Amino acid dipepetide frequency for Flammeovirga sp. MY04

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.701AlaAla: 3.701 ± 0.059
0.477AlaCys: 0.477 ± 0.015
3.326AlaAsp: 3.326 ± 0.049
3.819AlaGlu: 3.819 ± 0.056
3.0AlaPhe: 3.0 ± 0.043
3.852AlaGly: 3.852 ± 0.057
1.12AlaHis: 1.12 ± 0.022
4.307AlaIle: 4.307 ± 0.048
4.017AlaLys: 4.017 ± 0.053
5.331AlaLeu: 5.331 ± 0.059
1.442AlaMet: 1.442 ± 0.029
3.16AlaAsn: 3.16 ± 0.044
1.944AlaPro: 1.944 ± 0.038
2.467AlaGln: 2.467 ± 0.037
1.773AlaArg: 1.773 ± 0.032
4.063AlaSer: 4.063 ± 0.05
3.394AlaThr: 3.394 ± 0.052
3.597AlaVal: 3.597 ± 0.046
0.673AlaTrp: 0.673 ± 0.017
2.482AlaTyr: 2.482 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
0.399CysAla: 0.399 ± 0.016
0.084CysCys: 0.084 ± 0.007
0.456CysAsp: 0.456 ± 0.016
0.471CysGlu: 0.471 ± 0.017
0.384CysPhe: 0.384 ± 0.014
0.54CysGly: 0.54 ± 0.018
0.19CysHis: 0.19 ± 0.012
0.536CysIle: 0.536 ± 0.016
0.414CysLys: 0.414 ± 0.014
0.633CysLeu: 0.633 ± 0.017
0.162CysMet: 0.162 ± 0.008
0.378CysAsn: 0.378 ± 0.013
0.258CysPro: 0.258 ± 0.012
0.258CysGln: 0.258 ± 0.01
0.201CysArg: 0.201 ± 0.009
0.543CysSer: 0.543 ± 0.017
0.411CysThr: 0.411 ± 0.015
0.433CysVal: 0.433 ± 0.014
0.08CysTrp: 0.08 ± 0.006
0.304CysTyr: 0.304 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.688AspAla: 3.688 ± 0.053
0.423AspCys: 0.423 ± 0.016
3.357AspAsp: 3.357 ± 0.048
4.129AspGlu: 4.129 ± 0.055
3.504AspPhe: 3.504 ± 0.039
4.247AspGly: 4.247 ± 0.055
1.315AspHis: 1.315 ± 0.028
4.801AspIle: 4.801 ± 0.051
4.304AspLys: 4.304 ± 0.057
5.521AspLeu: 5.521 ± 0.057
1.313AspMet: 1.313 ± 0.027
3.467AspAsn: 3.467 ± 0.048
2.152AspPro: 2.152 ± 0.039
2.648AspGln: 2.648 ± 0.037
2.133AspArg: 2.133 ± 0.034
2.968AspSer: 2.968 ± 0.055
2.691AspThr: 2.691 ± 0.046
3.937AspVal: 3.937 ± 0.047
0.916AspTrp: 0.916 ± 0.024
2.907AspTyr: 2.907 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
4.274GluAla: 4.274 ± 0.06
0.376GluCys: 0.376 ± 0.013
4.016GluAsp: 4.016 ± 0.051
5.942GluGlu: 5.942 ± 0.084
3.023GluPhe: 3.023 ± 0.038
4.559GluGly: 4.559 ± 0.055
1.286GluHis: 1.286 ± 0.027
5.375GluIle: 5.375 ± 0.049
5.914GluLys: 5.914 ± 0.075
6.3GluLeu: 6.3 ± 0.064
1.848GluMet: 1.848 ± 0.03
4.533GluAsn: 4.533 ± 0.051
1.432GluPro: 1.432 ± 0.028
2.359GluGln: 2.359 ± 0.037
2.45GluArg: 2.45 ± 0.039
3.492GluSer: 3.492 ± 0.045
3.353GluThr: 3.353 ± 0.04
5.044GluVal: 5.044 ± 0.053
0.893GluTrp: 0.893 ± 0.024
2.825GluTyr: 2.825 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
2.727PheAla: 2.727 ± 0.041
0.418PheCys: 0.418 ± 0.014
3.856PheAsp: 3.856 ± 0.046
3.414PheGlu: 3.414 ± 0.039
2.645PhePhe: 2.645 ± 0.044
3.45PheGly: 3.45 ± 0.046
0.899PheHis: 0.899 ± 0.018
3.79PheIle: 3.79 ± 0.051
3.425PheLys: 3.425 ± 0.044
4.188PheLeu: 4.188 ± 0.057
1.145PheMet: 1.145 ± 0.028
3.112PheAsn: 3.112 ± 0.039
1.615PhePro: 1.615 ± 0.028
1.55PheGln: 1.55 ± 0.029
1.646PheArg: 1.646 ± 0.031
3.882PheSer: 3.882 ± 0.043
3.262PheThr: 3.262 ± 0.051
2.902PheVal: 2.902 ± 0.041
0.549PheTrp: 0.549 ± 0.017
2.214PheTyr: 2.214 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
4.0GlyAla: 4.0 ± 0.06
0.557GlyCys: 0.557 ± 0.02
3.913GlyAsp: 3.913 ± 0.052
4.22GlyGlu: 4.22 ± 0.054
3.388GlyPhe: 3.388 ± 0.047
4.826GlyGly: 4.826 ± 0.076
1.22GlyHis: 1.22 ± 0.024
5.073GlyIle: 5.073 ± 0.055
4.98GlyLys: 4.98 ± 0.063
5.5GlyLeu: 5.5 ± 0.061
1.69GlyMet: 1.69 ± 0.033
3.798GlyAsn: 3.798 ± 0.058
1.408GlyPro: 1.408 ± 0.026
2.37GlyGln: 2.37 ± 0.035
2.18GlyArg: 2.18 ± 0.035
3.966GlySer: 3.966 ± 0.055
3.87GlyThr: 3.87 ± 0.059
4.794GlyVal: 4.794 ± 0.057
0.865GlyTrp: 0.865 ± 0.024
3.077GlyTyr: 3.077 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
0.944HisAla: 0.944 ± 0.025
0.161HisCys: 0.161 ± 0.01
1.013HisAsp: 1.013 ± 0.023
1.098HisGlu: 1.098 ± 0.023
1.165HisPhe: 1.165 ± 0.026
1.166HisGly: 1.166 ± 0.027
0.601HisHis: 0.601 ± 0.02
1.396HisIle: 1.396 ± 0.027
1.191HisLys: 1.191 ± 0.026
2.045HisLeu: 2.045 ± 0.038
0.383HisMet: 0.383 ± 0.015
0.964HisAsn: 0.964 ± 0.021
0.98HisPro: 0.98 ± 0.024
1.175HisGln: 1.175 ± 0.025
0.722HisArg: 0.722 ± 0.019
1.163HisSer: 1.163 ± 0.026
0.995HisThr: 0.995 ± 0.024
0.988HisVal: 0.988 ± 0.023
0.301HisTrp: 0.301 ± 0.013
0.959HisTyr: 0.959 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
4.496IleAla: 4.496 ± 0.044
0.585IleCys: 0.585 ± 0.017
5.207IleAsp: 5.207 ± 0.053
5.307IleGlu: 5.307 ± 0.059
3.341IlePhe: 3.341 ± 0.05
4.884IleGly: 4.884 ± 0.06
1.546IleHis: 1.546 ± 0.029
5.34IleIle: 5.34 ± 0.068
5.537IleLys: 5.537 ± 0.06
6.23IleLeu: 6.23 ± 0.067
1.351IleMet: 1.351 ± 0.026
4.641IleAsn: 4.641 ± 0.054
2.916IlePro: 2.916 ± 0.044
2.75IleGln: 2.75 ± 0.043
2.495IleArg: 2.495 ± 0.038
5.549IleSer: 5.549 ± 0.059
4.728IleThr: 4.728 ± 0.07
4.306IleVal: 4.306 ± 0.044
0.7IleTrp: 0.7 ± 0.018
3.032IleTyr: 3.032 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.335LysAla: 4.335 ± 0.059
0.363LysCys: 0.363 ± 0.014
4.531LysAsp: 4.531 ± 0.049
6.592LysGlu: 6.592 ± 0.078
2.86LysPhe: 2.86 ± 0.041
5.009LysGly: 5.009 ± 0.054
1.377LysHis: 1.377 ± 0.028
5.306LysIle: 5.306 ± 0.056
6.633LysLys: 6.633 ± 0.09
6.121LysLeu: 6.121 ± 0.063
1.968LysMet: 1.968 ± 0.032
4.633LysAsn: 4.633 ± 0.051
1.99LysPro: 1.99 ± 0.035
2.479LysGln: 2.479 ± 0.04
2.624LysArg: 2.624 ± 0.046
4.561LysSer: 4.561 ± 0.052
3.836LysThr: 3.836 ± 0.045
5.429LysVal: 5.429 ± 0.057
0.867LysTrp: 0.867 ± 0.022
3.282LysTyr: 3.282 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
4.744LeuAla: 4.744 ± 0.055
0.661LeuCys: 0.661 ± 0.019
5.251LeuAsp: 5.251 ± 0.05
6.135LeuGlu: 6.135 ± 0.06
4.677LeuPhe: 4.677 ± 0.056
5.568LeuGly: 5.568 ± 0.062
1.638LeuHis: 1.638 ± 0.028
6.419LeuIle: 6.419 ± 0.067
6.958LeuLys: 6.958 ± 0.07
8.166LeuLeu: 8.166 ± 0.085
2.283LeuMet: 2.283 ± 0.034
5.36LeuAsn: 5.36 ± 0.056
3.667LeuPro: 3.667 ± 0.041
3.105LeuGln: 3.105 ± 0.038
3.029LeuArg: 3.029 ± 0.041
7.199LeuSer: 7.199 ± 0.064
4.977LeuThr: 4.977 ± 0.051
4.723LeuVal: 4.723 ± 0.046
0.936LeuTrp: 0.936 ± 0.024
3.319LeuTyr: 3.319 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
1.454MetAla: 1.454 ± 0.028
0.153MetCys: 0.153 ± 0.009
1.365MetAsp: 1.365 ± 0.028
1.515MetGlu: 1.515 ± 0.028
0.935MetPhe: 0.935 ± 0.021
1.556MetGly: 1.556 ± 0.028
0.445MetHis: 0.445 ± 0.014
1.763MetIle: 1.763 ± 0.029
2.283MetLys: 2.283 ± 0.035
1.942MetLeu: 1.942 ± 0.034
0.76MetMet: 0.76 ± 0.023
1.505MetAsn: 1.505 ± 0.027
0.867MetPro: 0.867 ± 0.022
0.768MetGln: 0.768 ± 0.021
0.887MetArg: 0.887 ± 0.022
1.658MetSer: 1.658 ± 0.027
1.263MetThr: 1.263 ± 0.025
1.326MetVal: 1.326 ± 0.024
0.229MetTrp: 0.229 ± 0.01
0.872MetTyr: 0.872 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.533AsnAla: 3.533 ± 0.05
0.406AsnCys: 0.406 ± 0.016
3.596AsnAsp: 3.596 ± 0.047
3.811AsnGlu: 3.811 ± 0.047
2.886AsnPhe: 2.886 ± 0.042
4.303AsnGly: 4.303 ± 0.067
1.211AsnHis: 1.211 ± 0.026
4.712AsnIle: 4.712 ± 0.052
4.217AsnLys: 4.217 ± 0.049
4.993AsnLeu: 4.993 ± 0.06
1.305AsnMet: 1.305 ± 0.024
3.999AsnAsn: 3.999 ± 0.059
2.538AsnPro: 2.538 ± 0.041
2.433AsnGln: 2.433 ± 0.036
1.988AsnArg: 1.988 ± 0.028
3.742AsnSer: 3.742 ± 0.052
3.543AsnThr: 3.543 ± 0.049
3.644AsnVal: 3.644 ± 0.05
0.787AsnTrp: 0.787 ± 0.019
2.942AsnTyr: 2.942 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
1.767ProAla: 1.767 ± 0.035
0.191ProCys: 0.191 ± 0.011
1.942ProAsp: 1.942 ± 0.031
2.62ProGlu: 2.62 ± 0.038
1.893ProPhe: 1.893 ± 0.035
1.74ProGly: 1.74 ± 0.032
0.726ProHis: 0.726 ± 0.021
2.609ProIle: 2.609 ± 0.041
2.436ProLys: 2.436 ± 0.036
2.968ProLeu: 2.968 ± 0.045
0.779ProMet: 0.779 ± 0.019
2.304ProAsn: 2.304 ± 0.034
0.862ProPro: 0.862 ± 0.024
1.315ProGln: 1.315 ± 0.025
0.952ProArg: 0.952 ± 0.021
2.583ProSer: 2.583 ± 0.044
2.159ProThr: 2.159 ± 0.039
2.121ProVal: 2.121 ± 0.033
0.411ProTrp: 0.411 ± 0.014
1.513ProTyr: 1.513 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
1.957GlnAla: 1.957 ± 0.033
0.181GlnCys: 0.181 ± 0.009
1.866GlnAsp: 1.866 ± 0.026
2.685GlnGlu: 2.685 ± 0.038
1.912GlnPhe: 1.912 ± 0.028
2.108GlnGly: 2.108 ± 0.037
0.699GlnHis: 0.699 ± 0.018
2.606GlnIle: 2.606 ± 0.036
3.155GlnLys: 3.155 ± 0.045
3.906GlnLeu: 3.906 ± 0.051
0.929GlnMet: 0.929 ± 0.022
2.264GlnAsn: 2.264 ± 0.035
1.256GlnPro: 1.256 ± 0.025
1.512GlnGln: 1.512 ± 0.036
1.347GlnArg: 1.347 ± 0.029
2.225GlnSer: 2.225 ± 0.032
1.961GlnThr: 1.961 ± 0.033
2.214GlnVal: 2.214 ± 0.042
0.515GlnTrp: 0.515 ± 0.016
1.499GlnTyr: 1.499 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
1.842ArgAla: 1.842 ± 0.027
0.188ArgCys: 0.188 ± 0.01
1.793ArgAsp: 1.793 ± 0.034
2.14ArgGlu: 2.14 ± 0.035
1.854ArgPhe: 1.854 ± 0.032
2.056ArgGly: 2.056 ± 0.033
0.601ArgHis: 0.601 ± 0.017
2.603ArgIle: 2.603 ± 0.037
2.593ArgLys: 2.593 ± 0.042
3.199ArgLeu: 3.199 ± 0.038
0.94ArgMet: 0.94 ± 0.024
2.052ArgAsn: 2.052 ± 0.033
1.187ArgPro: 1.187 ± 0.024
1.125ArgGln: 1.125 ± 0.025
1.325ArgArg: 1.325 ± 0.031
2.004ArgSer: 2.004 ± 0.032
1.781ArgThr: 1.781 ± 0.032
2.256ArgVal: 2.256 ± 0.038
0.473ArgTrp: 0.473 ± 0.017
1.595ArgTyr: 1.595 ± 0.026
0.0ArgXaa: 0.0 ± 0.0
Ser
3.626SerAla: 3.626 ± 0.05
0.653SerCys: 0.653 ± 0.021
4.062SerAsp: 4.062 ± 0.045
4.146SerGlu: 4.146 ± 0.048
3.907SerPhe: 3.907 ± 0.048
4.388SerGly: 4.388 ± 0.062
1.144SerHis: 1.144 ± 0.024
5.613SerIle: 5.613 ± 0.062
4.79SerLys: 4.79 ± 0.053
6.161SerLeu: 6.161 ± 0.055
1.476SerMet: 1.476 ± 0.028
4.103SerAsn: 4.103 ± 0.052
2.167SerPro: 2.167 ± 0.034
2.139SerGln: 2.139 ± 0.033
2.087SerArg: 2.087 ± 0.036
4.814SerSer: 4.814 ± 0.063
3.95SerThr: 3.95 ± 0.061
4.093SerVal: 4.093 ± 0.055
0.822SerTrp: 0.822 ± 0.021
2.796SerTyr: 2.796 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
3.402ThrAla: 3.402 ± 0.055
0.345ThrCys: 0.345 ± 0.014
3.378ThrAsp: 3.378 ± 0.047
3.436ThrGlu: 3.436 ± 0.037
3.188ThrPhe: 3.188 ± 0.054
3.691ThrGly: 3.691 ± 0.059
1.024ThrHis: 1.024 ± 0.024
4.34ThrIle: 4.34 ± 0.063
3.592ThrLys: 3.592 ± 0.048
5.494ThrLeu: 5.494 ± 0.058
1.004ThrMet: 1.004 ± 0.019
3.09ThrAsn: 3.09 ± 0.052
2.548ThrPro: 2.548 ± 0.039
1.919ThrGln: 1.919 ± 0.039
1.519ThrArg: 1.519 ± 0.028
4.218ThrSer: 4.218 ± 0.05
3.533ThrThr: 3.533 ± 0.055
3.804ThrVal: 3.804 ± 0.066
0.689ThrTrp: 0.689 ± 0.022
2.569ThrTyr: 2.569 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
3.878ValAla: 3.878 ± 0.055
0.489ValCys: 0.489 ± 0.016
4.079ValAsp: 4.079 ± 0.053
4.467ValGlu: 4.467 ± 0.05
3.089ValPhe: 3.089 ± 0.036
4.089ValGly: 4.089 ± 0.051
1.059ValHis: 1.059 ± 0.022
4.672ValIle: 4.672 ± 0.057
4.418ValLys: 4.418 ± 0.053
5.268ValLeu: 5.268 ± 0.057
1.548ValMet: 1.548 ± 0.03
3.758ValAsn: 3.758 ± 0.052
2.182ValPro: 2.182 ± 0.029
1.947ValGln: 1.947 ± 0.033
2.174ValArg: 2.174 ± 0.036
4.502ValSer: 4.502 ± 0.055
3.829ValThr: 3.829 ± 0.068
4.215ValVal: 4.215 ± 0.047
0.725ValTrp: 0.725 ± 0.021
2.64ValTyr: 2.64 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
0.681TrpAla: 0.681 ± 0.019
0.104TrpCys: 0.104 ± 0.006
0.761TrpAsp: 0.761 ± 0.02
0.915TrpGlu: 0.915 ± 0.021
0.509TrpPhe: 0.509 ± 0.015
0.895TrpGly: 0.895 ± 0.027
0.277TrpHis: 0.277 ± 0.012
0.773TrpIle: 0.773 ± 0.021
0.944TrpLys: 0.944 ± 0.021
0.947TrpLeu: 0.947 ± 0.023
0.376TrpMet: 0.376 ± 0.012
0.772TrpAsn: 0.772 ± 0.019
0.274TrpPro: 0.274 ± 0.013
0.421TrpGln: 0.421 ± 0.014
0.476TrpArg: 0.476 ± 0.015
0.858TrpSer: 0.858 ± 0.019
0.679TrpThr: 0.679 ± 0.018
0.816TrpVal: 0.816 ± 0.019
0.195TrpTrp: 0.195 ± 0.01
0.515TrpTyr: 0.515 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.496TyrAla: 2.496 ± 0.035
0.319TyrCys: 0.319 ± 0.014
2.654TyrAsp: 2.654 ± 0.039
2.432TyrGlu: 2.432 ± 0.035
2.531TyrPhe: 2.531 ± 0.037
2.768TyrGly: 2.768 ± 0.041
1.032TyrHis: 1.032 ± 0.022
2.909TyrIle: 2.909 ± 0.034
2.994TyrLys: 2.994 ± 0.04
3.902TyrLeu: 3.902 ± 0.05
0.845TyrMet: 0.845 ± 0.021
2.696TyrAsn: 2.696 ± 0.043
1.646TyrPro: 1.646 ± 0.031
2.055TyrGln: 2.055 ± 0.035
1.599TyrArg: 1.599 ± 0.029
2.947TyrSer: 2.947 ± 0.04
2.573TyrThr: 2.573 ± 0.043
2.383TyrVal: 2.383 ± 0.039
0.562TyrTrp: 0.562 ± 0.017
2.16TyrTyr: 2.16 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5417 proteins (2124546 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski