Amino acid dipepetide frequency for Shigella dysenteriae serotype 1 (strain Sd197)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.439AlaAla: 9.439 ± 0.141	1.122AlaCys: 1.122 ± 0.036	4.897AlaAsp: 4.897 ± 0.077	5.875AlaGlu: 5.875 ± 0.087	3.496AlaPhe: 3.496 ± 0.049	7.115AlaGly: 7.115 ± 0.097	1.872AlaHis: 1.872 ± 0.041	5.662AlaIle: 5.662 ± 0.081	4.112AlaLys: 4.112 ± 0.075	11.111AlaLeu: 11.111 ± 0.107	2.991AlaMet: 2.991 ± 0.056	3.066AlaAsn: 3.066 ± 0.055	3.527AlaPro: 3.527 ± 0.072	4.283AlaGln: 4.283 ± 0.072	5.597AlaArg: 5.597 ± 0.068	5.115AlaSer: 5.115 ± 0.077	4.673AlaThr: 4.673 ± 0.068	6.684AlaVal: 6.684 ± 0.079	1.495AlaTrp: 1.495 ± 0.04	2.059AlaTyr: 2.059 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.017CysAla: 1.017 ± 0.029	0.243CysCys: 0.243 ± 0.015	0.627CysAsp: 0.627 ± 0.028	0.737CysGlu: 0.737 ± 0.028	0.525CysPhe: 0.525 ± 0.022	1.132CysGly: 1.132 ± 0.031	0.344CysHis: 0.344 ± 0.018	0.563CysIle: 0.563 ± 0.022	0.402CysLys: 0.402 ± 0.019	1.068CysLeu: 1.068 ± 0.032	0.253CysMet: 0.253 ± 0.017	0.357CysAsn: 0.357 ± 0.017	0.571CysPro: 0.571 ± 0.025	0.532CysGln: 0.532 ± 0.021	0.836CysArg: 0.836 ± 0.028	0.769CysSer: 0.769 ± 0.028	0.529CysThr: 0.529 ± 0.023	0.754CysVal: 0.754 ± 0.024	0.212CysTrp: 0.212 ± 0.013	0.44CysTyr: 0.44 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.925AspAla: 4.925 ± 0.07	0.558AspCys: 0.558 ± 0.021	2.929AspAsp: 2.929 ± 0.062	3.708AspGlu: 3.708 ± 0.064	2.035AspPhe: 2.035 ± 0.046	3.702AspGly: 3.702 ± 0.066	0.933AspHis: 0.933 ± 0.031	3.369AspIle: 3.369 ± 0.062	2.639AspLys: 2.639 ± 0.048	4.666AspLeu: 4.666 ± 0.067	1.285AspMet: 1.285 ± 0.037	2.261AspAsn: 2.261 ± 0.049	2.097AspPro: 2.097 ± 0.047	1.565AspGln: 1.565 ± 0.043	2.589AspArg: 2.589 ± 0.053	2.669AspSer: 2.669 ± 0.048	2.476AspThr: 2.476 ± 0.048	3.844AspVal: 3.844 ± 0.062	0.872AspTrp: 0.872 ± 0.028	1.856AspTyr: 1.856 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.222GluAla: 5.222 ± 0.084	0.503GluCys: 0.503 ± 0.025	2.347GluAsp: 2.347 ± 0.05	3.564GluGlu: 3.564 ± 0.078	1.843GluPhe: 1.843 ± 0.039	3.602GluGly: 3.602 ± 0.069	1.488GluHis: 1.488 ± 0.042	3.633GluIle: 3.633 ± 0.057	3.576GluLys: 3.576 ± 0.059	6.447GluLeu: 6.447 ± 0.082	1.9GluMet: 1.9 ± 0.046	2.597GluAsn: 2.597 ± 0.048	2.044GluPro: 2.044 ± 0.051	3.551GluGln: 3.551 ± 0.066	3.948GluArg: 3.948 ± 0.064	3.088GluSer: 3.088 ± 0.044	2.95GluThr: 2.95 ± 0.049	3.797GluVal: 3.797 ± 0.065	0.795GluTrp: 0.795 ± 0.026	1.562GluTyr: 1.562 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.679PheAla: 3.679 ± 0.058	0.586PheCys: 0.586 ± 0.024	2.219PheAsp: 2.219 ± 0.052	1.72PheGlu: 1.72 ± 0.042	1.602PhePhe: 1.602 ± 0.044	3.082PheGly: 3.082 ± 0.066	0.768PheHis: 0.768 ± 0.026	2.452PheIle: 2.452 ± 0.052	1.289PheLys: 1.289 ± 0.035	3.253PheLeu: 3.253 ± 0.069	1.022PheMet: 1.022 ± 0.033	1.776PheAsn: 1.776 ± 0.041	1.496PhePro: 1.496 ± 0.042	1.062PheGln: 1.062 ± 0.032	2.041PheArg: 2.041 ± 0.045	3.091PheSer: 3.091 ± 0.053	2.359PheThr: 2.359 ± 0.051	2.529PheVal: 2.529 ± 0.05	0.671PheTrp: 0.671 ± 0.032	1.265PheTyr: 1.265 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.8GlyAla: 5.8 ± 0.09	1.054GlyCys: 1.054 ± 0.036	3.585GlyAsp: 3.585 ± 0.068	4.492GlyGlu: 4.492 ± 0.072	3.039GlyPhe: 3.039 ± 0.052	5.154GlyGly: 5.154 ± 0.085	1.722GlyHis: 1.722 ± 0.038	5.009GlyIle: 5.009 ± 0.077	4.12GlyLys: 4.12 ± 0.075	7.223GlyLeu: 7.223 ± 0.082	2.367GlyMet: 2.367 ± 0.048	2.818GlyAsn: 2.818 ± 0.055	1.951GlyPro: 1.951 ± 0.047	2.721GlyGln: 2.721 ± 0.054	3.858GlyArg: 3.858 ± 0.068	4.129GlySer: 4.129 ± 0.063	3.758GlyThr: 3.758 ± 0.068	5.632GlyVal: 5.632 ± 0.07	1.279GlyTrp: 1.279 ± 0.036	2.582GlyTyr: 2.582 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.873HisAla: 1.873 ± 0.046	0.352HisCys: 0.352 ± 0.019	1.138HisAsp: 1.138 ± 0.037	1.297HisGlu: 1.297 ± 0.039	0.982HisPhe: 0.982 ± 0.03	1.697HisGly: 1.697 ± 0.039	0.814HisHis: 0.814 ± 0.028	1.367HisIle: 1.367 ± 0.034	0.781HisLys: 0.781 ± 0.027	2.335HisLeu: 2.335 ± 0.052	0.593HisMet: 0.593 ± 0.026	0.937HisAsn: 0.937 ± 0.028	1.287HisPro: 1.287 ± 0.036	1.263HisGln: 1.263 ± 0.037	1.25HisArg: 1.25 ± 0.044	1.331HisSer: 1.331 ± 0.031	1.085HisThr: 1.085 ± 0.034	1.388HisVal: 1.388 ± 0.034	0.446HisTrp: 0.446 ± 0.019	0.997HisTyr: 0.997 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.137IleAla: 6.137 ± 0.083	0.863IleCys: 0.863 ± 0.028	3.388IleAsp: 3.388 ± 0.059	3.397IleGlu: 3.397 ± 0.049	2.122IlePhe: 2.122 ± 0.051	4.521IleGly: 4.521 ± 0.073	1.416IleHis: 1.416 ± 0.034	3.511IleIle: 3.511 ± 0.065	2.527IleLys: 2.527 ± 0.055	5.012IleLeu: 5.012 ± 0.07	1.406IleMet: 1.406 ± 0.036	2.724IleAsn: 2.724 ± 0.065	2.696IlePro: 2.696 ± 0.053	1.935IleGln: 1.935 ± 0.043	3.191IleArg: 3.191 ± 0.053	3.965IleSer: 3.965 ± 0.068	3.611IleThr: 3.611 ± 0.054	3.99IleVal: 3.99 ± 0.06	0.721IleTrp: 0.721 ± 0.025	