Amino acid dipepetide frequency for Xylaria hypoxylon

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.738AlaAla: 8.738 ± 0.054	0.978AlaCys: 0.978 ± 0.013	4.363AlaAsp: 4.363 ± 0.03	4.99AlaGlu: 4.99 ± 0.042	3.159AlaPhe: 3.159 ± 0.027	5.664AlaGly: 5.664 ± 0.035	1.798AlaHis: 1.798 ± 0.017	4.461AlaIle: 4.461 ± 0.032	4.006AlaLys: 4.006 ± 0.03	7.751AlaLeu: 7.751 ± 0.047	1.856AlaMet: 1.856 ± 0.019	3.09AlaAsn: 3.09 ± 0.024	4.445AlaPro: 4.445 ± 0.039	3.296AlaGln: 3.296 ± 0.027	4.792AlaArg: 4.792 ± 0.034	7.163AlaSer: 7.163 ± 0.039	5.548AlaThr: 5.548 ± 0.032	5.447AlaVal: 5.447 ± 0.035	1.139AlaTrp: 1.139 ± 0.013	2.195AlaTyr: 2.195 ± 0.02	0.001AlaXaa: 0.001 ± 0.0
Cys	0.882CysAla: 0.882 ± 0.011	0.205CysCys: 0.205 ± 0.007	0.636CysAsp: 0.636 ± 0.011	0.596CysGlu: 0.596 ± 0.011	0.49CysPhe: 0.49 ± 0.009	0.85CysGly: 0.85 ± 0.014	0.318CysHis: 0.318 ± 0.008	0.656CysIle: 0.656 ± 0.013	0.468CysLys: 0.468 ± 0.011	1.155CysLeu: 1.155 ± 0.014	0.236CysMet: 0.236 ± 0.007	0.417CysAsn: 0.417 ± 0.009	0.616CysPro: 0.616 ± 0.012	0.418CysGln: 0.418 ± 0.008	0.676CysArg: 0.676 ± 0.011	0.845CysSer: 0.845 ± 0.014	0.647CysThr: 0.647 ± 0.012	0.725CysVal: 0.725 ± 0.012	0.184CysTrp: 0.184 ± 0.005	0.346CysTyr: 0.346 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.813AspAla: 4.813 ± 0.031	0.615AspCys: 0.615 ± 0.012	4.604AspAsp: 4.604 ± 0.04	4.568AspGlu: 4.568 ± 0.038	2.26AspPhe: 2.26 ± 0.024	4.247AspGly: 4.247 ± 0.033	1.255AspHis: 1.255 ± 0.017	3.357AspIle: 3.357 ± 0.024	2.457AspLys: 2.457 ± 0.024	5.152AspLeu: 5.152 ± 0.035	1.275AspMet: 1.275 ± 0.016	2.094AspAsn: 2.094 ± 0.022	3.311AspPro: 3.311 ± 0.023	1.861AspGln: 1.861 ± 0.021	2.989AspArg: 2.989 ± 0.026	4.32AspSer: 4.32 ± 0.033	3.186AspThr: 3.186 ± 0.027	3.797AspVal: 3.797 ± 0.028	0.911AspTrp: 0.911 ± 0.012	1.686AspTyr: 1.686 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.276GluAla: 5.276 ± 0.042	0.615GluCys: 0.615 ± 0.01	4.192GluAsp: 4.192 ± 0.037	5.0GluGlu: 5.0 ± 0.052	2.015GluPhe: 2.015 ± 0.018	3.638GluGly: 3.638 ± 0.031	1.396GluHis: 1.396 ± 0.016	3.192GluIle: 3.192 ± 0.029	3.556GluLys: 3.556 ± 0.032	5.359GluLeu: 5.359 ± 0.041	1.377GluMet: 1.377 ± 0.015	2.422GluAsn: 2.422 ± 0.022	2.828GluPro: 2.828 ± 0.031	2.401GluGln: 2.401 ± 0.026	3.803GluArg: 3.803 ± 0.034	4.319GluSer: 4.319 ± 0.03	3.591GluThr: 3.591 ± 0.028	3.536GluVal: 3.536 ± 0.029	0.895GluTrp: 0.895 ± 0.014	