 8.352 ± 0.149	1.677AsnMet: 1.677 ± 0.045	4.723AsnAsn: 4.723 ± 0.118	2.493AsnPro: 2.493 ± 0.069	1.611AsnGln: 1.611 ± 0.061	1.915AsnArg: 1.915 ± 0.056	4.256AsnSer: 4.256 ± 0.093	4.008AsnThr: 4.008 ± 0.095	4.134AsnVal: 4.134 ± 0.096	0.231AsnTrp: 0.231 ± 0.02	2.504AsnTyr: 2.504 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.527ProAla: 1.527 ± 0.057	0.333ProCys: 0.333 ± 0.021	1.083ProAsp: 1.083 ± 0.041	1.103ProGlu: 1.103 ± 0.04	1.748ProPhe: 1.748 ± 0.051	0.96ProGly: 0.96 ± 0.041	0.734ProHis: 0.734 ± 0.033	2.156ProIle: 2.156 ± 0.056	2.508ProLys: 2.508 ± 0.072	3.338ProLeu: 3.338 ± 0.071	0.481ProMet: 0.481 ± 0.03	1.971ProAsn: 1.971 ± 0.05	1.118ProPro: 1.118 ± 0.047	1.489ProGln: 1.489 ± 0.052	0.958ProArg: 0.958 ± 0.035	1.802ProSer: 1.802 ± 0.056	1.922ProThr: 1.922 ± 0.058	1.202ProVal: 1.202 ± 0.042	0.162ProTrp: 0.162 ± 0.013	1.241ProTyr: 1.241 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	1.688GlnAla: 1.688 ± 0.051	0.198GlnCys: 0.198 ± 0.015	3.019GlnAsp: 3.019 ± 0.075	2.229GlnGlu: 2.229 ± 0.07	1.023GlnPhe: 1.023 ± 0.04	1.98GlnGly: 1.98 ± 0.064	0.499GlnHis: 0.499 ± 0.024	2.817GlnIle: 2.817 ± 0.067	3.306GlnLys: 3.306 ± 0.074	1.844GlnLeu: 1.844 ± 0.056	0.689GlnMet: 0.689 ± 0.033	4.057GlnAsn: 4.057 ± 0.086	0.703GlnPro: 0.703 ± 0.037	0.945GlnGln: 0.945 ± 0.05	1.06GlnArg: 1.06 ± 0.041	2.259GlnSer: 2.259 ± 0.06	1.645GlnThr: 1.645 ± 0.053	1.581GlnVal: 1.581 ± 0.048	0.16GlnTrp: 0.16 ± 0.015	1.073GlnTyr: 1.073 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	2.32ArgAla: 2.32 ± 0.054	0.213ArgCys: 0.213 ± 0.017	2.254ArgAsp: 2.254 ± 0.061	2.606ArgGlu: 2.606 ± 0.077	2.275ArgPhe: 2.275 ± 0.057	1.93ArgGly: 1.93 ± 0.057	0.605ArgHis: 0.605 ± 0.031	3.204ArgIle: 3.204 ± 0.063	2.361ArgLys: 2.361 ± 0.063	3.634ArgLeu: 3.634 ± 0.078	0.739ArgMet: 0.739 ± 0.034	2.029ArgAsn: 2.029 ± 0.054	0.892ArgPro: 0.892 ± 0.038	1.099ArgGln: 1.099 ± 0.044	1.14ArgArg: 1.14 ± 0.042	1.632ArgSer: 1.632 ± 0.049	1.228ArgThr: 1.228 ± 0.042	2.108ArgVal: 2.108 ± 0.052	0.211ArgTrp: 0.211 ± 0.016	1.485ArgTyr: 1.485 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	4.256SerAla: 4.256 ± 0.089	0.75SerCys: 0.75 ± 0.032	3.523SerAsp: 3.523 ± 0.069	3.954SerGlu: 3.954 ± 0.091	4.092SerPhe: 4.092 ± 0.072	4.579SerGly: 4.579 ± 0.096	1.352SerHis: 1.352 ± 0.043	7.713SerIle: 7.713 ± 0.109	10.796SerLys: 10.796 ± 0.183	7.601SerLeu: 7.601 ± 0.125	1.811SerMet: 1.811 ± 0.051	6.7SerAsn: 6.7 ± 0.145	2.158SerPro: 2.158 ± 0.052	2.771SerGln: 2.771 ± 0.072	2.523SerArg: 2.523 ± 0.064	5.325SerSer: 5.325 ± 0.107	3.232SerThr: 3.232 ± 0.08	4.179SerVal: 4.179 ± 0.086	