Amino acid dipepetide frequency for Aquimarina aggregata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.693AlaAla: 3.693 ± 0.066	0.506AlaCys: 0.506 ± 0.018	3.01AlaAsp: 3.01 ± 0.054	3.281AlaGlu: 3.281 ± 0.059	2.906AlaPhe: 2.906 ± 0.048	3.763AlaGly: 3.763 ± 0.069	1.069AlaHis: 1.069 ± 0.025	5.395AlaIle: 5.395 ± 0.056	4.444AlaLys: 4.444 ± 0.061	5.562AlaLeu: 5.562 ± 0.066	1.284AlaMet: 1.284 ± 0.031	3.452AlaAsn: 3.452 ± 0.05	1.855AlaPro: 1.855 ± 0.04	2.165AlaGln: 2.165 ± 0.035	1.83AlaArg: 1.83 ± 0.038	4.006AlaSer: 4.006 ± 0.056	3.634AlaThr: 3.634 ± 0.062	3.473AlaVal: 3.473 ± 0.057	0.573AlaTrp: 0.573 ± 0.02	2.366AlaTyr: 2.366 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.401CysAla: 0.401 ± 0.015	0.086CysCys: 0.086 ± 0.007	0.435CysAsp: 0.435 ± 0.021	0.447CysGlu: 0.447 ± 0.019	0.399CysPhe: 0.399 ± 0.016	0.548CysGly: 0.548 ± 0.02	0.165CysHis: 0.165 ± 0.011	0.613CysIle: 0.613 ± 0.018	0.488CysLys: 0.488 ± 0.018	0.624CysLeu: 0.624 ± 0.022	0.13CysMet: 0.13 ± 0.008	0.452CysAsn: 0.452 ± 0.017	0.303CysPro: 0.303 ± 0.014	0.216CysGln: 0.216 ± 0.009	0.199CysArg: 0.199 ± 0.011	0.586CysSer: 0.586 ± 0.023	0.46CysThr: 0.46 ± 0.021	0.409CysVal: 0.409 ± 0.017	0.076CysTrp: 0.076 ± 0.007	0.324CysTyr: 0.324 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.415AspAla: 3.415 ± 0.054	0.422AspCys: 0.422 ± 0.016	3.077AspAsp: 3.077 ± 0.052	3.372AspGlu: 3.372 ± 0.055	3.706AspPhe: 3.706 ± 0.051	3.882AspGly: 3.882 ± 0.072	1.12AspHis: 1.12 ± 0.028	4.972AspIle: 4.972 ± 0.056	4.172AspLys: 4.172 ± 0.052	5.117AspLeu: 5.117 ± 0.056	1.005AspMet: 1.005 ± 0.03	3.561AspAsn: 3.561 ± 0.058	2.032AspPro: 2.032 ± 0.044	2.097AspGln: 2.097 ± 0.036	1.995AspArg: 1.995 ± 0.038	3.334AspSer: 3.334 ± 0.043	3.217AspThr: 3.217 ± 0.055	3.464AspVal: 3.464 ± 0.051	0.816AspTrp: 0.816 ± 0.021	2.607AspTyr: 2.607 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	3.797GluAla: 3.797 ± 0.061	0.345GluCys: 0.345 ± 0.015	3.492GluAsp: 3.492 ± 0.052	4.824GluGlu: 4.824 ± 0.082	2.92GluPhe: 2.92 ± 0.047	3.56GluGly: 3.56 ± 0.052	1.127GluHis: 1.127 ± 0.028	5.779GluIle: 5.779 ± 0.061	5.752GluLys: 5.752 ± 0.078	6.018GluLeu: 6.018 ± 0.067	1.401GluMet: 1.401 ± 0.029	4.591GluAsn: 4.591 ± 0.05	1.461GluPro: 1.461 ± 0.035	2.205GluGln: 2.205 ± 0.04	2.282GluArg: 2.282 ± 0.045	3.357GluSer: 3.357 ± 0.044	3.561GluThr: 3.561 ± 0.048	4.097GluVal: 4.097 ± 0.052	0.626GluTrp: 0.626 ± 0.017	2.61GluTyr: 2.61 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	2.711PheAla: 2.711 ± 0.047	0.416PheCys: 0.416 ± 0.019	3.419PheAsp: 3.419 ± 0.048	3.32PheGlu: 3.32 ± 0.046	2.87PhePhe: 2.87 ± 0.053	3.486PheGly: 3.486 ± 0.044	0.769PheHis: 0.769 ± 0.023	4.034PheIle: 4.034 ± 0.058	3.91PheLys: 3.91 ± 0.052	4.626PheLeu: 4.626 ± 0.063	1.007PheMet: 1.007 ± 0.023	3.366PheAsn: 3.366 ± 0.052	1.668PhePro: 1.668 ± 0.035	1.486PheGln: 1.486 ± 0.03	1.727PheArg: 1.727 ± 0.031	4.082PheSer: 4.082 ± 0.055	3.295PheThr: 3.295 ± 0.049	2.867PheVal: 2.867 ± 0.042	0.593PheTrp: 0.593 ± 0.018	2.219PheTyr: 2.219 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	3.905GlyAla: 3.905 ± 0.066	0.572GlyCys: 0.572 ± 0.026	3.577GlyAsp: 3.577 ± 0.063	3.537GlyGlu: 3.537 ± 0.059	3.738GlyPhe: 3.738 ± 0.048	4.653GlyGly: 4.653 ± 0.087	1.073GlyHis: 1.073 ± 0.026	5.533GlyIle: 5.533 ± 0.062	4.795GlyLys: 4.795 ± 0.056	5.471GlyLeu: 5.471 ± 0.064	1.341GlyMet: 1.341 ± 0.027	4.105GlyAsn: 4.105 ± 0.069	1.411GlyPro: 1.411 ± 0.035	1.853GlyGln: 1.853 ± 0.035	2.069GlyArg: 2.069 ± 0.039	4.023GlySer: 4.023 ± 0.055	4.229GlyThr: 4.229 ± 0.078	4.282GlyVal: 4.282 ± 0.059	0.813GlyTrp: 0.813 ± 0.03	2.868GlyTyr: 2.868 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	0.852HisAla: 0.852 ± 0.022	0.176HisCys: 0.176 ± 0.011	0.886HisAsp: 0.886 ± 0.024	0.964HisGlu: 0.964 ± 0.026	1.107HisPhe: 1.107 ± 0.026	0.987HisGly: 0.987 ± 0.026	0.532HisHis: 0.532 ± 0.018	1.481HisIle: 1.481 ± 0.035	1.451HisLys: 1.451 ± 0.031	1.689HisLeu: 1.689 ± 0.036	0.333HisMet: 0.333 ± 0.014	1.047HisAsn: 1.047 ± 0.027	0.829HisPro: 0.829 ± 0.022	0.736HisGln: 0.736 ± 0.023	0.65HisArg: 0.65 ± 0.018	1.046HisSer: 1.046 ± 0.026	1.041HisThr: 1.041 ± 0.026	0.844HisVal: 0.844 ± 0.024	0.237HisTrp: 0.237 ± 0.014	0.827HisTyr: 0.827 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.528IleAla: 5.528 ± 0.068	0.62IleCys: 0.62 ± 0.022	5.388IleAsp: 5.388 ± 0.052	5.548IleGlu: 5.548 ± 0.068	3.595IlePhe: 3.595 ± 0.06	5.331IleGly: 5.331 ± 0.059	1.493IleHis: 1.493 ± 0.032	6.415IleIle: 6.415 ± 0.083	6.577IleLys: 6.577 ± 0.07	7.263IleLeu: 7.263 ± 0.081	1.346IleMet: 1.346 ± 0.03	5.223IleAsn: 5.223 ± 0.057	3.399IlePro: 3.399 ± 0.046	2.786IleGln: 2.786 ± 0.041	2.733IleArg: 2.733 ± 0.038	6.261IleSer: 6.261 ± 0.068	5.504IleThr: 5.504 ± 0.057	4.881IleVal: 4.881 ± 0.058	0.778IleTrp: 0.778 ± 0.025	2.984IleTyr: 2.984 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	4.47LysAla: 4.47 ± 0.066	0.355LysCys: 0.355 ± 0.014	4.614LysAsp: 4.614 ± 0.054	6.678LysGlu: 6.678 ± 0.087	2.928LysPhe: 2.928 ± 0.047	4.739LysGly: 4.739 ± 0.064	1.418LysHis: 1.418 ± 0.03	6.611LysIle: 6.611 ± 0.082	7.629LysLys: 7.629 ± 0.101	6.647LysLeu: 6.647 ± 0.082	1.824LysMet: 1.824 ± 0.034	5.713LysAsn: 5.713 ± 0.079	2.345LysPro: 2.345 ± 0.043	2.706LysGln: 2.706 ± 0.041	2.898LysArg: 2.898 ± 0.043	4.837LysSer: 4.837 ± 0.064	4.851LysThr: 4.851 ± 0.06	4.643LysVal: 4.643 ± 0.051	0.861LysTrp: 0.861 ± 0.025	3.114LysTyr: 3.114 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	5.058LeuAla: 5.058 ± 0.063	0.654LeuCys: 0.654 ± 0.018	5.248LeuAsp: 5.248 ± 0.053	5.952LeuGlu: 5.952 ± 0.066	4.736LeuPhe: 4.736 ± 0.055	5.622LeuGly: 5.622 ± 0.064	1.503LeuHis: 1.503 ± 0.029	7.103LeuIle: 7.103 ± 0.094	7.638LeuLys: 7.638 ± 0.1	8.42LeuLeu: 8.42 ± 0.099	1.768LeuMet: 1.768 ± 0.032	5.469LeuAsn: 5.469 ± 0.064	3.335LeuPro: 3.335 ± 0.051	3.222LeuGln: 3.222 ± 0.045	3.101LeuArg: 3.101 ± 0.042	6.701LeuSer: 6.701 ± 0.074	5.18LeuThr: 5.18 ± 0.056	5.084LeuVal: 5.084 ± 0.059	0.859LeuTrp: 0.859 ± 0.025	3.234LeuTyr: 3.234 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	1.302MetAla: 1.302 ± 0.03	0.123MetCys: 0.123 ± 0.01	1.003MetAsp: 1.003 ± 0.024	0.992MetGlu: 0.992 ± 0.022	0.781MetPhe: 0.781 ± 0.022	1.188MetGly: 1.188 ± 0.029	0.349MetHis: 0.349 ± 0.016	1.644MetIle: 1.644 ± 0.031	1.996MetLys: 1.996 ± 0.034	1.693MetLeu: 1.693 ± 0.029	0.494MetMet: 0.494 ± 0.017	1.342MetAsn: 1.342 ± 0.027	0.747MetPro: 0.747 ± 0.021	0.711MetGln: 0.711 ± 0.022	0.767MetArg: 0.767 ± 0.02	1.275MetSer: 1.275 ± 0.029	1.1MetThr: 1.1 ± 0.027	1.114MetVal: 1.114 ± 0.027	0.16MetTrp: 0.16 ± 0.01	0.715MetTyr: 0.715 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.878AsnAla: 3.878 ± 0.051	0.482AsnCys: 0.482 ± 0.017	3.8AsnAsp: 3.8 ± 0.056	3.796AsnGlu: 3.796 ± 0.049	3.202AsnPhe: 3.202 ± 0.046	4.524AsnGly: 4.524 ± 0.073	1.119AsnHis: 1.119 ± 0.026	5.125AsnIle: 5.125 ± 0.056	4.635AsnLys: 4.635 ± 0.056	5.384AsnLeu: 5.384 ± 0.061	1.196AsnMet: 1.196 ± 0.027	4.432AsnAsn: 4.432 ± 0.073	2.849AsnPro: 2.849 ± 0.051	2.4AsnGln: 2.4 ± 0.046	2.36AsnArg: 2.36 ± 0.037	4.124AsnSer: 4.124 ± 0.056	4.525AsnThr: 4.525 ± 0.064	3.499AsnVal: 3.499 ± 0.051	0.851AsnTrp: 0.851 ± 0.023	2.79AsnTyr: 2.79 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	1.734ProAla: 1.734 ± 0.046	0.209ProCys: 0.209 ± 0.011	2.222ProAsp: 2.222 ± 0.046	2.698ProGlu: 2.698 ± 0.044	1.824ProPhe: 1.824 ± 0.032	2.006ProGly: 2.006 ± 0.04	0.564ProHis: 0.564 ± 0.017	2.809ProIle: 2.809 ± 0.044	2.646ProLys: 2.646 ± 0.042	2.788ProLeu: 2.788 ± 0.039	0.612ProMet: 0.612 ± 0.017	2.429ProAsn: 2.429 ± 0.046	0.856ProPro: 0.856 ± 0.028	1.082ProGln: 1.082 ± 0.024	0.959ProArg: 0.959 ± 0.026	2.238ProSer: 2.238 ± 0.037	2.006ProThr: 2.006 ± 0.044	2.138ProVal: 2.138 ± 0.039	0.363ProTrp: 0.363 ± 0.014	1.335ProTyr: 1.335 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	1.76GlnAla: 1.76 ± 0.031	0.192GlnCys: 0.192 ± 0.011	1.778GlnAsp: 1.778 ± 0.033	2.586GlnGlu: 2.586 ± 0.04	1.662GlnPhe: 1.662 ± 0.033	1.945GlnGly: 1.945 ± 0.04	0.606GlnHis: 0.606 ± 0.02	2.713GlnIle: 2.713 ± 0.038	3.112GlnLys: 3.112 ± 0.048	3.277GlnLeu: 3.277 ± 0.045	0.685GlnMet: 0.685 ± 0.019	2.431GlnAsn: 2.431 ± 0.045	1.008GlnPro: 1.008 ± 0.024	1.454GlnGln: 1.454 ± 0.035	1.275GlnArg: 1.275 ± 0.036	2.02GlnSer: 2.02 ± 0.036	1.916GlnThr: 1.916 ± 0.04	1.862GlnVal: 1.862 ± 0.035	0.403GlnTrp: 0.403 ± 0.016	1.44GlnTyr: 1.44 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	1.911ArgAla: 1.911 ± 0.03	0.205ArgCys: 0.205 ± 0.013	1.852ArgAsp: 1.852 ± 0.031	2.056ArgGlu: 2.056 ± 0.037	1.945ArgPhe: 1.945 ± 0.033	1.942ArgGly: 1.942 ± 0.034	0.576ArgHis: 0.576 ± 0.019	3.085ArgIle: 3.085 ± 0.045	2.767ArgLys: 2.767 ± 0.047	3.277ArgLeu: 3.277 ± 0.054	0.797ArgMet: 0.797 ± 0.02	2.242ArgAsn: 2.242 ± 0.036	1.074ArgPro: 1.074 ± 0.028	1.05ArgGln: 1.05 ± 0.026	1.271ArgArg: 1.271 ± 0.03	2.07ArgSer: 2.07 ± 0.043	1.937ArgThr: 1.937 ± 0.034	2.074ArgVal: 2.074 ± 0.039	0.418ArgTrp: 0.418 ± 0.017	1.616ArgTyr: 1.616 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.529SerAla: 3.529 ± 0.05	0.697SerCys: 0.697 ± 0.019	3.63SerAsp: 3.63 ± 0.051	4.015SerGlu: 4.015 ± 0.046	3.97SerPhe: 3.97 ± 0.05	4.808SerGly: 4.808 ± 0.076	1.081SerHis: 1.081 ± 0.028	5.777SerIle: 5.777 ± 0.063	5.369SerLys: 5.369 ± 0.064	6.004SerLeu: 6.004 ± 0.072	1.167SerMet: 1.167 ± 0.03	4.377SerAsn: 4.377 ± 0.06	2.06SerPro: 2.06 ± 0.036	2.203SerGln: 2.203 ± 0.038	2.197SerArg: 2.197 ± 0.037	4.711SerSer: 4.711 ± 0.058	3.89SerThr: 3.89 ± 0.052	3.791SerVal: 3.791 ± 0.046	0.802SerTrp: 0.802 ± 0.024	2.969SerTyr: 2.969 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	3.771ThrAla: 3.771 ± 0.079	0.391ThrCys: 0.391 ± 0.02	3.36ThrAsp: 3.36 ± 0.055	3.377ThrGlu: 3.377 ± 0.039	3.169ThrPhe: 3.169 ± 0.047	4.172ThrGly: 4.172 ± 0.073	1.041ThrHis: 1.041 ± 0.027	5.909ThrIle: 5.909 ± 0.057	4.328ThrLys: 4.328 ± 0.055	5.567ThrLeu: 5.567 ± 0.057	0.967ThrMet: 0.967 ± 0.025	3.848ThrAsn: 3.848 ± 0.061	2.565ThrPro: 2.565 ± 0.051	1.94ThrGln: 1.94 ± 0.036	1.813ThrArg: 1.813 ± 0.034	4.421ThrSer: 4.421 ± 0.053	4.107ThrThr: 4.107 ± 0.058	3.717ThrVal: 3.717 ± 0.062	0.632ThrTrp: 0.632 ± 0.023	2.586ThrTyr: 2.586 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	3.619ValAla: 3.619 ± 0.053	0.463ValCys: 0.463 ± 0.018	3.408ValAsp: 3.408 ± 0.054	3.373ValGlu: 3.373 ± 0.041	3.397ValPhe: 3.397 ± 0.048	3.486ValGly: 3.486 ± 0.055	0.985ValHis: 0.985 ± 0.024	4.796ValIle: 4.796 ± 0.056	4.077ValLys: 4.077 ± 0.05	5.716ValLeu: 5.716 ± 0.072	1.167ValMet: 1.167 ± 0.03	3.553ValAsn: 3.553 ± 0.043	2.022ValPro: 2.022 ± 0.04	1.812ValGln: 1.812 ± 0.035	1.883ValArg: 1.883 ± 0.037	4.543ValSer: 4.543 ± 0.05	3.846ValThr: 3.846 ± 0.086	3.855ValVal: 3.855 ± 0.064	0.59ValTrp: 0.59 ± 0.019	2.311ValTyr: 2.311 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.568TrpAla: 0.568 ± 0.019	0.106TrpCys: 0.106 ± 0.008	0.674TrpAsp: 0.674 ± 0.025	0.693TrpGlu: 0.693 ± 0.021	0.596TrpPhe: 0.596 ± 0.019	0.724TrpGly: 0.724 ± 0.024	0.24TrpHis: 0.24 ± 0.011	0.855TrpIle: 0.855 ± 0.024	0.897TrpLys: 0.897 ± 0.026	0.937TrpLeu: 0.937 ± 0.021	0.294TrpMet: 0.294 ± 0.011	0.74TrpAsn: 0.74 ± 0.023	0.264TrpPro: 0.264 ± 0.013	0.434TrpGln: 0.434 ± 0.016	0.437TrpArg: 0.437 ± 0.016	0.747TrpSer: 0.747 ± 0.023	0.639TrpThr: 0.639 ± 0.023	0.63TrpVal: 0.63 ± 0.019	0.177TrpTrp: 0.177 ± 0.01	0.473TrpTyr: 0.473 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.362TyrAla: 2.362 ± 0.035	0.342TyrCys: 0.342 ± 0.017	2.51TyrAsp: 2.51 ± 0.043	2.297TyrGlu: 2.297 ± 0.039	2.421TyrPhe: 2.421 ± 0.042	2.484TyrGly: 2.484 ± 0.037	0.887TyrHis: 0.887 ± 0.023	3.002TyrIle: 3.002 ± 0.048	3.199TyrLys: 3.199 ± 0.05	3.807TyrLeu: 3.807 ± 0.056	0.68TyrMet: 0.68 ± 0.02	2.596TyrAsn: 2.596 ± 0.043	1.436TyrPro: 1.436 ± 0.029	1.564TyrGln: 1.564 ± 0.036	1.72TyrArg: 1.72 ± 0.031	2.663TyrSer: 2.663 ± 0.038	2.743TyrThr: 2.743 ± 0.043	2.176TyrVal: 2.176 ± 0.039	0.497TyrTrp: 0.497 ± 0.018	1.923TyrTyr: 1.923 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5047 proteins (1774003 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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