1.704GluTyr: 1.704 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.062PheAla: 3.062 ± 0.024	0.503PheCys: 0.503 ± 0.01	2.382PheAsp: 2.382 ± 0.02	2.221PheGlu: 2.221 ± 0.021	1.561PhePhe: 1.561 ± 0.02	2.896PheGly: 2.896 ± 0.029	0.896PheHis: 0.896 ± 0.013	1.872PheIle: 1.872 ± 0.02	1.556PheLys: 1.556 ± 0.017	3.406PheLeu: 3.406 ± 0.027	0.745PheMet: 0.745 ± 0.011	1.475PheAsn: 1.475 ± 0.018	1.932PhePro: 1.932 ± 0.02	1.412PheGln: 1.412 ± 0.013	1.967PheArg: 1.967 ± 0.022	2.979PheSer: 2.979 ± 0.025	2.203PheThr: 2.203 ± 0.02	2.417PheVal: 2.417 ± 0.023	0.643PheTrp: 0.643 ± 0.012	1.121PheTyr: 1.121 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.322GlyAla: 5.322 ± 0.037	0.812GlyCys: 0.812 ± 0.014	3.85GlyAsp: 3.85 ± 0.024	3.611GlyGlu: 3.611 ± 0.022	2.81GlyPhe: 2.81 ± 0.024	5.73GlyGly: 5.73 ± 0.062	1.761GlyHis: 1.761 ± 0.018	3.695GlyIle: 3.695 ± 0.027	3.352GlyLys: 3.352 ± 0.027	6.096GlyLeu: 6.096 ± 0.039	1.44GlyMet: 1.44 ± 0.015	2.712GlyAsn: 2.712 ± 0.025	3.308GlyPro: 3.308 ± 0.035	2.48GlyGln: 2.48 ± 0.024	4.06GlyArg: 4.06 ± 0.035	5.745GlySer: 5.745 ± 0.047	4.097GlyThr: 4.097 ± 0.031	4.403GlyVal: 4.403 ± 0.03	1.138GlyTrp: 1.138 ± 0.015	2.125GlyTyr: 2.125 ± 0.023	0.001GlyXaa: 0.001 ± 0.0
His	1.8HisAla: 1.8 ± 0.018	0.319HisCys: 0.319 ± 0.008	1.398HisAsp: 1.398 ± 0.016	1.394HisGlu: 1.394 ± 0.017	0.917HisPhe: 0.917 ± 0.013	1.749HisGly: 1.749 ± 0.02	0.86HisHis: 0.86 ± 0.017	1.274HisIle: 1.274 ± 0.016	0.927HisLys: 0.927 ± 0.013	2.195HisLeu: 2.195 ± 0.019	0.501HisMet: 0.501 ± 0.009	0.898HisAsn: 0.898 ± 0.014	1.607HisPro: 1.607 ± 0.02	1.0HisGln: 1.0 ± 0.014	1.5HisArg: 1.5 ± 0.019	1.835HisSer: 1.835 ± 0.019	1.29HisThr: 1.29 ± 0.014	1.472HisVal: 1.472 ± 0.017	0.329HisTrp: 0.329 ± 0.009	0.713HisTyr: 0.713 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.416IleAla: 4.416 ± 0.032	0.715IleCys: 0.715 ± 0.011	3.171IleAsp: 3.171 ± 0.029	3.078IleGlu: 3.078 ± 0.027	2.03IlePhe: 2.03 ± 0.025	3.367IleGly: 3.367 ± 0.029	1.226IleHis: 1.226 ± 0.015	2.76IleIle: 2.76 ± 0.027	2.262IleLys: 2.262 ± 0.022	4.658IleLeu: 4.658 ± 0.037	1.05IleMet: 1.05 ± 0.013	1.917IleAsn: 1.917 ± 0.02	3.159IlePro: 3.159 ± 0.025	1.992IleGln: 1.992 ± 0.02	2.92IleArg: 2.92 ± 0.024	4.059IleSer: 4.059 ± 0.03	3.08IleThr: 3.08 ± 0.026	3.339IleVal: 3.339 ± 0.026	0.749IleTrp: 0.749 ± 0.012	1.416IleTyr: 1.416 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.197LysAla: 