1.464IleTyr: 1.464 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.472LysAla: 4.472 ± 0.084	0.306LysCys: 0.306 ± 0.018	2.204LysAsp: 2.204 ± 0.046	2.794LysGlu: 2.794 ± 0.054	1.208LysPhe: 1.208 ± 0.032	2.993LysGly: 2.993 ± 0.061	1.08LysHis: 1.08 ± 0.031	2.467LysIle: 2.467 ± 0.049	2.33LysLys: 2.33 ± 0.048	4.497LysLeu: 4.497 ± 0.061	1.325LysMet: 1.325 ± 0.037	1.934LysAsn: 1.934 ± 0.049	2.213LysPro: 2.213 ± 0.047	2.054LysGln: 2.054 ± 0.047	2.863LysArg: 2.863 ± 0.047	2.44LysSer: 2.44 ± 0.053	2.791LysThr: 2.791 ± 0.051	3.105LysVal: 3.105 ± 0.053	0.462LysTrp: 0.462 ± 0.02	1.217LysTyr: 1.217 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	11.211LeuAla: 11.211 ± 0.111	1.377LeuCys: 1.377 ± 0.032	5.19LeuAsp: 5.19 ± 0.072	5.639LeuGlu: 5.639 ± 0.092	4.078LeuPhe: 4.078 ± 0.084	6.982LeuGly: 6.982 ± 0.088	2.345LeuHis: 2.345 ± 0.049	5.914LeuIle: 5.914 ± 0.093	4.863LeuLys: 4.863 ± 0.067	11.608LeuLeu: 11.608 ± 0.14	2.964LeuMet: 2.964 ± 0.062	4.348LeuAsn: 4.348 ± 0.069	5.619LeuPro: 5.619 ± 0.077	4.046LeuGln: 4.046 ± 0.067	6.424LeuArg: 6.424 ± 0.085	6.74LeuSer: 6.74 ± 0.088	6.627LeuThr: 6.627 ± 0.091	6.952LeuVal: 6.952 ± 0.099	1.491LeuTrp: 1.491 ± 0.039	2.588LeuTyr: 2.588 ± 0.051	0.001LeuXaa: 0.001 ± 0.001
Met	3.382MetAla: 3.382 ± 0.064	0.242MetCys: 0.242 ± 0.014	1.188MetAsp: 1.188 ± 0.032	1.367MetGlu: 1.367 ± 0.033	0.934MetPhe: 0.934 ± 0.029	1.944MetGly: 1.944 ± 0.045	0.509MetHis: 0.509 ± 0.022	1.58MetIle: 1.58 ± 0.04	1.433MetLys: 1.433 ± 0.035	3.244MetLeu: 3.244 ± 0.045	0.9MetMet: 0.9 ± 0.033	1.17MetAsn: 1.17 ± 0.035	1.416MetPro: 1.416 ± 0.036	1.256MetGln: 1.256 ± 0.034	1.582MetArg: 1.582 ± 0.037	1.941MetSer: 1.941 ± 0.042	1.845MetThr: 1.845 ± 0.039	1.965MetVal: 1.965 ± 0.042	0.268MetTrp: 0.268 ± 0.013	0.527MetTyr: 0.527 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.68AsnAla: 3.68 ± 0.067	0.424AsnCys: 0.424 ± 0.021	2.015AsnAsp: 2.015 ± 0.047	2.101AsnGlu: 2.101 ± 0.043	1.315AsnPhe: 1.315 ± 0.036	3.217AsnGly: 3.217 ± 0.064	0.874AsnHis: 0.874 ± 0.027	2.497AsnIle: 2.497 ± 0.052	1.636AsnLys: 1.636 ± 0.039	3.728AsnLeu: 3.728 ± 0.056	0.974AsnMet: 0.974 ± 0.031	1.757AsnAsn: 1.757 ± 0.041	2.055AsnPro: 2.055 ± 0.042	1.74AsnGln: 1.74 ± 0.04	2.166AsnArg: 2.166 ± 0.05	2.133AsnSer: 2.133 ± 0.047	2.12AsnThr: 2.12 ± 0.046	2.631AsnVal: 2.631 ± 0.046	0.594AsnTrp: 0.594 ± 0.024	1.173AsnTyr: 1.173 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.168ProAla: 