0.52SerTrp: 0.52 ± 0.029	2.936SerTyr: 2.936 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	2.303ThrAla: 2.303 ± 0.065	0.476ThrCys: 0.476 ± 0.027	1.815ThrAsp: 1.815 ± 0.057	1.795ThrGlu: 1.795 ± 0.048	2.734ThrPhe: 2.734 ± 0.065	1.987ThrGly: 1.987 ± 0.071	1.328ThrHis: 1.328 ± 0.044	3.422ThrIle: 3.422 ± 0.088	3.869ThrLys: 3.869 ± 0.082	5.523ThrLeu: 5.523 ± 0.102	0.855ThrMet: 0.855 ± 0.036	3.314ThrAsn: 3.314 ± 0.094	2.254ThrPro: 2.254 ± 0.066	3.143ThrGln: 3.143 ± 0.07	1.753ThrArg: 1.753 ± 0.049	2.964ThrSer: 2.964 ± 0.079	2.556ThrThr: 2.556 ± 0.083	0.502ThrVal: 0.502 ± 0.034	0.342ThrTrp: 0.342 ± 0.025	1.772ThrTyr: 1.772 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	3.851ValAla: 3.851 ± 0.088	0.705ValCys: 0.705 ± 0.036	2.956ValAsp: 2.956 ± 0.072	3.01ValGlu: 3.01 ± 0.065	2.623ValPhe: 2.623 ± 0.061	3.893ValGly: 3.893 ± 0.082	0.581ValHis: 0.581 ± 0.03	4.56ValIle: 4.56 ± 0.071	3.713ValLys: 3.713 ± 0.073	4.864ValLeu: 4.864 ± 0.099	1.174ValMet: 1.174 ± 0.038	2.698ValAsn: 2.698 ± 0.064	1.463ValPro: 1.463 ± 0.051	1.404ValGln: 1.404 ± 0.045	2.085ValArg: 2.085 ± 0.057	3.555ValSer: 3.555 ± 0.072	2.147ValThr: 2.147 ± 0.061	3.26ValVal: 3.26 ± 0.078	0.402ValTrp: 0.402 ± 0.023	1.672ValTyr: 1.672 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.429TrpAla: 0.429 ± 0.026	0.112TrpCys: 0.112 ± 0.011	0.398TrpAsp: 0.398 ± 0.033	0.397TrpGlu: 0.397 ± 0.024	0.287TrpPhe: 0.287 ± 0.026	0.509TrpGly: 0.509 ± 0.033	0.166TrpHis: 0.166 ± 0.014	0.489TrpIle: 0.489 ± 0.025	0.37TrpLys: 0.37 ± 0.023	0.811TrpLeu: 0.811 ± 0.038	0.119TrpMet: 0.119 ± 0.015	0.447TrpAsn: 0.447 ± 0.028	0.064TrpPro: 0.064 ± 0.01	0.334TrpGln: 0.334 ± 0.019	0.29TrpArg: 0.29 ± 0.02	0.379TrpSer: 0.379 ± 0.025	0.204TrpThr: 0.204 ± 0.018	0.422TrpVal: 0.422 ± 0.025	0.085TrpTrp: 0.085 ± 0.011	0.245TrpTyr: 0.245 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.621TyrAla: 2.621 ± 0.065	0.417TyrCys: 0.417 ± 0.023	2.247TyrAsp: 2.247 ± 0.063	2.377TyrGlu: 2.377 ± 0.066	2.492TyrPhe: 2.492 ± 0.064	2.231TyrGly: 2.231 ± 0.069	0.701TyrHis: 0.701 ± 0.031	3.124TyrIle: 3.124 ± 0.066	3.752TyrLys: 3.752 ± 0.093	3.555TyrLeu: 3.555 ± 0.073	0.778TyrMet: 0.778 ± 0.034	2.714TyrAsn: 2.714 ± 0.077	1.272TyrPro: 1.272 ± 0.039	1.1TyrGln: 1.1 ± 0.042	1.397TyrArg: 1.397 ± 0.044	2.25TyrSer: 2.25 ± 0.056	2.066TyrThr: 2.066 ± 0.063	1.78TyrVal: 1.78 ± 0.053	0.194TyrTrp: 0.194 ± 0.016	1.803TyrTyr: 1.803 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2259 proteins (738759 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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