4.197 ± 0.032	0.445LysCys: 0.445 ± 0.01	2.758LysAsp: 2.758 ± 0.025	3.147LysGlu: 3.147 ± 0.034	1.479LysPhe: 1.479 ± 0.017	2.964LysGly: 2.964 ± 0.023	1.119LysHis: 1.119 ± 0.015	2.335LysIle: 2.335 ± 0.023	3.191LysLys: 3.191 ± 0.043	4.202LysLeu: 4.202 ± 0.032	0.962LysMet: 0.962 ± 0.014	1.756LysAsn: 1.756 ± 0.02	2.757LysPro: 2.757 ± 0.026	1.814LysGln: 1.814 ± 0.021	3.323LysArg: 3.323 ± 0.024	3.475LysSer: 3.475 ± 0.03	2.9LysThr: 2.9 ± 0.022	2.752LysVal: 2.752 ± 0.028	0.68LysTrp: 0.68 ± 0.012	1.412LysTyr: 1.412 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.868LeuAla: 7.868 ± 0.042	1.146LeuCys: 1.146 ± 0.016	5.331LeuAsp: 5.331 ± 0.032	5.56LeuGlu: 5.56 ± 0.042	3.321LeuPhe: 3.321 ± 0.028	6.047LeuGly: 6.047 ± 0.037	2.206LeuHis: 2.206 ± 0.023	4.049LeuIle: 4.049 ± 0.032	4.199LeuLys: 4.199 ± 0.033	8.317LeuLeu: 8.317 ± 0.059	1.677LeuMet: 1.677 ± 0.019	3.24LeuAsn: 3.24 ± 0.027	5.37LeuPro: 5.37 ± 0.031	3.766LeuGln: 3.766 ± 0.032	5.708LeuArg: 5.708 ± 0.035	7.298LeuSer: 7.298 ± 0.04	4.883LeuThr: 4.883 ± 0.029	5.57LeuVal: 5.57 ± 0.04	1.226LeuTrp: 1.226 ± 0.018	2.34LeuTyr: 2.34 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.125MetAla: 2.125 ± 0.02	0.211MetCys: 0.211 ± 0.006	1.187MetAsp: 1.187 ± 0.016	1.189MetGlu: 1.189 ± 0.015	0.696MetPhe: 0.696 ± 0.012	1.337MetGly: 1.337 ± 0.018	0.458MetHis: 0.458 ± 0.009	0.991MetIle: 0.991 ± 0.013	0.993MetLys: 0.993 ± 0.013	1.739MetLeu: 1.739 ± 0.02	0.567MetMet: 0.567 ± 0.011	0.815MetAsn: 0.815 ± 0.013	1.221MetPro: 1.221 ± 0.017	0.811MetGln: 0.811 ± 0.015	1.28MetArg: 1.28 ± 0.016	1.764MetSer: 1.764 ± 0.018	1.279MetThr: 1.279 ± 0.015	1.247MetVal: 1.247 ± 0.015	0.252MetTrp: 0.252 ± 0.006	0.505MetTyr: 0.505 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.181AsnAla: 3.181 ± 0.023	0.444AsnCys: 0.444 ± 0.01	2.104AsnAsp: 2.104 ± 0.02	2.183AsnGlu: 2.183 ± 0.018	1.416AsnPhe: 1.416 ± 0.015	3.074AsnGly: 3.074 ± 0.026	0.899AsnHis: 0.899 ± 0.015	2.226AsnIle: 2.226 ± 0.019	1.635AsnLys: 1.635 ± 0.016	3.344AsnLeu: 3.344 ± 0.023	0.877AsnMet: 0.877 ± 0.012	1.668AsnAsn: 1.668 ± 0.021	2.538AsnPro: 2.538 ± 0.025	1.394AsnGln: 1.394 ± 0.017	2.012AsnArg: 2.012 ± 0.02	2.976AsnSer: 2.976 ± 0.024	2.435AsnThr: 2.435 ± 0.024	2.317AsnVal: 2.317 ± 0.024	0.593AsnTrp: 0.593 ± 0.01	1.111AsnTyr: 1.111 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.761ProAla: 4.761 ± 0.037	0.452ProCys: 