Amino acid dipepetide frequency for Candidatus Regiella insecticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.147AlaAla: 7.147 ± 0.134
1.056AlaCys: 1.056 ± 0.046
4.208AlaAsp: 4.208 ± 0.099
4.912AlaGlu: 4.912 ± 0.116
2.964AlaPhe: 2.964 ± 0.081
5.571AlaGly: 5.571 ± 0.114
1.816AlaHis: 1.816 ± 0.058
5.996AlaIle: 5.996 ± 0.126
5.075AlaLys: 5.075 ± 0.121
9.752AlaLeu: 9.752 ± 0.154
2.084AlaMet: 2.084 ± 0.069
2.933AlaAsn: 2.933 ± 0.076
2.654AlaPro: 2.654 ± 0.07
4.032AlaGln: 4.032 ± 0.101
4.305AlaArg: 4.305 ± 0.087
4.823AlaSer: 4.823 ± 0.1
4.53AlaThr: 4.53 ± 0.097
5.238AlaVal: 5.238 ± 0.102
0.865AlaTrp: 0.865 ± 0.045
2.039AlaTyr: 2.039 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.87CysAla: 0.87 ± 0.042
0.229CysCys: 0.229 ± 0.021
0.725CysAsp: 0.725 ± 0.037
0.547CysGlu: 0.547 ± 0.033
0.52CysPhe: 0.52 ± 0.033
0.915CysGly: 0.915 ± 0.044
0.554CysHis: 0.554 ± 0.031
0.682CysIle: 0.682 ± 0.035
0.628CysLys: 0.628 ± 0.037
1.204CysLeu: 1.204 ± 0.053
0.362CysMet: 0.362 ± 0.028
0.457CysAsn: 0.457 ± 0.027
0.461CysPro: 0.461 ± 0.026
0.646CysGln: 0.646 ± 0.04
0.768CysArg: 0.768 ± 0.037
0.81CysSer: 0.81 ± 0.037
0.675CysThr: 0.675 ± 0.033
0.841CysVal: 0.841 ± 0.037
0.171CysTrp: 0.171 ± 0.016
0.77CysTyr: 0.77 ± 0.041
0.0CysXaa: 0.0 ± 0.0
Asp
3.607AspAla: 3.607 ± 0.085
0.642AspCys: 0.642 ± 0.035
2.724AspAsp: 2.724 ± 0.08
3.202AspGlu: 3.202 ± 0.081
2.055AspPhe: 2.055 ± 0.065
2.844AspGly: 2.844 ± 0.085
1.027AspHis: 1.027 ± 0.042
4.003AspIle: 4.003 ± 0.099
3.565AspLys: 3.565 ± 0.089
4.652AspLeu: 4.652 ± 0.107
1.458AspMet: 1.458 ± 0.053
2.596AspAsn: 2.596 ± 0.079
2.008AspPro: 2.008 ± 0.064
1.818AspGln: 1.818 ± 0.059
2.528AspArg: 2.528 ± 0.067
2.681AspSer: 2.681 ± 0.079
2.693AspThr: 2.693 ± 0.072
3.295AspVal: 3.295 ± 0.088
0.723AspTrp: 0.723 ± 0.039
1.83AspTyr: 1.83 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
4.445GluAla: 4.445 ± 0.115
0.62GluCys: 0.62 ± 0.03
2.08GluAsp: 2.08 ± 0.073
3.497GluGlu: 3.497 ± 0.092
1.88GluPhe: 1.88 ± 0.054
3.111GluGly: 3.111 ± 0.08
1.419GluHis: 1.419 ± 0.048
4.094GluIle: 4.094 ± 0.099
4.829GluLys: 4.829 ± 0.113
5.918GluLeu: 5.918 ± 0.118
1.58GluMet: 1.58 ± 0.054
2.883GluAsn: 2.883 ± 0.082
1.555GluPro: 1.555 ± 0.047
3.394GluGln: 3.394 ± 0.097
3.881GluArg: 3.881 ± 0.105
2.76GluSer: 2.76 ± 0.082
2.733GluThr: 2.733 ± 0.074
3.293GluVal: 3.293 ± 0.092
0.512GluTrp: 0.512 ± 0.03
