Amino acid dipepetide frequency for Sulfolobus monocaudavirus SMV2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.202AlaCys: 0.202 ± 0.111
2.151AlaAsp: 2.151 ± 0.318
3.428AlaGlu: 3.428 ± 0.539
2.218AlaPhe: 2.218 ± 0.585
2.151AlaGly: 2.151 ± 0.339
0.471AlaHis: 0.471 ± 0.242
4.302AlaIle: 4.302 ± 0.703
4.033AlaLys: 4.033 ± 0.658
7.864AlaLeu: 7.864 ± 1.103
1.546AlaMet: 1.546 ± 0.371
3.63AlaAsn: 3.63 ± 0.556
2.285AlaPro: 2.285 ± 0.483
3.294AlaGln: 3.294 ± 1.037
1.68AlaArg: 1.68 ± 0.386
5.377AlaSer: 5.377 ± 0.799
3.563AlaThr: 3.563 ± 0.86
5.714AlaVal: 5.714 ± 0.7
0.471AlaTrp: 0.471 ± 0.274
3.226AlaTyr: 3.226 ± 0.559
0.471AlaXaa: 0.471 ± 0.184
Cys
0.202CysAla: 0.202 ± 0.155
0.0CysCys: 0.0 ± 0.0
0.403CysAsp: 0.403 ± 0.168
0.538CysGlu: 0.538 ± 0.23
0.134CysPhe: 0.134 ± 0.084
0.067CysGly: 0.067 ± 0.066
0.0CysHis: 0.0 ± 0.0
0.202CysIle: 0.202 ± 0.107
0.269CysLys: 0.269 ± 0.147
0.471CysLeu: 0.471 ± 0.164
0.067CysMet: 0.067 ± 0.063
0.202CysAsn: 0.202 ± 0.103
0.134CysPro: 0.134 ± 0.082
0.067CysGln: 0.067 ± 0.069
0.067CysArg: 0.067 ± 0.066
0.403CysSer: 0.403 ± 0.201
0.202CysThr: 0.202 ± 0.108
0.202CysVal: 0.202 ± 0.116
0.067CysTrp: 0.067 ± 0.06
0.067CysTyr: 0.067 ± 0.068
0.0CysXaa: 0.0 ± 0.0
Asp
2.554AspAla: 2.554 ± 0.39
0.336AspCys: 0.336 ± 0.163
2.823AspAsp: 2.823 ± 0.546
3.428AspGlu: 3.428 ± 0.707
2.353AspPhe: 2.353 ± 0.364
2.689AspGly: 2.689 ± 0.37
0.403AspHis: 0.403 ± 0.145
3.495AspIle: 3.495 ± 0.575
2.554AspLys: 2.554 ± 0.51
5.041AspLeu: 5.041 ± 0.568
1.075AspMet: 1.075 ± 0.28
1.949AspAsn: 1.949 ± 0.338
1.412AspPro: 1.412 ± 0.301
1.277AspGln: 1.277 ± 0.21
1.882AspArg: 1.882 ± 0.423
1.815AspSer: 1.815 ± 0.372
1.344AspThr: 1.344 ± 0.25
3.831AspVal: 3.831 ± 0.6
0.538AspTrp: 0.538 ± 0.175
2.218AspTyr: 2.218 ± 0.474
0.134AspXaa: 0.134 ± 0.092
Glu
4.84GluAla: 4.84 ± 0.737
0.067GluCys: 0.067 ± 0.067
3.092GluAsp: 3.092 ± 0.57
7.528GluGlu: 7.528 ± 1.71
2.823GluPhe: 2.823 ± 0.631
3.899GluGly: 3.899 ± 1.207
0.471GluHis: 0.471 ± 0.162
5.915GluIle: 5.915 ± 0.884
5.512GluLys: 5.512 ± 0.772