0.452 ± 0.01	3.246ProAsp: 3.246 ± 0.027	3.781ProGlu: 3.781 ± 0.029	2.054ProPhe: 2.054 ± 0.019	3.923ProGly: 3.923 ± 0.033	1.31ProHis: 1.31 ± 0.017	2.719ProIle: 2.719 ± 0.022	2.652ProLys: 2.652 ± 0.025	4.697ProLeu: 4.697 ± 0.032	1.031ProMet: 1.031 ± 0.016	2.333ProAsn: 2.333 ± 0.024	4.878ProPro: 4.878 ± 0.066	2.387ProGln: 2.387 ± 0.03	3.34ProArg: 3.34 ± 0.025	5.832ProSer: 5.832 ± 0.046	4.14ProThr: 4.14 ± 0.039	3.479ProVal: 3.479 ± 0.027	0.762ProTrp: 0.762 ± 0.012	1.542ProTyr: 1.542 ± 0.016	0.001ProXaa: 0.001 ± 0.0
Gln	3.307GlnAla: 3.307 ± 0.027	0.425GlnCys: 0.425 ± 0.01	2.144GlnAsp: 2.144 ± 0.023	2.298GlnGlu: 2.298 ± 0.024	1.327GlnPhe: 1.327 ± 0.015	2.401GlnGly: 2.401 ± 0.02	1.062GlnHis: 1.062 ± 0.016	1.97GlnIle: 1.97 ± 0.018	1.901GlnLys: 1.901 ± 0.022	3.509GlnLeu: 3.509 ± 0.027	0.814GlnMet: 0.814 ± 0.014	1.573GlnAsn: 1.573 ± 0.017	2.503GlnPro: 2.503 ± 0.03	2.391GlnGln: 2.391 ± 0.052	2.541GlnArg: 2.541 ± 0.024	3.095GlnSer: 3.095 ± 0.029	2.313GlnThr: 2.313 ± 0.022	2.209GlnVal: 2.209 ± 0.02	0.597GlnTrp: 0.597 ± 0.011	1.191GlnTyr: 1.191 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.655ArgAla: 4.655 ± 0.033	0.65ArgCys: 0.65 ± 0.011	3.521ArgAsp: 3.521 ± 0.026	3.791ArgGlu: 3.791 ± 0.035	2.181ArgPhe: 2.181 ± 0.019	3.719ArgGly: 3.719 ± 0.035	1.576ArgHis: 1.576 ± 0.018	2.975ArgIle: 2.975 ± 0.026	3.31ArgLys: 3.31 ± 0.031	5.401ArgLeu: 5.401 ± 0.035	1.245ArgMet: 1.245 ± 0.012	2.312ArgAsn: 2.312 ± 0.023	3.419ArgPro: 3.419 ± 0.036	2.59ArgGln: 2.59 ± 0.022	4.838ArgArg: 4.838 ± 0.046	4.587ArgSer: 4.587 ± 0.033	3.222ArgThr: 3.222 ± 0.025	3.404ArgVal: 3.404 ± 0.024	0.93ArgTrp: 0.93 ± 0.012	1.654ArgTyr: 1.654 ± 0.016	0.001ArgXaa: 0.001 ± 0.0
Ser	6.45SerAla: 6.45 ± 0.043	0.795SerCys: 0.795 ± 0.015	4.288SerAsp: 4.288 ± 0.028	4.163SerGlu: 4.163 ± 0.028	3.058SerPhe: 3.058 ± 0.024	5.56SerGly: 5.56 ± 0.035	1.999SerHis: 1.999 ± 0.024	4.226SerIle: 4.226 ± 0.036	3.683SerLys: 3.683 ± 0.033	7.179SerLeu: 7.179 ± 0.041	1.647SerMet: 1.647 ± 0.021	3.206SerAsn: 3.206 ± 0.028	5.365SerPro: 5.365 ± 0.048	3.383SerGln: 3.383 ± 0.032	5.02SerArg: 5.02 ± 0.043	8.762SerSer: 8.762 ± 0.07	5.729SerThr: 5.729 ± 0.038	4.592SerVal: 4.592 ± 0.028	1.147SerTrp: 1.147 ± 0.014	2.153SerTyr: 2.153 ± 0.024	0.001SerXaa: 0.001 ± 0.0
