Amino acid dipepetide frequency for Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans R2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.431AlaAla: 13.431 ± 0.186	1.168AlaCys: 1.168 ± 0.034	5.529AlaAsp: 5.529 ± 0.096	7.063AlaGlu: 7.063 ± 0.105	3.08AlaPhe: 3.08 ± 0.07	7.577AlaGly: 7.577 ± 0.115	1.523AlaHis: 1.523 ± 0.041	9.236AlaIle: 9.236 ± 0.133	2.794AlaLys: 2.794 ± 0.068	11.668AlaLeu: 11.668 ± 0.123	2.0AlaMet: 2.0 ± 0.054	2.694AlaAsn: 2.694 ± 0.064	4.316AlaPro: 4.316 ± 0.095	5.733AlaGln: 5.733 ± 0.09	5.288AlaArg: 5.288 ± 0.088	5.561AlaSer: 5.561 ± 0.092	5.566AlaThr: 5.566 ± 0.084	7.311AlaVal: 7.311 ± 0.096	1.58AlaTrp: 1.58 ± 0.05	2.329AlaTyr: 2.329 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.722CysAla: 0.722 ± 0.029	0.21CysCys: 0.21 ± 0.016	0.818CysAsp: 0.818 ± 0.032	0.534CysGlu: 0.534 ± 0.025	0.414CysPhe: 0.414 ± 0.021	0.909CysGly: 0.909 ± 0.038	0.284CysHis: 0.284 ± 0.018	0.428CysIle: 0.428 ± 0.023	0.208CysLys: 0.208 ± 0.014	1.39CysLeu: 1.39 ± 0.047	0.163CysMet: 0.163 ± 0.017	0.29CysAsn: 0.29 ± 0.02	0.677CysPro: 0.677 ± 0.036	0.715CysGln: 0.715 ± 0.032	0.792CysArg: 0.792 ± 0.032	0.701CysSer: 0.701 ± 0.03	0.467CysThr: 0.467 ± 0.028	0.578CysVal: 0.578 ± 0.029	0.217CysTrp: 0.217 ± 0.014	0.304CysTyr: 0.304 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.1AspAla: 4.1 ± 0.077	0.809AspCys: 0.809 ± 0.03	2.057AspAsp: 2.057 ± 0.063	2.356AspGlu: 2.356 ± 0.066	2.113AspPhe: 2.113 ± 0.053	3.095AspGly: 3.095 ± 0.076	0.888AspHis: 0.888 ± 0.031	2.07AspIle: 2.07 ± 0.061	0.99AspLys: 0.99 ± 0.037	7.014AspLeu: 7.014 ± 0.098	0.633AspMet: 0.633 ± 0.028	1.218AspAsn: 1.218 ± 0.037	3.473AspPro: 3.473 ± 0.062	2.692AspGln: 2.692 ± 0.055	7.415AspArg: 7.415 ± 0.122	2.707AspSer: 2.707 ± 0.065	1.881AspThr: 1.881 ± 0.054	2.733AspVal: 2.733 ± 0.074	1.417AspTrp: 1.417 ± 0.046	1.706AspTyr: 1.706 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.326GluAla: 7.326 ± 0.103	0.331GluCys: 0.331 ± 0.022	2.455GluAsp: 2.455 ± 0.061	3.125GluGlu: 3.125 ± 0.079	1.832GluPhe: 1.832 ± 0.05	3.466GluGly: 3.466 ± 0.077	0.944GluHis: 0.944 ± 0.037	3.367GluIle: 3.367 ± 0.071	1.782GluLys: 1.782 ± 0.059	7.044GluLeu: 7.044 ± 0.105	0.961GluMet: 0.961 ± 0.04	1.42GluAsn: 1.42 ± 0.04	2.893GluPro: 2.893 ± 0.069	3.95GluGln: 3.95 ± 0.087	3.765GluArg: 3.765 ± 0.078	3.052GluSer: 3.052 ± 0.059	3.47GluThr: 3.47 ± 0.07	4.095GluVal: 4.095 ± 0.072	0.713GluTrp: 0.713 ± 0.031	1.068GluTyr: 1.068 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.231PheAla: 3.231 ± 0.067	0.549PheCys: 0.549 ± 0.022	2.093PheAsp: 2.093 ± 0.053	1.96PheGlu: 1.96 ± 0.051	1.327PhePhe: 1.327 ± 0.041	3.049PheGly: 3.049 ± 0.082	0.591PheHis: 0.591 ± 0.028	1.517PheIle: 1.517 ± 0.045	0.843PheLys: 0.843 ± 0.033	3.919PheLeu: 3.919 ± 0.083	0.497PheMet: 0.497 ± 0.023	1.161PheAsn: 1.161 ± 0.04	1.671PhePro: 1.671 ± 0.046	1.993PheGln: 1.993 ± 0.051	2.173PheArg: 2.173 ± 0.052	2.437PheSer: 2.437 ± 0.055	1.642PheThr: 1.642 ± 0.046	2.167PheVal: 2.167 ± 0.052	0.783PheTrp: 0.783 ± 0.032	1.045PheTyr: 1.045 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.04GlyAla: 6.04 ± 0.113	0.998GlyCys: 0.998 ± 0.035	4.126GlyAsp: 4.126 ± 0.092	3.675GlyGlu: 3.675 ± 0.068	3.054GlyPhe: 3.054 ± 0.072	5.21GlyGly: 5.21 ± 0.111	1.325GlyHis: 1.325 ± 0.046	4.311GlyIle: 4.311 ± 0.09	2.375GlyLys: 2.375 ± 0.065	9.397GlyLeu: 9.397 ± 0.124	1.415GlyMet: 1.415 ± 0.048	2.181GlyAsn: 2.181 ± 0.064	2.475GlyPro: 2.475 ± 0.052	4.14GlyGln: 4.14 ± 0.079	4.58GlyArg: 4.58 ± 0.093	4.598GlySer: 4.598 ± 0.084	3.604GlyThr: 3.604 ± 0.079	4.732GlyVal: 4.732 ± 0.077	1.526GlyTrp: 1.526 ± 0.052	2.185GlyTyr: 2.185 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.255HisAla: 1.255 ± 0.037	0.377HisCys: 0.377 ± 0.024	0.843HisAsp: 0.843 ± 0.032	0.836HisGlu: 0.836 ± 0.035	0.703HisPhe: 0.703 ± 0.029	1.163HisGly: 1.163 ± 0.044	0.557HisHis: 0.557 ± 0.029	0.68HisIle: 0.68 ± 0.03	0.383HisLys: 0.383 ± 0.023	2.325HisLeu: 2.325 ± 0.057	0.201HisMet: 0.201 ± 0.016	0.458HisAsn: 0.458 ± 0.028	1.411HisPro: 1.411 ± 0.042	1.027HisGln: 1.027 ± 0.037	1.284HisArg: 1.284 ± 0.04	1.014HisSer: 1.014 ± 0.031	0.665HisThr: 0.665 ± 0.029	0.897HisVal: 0.897 ± 0.036	0.498HisTrp: 0.498 ± 0.027	0.662HisTyr: 0.662 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	9.086IleAla: 9.086 ± 0.114	0.66IleCys: 0.66 ± 0.029	3.259IleAsp: 3.259 ± 0.074	3.346IleGlu: 3.346 ± 0.068	1.642IlePhe: 1.642 ± 0.046	4.358IleGly: 4.358 ± 0.096	0.939IleHis: 0.939 ± 0.038	2.015IleIle: 2.015 ± 0.063	1.191IleLys: 1.191 ± 0.042	5.607IleLeu: 5.607 ± 0.087	0.487IleMet: 0.487 ± 0.027	1.616IleAsn: 1.616 ± 0.052	2.899IlePro: 2.899 ± 0.066	2.629IleGln: 2.629 ± 0.061	3.15IleArg: 3.15 ± 0.071	2.967IleSer: 2.967 ± 0.072	2.785IleThr: 2.785 ± 0.06	3.722IleVal: 3.722 ± 0.068	0.773IleTrp: 0.773 ± 0.032	1.285IleTyr: 1.285 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	2.938LysAla: 2.938 ± 0.069	0.133LysCys: 0.133 ± 0.013	1.155LysAsp: 1.155 ± 0.045	1.338LysGlu: 1.338 ± 0.044	0.77LysPhe: 0.77 ± 0.032	1.751LysGly: 1.751 ± 0.044	0.436LysHis: 0.436 ± 0.025	1.449LysIle: 1.449 ± 0.047	0.866LysLys: 0.866 ± 0.041	3.215LysLeu: 3.215 ± 0.077	0.377LysMet: 0.377 ± 0.022	0.739LysAsn: 0.739 ± 0.031	1.569LysPro: 1.569 ± 0.053	1.505LysGln: 1.505 ± 0.042	1.773LysArg: 1.773 ± 0.046	1.443LysSer: 1.443 ± 0.052	1.727LysThr: 1.727 ± 0.048	1.978LysVal: 1.978 ± 0.062	0.203LysTrp: 0.203 ± 0.015	0.509LysTyr: 0.509 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.133LeuAla: 13.133 ± 0.159	1.169LeuCys: 1.169 ± 0.04	6.117LeuAsp: 6.117 ± 0.108	7.544LeuGlu: 7.544 ± 0.117	3.696LeuPhe: 3.696 ± 0.084	9.31LeuGly: 9.31 ± 0.141	1.956LeuHis: 1.956 ± 0.058	6.268LeuIle: 6.268 ± 0.095	3.581LeuLys: 3.581 ± 0.077	14.553LeuLeu: 14.553 ± 0.219	1.902LeuMet: 1.902 ± 0.053	3.468LeuAsn: 3.468 ± 0.068	7.484LeuPro: 7.484 ± 0.119	8.033LeuGln: 8.033 ± 0.124	8.042LeuArg: 8.042 ± 0.11	7.998LeuSer: 7.998 ± 0.104	6.832LeuThr: 6.832 ± 0.081	7.661LeuVal: 7.661 ± 0.102	1.857LeuTrp: 1.857 ± 0.061	2.513LeuTyr: 2.513 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.84MetAla: 1.84 ± 0.048	0.088MetCys: 0.088 ± 0.011	0.652MetAsp: 0.652 ± 0.031	0.728MetGlu: 0.728 ± 0.031	0.386MetPhe: 0.386 ± 0.02	1.276MetGly: 1.276 ± 0.042	0.203MetHis: 0.203 ± 0.018	0.796MetIle: 0.796 ± 0.029	0.504MetLys: 0.504 ± 0.028	1.734MetLeu: 1.734 ± 0.055	0.34MetMet: 0.34 ± 0.027	0.46MetAsn: 0.46 ± 0.028	0.99MetPro: 0.99 ± 0.034	0.77MetGln: 0.77 ± 0.032	0.995MetArg: 0.995 ± 0.038	1.168MetSer: 1.168 ± 0.035	1.264MetThr: 1.264 ± 0.042	1.138MetVal: 1.138 ± 0.047	0.093MetTrp: 0.093 ± 0.011	0.204MetTyr: 0.204 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.375AsnAla: 2.375 ± 0.058	0.374AsnCys: 0.374 ± 0.021	1.211AsnAsp: 1.211 ± 0.042	1.101AsnGlu: 1.101 ± 0.044	1.165AsnPhe: 1.165 ± 0.044	2.119AsnGly: 2.119 ± 0.087	0.525AsnHis: 0.525 ± 0.024	1.243AsnIle: 1.243 ± 0.046	0.615AsnLys: 0.615 ± 0.028	3.641AsnLeu: 3.641 ± 0.075	0.352AsnMet: 0.352 ± 0.021	0.866AsnAsn: 0.866 ± 0.04	2.22AsnPro: 2.22 ± 0.054	1.656AsnGln: 1.656 ± 0.056	2.105AsnArg: 2.105 ± 0.05	1.619AsnSer: 1.619 ± 0.046	1.299AsnThr: 1.299 ± 0.047	1.62AsnVal: 1.62 ± 0.051	0.584AsnTrp: 0.584 ± 0.029	0.798AsnTyr: 0.798 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.865ProAla: 5.865 ± 0.112	0.465ProCys: 0.465 ± 0.025	3.379ProAsp: 3.379 ± 0.061	4.494ProGlu: 4.494 ± 0.082	1.787ProPhe: 1.787 ± 0.052	3.342ProGly: 3.342 ± 0.078	0.939ProHis: 0.939 ± 0.037	2.9ProIle: 2.9 ± 0.071	1.442ProLys: 1.442 ± 0.042	6.491ProLeu: 6.491 ± 0.1	0.834ProMet: 0.834 ± 0.036	1.651ProAsn: 1.651 ± 0.05	2.689ProPro: 2.689 ± 0.08	3.133ProGln: 3.133 ± 0.076	2.826ProArg: 2.826 ± 0.071	3.364ProSer: 3.364 ± 0.064	3.237ProThr: 3.237 ± 0.074	3.862ProVal: 3.862 ± 0.077	0.933ProTrp: 0.933 ± 0.037	1.289ProTyr: 1.289 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	7.252GlnAla: 7.252 ± 0.115	0.353GlnCys: 0.353 ± 0.024	2.107GlnAsp: 2.107 ± 0.057	3.041GlnGlu: 3.041 ± 0.085	2.042GlnPhe: 2.042 ± 0.057	4.189GlnGly: 4.189 ± 0.067	1.014GlnHis: 1.014 ± 0.037	3.172GlnIle: 3.172 ± 0.065	1.479GlnLys: 1.479 ± 0.047	7.806GlnLeu: 7.806 ± 0.138	0.855GlnMet: 0.855 ± 0.03	1.217GlnAsn: 1.217 ± 0.037	3.975GlnPro: 3.975 ± 0.085	5.4GlnGln: 5.4 ± 0.153	4.798GlnArg: 4.798 ± 0.091	3.255GlnSer: 3.255 ± 0.063	3.348GlnThr: 3.348 ± 0.082	4.19GlnVal: 4.19 ± 0.072	1.006GlnTrp: 1.006 ± 0.04	0.942GlnTyr: 0.942 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	4.772ArgAla: 4.772 ± 0.081	0.806ArgCys: 0.806 ± 0.035	3.963ArgAsp: 3.963 ± 0.08	3.446ArgGlu: 3.446 ± 0.065	2.875ArgPhe: 2.875 ± 0.064	3.922ArgGly: 3.922 ± 0.079	1.329ArgHis: 1.329 ± 0.046	3.555ArgIle: 3.555 ± 0.066	1.647ArgLys: 1.647 ± 0.045	8.896ArgLeu: 8.896 ± 0.112	1.119ArgMet: 1.119 ± 0.038	1.94ArgAsn: 1.94 ± 0.051	3.372ArgPro: 3.372 ± 0.068	5.209ArgGln: 5.209 ± 0.102	4.945ArgArg: 4.945 ± 0.101	5.453ArgSer: 5.453 ± 0.085	2.748ArgThr: 2.748 ± 0.058	3.942ArgVal: 3.942 ± 0.084	1.688ArgTrp: 1.688 ± 0.055	2.332ArgTyr: 2.332 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.387SerAla: 5.387 ± 0.082	0.55SerCys: 0.55 ± 0.026	3.579SerAsp: 3.579 ± 0.069	3.206SerGlu: 3.206 ± 0.065	2.201SerPhe: 2.201 ± 0.062	4.79SerGly: 4.79 ± 0.097	1.112SerHis: 1.112 ± 0.043	2.792SerIle: 2.792 ± 0.074	1.375SerLys: 1.375 ± 0.047	8.402SerLeu: 8.402 ± 0.112	1.039SerMet: 1.039 ± 0.036	1.673SerAsn: 1.673 ± 0.049	3.67SerPro: 3.67 ± 0.067	3.592SerGln: 3.592 ± 0.071	3.97SerArg: 3.97 ± 0.08	3.827SerSer: 3.827 ± 0.075	2.956SerThr: 2.956 ± 0.062	3.752SerVal: 3.752 ± 0.064	0.951SerTrp: 0.951 ± 0.037	1.395SerTyr: 1.395 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.267ThrAla: 6.267 ± 0.091	0.508ThrCys: 0.508 ± 0.024	2.513ThrAsp: 2.513 ± 0.056	3.016ThrGlu: 3.016 ± 0.059	1.682ThrPhe: 1.682 ± 0.049	4.134ThrGly: 4.134 ± 0.082	0.848ThrHis: 0.848 ± 0.031	2.888ThrIle: 2.888 ± 0.062	1.098ThrLys: 1.098 ± 0.039	6.272ThrLeu: 6.272 ± 0.096	0.665ThrMet: 0.665 ± 0.032	1.308ThrAsn: 1.308 ± 0.049	3.607ThrPro: 3.607 ± 0.077	2.382ThrGln: 2.382 ± 0.056	2.523ThrArg: 2.523 ± 0.061	2.721ThrSer: 2.721 ± 0.057	3.082ThrThr: 3.082 ± 0.069	4.4ThrVal: 4.4 ± 0.072	0.851ThrTrp: 0.851 ± 0.038	1.327ThrTyr: 1.327 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.069ValAla: 7.069 ± 0.116	0.74ValCys: 0.74 ± 0.034	3.437ValAsp: 3.437 ± 0.068	4.133ValGlu: 4.133 ± 0.078	2.254ValPhe: 2.254 ± 0.058	4.897ValGly: 4.897 ± 0.087	1.009ValHis: 1.009 ± 0.038	3.876ValIle: 3.876 ± 0.082	1.798ValLys: 1.798 ± 0.057	7.956ValLeu: 7.956 ± 0.11	1.222ValMet: 1.222 ± 0.039	1.983ValAsn: 1.983 ± 0.061	3.225ValPro: 3.225 ± 0.074	3.389ValGln: 3.389 ± 0.075	4.017ValArg: 4.017 ± 0.077	3.918ValSer: 3.918 ± 0.068	3.825ValThr: 3.825 ± 0.079	4.988ValVal: 4.988 ± 0.088	0.975ValTrp: 0.975 ± 0.039	1.577ValTyr: 1.577 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.286TrpAla: 1.286 ± 0.044	0.159TrpCys: 0.159 ± 0.013	0.702TrpAsp: 0.702 ± 0.032	0.775TrpGlu: 0.775 ± 0.032	0.638TrpPhe: 0.638 ± 0.03	1.27TrpGly: 1.27 ± 0.042	0.346TrpHis: 0.346 ± 0.019	0.87TrpIle: 0.87 ± 0.036	0.382TrpLys: 0.382 ± 0.02	2.821TrpLeu: 2.821 ± 0.081	0.293TrpMet: 0.293 ± 0.019	0.441TrpAsn: 0.441 ± 0.024	0.893TrpPro: 0.893 ± 0.042	1.902TrpGln: 1.902 ± 0.069	1.276TrpArg: 1.276 ± 0.043	0.953TrpSer: 0.953 ± 0.037	0.754TrpThr: 0.754 ± 0.029	1.11TrpVal: 1.11 ± 0.037	0.276TrpTrp: 0.276 ± 0.018	0.343TrpTyr: 0.343 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.073TyrAla: 2.073 ± 0.054	0.374TyrCys: 0.374 ± 0.026	1.371TyrAsp: 1.371 ± 0.034	1.341TyrGlu: 1.341 ± 0.043	0.988TyrPhe: 0.988 ± 0.041	2.118TyrGly: 2.118 ± 0.054	0.471TyrHis: 0.471 ± 0.025	0.985TyrIle: 0.985 ± 0.036	0.524TyrLys: 0.524 ± 0.025	2.965TyrLeu: 2.965 ± 0.061	0.269TyrMet: 0.269 ± 0.019	0.704TyrAsn: 0.704 ± 0.029	1.416TyrPro: 1.416 ± 0.046	1.589TyrGln: 1.589 ± 0.051	2.24TyrArg: 2.24 ± 0.057	1.467TyrSer: 1.467 ± 0.039	0.94TyrThr: 0.94 ± 0.036	1.412TyrVal: 1.412 ± 0.046	0.563TyrTrp: 0.563 ± 0.025	0.731TyrTyr: 0.731 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2659 proteins (809334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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