1.376GluTyr: 1.376 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.646PheAla: 2.646 ± 0.075
0.729PheCys: 0.729 ± 0.039
2.123PheAsp: 2.123 ± 0.068
1.931PheGlu: 1.931 ± 0.061
1.737PhePhe: 1.737 ± 0.078
2.863PheGly: 2.863 ± 0.086
1.093PheHis: 1.093 ± 0.049
3.507PheIle: 3.507 ± 0.091
1.704PheLys: 1.704 ± 0.069
3.639PheLeu: 3.639 ± 0.097
1.107PheMet: 1.107 ± 0.048
1.871PheAsn: 1.871 ± 0.066
1.448PhePro: 1.448 ± 0.052
1.322PheGln: 1.322 ± 0.048
1.719PheArg: 1.719 ± 0.054
3.462PheSer: 3.462 ± 0.081
2.22PheThr: 2.22 ± 0.074
1.999PheVal: 1.999 ± 0.067
0.44PheTrp: 0.44 ± 0.03
1.235PheTyr: 1.235 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.749GlyAla: 4.749 ± 0.096
0.985GlyCys: 0.985 ± 0.047
2.884GlyAsp: 2.884 ± 0.075
3.416GlyGlu: 3.416 ± 0.082
3.177GlyPhe: 3.177 ± 0.086
3.949GlyGly: 3.949 ± 0.108
1.522GlyHis: 1.522 ± 0.051
5.211GlyIle: 5.211 ± 0.12
4.453GlyLys: 4.453 ± 0.098
6.397GlyLeu: 6.397 ± 0.128
1.824GlyMet: 1.824 ± 0.062
2.357GlyAsn: 2.357 ± 0.072
1.095GlyPro: 1.095 ± 0.05
2.667GlyGln: 2.667 ± 0.068
3.348GlyArg: 3.348 ± 0.081
3.67GlySer: 3.67 ± 0.085
2.834GlyThr: 2.834 ± 0.084
4.621GlyVal: 4.621 ± 0.099
0.915GlyTrp: 0.915 ± 0.043
2.206GlyTyr: 2.206 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
2.119HisAla: 2.119 ± 0.067
0.403HisCys: 0.403 ± 0.031
1.192HisAsp: 1.192 ± 0.047
1.182HisGlu: 1.182 ± 0.047
1.277HisPhe: 1.277 ± 0.05
1.235HisGly: 1.235 ± 0.043
0.76HisHis: 0.76 ± 0.042
1.671HisIle: 1.671 ± 0.051
1.074HisLys: 1.074 ± 0.047
2.588HisLeu: 2.588 ± 0.071
0.477HisMet: 0.477 ± 0.031
1.12HisAsn: 1.12 ± 0.044
1.374HisPro: 1.374 ± 0.057
1.491HisGln: 1.491 ± 0.055
1.357HisArg: 1.357 ± 0.055
1.407HisSer: 1.407 ± 0.048
0.921HisThr: 0.921 ± 0.043
1.308HisVal: 1.308 ± 0.049
0.419HisTrp: 0.419 ± 0.028
0.882HisTyr: 0.882 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
6.116IleAla: 6.116 ± 0.131
0.826IleCys: 0.826 ± 0.04
4.604IleAsp: 4.604 ± 0.094
4.383IleGlu: 4.383 ± 0.112
2.561IlePhe: 2.561 ± 0.079
4.522IleGly: 4.522 ± 0.122
1.434IleHis: 1.434 ± 0.054
4.472IleIle: 4.472 ± 0.123
4.679IleLys: 4.679 ± 0.097
6.397IleLeu: 6.397 ± 0.127
1.469IleMet: 1.469 ± 0.054
3.836IleAsn: 3.836 ± 0.086
3.02IlePro: 3.02 ± 0.07
2.411IleGln: 2.411 ± 0.076
3.759IleArg: 3.759 ± 0.087
4.455IleSer: 4.455 ± 0.091
4.437IleThr: 4.437 ± 0.099
4.154IleVal: 4.154 ± 0.094
0.651IleTrp: 0.651 ± 0.035
1.807IleTyr: 1.807 ± 0.058
0.002IleXaa: 0.002 ± 0.002
Lys