Thr	5.336ThrAla: 5.336 ± 0.034	0.714ThrCys: 0.714 ± 0.013	3.011ThrAsp: 3.011 ± 0.026	3.209ThrGlu: 3.209 ± 0.029	2.252ThrPhe: 2.252 ± 0.019	4.256ThrGly: 4.256 ± 0.03	1.353ThrHis: 1.353 ± 0.015	3.308ThrIle: 3.308 ± 0.026	2.74ThrLys: 2.74 ± 0.024	5.358ThrLeu: 5.358 ± 0.033	1.211ThrMet: 1.211 ± 0.016	2.346ThrAsn: 2.346 ± 0.022	4.4ThrPro: 4.4 ± 0.036	2.194ThrGln: 2.194 ± 0.021	3.259ThrArg: 3.259 ± 0.025	5.521ThrSer: 5.521 ± 0.039	4.593ThrThr: 4.593 ± 0.044	3.771ThrVal: 3.771 ± 0.033	0.879ThrTrp: 0.879 ± 0.014	1.701ThrTyr: 1.701 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.363ValAla: 5.363 ± 0.035	0.742ValCys: 0.742 ± 0.011	3.893ValAsp: 3.893 ± 0.031	3.862ValGlu: 3.862 ± 0.032	2.461ValPhe: 2.461 ± 0.025	4.034ValGly: 4.034 ± 0.034	1.381ValHis: 1.381 ± 0.016	3.102ValIle: 3.102 ± 0.028	2.876ValLys: 2.876 ± 0.025	5.624ValLeu: 5.624 ± 0.037	1.221ValMet: 1.221 ± 0.016	2.341ValAsn: 2.341 ± 0.022	3.514ValPro: 3.514 ± 0.025	2.285ValGln: 2.285 ± 0.022	3.377ValArg: 3.377 ± 0.025	4.699ValSer: 4.699 ± 0.028	3.682ValThr: 3.682 ± 0.028	4.371ValVal: 4.371 ± 0.035	0.854ValTrp: 0.854 ± 0.012	1.741ValTyr: 1.741 ± 0.017	0.001ValXaa: 0.001 ± 0.0
Trp	1.161TrpAla: 1.161 ± 0.014	0.188TrpCys: 0.188 ± 0.006	0.945TrpAsp: 0.945 ± 0.014	0.871TrpGlu: 0.871 ± 0.013	0.555TrpPhe: 0.555 ± 0.01	0.953TrpGly: 0.953 ± 0.013	0.36TrpHis: 0.36 ± 0.008	0.763TrpIle: 0.763 ± 0.012	0.78TrpLys: 0.78 ± 0.012	1.343TrpLeu: 1.343 ± 0.019	0.342TrpMet: 0.342 ± 0.008	0.655TrpAsn: 0.655 ± 0.011	0.617TrpPro: 0.617 ± 0.011	0.587TrpGln: 0.587 ± 0.01	0.951TrpArg: 0.951 ± 0.013	1.039TrpSer: 1.039 ± 0.015	0.904TrpThr: 0.904 ± 0.015	0.914TrpVal: 0.914 ± 0.015	0.279TrpTrp: 0.279 ± 0.008	0.439TrpTyr: 0.439 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.163TyrAla: 2.163 ± 0.021	0.391TyrCys: 0.391 ± 0.008	1.733TyrAsp: 1.733 ± 0.018	1.605TyrGlu: 1.605 ± 0.017	1.207TyrPhe: 1.207 ± 0.015	2.136TyrGly: 2.136 ± 0.022	0.746TyrHis: 0.746 ± 0.012	1.435TyrIle: 1.435 ± 0.016	1.125TyrLys: 1.125 ± 0.014	2.636TyrLeu: 2.636 ± 0.022	0.594TyrMet: 0.594 ± 0.01	1.158TyrAsn: 1.158 ± 0.015	1.532TyrPro: 1.532 ± 0.021	1.109TyrGln: 1.109 ± 0.016	1.626TyrArg: 1.626 ± 0.017	2.088TyrSer: 2.088 ± 0.02	1.689TyrThr: 1.689 ± 0.019	1.661TyrVal: 1.661 ± 0.017	0.46TyrTrp: 0.46 ± 0.009	0.991TyrTyr: 0.991 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.0

Statistics based on 11037 proteins (5574772 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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