4.168 ± 0.074	0.384ProCys: 0.384 ± 0.017	2.691ProAsp: 2.691 ± 0.06	3.466ProGlu: 3.466 ± 0.066	1.86ProPhe: 1.86 ± 0.043	3.282ProGly: 3.282 ± 0.062	1.037ProHis: 1.037 ± 0.036	1.821ProIle: 1.821 ± 0.042	1.645ProLys: 1.645 ± 0.042	4.875ProLeu: 4.875 ± 0.075	1.138ProMet: 1.138 ± 0.032	1.366ProAsn: 1.366 ± 0.042	1.663ProPro: 1.663 ± 0.039	2.268ProGln: 2.268 ± 0.061	2.043ProArg: 2.043 ± 0.054	2.087ProSer: 2.087 ± 0.042	2.12ProThr: 2.12 ± 0.049	3.787ProVal: 3.787 ± 0.076	0.725ProTrp: 0.725 ± 0.031	1.113ProTyr: 1.113 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.294GlnAla: 4.294 ± 0.086	0.396GlnCys: 0.396 ± 0.019	1.647GlnAsp: 1.647 ± 0.039	2.346GlnGlu: 2.346 ± 0.051	1.552GlnPhe: 1.552 ± 0.037	2.85GlnGly: 2.85 ± 0.057	1.269GlnHis: 1.269 ± 0.033	2.356GlnIle: 2.356 ± 0.049	1.885GlnLys: 1.885 ± 0.04	5.08GlnLeu: 5.08 ± 0.078	1.312GlnMet: 1.312 ± 0.037	1.504GlnAsn: 1.504 ± 0.042	2.104GlnPro: 2.104 ± 0.063	3.17GlnGln: 3.17 ± 0.095	3.158GlnArg: 3.158 ± 0.057	2.21GlnSer: 2.21 ± 0.049	2.263GlnThr: 2.263 ± 0.045	2.886GlnVal: 2.886 ± 0.053	0.768GlnTrp: 0.768 ± 0.026	1.284GlnTyr: 1.284 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	4.408ArgAla: 4.408 ± 0.056	0.694ArgCys: 0.694 ± 0.027	3.14ArgAsp: 3.14 ± 0.05	4.126ArgGlu: 4.126 ± 0.082	2.505ArgPhe: 2.505 ± 0.049	3.437ArgGly: 3.437 ± 0.061	1.633ArgHis: 1.633 ± 0.04	3.545ArgIle: 3.545 ± 0.064	2.918ArgLys: 2.918 ± 0.065	6.688ArgLeu: 6.688 ± 0.094	1.677ArgMet: 1.677 ± 0.032	2.205ArgAsn: 2.205 ± 0.048	2.098ArgPro: 2.098 ± 0.046	3.172ArgGln: 3.172 ± 0.055	3.742ArgArg: 3.742 ± 0.072	2.866ArgSer: 2.866 ± 0.056	2.954ArgThr: 2.954 ± 0.058	3.87ArgVal: 3.87 ± 0.066	0.992ArgTrp: 0.992 ± 0.033	2.169ArgTyr: 2.169 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	5.088SerAla: 5.088 ± 0.071	0.684SerCys: 0.684 ± 0.024	3.08SerAsp: 3.08 ± 0.053	3.173SerGlu: 3.173 ± 0.054	2.363SerPhe: 2.363 ± 0.048	5.058SerGly: 5.058 ± 0.084	1.432SerHis: 1.432 ± 0.036	2.95SerIle: 2.95 ± 0.054	2.245SerLys: 2.245 ± 0.047	6.584SerLeu: 6.584 ± 0.086	1.593SerMet: 1.593 ± 0.034	1.975SerAsn: 1.975 ± 0.039	2.606SerPro: 2.606 ± 0.047	2.509SerGln: 2.509 ± 0.055	3.702SerArg: 3.702 ± 0.06	3.431SerSer: 3.431 ± 0.061	2.888SerThr: 2.888 ± 0.052	4.227SerVal: 4.227 ± 0.068	0.919SerTrp: 0.919 ± 0.033	1.644SerTyr: 1.644 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.014ThrAla: 5.014 ± 0.076	0.653ThrCys: 0.653 ± 0.028	2.755ThrAsp: 2.755 ± 0.053	2.664ThrGlu: 2.664 ± 0.047	2.176ThrPhe: 2.176 ± 0.047	4.508ThrGly: 4.508 ± 0.064	1.182ThrHis: 1.182 ± 0.033	3.007ThrIle: 3.007 ± 0.063	1.666ThrLys: 1.666 ± 0.049	7.074ThrLeu: 7.074 ± 0.078	1.472ThrMet: 1.472 ± 0.045	1.637ThrAsn: 1.637 ± 0.041	3.134ThrPro: 3.134 ± 0.051	2.207ThrGln: 2.207 ± 0.055	3.206ThrArg: 3.206 ± 0.05	3.097ThrSer: 3.097 ± 0.052	2.992ThrThr: 2.992 ± 0.054	3.995ThrVal: 3.995 ± 0.1	0.777ThrTrp: 0.777 ± 0.029	1.29ThrTyr: 1.29 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.937ValAla: 6.937 ± 0.1	0.778ValCys: 0.778 ± 0.032	3.696ValAsp: 3.696 ± 0.06	4.118ValGlu: 4.118 ± 0.063	2.508ValPhe: 2.508 ± 0.055	4.79ValGly: 4.79 ± 0.074	1.249ValHis: 1.249 ± 0.036	4.718ValIle: 4.718 ± 0.069	3.194ValLys: 3.194 ± 0.059	7.195ValLeu: 7.195 ± 0.086	2.307ValMet: 2.307 ± 0.044	2.79ValAsn: 2.79 ± 0.05	2.98ValPro: 2.98 ± 0.053	2.294ValGln: 2.294 ± 0.056	3.615ValArg: 3.615 ± 0.062	4.422ValSer: 4.422 ± 0.066	4.342ValThr: 4.342 ± 0.085	5.55ValVal: 5.55 ± 0.085	1.006ValTrp: 1.006 ± 0.028	1.735ValTyr: 1.735 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.016TrpAla: 1.016 ± 0.032	0.249TrpCys: 0.249 ± 0.014	0.582TrpAsp: 0.582 ± 0.026	0.58TrpGlu: 0.58 ± 0.023	0.684TrpPhe: 0.684 ± 0.025	1.006TrpGly: 1.006 ± 0.032	0.475TrpHis: 0.475 ± 0.021	0.712TrpIle: 0.712 ± 0.025	0.539TrpLys: 0.539 ± 0.024	2.361TrpLeu: 2.361 ± 0.058	0.534TrpMet: 0.534 ± 0.021	0.461TrpAsn: 0.461 ± 0.02	0.66TrpPro: 0.66 ± 0.027	1.172TrpGln: 1.172 ± 0.038	1.091TrpArg: 1.091 ± 0.037	0.874TrpSer: 0.874 ± 0.035	0.523TrpThr: 0.523 ± 0.024	0.961TrpVal: 0.961 ± 0.03	0.209TrpTrp: 0.209 ± 0.014	0.471TrpTyr: 0.471 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.43TyrAla: 2.43 ± 0.047	0.445TyrCys: 0.445 ± 0.017	1.659TyrAsp: 1.659 ± 0.046	1.293TyrGlu: 1.293 ± 0.032	1.135TyrPhe: 1.135 ± 0.037	2.223TyrGly: 2.223 ± 0.048	0.767TyrHis: 0.767 ± 0.027	1.465TyrIle: 1.465 ± 0.044	0.955TyrLys: 0.955 ± 0.031	2.955TyrLeu: 2.955 ± 0.051	0.679TyrMet: 0.679 ± 0.03	1.145TyrAsn: 1.145 ± 0.036	1.321TyrPro: 1.321 ± 0.032	1.534TyrGln: 1.534 ± 0.039	1.94TyrArg: 1.94 ± 0.045	1.753TyrSer: 1.753 ± 0.042	1.6TyrThr: 1.6 ± 0.038	1.678TyrVal: 1.678 ± 0.034	0.46TyrTrp: 0.46 ± 0.023	0.925TyrTyr: 0.925 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3897 proteins (1094416 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---