4.637LysAla: 4.637 ± 0.114
0.58LysCys: 0.58 ± 0.032
2.551LysAsp: 2.551 ± 0.067
3.923LysGlu: 3.923 ± 0.106
1.64LysPhe: 1.64 ± 0.061
3.766LysGly: 3.766 ± 0.089
1.115LysHis: 1.115 ± 0.054
4.807LysIle: 4.807 ± 0.11
5.375LysLys: 5.375 ± 0.119
6.217LysLeu: 6.217 ± 0.118
1.931LysMet: 1.931 ± 0.066
3.974LysAsn: 3.974 ± 0.092
2.524LysPro: 2.524 ± 0.067
3.003LysGln: 3.003 ± 0.082
3.892LysArg: 3.892 ± 0.085
3.098LysSer: 3.098 ± 0.08
3.555LysThr: 3.555 ± 0.082
3.352LysVal: 3.352 ± 0.08
0.593LysTrp: 0.593 ± 0.035
1.495LysTyr: 1.495 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
9.863LeuAla: 9.863 ± 0.16
1.465LeuCys: 1.465 ± 0.052
5.269LeuAsp: 5.269 ± 0.103
5.759LeuGlu: 5.759 ± 0.102
4.286LeuPhe: 4.286 ± 0.113
5.988LeuGly: 5.988 ± 0.137
2.266LeuHis: 2.266 ± 0.073
6.982LeuIle: 6.982 ± 0.134
6.129LeuLys: 6.129 ± 0.109
12.397LeuLeu: 12.397 ± 0.224
3.028LeuMet: 3.028 ± 0.093
4.701LeuAsn: 4.701 ± 0.104
5.875LeuPro: 5.875 ± 0.115
4.315LeuGln: 4.315 ± 0.098
6.062LeuArg: 6.062 ± 0.129
7.979LeuSer: 7.979 ± 0.134
6.207LeuThr: 6.207 ± 0.112
6.108LeuVal: 6.108 ± 0.124
1.233LeuTrp: 1.233 ± 0.057
2.788LeuTyr: 2.788 ± 0.078
0.002LeuXaa: 0.002 ± 0.002
Met
2.444MetAla: 2.444 ± 0.07
0.194MetCys: 0.194 ± 0.023
1.016MetAsp: 1.016 ± 0.041
1.465MetGlu: 1.465 ± 0.057
0.678MetPhe: 0.678 ± 0.035
1.723MetGly: 1.723 ± 0.057
0.454MetHis: 0.454 ± 0.028
1.617MetIle: 1.617 ± 0.061
1.537MetLys: 1.537 ± 0.057
2.908MetLeu: 2.908 ± 0.083
1.058MetMet: 1.058 ± 0.045
1.165MetAsn: 1.165 ± 0.05
1.225MetPro: 1.225 ± 0.047
1.07MetGln: 1.07 ± 0.045
1.433MetArg: 1.433 ± 0.051
1.572MetSer: 1.572 ± 0.053
2.128MetThr: 2.128 ± 0.06
1.56MetVal: 1.56 ± 0.059
0.167MetTrp: 0.167 ± 0.018
0.758MetTyr: 0.758 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.474AsnAla: 3.474 ± 0.084
0.446AsnCys: 0.446 ± 0.03
2.159AsnAsp: 2.159 ± 0.068
2.266AsnGlu: 2.266 ± 0.065
1.774AsnPhe: 1.774 ± 0.052
2.539AsnGly: 2.539 ± 0.066
1.051AsnHis: 1.051 ± 0.042
3.274AsnIle: 3.274 ± 0.074
3.493AsnLys: 3.493 ± 0.08
4.082AsnLeu: 4.082 ± 0.103
0.991AsnMet: 0.991 ± 0.04
2.679AsnAsn: 2.679 ± 0.081
2.016AsnPro: 2.016 ± 0.067
2.127AsnGln: 2.127 ± 0.067
2.799AsnArg: 2.799 ± 0.069
2.404AsnSer: 2.404 ± 0.073
2.704AsnThr: 2.704 ± 0.075
2.375AsnVal: 2.375 ± 0.073
0.529AsnTrp: 0.529 ± 0.035
1.299AsnTyr: 1.299 ± 0.051
0.0AsnXaa: 0.0 ± 0.0
Pro
3.268ProAla: 3.268 ± 0.08
0.632ProCys: 0.632 ± 0.032
2.305ProAsp: 2.305 ± 0.074
2.675ProGlu: 2.675 ± 0.075
1.576ProPhe: 1.576 ± 0.052
2.379ProGly: 2.379 ± 0.072
0.921ProHis: 0.921 ± 0.046
2.642ProIle: 2.642 ± 0.072
2.239ProLys: 2.239 ± 0.072
5.026ProLeu: 5.026 ± 0.103
1.024ProMet: 1.024 ± 0.042
1.524ProAsn: 1.524 ± 0.056
1.574ProPro: 1.574 ± 0.059
1.735ProGln: 1.735 ± 0.062
1.719ProArg: 1.719 ± 0.053
2.377ProSer: 2.377 ± 0.07
2.398ProThr: 2.398 ± 0.072
2.869ProVal: 2.869 ± 0.072
0.508ProTrp: 0.508 ± 0.032
1.322ProTyr: 1.322 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
4.024GlnAla: 4.024 ± 0.096
0.514GlnCys: 0.514 ± 0.031
2.035GlnAsp: 2.035 ± 0.069
2.202GlnGlu: 2.202 ± 0.07
1.528GlnPhe: 1.528 ± 0.062
3.383GlnGly: 3.383 ± 0.087
1.706GlnHis: 1.706 ± 0.064
3.003GlnIle: 3.003 ± 0.079
2.815GlnLys: 2.815 ± 0.08
5.129GlnLeu: 5.129 ± 0.125
1.039GlnMet: 1.039 ± 0.045
1.595GlnAsn: 1.595 ± 0.062
1.741GlnPro: 1.741 ± 0.062
3.627GlnGln: 3.627 ± 0.122
3.228GlnArg: 3.228 ± 0.081
2.563GlnSer: 2.563 ± 0.069
2.059GlnThr: 2.059 ± 0.061
2.665GlnVal: 2.665 ± 0.075
0.626GlnTrp: 0.626 ± 0.035
1.442GlnTyr: 1.442 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
4.168ArgAla: 4.168 ± 0.091
0.775ArgCys: 0.775 ± 0.046
2.925ArgAsp: 2.925 ± 0.088
3.059ArgGlu: 3.059 ± 0.086
2.627ArgPhe: 2.627 ± 0.068
2.927ArgGly: 2.927 ± 0.078
1.874ArgHis: 1.874 ± 0.065
3.922ArgIle: 3.922 ± 0.082
3.452ArgLys: 3.452 ± 0.094
6.513ArgLeu: 6.513 ± 0.141
1.237ArgMet: 1.237 ± 0.045
2.274ArgAsn: 2.274 ± 0.076
2.208ArgPro: 2.208 ± 0.068
3.419ArgGln: 3.419 ± 0.073
4.449ArgArg: 4.449 ± 0.139
2.853ArgSer: 2.853 ± 0.079
2.365ArgThr: 2.365 ± 0.062
3.699ArgVal: 3.699 ± 0.085
1.033ArgTrp: 1.033 ± 0.038
1.799ArgTyr: 1.799 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.488SerAla: 5.488 ± 0.09
0.894SerCys: 0.894 ± 0.041
3.121SerAsp: 3.121 ± 0.074
3.109SerGlu: 3.109 ± 0.087
2.21SerPhe: 2.21 ± 0.064
4.369SerGly: 4.369 ± 0.094
1.512SerHis: 1.512 ± 0.056
4.032SerIle: 4.032 ± 0.085
3.164SerLys: 3.164 ± 0.08
7.027SerLeu: 7.027 ± 0.131
1.622SerMet: 1.622 ± 0.051
2.297SerAsn: 2.297 ± 0.075
2.506SerPro: 2.506 ± 0.065
2.706SerGln: 2.706 ± 0.078
3.261SerArg: 3.261 ± 0.09
3.935SerSer: 3.935 ± 0.102
3.243SerThr: 3.243 ± 0.082
3.821SerVal: 3.821 ± 0.087
0.709SerTrp: 0.709 ± 0.031
1.673SerTyr: 1.673 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
4.567ThrAla: 4.567 ± 0.099
0.481ThrCys: 0.481 ± 0.034
2.786ThrAsp: 2.786 ± 0.075
3.138ThrGlu: 3.138 ± 0.087
1.944ThrPhe: 1.944 ± 0.06
3.72ThrGly: 3.72 ± 0.099
1.336ThrHis: 1.336 ± 0.05
2.952ThrIle: 2.952 ± 0.077
2.607ThrLys: 2.607 ± 0.07
6.944ThrLeu: 6.944 ± 0.128
1.051ThrMet: 1.051 ± 0.042
1.861ThrAsn: 1.861 ± 0.069
2.958ThrPro: 2.958 ± 0.073
2.196ThrGln: 2.196 ± 0.067
3.061ThrArg: 3.061 ± 0.091
2.943ThrSer: 2.943 ± 0.083
3.01ThrThr: 3.01 ± 0.081
3.968ThrVal: 3.968 ± 0.088
0.533ThrTrp: 0.533 ± 0.034
1.929ThrTyr: 1.929 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
5.224ValAla: 5.224 ± 0.117
0.727ValCys: 0.727 ± 0.039
3.293ValAsp: 3.293 ± 0.081
3.478ValGlu: 3.478 ± 0.093
2.52ValPhe: 2.52 ± 0.073
4.017ValGly: 4.017 ± 0.097
1.074ValHis: 1.074 ± 0.045
4.637ValIle: 4.637 ± 0.092
3.458ValLys: 3.458 ± 0.089
6.531ValLeu: 6.531 ± 0.127
2.033ValMet: 2.033 ± 0.064
2.706ValAsn: 2.706 ± 0.089
2.13ValPro: 2.13 ± 0.067
2.041ValGln: 2.041 ± 0.06
3.237ValArg: 3.237 ± 0.091
4.303ValSer: 4.303 ± 0.091
3.637ValThr: 3.637 ± 0.086
4.123ValVal: 4.123 ± 0.1
0.713ValTrp: 0.713 ± 0.04
1.526ValTyr: 1.526 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.909TrpAla: 0.909 ± 0.041
0.192TrpCys: 0.192 ± 0.019
0.471TrpAsp: 0.471 ± 0.032
0.407TrpGlu: 0.407 ± 0.025
0.461TrpPhe: 0.461 ± 0.032
0.597TrpGly: 0.597 ± 0.037
0.392TrpHis: 0.392 ± 0.028
0.768TrpIle: 0.768 ± 0.043
0.531TrpLys: 0.531 ± 0.033
1.733TrpLeu: 1.733 ± 0.062
0.3TrpMet: 0.3 ± 0.024
0.599TrpAsn: 0.599 ± 0.032
0.52TrpPro: 0.52 ± 0.032
0.967TrpGln: 0.967 ± 0.045
0.808TrpArg: 0.808 ± 0.044
0.638TrpSer: 0.638 ± 0.033
0.314TrpThr: 0.314 ± 0.025
0.818TrpVal: 0.818 ± 0.04
0.174TrpTrp: 0.174 ± 0.018
0.345TrpTyr: 0.345 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.235TyrAla: 2.235 ± 0.06
0.446TyrCys: 0.446 ± 0.031
1.479TyrAsp: 1.479 ± 0.06
1.308TyrGlu: 1.308 ± 0.05
1.378TyrPhe: 1.378 ± 0.05
1.859TyrGly: 1.859 ± 0.065
0.932TyrHis: 0.932 ± 0.043
1.725TyrIle: 1.725 ± 0.053
1.219TyrLys: 1.219 ± 0.048
3.648TyrLeu: 3.648 ± 0.084
0.496TyrMet: 0.496 ± 0.027
1.053TyrAsn: 1.053 ± 0.052
1.816TyrPro: 1.816 ± 0.063
1.935TyrGln: 1.935 ± 0.054
1.966TyrArg: 1.966 ± 0.064
1.968TyrSer: 1.968 ± 0.068
1.324TyrThr: 1.324 ± 0.059
1.301TyrVal: 1.301 ± 0.047
0.43TyrTrp: 0.43 ± 0.03
0.872TyrTyr: 0.872 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.002XaaPro: 0.002 ± 0.002
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1994 proteins (515872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski