Amino acid dipepetide frequency for Alkaliphilus pronyensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.424AlaAla: 4.424 ± 0.098	0.62AlaCys: 0.62 ± 0.03	2.697AlaAsp: 2.697 ± 0.057	3.889AlaGlu: 3.889 ± 0.067	2.613AlaPhe: 2.613 ± 0.06	4.044AlaGly: 4.044 ± 0.079	0.914AlaHis: 0.914 ± 0.037	6.555AlaIle: 6.555 ± 0.098	4.476AlaLys: 4.476 ± 0.078	6.528AlaLeu: 6.528 ± 0.096	1.709AlaMet: 1.709 ± 0.046	2.79AlaAsn: 2.79 ± 0.055	1.536AlaPro: 1.536 ± 0.045	1.562AlaGln: 1.562 ± 0.046	2.099AlaArg: 2.099 ± 0.053	3.579AlaSer: 3.579 ± 0.069	3.302AlaThr: 3.302 ± 0.068	4.486AlaVal: 4.486 ± 0.092	0.376AlaTrp: 0.376 ± 0.021	2.184AlaTyr: 2.184 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.395CysAla: 0.395 ± 0.022	0.14CysCys: 0.14 ± 0.015	0.502CysAsp: 0.502 ± 0.025	0.478CysGlu: 0.478 ± 0.024	0.436CysPhe: 0.436 ± 0.021	0.964CysGly: 0.964 ± 0.04	0.22CysHis: 0.22 ± 0.017	0.884CysIle: 0.884 ± 0.034	0.745CysLys: 0.745 ± 0.032	0.715CysLeu: 0.715 ± 0.027	0.222CysMet: 0.222 ± 0.016	0.618CysAsn: 0.618 ± 0.028	0.431CysPro: 0.431 ± 0.025	0.283CysGln: 0.283 ± 0.018	0.391CysArg: 0.391 ± 0.025	0.695CysSer: 0.695 ± 0.032	0.409CysThr: 0.409 ± 0.022	0.531CysVal: 0.531 ± 0.025	0.089CysTrp: 0.089 ± 0.01	0.364CysTyr: 0.364 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.597AspAla: 2.597 ± 0.065	0.518AspCys: 0.518 ± 0.026	2.469AspAsp: 2.469 ± 0.069	4.21AspGlu: 4.21 ± 0.071	2.698AspPhe: 2.698 ± 0.069	3.214AspGly: 3.214 ± 0.074	0.732AspHis: 0.732 ± 0.031	6.109AspIle: 6.109 ± 0.094	4.408AspLys: 4.408 ± 0.068	4.867AspLeu: 4.867 ± 0.08	1.444AspMet: 1.444 ± 0.045	2.895AspAsn: 2.895 ± 0.062	1.477AspPro: 1.477 ± 0.04	1.038AspGln: 1.038 ± 0.039	1.947AspArg: 1.947 ± 0.047	2.867AspSer: 2.867 ± 0.057	2.57AspThr: 2.57 ± 0.058	3.47AspVal: 3.47 ± 0.068	0.432AspTrp: 0.432 ± 0.023	2.615AspTyr: 2.615 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	5.853GluAla: 5.853 ± 0.095	0.49GluCys: 0.49 ± 0.027	4.304GluAsp: 4.304 ± 0.076	7.655GluGlu: 7.655 ± 0.125	2.567GluPhe: 2.567 ± 0.058	4.855GluGly: 4.855 ± 0.086	0.943GluHis: 0.943 ± 0.036	7.409GluIle: 7.409 ± 0.093	6.969GluLys: 6.969 ± 0.087	7.05GluLeu: 7.05 ± 0.095	2.213GluMet: 2.213 ± 0.05	4.068GluAsn: 4.068 ± 0.077	1.63GluPro: 1.63 ± 0.05	1.49GluGln: 1.49 ± 0.047	2.817GluArg: 2.817 ± 0.056	3.212GluSer: 3.212 ± 0.056	3.055GluThr: 3.055 ± 0.061	5.643GluVal: 5.643 ± 0.091	0.525GluTrp: 0.525 ± 0.027	2.79GluTyr: 2.79 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.163PheAla: 2.163 ± 0.054	0.437PheCys: 0.437 ± 0.025	2.138PheAsp: 2.138 ± 0.06	2.392PheGlu: 2.392 ± 0.055	1.954PhePhe: 1.954 ± 0.052	2.635PheGly: 2.635 ± 0.068	0.652PheHis: 0.652 ± 0.028	4.233PheIle: 4.233 ± 0.08	3.197PheLys: 3.197 ± 0.066	3.848PheLeu: 3.848 ± 0.092	1.094PheMet: 1.094 ± 0.042	2.752PheAsn: 2.752 ± 0.061	1.302PhePro: 1.302 ± 0.042	1.176PheGln: 1.176 ± 0.035	1.292PheArg: 1.292 ± 0.043	2.918PheSer: 2.918 ± 0.066	2.509PheThr: 2.509 ± 0.056	2.552PheVal: 2.552 ± 0.055	0.323PheTrp: 0.323 ± 0.02	1.709PheTyr: 1.709 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.098GlyAla: 4.098 ± 0.077	0.815GlyCys: 0.815 ± 0.033	3.286GlyAsp: 3.286 ± 0.074	4.55GlyGlu: 4.55 ± 0.074	3.301GlyPhe: 3.301 ± 0.066	4.663GlyGly: 4.663 ± 0.077	1.17GlyHis: 1.17 ± 0.04	6.599GlyIle: 6.599 ± 0.101	5.215GlyLys: 5.215 ± 0.083	6.33GlyLeu: 6.33 ± 0.094	1.809GlyMet: 1.809 ± 0.05	3.186GlyAsn: 3.186 ± 0.078	1.378GlyPro: 1.378 ± 0.041	1.614GlyGln: 1.614 ± 0.042	2.507GlyArg: 2.507 ± 0.059	3.585GlySer: 3.585 ± 0.065	3.409GlyThr: 3.409 ± 0.072	4.823GlyVal: 4.823 ± 0.073	0.541GlyTrp: 0.541 ± 0.024	3.128GlyTyr: 3.128 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.749HisAla: 0.749 ± 0.031	0.209HisCys: 0.209 ± 0.015	0.74HisAsp: 0.74 ± 0.032	1.021HisGlu: 1.021 ± 0.036	0.753HisPhe: 0.753 ± 0.028	1.105HisGly: 1.105 ± 0.043	0.426HisHis: 0.426 ± 0.025	1.561HisIle: 1.561 ± 0.037	1.235HisLys: 1.235 ± 0.033	1.509HisLeu: 1.509 ± 0.046	0.446HisMet: 0.446 ± 0.023	0.907HisAsn: 0.907 ± 0.033	0.736HisPro: 0.736 ± 0.032	0.663HisGln: 0.663 ± 0.027	0.753HisArg: 0.753 ± 0.03	1.061HisSer: 1.061 ± 0.038	0.797HisThr: 0.797 ± 0.036	0.903HisVal: 0.903 ± 0.031	0.162HisTrp: 0.162 ± 0.014	0.697HisTyr: 0.697 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.346IleAla: 6.346 ± 0.095	0.956IleCys: 0.956 ± 0.035	6.03IleAsp: 6.03 ± 0.102	7.629IleGlu: 7.629 ± 0.117	3.646IlePhe: 3.646 ± 0.071	6.582IleGly: 6.582 ± 0.109	1.587IleHis: 1.587 ± 0.043	9.758IleIle: 9.758 ± 0.131	7.974IleLys: 7.974 ± 0.1	8.531IleLeu: 8.531 ± 0.118	2.286IleMet: 2.286 ± 0.052	5.759IleAsn: 5.759 ± 0.085	3.547IlePro: 3.547 ± 0.063	2.582IleGln: 2.582 ± 0.053	3.322IleArg: 3.322 ± 0.063	6.399IleSer: 6.399 ± 0.095	5.304IleThr: 5.304 ± 0.077	6.34IleVal: 6.34 ± 0.083	0.562IleTrp: 0.562 ± 0.026	3.528IleTyr: 3.528 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	5.224LysAla: 5.224 ± 0.088	0.602LysCys: 0.602 ± 0.027	4.927LysAsp: 4.927 ± 0.075	8.096LysGlu: 8.096 ± 0.106	2.033LysPhe: 2.033 ± 0.046	5.381LysGly: 5.381 ± 0.082	1.395LysHis: 1.395 ± 0.043	6.889LysIle: 6.889 ± 0.093	7.145LysLys: 7.145 ± 0.105	7.452LysLeu: 7.452 ± 0.109	2.124LysMet: 2.124 ± 0.045	4.81LysAsn: 4.81 ± 0.085	2.264LysPro: 2.264 ± 0.055	2.461LysGln: 2.461 ± 0.059	3.377LysArg: 3.377 ± 0.065	4.451LysSer: 4.451 ± 0.075	4.005LysThr: 4.005 ± 0.068	5.061LysVal: 5.061 ± 0.083	0.56LysTrp: 0.56 ± 0.025	3.259LysTyr: 3.259 ± 0.065	0.0LysXaa: 0.0 ± 0.0
Leu	5.961LeuAla: 5.961 ± 0.105	0.889LeuCys: 0.889 ± 0.032	4.916LeuAsp: 4.916 ± 0.073	6.999LeuGlu: 6.999 ± 0.099	3.985LeuPhe: 3.985 ± 0.091	6.128LeuGly: 6.128 ± 0.104	1.44LeuHis: 1.44 ± 0.043	8.55LeuIle: 8.55 ± 0.116	8.413LeuLys: 8.413 ± 0.109	9.589LeuLeu: 9.589 ± 0.131	2.652LeuMet: 2.652 ± 0.066	5.271LeuAsn: 5.271 ± 0.081	3.23LeuPro: 3.23 ± 0.069	3.045LeuGln: 3.045 ± 0.059	3.504LeuArg: 3.504 ± 0.068	6.543LeuSer: 6.543 ± 0.1	4.873LeuThr: 4.873 ± 0.091	5.777LeuVal: 5.777 ± 0.091	0.617LeuTrp: 0.617 ± 0.025	3.276LeuTyr: 3.276 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.921MetAla: 1.921 ± 0.05	0.2MetCys: 0.2 ± 0.016	1.474MetAsp: 1.474 ± 0.04	2.226MetGlu: 2.226 ± 0.052	0.87MetPhe: 0.87 ± 0.032	1.963MetGly: 1.963 ± 0.054	0.302MetHis: 0.302 ± 0.023	2.244MetIle: 2.244 ± 0.054	2.376MetLys: 2.376 ± 0.057	2.549MetLeu: 2.549 ± 0.06	0.744MetMet: 0.744 ± 0.032	1.433MetAsn: 1.433 ± 0.041	0.847MetPro: 0.847 ± 0.035	0.667MetGln: 0.667 ± 0.027	0.96MetArg: 0.96 ± 0.034	1.459MetSer: 1.459 ± 0.041	1.324MetThr: 1.324 ± 0.044	1.801MetVal: 1.801 ± 0.046	0.125MetTrp: 0.125 ± 0.011	0.776MetTyr: 0.776 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.582AsnAla: 2.582 ± 0.057	0.541AsnCys: 0.541 ± 0.029	2.52AsnAsp: 2.52 ± 0.059	3.945AsnGlu: 3.945 ± 0.072	1.718AsnPhe: 1.718 ± 0.043	3.277AsnGly: 3.277 ± 0.078	1.041AsnHis: 1.041 ± 0.037	6.03AsnIle: 6.03 ± 0.082	4.737AsnLys: 4.737 ± 0.086	4.856AsnLeu: 4.856 ± 0.075	1.425AsnMet: 1.425 ± 0.04	3.686AsnAsn: 3.686 ± 0.082	2.199AsnPro: 2.199 ± 0.051	2.028AsnGln: 2.028 ± 0.043	2.466AsnArg: 2.466 ± 0.048	3.556AsnSer: 3.556 ± 0.072	2.951AsnThr: 2.951 ± 0.062	3.048AsnVal: 3.048 ± 0.062	0.479AsnTrp: 0.479 ± 0.025	2.446AsnTyr: 2.446 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	1.687ProAla: 1.687 ± 0.046	0.294ProCys: 0.294 ± 0.019	1.606ProAsp: 1.606 ± 0.045	2.283ProGlu: 2.283 ± 0.063	1.454ProPhe: 1.454 ± 0.039	1.809ProGly: 1.809 ± 0.045	0.636ProHis: 0.636 ± 0.024	3.123ProIle: 3.123 ± 0.065	2.267ProLys: 2.267 ± 0.055	2.9ProLeu: 2.9 ± 0.064	0.766ProMet: 0.766 ± 0.027	1.56ProAsn: 1.56 ± 0.041	0.895ProPro: 0.895 ± 0.04	1.124ProGln: 1.124 ± 0.037	0.957ProArg: 0.957 ± 0.034	1.84ProSer: 1.84 ± 0.046	1.71ProThr: 1.71 ± 0.04	2.349ProVal: 2.349 ± 0.054	0.241ProTrp: 0.241 ± 0.015	1.37ProTyr: 1.37 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.659GlnAla: 1.659 ± 0.041	0.254GlnCys: 0.254 ± 0.02	1.315GlnAsp: 1.315 ± 0.04	2.256GlnGlu: 2.256 ± 0.052	1.04GlnPhe: 1.04 ± 0.032	1.639GlnGly: 1.639 ± 0.046	0.54GlnHis: 0.54 ± 0.023	2.351GlnIle: 2.351 ± 0.056	2.159GlnLys: 2.159 ± 0.053	3.428GlnLeu: 3.428 ± 0.062	0.805GlnMet: 0.805 ± 0.032	1.382GlnAsn: 1.382 ± 0.043	0.847GlnPro: 0.847 ± 0.032	1.359GlnGln: 1.359 ± 0.053	1.249GlnArg: 1.249 ± 0.039	1.517GlnSer: 1.517 ± 0.044	1.16GlnThr: 1.16 ± 0.04	1.806GlnVal: 1.806 ± 0.047	0.3GlnTrp: 0.3 ± 0.022	1.292GlnTyr: 1.292 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	2.121ArgAla: 2.121 ± 0.049	0.367ArgCys: 0.367 ± 0.02	2.032ArgAsp: 2.032 ± 0.052	2.982ArgGlu: 2.982 ± 0.067	1.635ArgPhe: 1.635 ± 0.047	2.506ArgGly: 2.506 ± 0.06	0.644ArgHis: 0.644 ± 0.027	3.625ArgIle: 3.625 ± 0.062	2.877ArgLys: 2.877 ± 0.057	3.899ArgLeu: 3.899 ± 0.077	1.064ArgMet: 1.064 ± 0.04	1.999ArgAsn: 1.999 ± 0.042	1.021ArgPro: 1.021 ± 0.034	1.199ArgGln: 1.199 ± 0.034	1.853ArgArg: 1.853 ± 0.05	1.851ArgSer: 1.851 ± 0.05	1.575ArgThr: 1.575 ± 0.041	2.876ArgVal: 2.876 ± 0.059	0.291ArgTrp: 0.291 ± 0.019	1.518ArgTyr: 1.518 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	2.791SerAla: 2.791 ± 0.064	0.586SerCys: 0.586 ± 0.024	2.649SerAsp: 2.649 ± 0.06	3.458SerGlu: 3.458 ± 0.072	3.255SerPhe: 3.255 ± 0.07	3.761SerGly: 3.761 ± 0.076	1.107SerHis: 1.107 ± 0.038	6.629SerIle: 6.629 ± 0.102	5.009SerLys: 5.009 ± 0.085	6.147SerLeu: 6.147 ± 0.09	1.515SerMet: 1.515 ± 0.042	3.547SerAsn: 3.547 ± 0.071	1.846SerPro: 1.846 ± 0.043	1.797SerGln: 1.797 ± 0.049	2.268SerArg: 2.268 ± 0.051	3.898SerSer: 3.898 ± 0.076	3.004SerThr: 3.004 ± 0.06	3.481SerVal: 3.481 ± 0.065	0.434SerTrp: 0.434 ± 0.025	2.467SerTyr: 2.467 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.294ThrAla: 3.294 ± 0.067	0.41ThrCys: 0.41 ± 0.019	2.607ThrAsp: 2.607 ± 0.06	3.316ThrGlu: 3.316 ± 0.06	2.068ThrPhe: 2.068 ± 0.047	3.92ThrGly: 3.92 ± 0.078	0.915ThrHis: 0.915 ± 0.029	5.263ThrIle: 5.263 ± 0.082	3.44ThrLys: 3.44 ± 0.068	4.759ThrLeu: 4.759 ± 0.086	1.171ThrMet: 1.171 ± 0.037	2.477ThrAsn: 2.477 ± 0.061	2.017ThrPro: 2.017 ± 0.048	1.312ThrGln: 1.312 ± 0.038	1.771ThrArg: 1.771 ± 0.048	3.1ThrSer: 3.1 ± 0.061	3.036ThrThr: 3.036 ± 0.073	3.552ThrVal: 3.552 ± 0.067	0.351ThrTrp: 0.351 ± 0.022	1.968ThrTyr: 1.968 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.368ValAla: 4.368 ± 0.083	0.606ValCys: 0.606 ± 0.025	3.785ValAsp: 3.785 ± 0.072	5.077ValGlu: 5.077 ± 0.077	3.081ValPhe: 3.081 ± 0.07	4.263ValGly: 4.263 ± 0.08	0.872ValHis: 0.872 ± 0.034	6.454ValIle: 6.454 ± 0.088	5.406ValLys: 5.406 ± 0.086	6.307ValLeu: 6.307 ± 0.088	1.6ValMet: 1.6 ± 0.038	3.508ValAsn: 3.508 ± 0.065	2.137ValPro: 2.137 ± 0.052	1.386ValGln: 1.386 ± 0.039	2.224ValArg: 2.224 ± 0.058	3.914ValSer: 3.914 ± 0.073	3.456ValThr: 3.456 ± 0.078	4.727ValVal: 4.727 ± 0.093	0.408ValTrp: 0.408 ± 0.024	2.353ValTyr: 2.353 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.368TrpAla: 0.368 ± 0.023	0.069TrpCys: 0.069 ± 0.009	0.383TrpAsp: 0.383 ± 0.024	0.425TrpGlu: 0.425 ± 0.023	0.338TrpPhe: 0.338 ± 0.022	0.585TrpGly: 0.585 ± 0.03	0.149TrpHis: 0.149 ± 0.013	0.652TrpIle: 0.652 ± 0.027	0.512TrpLys: 0.512 ± 0.024	0.692TrpLeu: 0.692 ± 0.032	0.2TrpMet: 0.2 ± 0.016	0.4TrpAsn: 0.4 ± 0.019	0.178TrpPro: 0.178 ± 0.016	0.269TrpGln: 0.269 ± 0.015	0.362TrpArg: 0.362 ± 0.021	0.492TrpSer: 0.492 ± 0.03	0.339TrpThr: 0.339 ± 0.02	0.457TrpVal: 0.457 ± 0.023	0.099TrpTrp: 0.099 ± 0.01	0.293TrpTyr: 0.293 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.78TyrAla: 1.78 ± 0.046	0.509TyrCys: 0.509 ± 0.027	2.2TyrAsp: 2.2 ± 0.096	2.649TyrGlu: 2.649 ± 0.055	1.832TyrPhe: 1.832 ± 0.051	2.715TyrGly: 2.715 ± 0.054	0.746TyrHis: 0.746 ± 0.026	3.75TyrIle: 3.75 ± 0.068	2.958TyrLys: 2.958 ± 0.058	3.7TyrLeu: 3.7 ± 0.066	0.971TyrMet: 0.971 ± 0.035	2.483TyrAsn: 2.483 ± 0.047	1.354TyrPro: 1.354 ± 0.039	1.305TyrGln: 1.305 ± 0.042	1.814TyrArg: 1.814 ± 0.056	2.712TyrSer: 2.712 ± 0.059	1.96TyrThr: 1.96 ± 0.056	2.248TyrVal: 2.248 ± 0.054	0.346TyrTrp: 0.346 ± 0.022	1.855TyrTyr: 1.855 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2908 proteins (869982 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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