6.117GluLeu: 6.117 ± 0.745
1.748GluMet: 1.748 ± 0.399
3.697GluAsn: 3.697 ± 0.405
1.21GluPro: 1.21 ± 0.289
2.554GluGln: 2.554 ± 0.635
2.487GluArg: 2.487 ± 0.598
3.831GluSer: 3.831 ± 0.549
2.621GluThr: 2.621 ± 0.479
4.168GluVal: 4.168 ± 0.634
0.471GluTrp: 0.471 ± 0.246
3.294GluTyr: 3.294 ± 0.561
0.672GluXaa: 0.672 ± 0.378
Phe
3.294PheAla: 3.294 ± 0.605
0.134PheCys: 0.134 ± 0.143
2.353PheAsp: 2.353 ± 0.398
2.554PheGlu: 2.554 ± 0.43
2.017PhePhe: 2.017 ± 0.454
2.487PheGly: 2.487 ± 0.387
0.471PheHis: 0.471 ± 0.168
3.159PheIle: 3.159 ± 0.436
2.218PheLys: 2.218 ± 0.467
4.504PheLeu: 4.504 ± 0.726
1.075PheMet: 1.075 ± 0.291
2.554PheAsn: 2.554 ± 0.431
2.958PhePro: 2.958 ± 0.501
0.874PheGln: 0.874 ± 0.264
1.68PheArg: 1.68 ± 0.357
3.294PheSer: 3.294 ± 0.479
2.285PheThr: 2.285 ± 0.489
2.958PheVal: 2.958 ± 0.421
0.269PheTrp: 0.269 ± 0.161
3.294PheTyr: 3.294 ± 0.615
0.202PheXaa: 0.202 ± 0.118
Gly
2.218GlyAla: 2.218 ± 0.35
0.134GlyCys: 0.134 ± 0.089
2.285GlyAsp: 2.285 ± 0.336
4.705GlyGlu: 4.705 ± 1.491
2.756GlyPhe: 2.756 ± 0.513
4.033GlyGly: 4.033 ± 0.836
0.134GlyHis: 0.134 ± 0.091
5.176GlyIle: 5.176 ± 0.535
2.958GlyLys: 2.958 ± 0.582
4.369GlyLeu: 4.369 ± 0.551
0.874GlyMet: 0.874 ± 0.289
3.226GlyAsn: 3.226 ± 0.528
0.605GlyPro: 0.605 ± 0.231
2.487GlyGln: 2.487 ± 0.616
1.008GlyArg: 1.008 ± 0.276
3.831GlySer: 3.831 ± 0.698
4.1GlyThr: 4.1 ± 0.513
3.697GlyVal: 3.697 ± 0.546
0.471GlyTrp: 0.471 ± 0.183
2.151GlyTyr: 2.151 ± 0.349
0.538GlyXaa: 0.538 ± 0.173
His
0.403HisAla: 0.403 ± 0.148
0.0HisCys: 0.0 ± 0.0
0.605HisAsp: 0.605 ± 0.214
0.538HisGlu: 0.538 ± 0.195
0.403HisPhe: 0.403 ± 0.151
0.471HisGly: 0.471 ± 0.195
0.067HisHis: 0.067 ± 0.066
0.672HisIle: 0.672 ± 0.199
0.605HisLys: 0.605 ± 0.2
0.874HisLeu: 0.874 ± 0.182
0.067HisMet: 0.067 ± 0.069
0.538HisAsn: 0.538 ± 0.183
0.941HisPro: 0.941 ± 0.217
0.269HisGln: 0.269 ± 0.128
0.336HisArg: 0.336 ± 0.147
0.336HisSer: 0.336 ± 0.145
0.538HisThr: 0.538 ± 0.201
0.874HisVal: 0.874 ± 0.234
0.134HisTrp: 0.134 ± 0.097
0.538HisTyr: 0.538 ± 0.18
0.0HisXaa: 0.0 ± 0.0
Ile
5.915IleAla: 5.915 ± 0.772
0.605IleCys: 0.605 ± 0.214
3.831IleAsp: 3.831 ± 0.576
4.705IleGlu: 4.705 ± 0.714
3.092IlePhe: 3.092 ± 0.529
3.294IleGly: 3.294 ± 0.633
0.739IleHis: 0.739 ± 0.235
5.377IleIle: 5.377 ± 0.916
4.235IleLys: 4.235 ± 0.759
7.192IleLeu: 7.192 ± 1.064
2.42IleMet: 2.42 ± 0.488
5.848IleAsn: 5.848 ± 0.942
3.563IlePro: 3.563 ± 0.562
3.226IleGln: 3.226 ± 0.693
2.689IleArg: 2.689 ± 0.44
6.722IleSer: 6.722 ± 0.678
4.235IleThr: 4.235 ± 0.657
4.974IleVal: 4.974 ± 0.609
0.538IleTrp: 0.538 ± 0.192
4.1IleTyr: 4.1 ± 0.657
0.471IleXaa: 0.471 ± 0.215
Lys
3.831LysAla: 3.831 ± 0.532
0.403LysCys: 0.403 ± 0.172
3.092LysAsp: 3.092 ± 0.621
5.445LysGlu: 5.445 ± 0.82
2.689LysPhe: 2.689 ± 0.406
2.823LysGly: 2.823 ± 0.52
0.739LysHis: 0.739 ± 0.2
5.176LysIle: 5.176 ± 0.935
4.504LysLys: 4.504 ± 0.836
6.991LysLeu: 6.991 ± 0.994
1.479LysMet: 1.479 ± 0.304
3.899LysAsn: 3.899 ± 0.671
2.487LysPro: 2.487 ± 0.385
2.621LysGln: 2.621 ± 0.54
3.159LysArg: 3.159 ± 0.572
3.495LysSer: 3.495 ± 0.644
2.756LysThr: 2.756 ± 0.361
4.907LysVal: 4.907 ± 0.658
0.269LysTrp: 0.269 ± 0.137
3.428LysTyr: 3.428 ± 0.528
0.471LysXaa: 0.471 ± 0.228
Leu
6.386LeuAla: 6.386 ± 0.944
0.336LeuCys: 0.336 ± 0.154
3.697LeuAsp: 3.697 ± 0.52
6.52LeuGlu: 6.52 ± 0.931
4.369LeuPhe: 4.369 ± 0.475
4.772LeuGly: 4.772 ± 0.683
1.277LeuHis: 1.277 ± 0.324
6.318LeuIle: 6.318 ± 0.704
9.209LeuLys: 9.209 ± 1.292
10.688LeuLeu: 10.688 ± 0.891
1.613LeuMet: 1.613 ± 0.298
4.638LeuAsn: 4.638 ± 0.785
4.772LeuPro: 4.772 ± 0.694
6.453LeuGln: 6.453 ± 1.622
3.63LeuArg: 3.63 ± 0.621
7.327LeuSer: 7.327 ± 0.807
6.453LeuThr: 6.453 ± 0.666
6.318LeuVal: 6.318 ± 0.688
0.941LeuTrp: 0.941 ± 0.274
4.302LeuTyr: 4.302 ± 0.774
0.739LeuXaa: 0.739 ± 0.242
Met
1.344MetAla: 1.344 ± 0.331
0.067MetCys: 0.067 ± 0.067
1.143MetAsp: 1.143 ± 0.343
0.739MetGlu: 0.739 ± 0.279
1.075MetPhe: 1.075 ± 0.307
1.143MetGly: 1.143 ± 0.221
0.202MetHis: 0.202 ± 0.11
1.613MetIle: 1.613 ± 0.345
2.151MetLys: 2.151 ± 0.485
2.084MetLeu: 2.084 ± 0.417
0.471MetMet: 0.471 ± 0.191
1.277MetAsn: 1.277 ± 0.307
0.941MetPro: 0.941 ± 0.255
1.21MetGln: 1.21 ± 0.257
0.672MetArg: 0.672 ± 0.235
1.613MetSer: 1.613 ± 0.283
1.277MetThr: 1.277 ± 0.29
1.143MetVal: 1.143 ± 0.28
0.134MetTrp: 0.134 ± 0.096
0.672MetTyr: 0.672 ± 0.197
0.269MetXaa: 0.269 ± 0.129
Asn
3.831AsnAla: 3.831 ± 0.565
0.202AsnCys: 0.202 ± 0.152
2.554AsnAsp: 2.554 ± 0.42
3.899AsnGlu: 3.899 ± 0.542
2.151AsnPhe: 2.151 ± 0.399
4.571AsnGly: 4.571 ± 0.75
0.336AsnHis: 0.336 ± 0.109
4.772AsnIle: 4.772 ± 0.495
3.831AsnLys: 3.831 ± 0.738
5.445AsnLeu: 5.445 ± 0.591
1.075AsnMet: 1.075 ± 0.302
3.764AsnAsn: 3.764 ± 0.591
3.092AsnPro: 3.092 ± 0.629
1.882AsnGln: 1.882 ± 0.441
1.546AsnArg: 1.546 ± 0.361
4.571AsnSer: 4.571 ± 0.801
4.033AsnThr: 4.033 ± 0.605
4.638AsnVal: 4.638 ± 0.971
0.739AsnTrp: 0.739 ± 0.188
3.63AsnTyr: 3.63 ± 0.555
0.269AsnXaa: 0.269 ± 0.14
Pro
2.017ProAla: 2.017 ± 0.318
0.067ProCys: 0.067 ± 0.073
2.084ProAsp: 2.084 ± 0.417
3.428ProGlu: 3.428 ± 0.505
2.151ProPhe: 2.151 ± 0.588
1.412ProGly: 1.412 ± 0.246
0.134ProHis: 0.134 ± 0.086
2.487ProIle: 2.487 ± 0.356
1.882ProLys: 1.882 ± 0.337
4.1ProLeu: 4.1 ± 0.479
0.874ProMet: 0.874 ± 0.327
2.689ProAsn: 2.689 ± 0.811
2.42ProPro: 2.42 ± 0.48
2.756ProGln: 2.756 ± 0.425
1.479ProArg: 1.479 ± 0.389
3.495ProSer: 3.495 ± 0.639
2.285ProThr: 2.285 ± 0.469
3.361ProVal: 3.361 ± 0.591
0.605ProTrp: 0.605 ± 0.306
2.353ProTyr: 2.353 ± 0.494
0.336ProXaa: 0.336 ± 0.181
Gln
3.697GlnAla: 3.697 ± 1.082
0.134GlnCys: 0.134 ± 0.098
0.941GlnAsp: 0.941 ± 0.219
2.89GlnGlu: 2.89 ± 0.628
1.68GlnPhe: 1.68 ± 0.357
2.487GlnGly: 2.487 ± 0.659
0.134GlnHis: 0.134 ± 0.084
3.764GlnIle: 3.764 ± 0.753
2.151GlnLys: 2.151 ± 0.423
4.772GlnLeu: 4.772 ± 0.734
0.739GlnMet: 0.739 ± 0.196
2.958GlnAsn: 2.958 ± 0.747
1.748GlnPro: 1.748 ± 0.368
4.436GlnGln: 4.436 ± 1.495
1.479GlnArg: 1.479 ± 0.353
3.159GlnSer: 3.159 ± 0.768
2.084GlnThr: 2.084 ± 0.418
2.823GlnVal: 2.823 ± 0.475
0.202GlnTrp: 0.202 ± 0.114
3.764GlnTyr: 3.764 ± 0.725
0.471GlnXaa: 0.471 ± 0.183
Arg
1.277ArgAla: 1.277 ± 0.319
0.067ArgCys: 0.067 ± 0.066
1.479ArgAsp: 1.479 ± 0.349
2.487ArgGlu: 2.487 ± 0.45
1.479ArgPhe: 1.479 ± 0.355
1.68ArgGly: 1.68 ± 0.438
0.336ArgHis: 0.336 ± 0.167
3.563ArgIle: 3.563 ± 0.671
3.764ArgLys: 3.764 ± 0.613
3.092ArgLeu: 3.092 ± 0.521
0.672ArgMet: 0.672 ± 0.232
1.748ArgAsn: 1.748 ± 0.319
0.874ArgPro: 0.874 ± 0.213
0.807ArgGln: 0.807 ± 0.229
1.815ArgArg: 1.815 ± 0.464
1.748ArgSer: 1.748 ± 0.418
1.479ArgThr: 1.479 ± 0.349
1.815ArgVal: 1.815 ± 0.31
0.471ArgTrp: 0.471 ± 0.193
2.151ArgTyr: 2.151 ± 0.38
0.403ArgXaa: 0.403 ± 0.209
Ser
3.63SerAla: 3.63 ± 0.539
0.067SerCys: 0.067 ± 0.066
2.487SerAsp: 2.487 ± 0.486
5.646SerGlu: 5.646 ± 0.787
3.63SerPhe: 3.63 ± 0.639
3.63SerGly: 3.63 ± 0.716
0.672SerHis: 0.672 ± 0.232
6.117SerIle: 6.117 ± 0.786
3.159SerLys: 3.159 ± 0.581
7.327SerLeu: 7.327 ± 0.789
1.21SerMet: 1.21 ± 0.231
4.571SerAsn: 4.571 ± 0.718
3.831SerPro: 3.831 ± 0.816
4.168SerGln: 4.168 ± 0.79
2.151SerArg: 2.151 ± 0.472
7.932SerSer: 7.932 ± 1.834
4.705SerThr: 4.705 ± 1.074
4.705SerVal: 4.705 ± 0.966
0.269SerTrp: 0.269 ± 0.134
4.168SerTyr: 4.168 ± 0.55
0.874SerXaa: 0.874 ± 0.403
Thr
4.705ThrAla: 4.705 ± 0.735
0.134ThrCys: 0.134 ± 0.085
2.151ThrAsp: 2.151 ± 0.278
2.218ThrGlu: 2.218 ± 0.36
2.353ThrPhe: 2.353 ± 0.394
3.361ThrGly: 3.361 ± 0.482
0.471ThrHis: 0.471 ± 0.184
5.243ThrIle: 5.243 ± 0.563
2.554ThrLys: 2.554 ± 0.502
5.176ThrLeu: 5.176 ± 0.503
1.075ThrMet: 1.075 ± 0.269
3.092ThrAsn: 3.092 ± 0.758
3.563ThrPro: 3.563 ± 0.676
2.823ThrGln: 2.823 ± 0.359
1.143ThrArg: 1.143 ± 0.297
4.638ThrSer: 4.638 ± 1.044
4.369ThrThr: 4.369 ± 0.94
5.646ThrVal: 5.646 ± 0.963
0.403ThrTrp: 0.403 ± 0.146
2.151ThrTyr: 2.151 ± 0.379
0.403ThrXaa: 0.403 ± 0.169
Val
4.571ValAla: 4.571 ± 0.673
0.471ValCys: 0.471 ± 0.205
2.487ValAsp: 2.487 ± 0.411
2.958ValGlu: 2.958 ± 0.496
3.092ValPhe: 3.092 ± 0.461
3.294ValGly: 3.294 ± 0.529
0.807ValHis: 0.807 ± 0.195
5.041ValIle: 5.041 ± 0.55
5.377ValLys: 5.377 ± 0.643
7.394ValLeu: 7.394 ± 0.639
1.479ValMet: 1.479 ± 0.305
5.579ValAsn: 5.579 ± 0.854
2.487ValPro: 2.487 ± 0.405
2.823ValGln: 2.823 ± 0.502
1.882ValArg: 1.882 ± 0.366
5.646ValSer: 5.646 ± 0.974
5.848ValThr: 5.848 ± 1.129
5.377ValVal: 5.377 ± 0.603
0.672ValTrp: 0.672 ± 0.241
3.899ValTyr: 3.899 ± 0.563
0.336ValXaa: 0.336 ± 0.179
Trp
0.471TrpAla: 0.471 ± 0.155
0.134TrpCys: 0.134 ± 0.121
0.403TrpAsp: 0.403 ± 0.17
0.336TrpGlu: 0.336 ± 0.14
0.403TrpPhe: 0.403 ± 0.165
0.336TrpGly: 0.336 ± 0.148
0.336TrpHis: 0.336 ± 0.182
0.739TrpIle: 0.739 ± 0.243
0.538TrpLys: 0.538 ± 0.199
1.008TrpLeu: 1.008 ± 0.255
0.403TrpMet: 0.403 ± 0.169
0.336TrpAsn: 0.336 ± 0.161
0.134TrpPro: 0.134 ± 0.094
0.336TrpGln: 0.336 ± 0.175
0.269TrpArg: 0.269 ± 0.14
0.605TrpSer: 0.605 ± 0.23
0.269TrpThr: 0.269 ± 0.134
0.739TrpVal: 0.739 ± 0.247
0.067TrpTrp: 0.067 ± 0.056
0.471TrpTyr: 0.471 ± 0.17
0.269TrpXaa: 0.269 ± 0.154
Tyr
2.42TyrAla: 2.42 ± 0.316
0.202TyrCys: 0.202 ± 0.127
2.621TyrAsp: 2.621 ± 0.438
2.487TyrGlu: 2.487 ± 0.441
3.563TyrPhe: 3.563 ± 0.464
2.621TyrGly: 2.621 ± 0.436
0.941TyrHis: 0.941 ± 0.329
4.168TyrIle: 4.168 ± 0.646
2.554TyrLys: 2.554 ± 0.525
5.512TyrLeu: 5.512 ± 0.623
0.941TyrMet: 0.941 ± 0.302
4.1TyrAsn: 4.1 ± 0.611
2.823TyrPro: 2.823 ± 0.472
1.68TyrGln: 1.68 ± 0.469
2.017TyrArg: 2.017 ± 0.425
4.369TyrSer: 4.369 ± 0.683
2.958TyrThr: 2.958 ± 0.376
3.226TyrVal: 3.226 ± 0.538
0.807TyrTrp: 0.807 ± 0.289
2.756TyrTyr: 2.756 ± 0.437
0.134TyrXaa: 0.134 ± 0.091
Xaa
0.471XaaAla: 0.471 ± 0.227
0.0XaaCys: 0.0 ± 0.0
0.471XaaAsp: 0.471 ± 0.3
0.538XaaGlu: 0.538 ± 0.401
0.202XaaPhe: 0.202 ± 0.14
0.538XaaGly: 0.538 ± 0.315
0.067XaaHis: 0.067 ± 0.077
0.538XaaIle: 0.538 ± 0.21
0.605XaaLys: 0.605 ± 0.342
0.739XaaLeu: 0.739 ± 0.204
0.269XaaMet: 0.269 ± 0.167
0.538XaaAsn: 0.538 ± 0.15
0.134XaaPro: 0.134 ± 0.111
0.471XaaGln: 0.471 ± 0.172
0.134XaaArg: 0.134 ± 0.102
0.739XaaSer: 0.739 ± 0.302
0.269XaaThr: 0.269 ± 0.145
0.403XaaVal: 0.403 ± 0.206
0.067XaaTrp: 0.067 ± 0.073
0.269XaaTyr: 0.269 ± 0.174
1.882XaaXaa: 1.882 ± 0.624
Statistics based on 65 proteins (14878 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski