Amino acid dipepetide frequency for Hankyongella ginsenosidimutans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.025AlaAla: 20.025 ± 0.296
1.682AlaCys: 1.682 ± 0.072
7.646AlaAsp: 7.646 ± 0.148
6.677AlaGlu: 6.677 ± 0.161
3.957AlaPhe: 3.957 ± 0.098
11.971AlaGly: 11.971 ± 0.213
2.523AlaHis: 2.523 ± 0.088
5.74AlaIle: 5.74 ± 0.129
3.282AlaLys: 3.282 ± 0.102
15.376AlaLeu: 15.376 ± 0.253
3.59AlaMet: 3.59 ± 0.1
3.159AlaAsn: 3.159 ± 0.09
6.735AlaPro: 6.735 ± 0.164
5.665AlaGln: 5.665 ± 0.132
11.477AlaArg: 11.477 ± 0.186
7.463AlaSer: 7.463 ± 0.149
7.171AlaThr: 7.171 ± 0.142
8.718AlaVal: 8.718 ± 0.181
1.868AlaTrp: 1.868 ± 0.069
2.46AlaTyr: 2.46 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
1.716CysAla: 1.716 ± 0.066
0.383CysCys: 0.383 ± 0.042
0.448CysAsp: 0.448 ± 0.036
0.265CysGlu: 0.265 ± 0.024
0.323CysPhe: 0.323 ± 0.026
1.058CysGly: 1.058 ± 0.056
0.258CysHis: 0.258 ± 0.028
0.335CysIle: 0.335 ± 0.03
0.186CysLys: 0.186 ± 0.022
0.887CysLeu: 0.887 ± 0.051
0.275CysMet: 0.275 ± 0.022
0.181CysAsn: 0.181 ± 0.021
0.701CysPro: 0.701 ± 0.044
0.248CysGln: 0.248 ± 0.025
1.477CysArg: 1.477 ± 0.071
0.843CysSer: 0.843 ± 0.045
0.501CysThr: 0.501 ± 0.036
0.643CysVal: 0.643 ± 0.043
0.347CysTrp: 0.347 ± 0.032
0.173CysTyr: 0.173 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
8.005AspAla: 8.005 ± 0.162
0.451AspCys: 0.451 ± 0.035
3.429AspAsp: 3.429 ± 0.11
2.689AspGlu: 2.689 ± 0.089
2.048AspPhe: 2.048 ± 0.077
5.393AspGly: 5.393 ± 0.14
1.072AspHis: 1.072 ± 0.048
2.952AspIle: 2.952 ± 0.098
1.386AspLys: 1.386 ± 0.058
5.93AspLeu: 5.93 ± 0.132
1.125AspMet: 1.125 ± 0.051
1.292AspAsn: 1.292 ± 0.055
3.605AspPro: 3.605 ± 0.105
1.964AspGln: 1.964 ± 0.074
4.672AspArg: 4.672 ± 0.142
2.47AspSer: 2.47 ± 0.076
2.836AspThr: 2.836 ± 0.105
3.959AspVal: 3.959 ± 0.098
0.867AspTrp: 0.867 ± 0.047
1.443AspTyr: 1.443 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
6.829GluAla: 6.829 ± 0.145
0.318GluCys: 0.318 ± 0.027
2.33GluAsp: 2.33 ± 0.088
2.111GluGlu: 2.111 ± 0.089
1.234GluPhe: 1.234 ± 0.06
3.166GluGly: 3.166 ± 0.098
0.904GluHis: 0.904 ± 0.046
2.615GluIle: 2.615 ± 0.09
1.287GluLys: 1.287 ± 0.059
4.513GluLeu: 4.513 ± 0.118
0.957GluMet: 0.957 ± 0.047
1.321GluAsn: 1.321 ± 0.068
2.431GluPro: 2.431 ± 0.078
2.328GluGln: 2.328 ± 0.086
4.619GluArg: 4.619 ± 0.12
2.111GluSer: 2.111 ± 0.078
2.928GluThr: 2.928 ± 0.078
2.877GluVal: 2.877 ± 0.091
0.463GluTrp: 0.463 ± 0.028
0.708GluTyr: 0.708 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
4.272PheAla: 4.272 ± 0.106
0.407PheCys: 0.407 ± 0.033
2.328PheAsp: 2.328 ± 0.085
1.819PheGlu: 1.819 ± 0.064
0.872PhePhe: 0.872 ± 0.046
3.096PheGly: 3.096 ± 0.094
0.634PheHis: 0.634 ± 0.04
1.289PheIle: 1.289 ± 0.058
0.858PheLys: 0.858 ± 0.049
2.737PheLeu: 2.737 ± 0.075
0.684PheMet: 0.684 ± 0.036
0.933PheAsn: 0.933 ± 0.049
1.34PhePro: 1.34 ± 0.059
1.002PheGln: 1.002 ± 0.05
2.234PheArg: 2.234 ± 0.075
2.193PheSer: 2.193 ± 0.074
2.022PheThr: 2.022 ± 0.084
2.215PheVal: 2.215 ± 0.074
0.506PheTrp: 0.506 ± 0.041
0.663PheTyr: 0.663 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
9.923GlyAla: 9.923 ± 0.167
1.055GlyCys: 1.055 ± 0.052
5.272GlyAsp: 5.272 ± 0.184
3.643GlyGlu: 3.643 ± 0.106
3.272GlyPhe: 3.272 ± 0.085
7.415GlyGly: 7.415 ± 0.162
1.742GlyHis: 1.742 ± 0.07
3.595GlyIle: 3.595 ± 0.091
2.499GlyLys: 2.499 ± 0.09
8.88GlyLeu: 8.88 ± 0.146
1.86GlyMet: 1.86 ± 0.068
2.455GlyAsn: 2.455 ± 0.105
3.542GlyPro: 3.542 ± 0.091
3.345GlyGln: 3.345 ± 0.083
6.863GlyArg: 6.863 ± 0.15
4.612GlySer: 4.612 ± 0.123
4.19GlyThr: 4.19 ± 0.108
6.128GlyVal: 6.128 ± 0.125
1.468GlyTrp: 1.468 ± 0.063
2.082GlyTyr: 2.082 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
2.566HisAla: 2.566 ± 0.092
0.246HisCys: 0.246 ± 0.023
1.072HisAsp: 1.072 ± 0.051
0.855HisGlu: 0.855 ± 0.042
0.574HisPhe: 0.574 ± 0.034
1.858HisGly: 1.858 ± 0.08
0.545HisHis: 0.545 ± 0.037
0.757HisIle: 0.757 ± 0.043
0.419HisLys: 0.419 ± 0.028
1.995HisLeu: 1.995 ± 0.067
0.419HisMet: 0.419 ± 0.035
0.381HisAsn: 0.381 ± 0.035
1.219HisPro: 1.219 ± 0.055
0.586HisGln: 0.586 ± 0.043
1.812HisArg: 1.812 ± 0.084
0.969HisSer: 0.969 ± 0.049
0.689HisThr: 0.689 ± 0.042
1.294HisVal: 1.294 ± 0.071
0.325HisTrp: 0.325 ± 0.027
0.451HisTyr: 0.451 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
7.022IleAla: 7.022 ± 0.131
0.472IleCys: 0.472 ± 0.03
3.381IleAsp: 3.381 ± 0.095
2.827IleGlu: 2.827 ± 0.1
1.166IlePhe: 1.166 ± 0.06
4.19IleGly: 4.19 ± 0.121
0.636IleHis: 0.636 ± 0.036
1.776IleIle: 1.776 ± 0.067
1.176IleLys: 1.176 ± 0.059
4.015IleLeu: 4.015 ± 0.094
0.855IleMet: 0.855 ± 0.049
1.212IleAsn: 1.212 ± 0.055
1.959IlePro: 1.959 ± 0.067
1.147IleGln: 1.147 ± 0.06
3.041IleArg: 3.041 ± 0.088
2.634IleSer: 2.634 ± 0.083
2.342IleThr: 2.342 ± 0.09
3.711IleVal: 3.711 ± 0.097
0.496IleTrp: 0.496 ± 0.031
0.908IleTyr: 0.908 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
3.631LysAla: 3.631 ± 0.106
0.14LysCys: 0.14 ± 0.017
1.412LysAsp: 1.412 ± 0.073
0.887LysGlu: 0.887 ± 0.051
0.646LysPhe: 0.646 ± 0.039
1.766LysGly: 1.766 ± 0.077
0.516LysHis: 0.516 ± 0.032
1.2LysIle: 1.2 ± 0.066
0.716LysLys: 0.716 ± 0.045
2.694LysLeu: 2.694 ± 0.08
0.571LysMet: 0.571 ± 0.037
0.641LysAsn: 0.641 ± 0.042
1.892LysPro: 1.892 ± 0.083
0.901LysGln: 0.901 ± 0.05
2.224LysArg: 2.224 ± 0.07
1.655LysSer: 1.655 ± 0.069
1.622LysThr: 1.622 ± 0.07
1.752LysVal: 1.752 ± 0.074
0.248LysTrp: 0.248 ± 0.025
0.46LysTyr: 0.46 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
14.8LeuAla: 14.8 ± 0.236
1.048LeuCys: 1.048 ± 0.046
6.465LeuAsp: 6.465 ± 0.133
5.152LeuGlu: 5.152 ± 0.131
3.219LeuPhe: 3.219 ± 0.098
8.451LeuGly: 8.451 ± 0.162
1.976LeuHis: 1.976 ± 0.078
4.535LeuIle: 4.535 ± 0.111
3.012LeuLys: 3.012 ± 0.093
10.229LeuLeu: 10.229 ± 0.2
2.087LeuMet: 2.087 ± 0.067
2.815LeuAsn: 2.815 ± 0.091
5.663LeuPro: 5.663 ± 0.121
3.198LeuGln: 3.198 ± 0.093
7.728LeuArg: 7.728 ± 0.137
6.417LeuSer: 6.417 ± 0.11
5.636LeuThr: 5.636 ± 0.132
7.183LeuVal: 7.183 ± 0.135
1.337LeuTrp: 1.337 ± 0.062
1.949LeuTyr: 1.949 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
3.019MetAla: 3.019 ± 0.109
0.202MetCys: 0.202 ± 0.024
0.894MetAsp: 0.894 ± 0.048
0.865MetGlu: 0.865 ± 0.042
0.639MetPhe: 0.639 ± 0.038
1.429MetGly: 1.429 ± 0.056
0.434MetHis: 0.434 ± 0.034
1.089MetIle: 1.089 ± 0.054
0.66MetLys: 0.66 ± 0.042
2.419MetLeu: 2.419 ± 0.09
0.569MetMet: 0.569 ± 0.033
0.559MetAsn: 0.559 ± 0.04
1.61MetPro: 1.61 ± 0.06
0.708MetGln: 0.708 ± 0.042
1.998MetArg: 1.998 ± 0.074
1.427MetSer: 1.427 ± 0.051
1.612MetThr: 1.612 ± 0.061
1.496MetVal: 1.496 ± 0.063
0.19MetTrp: 0.19 ± 0.02
0.231MetTyr: 0.231 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.239AsnAla: 3.239 ± 0.1
0.234AsnCys: 0.234 ± 0.025
1.675AsnAsp: 1.675 ± 0.091
0.99AsnGlu: 0.99 ± 0.052
0.933AsnPhe: 0.933 ± 0.048
2.586AsnGly: 2.586 ± 0.076
0.427AsnHis: 0.427 ± 0.033
1.188AsnIle: 1.188 ± 0.054
0.605AsnLys: 0.605 ± 0.043
2.417AsnLeu: 2.417 ± 0.096
0.499AsnMet: 0.499 ± 0.039
0.689AsnAsn: 0.689 ± 0.055
1.788AsnPro: 1.788 ± 0.069
0.73AsnGln: 0.73 ± 0.05
1.993AsnArg: 1.993 ± 0.077
1.313AsnSer: 1.313 ± 0.066
1.369AsnThr: 1.369 ± 0.065
1.687AsnVal: 1.687 ± 0.067
0.318AsnTrp: 0.318 ± 0.025
0.525AsnTyr: 0.525 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
7.757ProAla: 7.757 ± 0.166
0.759ProCys: 0.759 ± 0.05
3.795ProAsp: 3.795 ± 0.11
3.26ProGlu: 3.26 ± 0.085
1.817ProPhe: 1.817 ± 0.066
4.742ProGly: 4.742 ± 0.118
1.07ProHis: 1.07 ± 0.055
2.121ProIle: 2.121 ± 0.076
1.383ProLys: 1.383 ± 0.061
5.07ProLeu: 5.07 ± 0.117
1.277ProMet: 1.277 ± 0.055
1.463ProAsn: 1.463 ± 0.061
3.253ProPro: 3.253 ± 0.118
1.983ProGln: 1.983 ± 0.082
3.831ProArg: 3.831 ± 0.117
3.154ProSer: 3.154 ± 0.101
2.906ProThr: 2.906 ± 0.08
4.13ProVal: 4.13 ± 0.132
0.725ProTrp: 0.725 ± 0.039
0.952ProTyr: 0.952 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
5.33GlnAla: 5.33 ± 0.124
0.248GlnCys: 0.248 ± 0.025
1.636GlnAsp: 1.636 ± 0.061
1.381GlnGlu: 1.381 ± 0.068
1.128GlnPhe: 1.128 ± 0.054
2.574GlnGly: 2.574 ± 0.085
0.701GlnHis: 0.701 ± 0.047
1.795GlnIle: 1.795 ± 0.065
0.834GlnLys: 0.834 ± 0.046
3.263GlnLeu: 3.263 ± 0.098
0.713GlnMet: 0.713 ± 0.044
0.957GlnAsn: 0.957 ± 0.053
2.439GlnPro: 2.439 ± 0.087
1.586GlnGln: 1.586 ± 0.064
3.275GlnArg: 3.275 ± 0.093
2.029GlnSer: 2.029 ± 0.07
2.215GlnThr: 2.215 ± 0.073
2.598GlnVal: 2.598 ± 0.085
0.4GlnTrp: 0.4 ± 0.029
0.578GlnTyr: 0.578 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
10.762ArgAla: 10.762 ± 0.2
1.253ArgCys: 1.253 ± 0.064
4.142ArgAsp: 4.142 ± 0.108
3.212ArgGlu: 3.212 ± 0.094
3.113ArgPhe: 3.113 ± 0.088
5.251ArgGly: 5.251 ± 0.129
2.002ArgHis: 2.002 ± 0.077
4.072ArgIle: 4.072 ± 0.104
2.178ArgLys: 2.178 ± 0.073
9.518ArgLeu: 9.518 ± 0.176
2.101ArgMet: 2.101 ± 0.069
1.774ArgAsn: 1.774 ± 0.056
4.747ArgPro: 4.747 ± 0.142
3.243ArgGln: 3.243 ± 0.1
9.345ArgArg: 9.345 ± 0.256
5.417ArgSer: 5.417 ± 0.119
4.612ArgThr: 4.612 ± 0.105
4.959ArgVal: 4.959 ± 0.124
1.588ArgTrp: 1.588 ± 0.065
1.853ArgTyr: 1.853 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
7.916SerAla: 7.916 ± 0.162
0.706SerCys: 0.706 ± 0.04
2.841SerAsp: 2.841 ± 0.09
2.166SerGlu: 2.166 ± 0.075
2.055SerPhe: 2.055 ± 0.078
5.916SerGly: 5.916 ± 0.139
0.923SerHis: 0.923 ± 0.051
2.747SerIle: 2.747 ± 0.078
1.255SerLys: 1.255 ± 0.06
5.759SerLeu: 5.759 ± 0.131
1.359SerMet: 1.359 ± 0.056
1.446SerAsn: 1.446 ± 0.064
3.369SerPro: 3.369 ± 0.08
1.733SerGln: 1.733 ± 0.065
4.819SerArg: 4.819 ± 0.11
3.675SerSer: 3.675 ± 0.116
3.135SerThr: 3.135 ± 0.087
4.036SerVal: 4.036 ± 0.095
0.718SerTrp: 0.718 ± 0.042
1.272SerTyr: 1.272 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
7.135ThrAla: 7.135 ± 0.158
0.525ThrCys: 0.525 ± 0.042
2.764ThrAsp: 2.764 ± 0.091
2.075ThrGlu: 2.075 ± 0.073
1.774ThrPhe: 1.774 ± 0.069
5.34ThrGly: 5.34 ± 0.126
0.872ThrHis: 0.872 ± 0.043
2.713ThrIle: 2.713 ± 0.08
1.198ThrLys: 1.198 ± 0.061
6.528ThrLeu: 6.528 ± 0.151
1.058ThrMet: 1.058 ± 0.058
1.205ThrAsn: 1.205 ± 0.057
3.899ThrPro: 3.899 ± 0.106
1.843ThrGln: 1.843 ± 0.066
4.0ThrArg: 4.0 ± 0.101
2.976ThrSer: 2.976 ± 0.097
3.024ThrThr: 3.024 ± 0.113
4.277ThrVal: 4.277 ± 0.104
0.639ThrTrp: 0.639 ± 0.036
1.195ThrTyr: 1.195 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
9.434ValAla: 9.434 ± 0.162
0.667ValCys: 0.667 ± 0.039
4.243ValAsp: 4.243 ± 0.092
3.836ValGlu: 3.836 ± 0.103
2.152ValPhe: 2.152 ± 0.076
4.978ValGly: 4.978 ± 0.113
1.116ValHis: 1.116 ± 0.049
3.142ValIle: 3.142 ± 0.084
1.858ValLys: 1.858 ± 0.073
6.974ValLeu: 6.974 ± 0.145
1.349ValMet: 1.349 ± 0.053
1.761ValAsn: 1.761 ± 0.07
3.362ValPro: 3.362 ± 0.092
2.299ValGln: 2.299 ± 0.077
5.815ValArg: 5.815 ± 0.149
4.378ValSer: 4.378 ± 0.115
4.239ValThr: 4.239 ± 0.109
5.121ValVal: 5.121 ± 0.153
0.86ValTrp: 0.86 ± 0.051
1.414ValTyr: 1.414 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
1.34TrpAla: 1.34 ± 0.064
0.205TrpCys: 0.205 ± 0.021
0.487TrpAsp: 0.487 ± 0.029
0.386TrpGlu: 0.386 ± 0.032
0.398TrpPhe: 0.398 ± 0.032
0.769TrpGly: 0.769 ± 0.037
0.32TrpHis: 0.32 ± 0.027
0.535TrpIle: 0.535 ± 0.032
0.325TrpLys: 0.325 ± 0.028
1.817TrpLeu: 1.817 ± 0.071
0.39TrpMet: 0.39 ± 0.03
0.299TrpAsn: 0.299 ± 0.031
0.894TrpPro: 0.894 ± 0.043
0.54TrpGln: 0.54 ± 0.038
2.145TrpArg: 2.145 ± 0.093
0.988TrpSer: 0.988 ± 0.051
0.8TrpThr: 0.8 ± 0.049
0.807TrpVal: 0.807 ± 0.042
0.284TrpTrp: 0.284 ± 0.029
0.246TrpTyr: 0.246 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.465TyrAla: 2.465 ± 0.075
0.246TyrCys: 0.246 ± 0.023
1.328TyrAsp: 1.328 ± 0.068
0.952TyrGlu: 0.952 ± 0.05
0.786TyrPhe: 0.786 ± 0.042
1.894TyrGly: 1.894 ± 0.075
0.361TyrHis: 0.361 ± 0.029
0.771TyrIle: 0.771 ± 0.045
0.46TyrLys: 0.46 ± 0.038
1.88TyrLeu: 1.88 ± 0.075
0.308TyrMet: 0.308 ± 0.026
0.663TyrAsn: 0.663 ± 0.047
1.002TyrPro: 1.002 ± 0.051
0.629TyrGln: 0.629 ± 0.037
1.776TyrArg: 1.776 ± 0.069
1.123TyrSer: 1.123 ± 0.055
1.19TyrThr: 1.19 ± 0.058
1.407TyrVal: 1.407 ± 0.066
0.325TyrTrp: 0.325 ± 0.03
0.547TyrTyr: 0.547 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1977 proteins (414989 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski