Amino acid dipepetide frequency for Streptococcus satellite phage Javan342

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.078AlaAla: 4.078 ± 1.134
0.816AlaCys: 0.816 ± 0.474
2.447AlaAsp: 2.447 ± 0.958
5.302AlaGlu: 5.302 ± 1.068
2.855AlaPhe: 2.855 ± 1.553
2.447AlaGly: 2.447 ± 1.062
0.408AlaHis: 0.408 ± 0.356
5.302AlaIle: 5.302 ± 1.288
6.525AlaLys: 6.525 ± 2.486
5.71AlaLeu: 5.71 ± 1.864
0.816AlaMet: 0.816 ± 0.505
4.486AlaAsn: 4.486 ± 1.314
0.408AlaPro: 0.408 ± 0.485
1.631AlaGln: 1.631 ± 0.711
2.855AlaArg: 2.855 ± 1.139
4.078AlaSer: 4.078 ± 0.977
2.447AlaThr: 2.447 ± 1.189
3.67AlaVal: 3.67 ± 1.232
0.408AlaTrp: 0.408 ± 0.448
4.078AlaTyr: 4.078 ± 1.594
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.408CysGly: 0.408 ± 0.345
0.0CysHis: 0.0 ± 0.0
0.408CysIle: 0.408 ± 0.345
0.0CysLys: 0.0 ± 0.0
0.408CysLeu: 0.408 ± 0.443
0.408CysMet: 0.408 ± 0.4
0.408CysAsn: 0.408 ± 0.339
0.816CysPro: 0.816 ± 0.504
0.408CysGln: 0.408 ± 0.407
0.816CysArg: 0.816 ± 0.47
0.0CysSer: 0.0 ± 0.0
0.408CysThr: 0.408 ± 0.4
0.408CysVal: 0.408 ± 0.356
0.0CysTrp: 0.0 ± 0.0
0.816CysTyr: 0.816 ± 0.683
0.0CysXaa: 0.0 ± 0.0
Asp
2.855AspAla: 2.855 ± 0.829
0.408AspCys: 0.408 ± 0.345
4.078AspAsp: 4.078 ± 1.387
5.302AspGlu: 5.302 ± 1.62
2.039AspPhe: 2.039 ± 0.639
2.855AspGly: 2.855 ± 0.946
0.408AspHis: 0.408 ± 0.417
4.078AspIle: 4.078 ± 0.867
8.157AspLys: 8.157 ± 1.004
4.894AspLeu: 4.894 ± 1.03
1.223AspMet: 1.223 ± 0.624
2.855AspAsn: 2.855 ± 0.753
0.816AspPro: 0.816 ± 0.534
3.263AspGln: 3.263 ± 1.169
1.223AspArg: 1.223 ± 0.788
1.223AspSer: 1.223 ± 0.707
3.263AspThr: 3.263 ± 0.948
6.525AspVal: 6.525 ± 1.048
0.0AspTrp: 0.0 ± 0.0
4.894AspTyr: 4.894 ± 1.111
0.0AspXaa: 0.0 ± 0.0
Glu
3.263GluAla: 3.263 ± 1.196
0.816GluCys: 0.816 ± 0.683
3.67GluAsp: 3.67 ± 1.185
7.749GluGlu: 7.749 ± 2.044
1.631GluPhe: 1.631 ± 0.972
2.855GluGly: 2.855 ± 1.2
1.223GluHis: 1.223 ± 0.638
8.157GluIle: 8.157 ± 1.852
9.38GluLys: 9.38 ± 0.905
15.498GluLeu: 15.498 ± 2.86
1.223GluMet: 1.223 ± 0.641
4.894GluAsn: 4.894 ± 1.494
1.223GluPro: 1.223 ± 0.968
5.71GluGln: 5.71 ± 1.809
3.67GluArg: 3.67 ± 1.429
4.894GluSer: 4.894 ± 1.112
4.078GluThr: 4.078 ± 0.919
2.447GluVal: 2.447 ± 0.984
2.039GluTrp: 2.039 ± 0.759
2.039GluTyr: 2.039 ± 0.974
0.0GluXaa: 0.0 ± 0.0
Phe
2.039PheAla: 2.039 ± 0.784
0.0PheCys: 0.0 ± 0.0
2.855PheAsp: 2.855 ± 1.019
1.223PheGlu: 1.223 ± 0.944
0.408PhePhe: 0.408 ± 0.443
1.631PheGly: 1.631 ± 0.721
0.816PheHis: 0.816 ± 0.481
2.447PheIle: 2.447 ± 1.001
2.447PheLys: 2.447 ± 1.011
4.894PheLeu: 4.894 ± 2.289
1.631PheMet: 1.631 ± 0.779
1.223PheAsn: 1.223 ± 0.656
0.816PhePro: 0.816 ± 0.53
0.816PheGln: 0.816 ± 0.504
0.816PheArg: 0.816 ± 0.533
4.078PheSer: 4.078 ± 1.099
2.447PheThr: 2.447 ± 0.612
2.447PheVal: 2.447 ± 1.082
0.0PheTrp: 0.0 ± 0.0
1.631PheTyr: 1.631 ± 0.956
0.0PheXaa: 0.0 ± 0.0
Gly
2.855GlyAla: 2.855 ± 0.924
0.408GlyCys: 0.408 ± 0.339
1.631GlyAsp: 1.631 ± 0.639
1.631GlyGlu: 1.631 ± 0.886
1.223GlyPhe: 1.223 ± 0.582
0.408GlyGly: 0.408 ± 0.356
1.223GlyHis: 1.223 ± 0.527
2.447GlyIle: 2.447 ± 1.172
6.525GlyLys: 6.525 ± 2.17
2.447GlyLeu: 2.447 ± 1.047
0.816GlyMet: 0.816 ± 0.504
3.263GlyAsn: 3.263 ± 1.37
0.0GlyPro: 0.0 ± 0.0
2.447GlyGln: 2.447 ± 1.225
0.816GlyArg: 0.816 ± 0.532
2.039GlySer: 2.039 ± 0.992
2.039GlyThr: 2.039 ± 1.085
5.302GlyVal: 5.302 ± 1.937
0.408GlyTrp: 0.408 ± 0.4
3.263GlyTyr: 3.263 ± 0.794
0.0GlyXaa: 0.0 ± 0.0
His
0.408HisAla: 0.408 ± 0.356
0.0HisCys: 0.0 ± 0.0
1.223HisAsp: 1.223 ± 0.622
2.039HisGlu: 2.039 ± 0.814
0.816HisPhe: 0.816 ± 0.513
1.223HisGly: 1.223 ± 0.666
0.408HisHis: 0.408 ± 0.448
0.0HisIle: 0.0 ± 0.0
0.816HisLys: 0.816 ± 0.624
2.447HisLeu: 2.447 ± 0.705
0.408HisMet: 0.408 ± 0.433
1.223HisAsn: 1.223 ± 0.594
0.408HisPro: 0.408 ± 0.417
1.223HisGln: 1.223 ± 0.654
1.223HisArg: 1.223 ± 0.683
0.408HisSer: 0.408 ± 0.339
1.223HisThr: 1.223 ± 1.018
0.0HisVal: 0.0 ± 0.0
0.408HisTrp: 0.408 ± 0.417
0.408HisTyr: 0.408 ± 0.443
0.0HisXaa: 0.0 ± 0.0
Ile
4.078IleAla: 4.078 ± 1.285
0.408IleCys: 0.408 ± 0.443
6.117IleAsp: 6.117 ± 1.53
4.894IleGlu: 4.894 ± 1.215
2.855IlePhe: 2.855 ± 1.273
4.486IleGly: 4.486 ± 0.927
0.408IleHis: 0.408 ± 0.407
4.894IleIle: 4.894 ± 1.312
7.341IleLys: 7.341 ± 1.182
8.564IleLeu: 8.564 ± 2.038
2.855IleMet: 2.855 ± 0.975
4.486IleAsn: 4.486 ± 1.299
2.039IlePro: 2.039 ± 1.016
4.078IleGln: 4.078 ± 1.137
1.631IleArg: 1.631 ± 0.742
4.894IleSer: 4.894 ± 1.283
3.263IleThr: 3.263 ± 1.087
2.447IleVal: 2.447 ± 0.875
0.816IleTrp: 0.816 ± 0.628
2.447IleTyr: 2.447 ± 0.984
0.0IleXaa: 0.0 ± 0.0
Lys
8.157LysAla: 8.157 ± 2.783
0.408LysCys: 0.408 ± 0.345
6.525LysAsp: 6.525 ± 1.45
12.643LysGlu: 12.643 ± 2.153
0.816LysPhe: 0.816 ± 0.489
4.078LysGly: 4.078 ± 0.957
2.039LysHis: 2.039 ± 1.033
6.933LysIle: 6.933 ± 1.879
9.788LysLys: 9.788 ± 2.072
7.341LysLeu: 7.341 ± 1.261
1.631LysMet: 1.631 ± 1.078
5.71LysAsn: 5.71 ± 0.855
4.078LysPro: 4.078 ± 1.107
6.525LysGln: 6.525 ± 1.456
8.157LysArg: 8.157 ± 2.095
2.855LysSer: 2.855 ± 1.075
6.117LysThr: 6.117 ± 1.584
2.039LysVal: 2.039 ± 0.71
1.631LysTrp: 1.631 ± 0.913
2.855LysTyr: 2.855 ± 1.262
0.0LysXaa: 0.0 ± 0.0
Leu
11.419LeuAla: 11.419 ± 3.712
1.223LeuCys: 1.223 ± 0.817
9.788LeuAsp: 9.788 ± 1.909
10.196LeuGlu: 10.196 ± 2.893
5.71LeuPhe: 5.71 ± 1.678
5.302LeuGly: 5.302 ± 1.173
2.039LeuHis: 2.039 ± 0.717
3.67LeuIle: 3.67 ± 1.602
11.419LeuLys: 11.419 ± 2.601
13.051LeuLeu: 13.051 ± 3.578
2.447LeuMet: 2.447 ± 0.934
5.302LeuAsn: 5.302 ± 1.712
1.223LeuPro: 1.223 ± 0.685
0.408LeuGln: 0.408 ± 0.339
4.078LeuArg: 4.078 ± 1.245
5.71LeuSer: 5.71 ± 1.86
3.67LeuThr: 3.67 ± 1.235
4.078LeuVal: 4.078 ± 1.225
0.816LeuTrp: 0.816 ± 0.621
4.486LeuTyr: 4.486 ± 1.769
0.0LeuXaa: 0.0 ± 0.0
Met
0.816MetAla: 0.816 ± 0.504
0.0MetCys: 0.0 ± 0.0
0.816MetAsp: 0.816 ± 0.578
3.67MetGlu: 3.67 ± 1.045
0.408MetPhe: 0.408 ± 0.407
1.631MetGly: 1.631 ± 0.997
0.408MetHis: 0.408 ± 0.448
1.631MetIle: 1.631 ± 0.66
1.631MetLys: 1.631 ± 0.785
3.67MetLeu: 3.67 ± 0.988
0.816MetMet: 0.816 ± 0.481
2.447MetAsn: 2.447 ± 0.727
0.0MetPro: 0.0 ± 0.0
0.408MetGln: 0.408 ± 0.467
1.223MetArg: 1.223 ± 0.771
1.223MetSer: 1.223 ± 0.595
3.263MetThr: 3.263 ± 0.964
0.816MetVal: 0.816 ± 0.69
0.0MetTrp: 0.0 ± 0.0
0.408MetTyr: 0.408 ± 0.433
0.0MetXaa: 0.0 ± 0.0
Asn
2.855AsnAla: 2.855 ± 1.427
0.0AsnCys: 0.0 ± 0.0
2.039AsnAsp: 2.039 ± 0.683
4.078AsnGlu: 4.078 ± 1.754
1.223AsnPhe: 1.223 ± 0.622
4.486AsnGly: 4.486 ± 0.877
1.631AsnHis: 1.631 ± 1.008
2.855AsnIle: 2.855 ± 0.772
5.71AsnLys: 5.71 ± 1.864
4.894AsnLeu: 4.894 ± 1.209
2.039AsnMet: 2.039 ± 0.66
2.039AsnAsn: 2.039 ± 0.962
1.223AsnPro: 1.223 ± 0.563
1.631AsnGln: 1.631 ± 0.751
2.447AsnArg: 2.447 ± 1.052
4.486AsnSer: 4.486 ± 1.238
3.263AsnThr: 3.263 ± 1.346
2.039AsnVal: 2.039 ± 0.686
2.039AsnTrp: 2.039 ± 0.903
4.078AsnTyr: 4.078 ± 1.284
0.0AsnXaa: 0.0 ± 0.0
Pro
1.223ProAla: 1.223 ± 0.658
0.0ProCys: 0.0 ± 0.0
0.816ProAsp: 0.816 ± 0.502
0.816ProGlu: 0.816 ± 0.522
1.631ProPhe: 1.631 ± 0.61
0.408ProGly: 0.408 ± 0.4
0.408ProHis: 0.408 ± 0.417
1.631ProIle: 1.631 ± 0.907
4.486ProLys: 4.486 ± 1.434
2.039ProLeu: 2.039 ± 0.858
0.0ProMet: 0.0 ± 0.0
0.408ProAsn: 0.408 ± 0.339
0.0ProPro: 0.0 ± 0.0
1.223ProGln: 1.223 ± 0.675
1.223ProArg: 1.223 ± 0.499
1.631ProSer: 1.631 ± 0.963
1.631ProThr: 1.631 ± 0.782
2.039ProVal: 2.039 ± 0.803
0.408ProTrp: 0.408 ± 0.443
0.816ProTyr: 0.816 ± 0.59
0.0ProXaa: 0.0 ± 0.0
Gln
3.67GlnAla: 3.67 ± 0.899
0.408GlnCys: 0.408 ± 0.417
1.631GlnAsp: 1.631 ± 0.771
3.263GlnGlu: 3.263 ± 1.327
1.631GlnPhe: 1.631 ± 0.638
1.223GlnGly: 1.223 ± 0.663
0.816GlnHis: 0.816 ± 0.581
3.67GlnIle: 3.67 ± 1.031
4.486GlnLys: 4.486 ± 0.891
4.486GlnLeu: 4.486 ± 1.16
0.408GlnMet: 0.408 ± 0.537
1.223GlnAsn: 1.223 ± 0.65
2.039GlnPro: 2.039 ± 0.812
2.447GlnGln: 2.447 ± 1.482
2.447GlnArg: 2.447 ± 0.991
3.67GlnSer: 3.67 ± 0.965
2.447GlnThr: 2.447 ± 0.796
2.039GlnVal: 2.039 ± 0.986
0.0GlnTrp: 0.0 ± 0.0
5.71GlnTyr: 5.71 ± 1.597
0.0GlnXaa: 0.0 ± 0.0
Arg
1.631ArgAla: 1.631 ± 0.85
0.0ArgCys: 0.0 ± 0.0
3.263ArgAsp: 3.263 ± 0.926
6.117ArgGlu: 6.117 ± 1.975
0.816ArgPhe: 0.816 ± 0.536
1.223ArgGly: 1.223 ± 1.016
0.816ArgHis: 0.816 ± 0.473
5.302ArgIle: 5.302 ± 1.094
4.894ArgLys: 4.894 ± 1.284
4.078ArgLeu: 4.078 ± 1.069
1.223ArgMet: 1.223 ± 0.672
1.631ArgAsn: 1.631 ± 0.768
1.223ArgPro: 1.223 ± 0.821
4.078ArgGln: 4.078 ± 1.032
1.631ArgArg: 1.631 ± 0.737
1.631ArgSer: 1.631 ± 0.59
1.631ArgThr: 1.631 ± 0.694
2.447ArgVal: 2.447 ± 0.948
0.408ArgTrp: 0.408 ± 0.443
1.631ArgTyr: 1.631 ± 0.718
0.0ArgXaa: 0.0 ± 0.0
Ser
1.223SerAla: 1.223 ± 0.776
0.408SerCys: 0.408 ± 0.345
4.894SerAsp: 4.894 ± 0.985
5.302SerGlu: 5.302 ± 0.801
2.447SerPhe: 2.447 ± 0.69
1.631SerGly: 1.631 ± 0.662
0.408SerHis: 0.408 ± 0.4
4.894SerIle: 4.894 ± 1.389
3.263SerLys: 3.263 ± 0.874
4.486SerLeu: 4.486 ± 1.089
2.447SerMet: 2.447 ± 0.868
5.71SerAsn: 5.71 ± 1.679
3.263SerPro: 3.263 ± 1.015
3.263SerGln: 3.263 ± 1.477
2.855SerArg: 2.855 ± 1.062
0.408SerSer: 0.408 ± 0.433
2.447SerThr: 2.447 ± 1.2
3.263SerVal: 3.263 ± 0.878
0.816SerTrp: 0.816 ± 0.533
1.223SerTyr: 1.223 ± 0.749
0.0SerXaa: 0.0 ± 0.0
Thr
2.855ThrAla: 2.855 ± 1.159
0.0ThrCys: 0.0 ± 0.0
2.855ThrAsp: 2.855 ± 1.223
5.302ThrGlu: 5.302 ± 1.695
1.223ThrPhe: 1.223 ± 0.842
2.855ThrGly: 2.855 ± 0.911
1.223ThrHis: 1.223 ± 0.551
4.486ThrIle: 4.486 ± 1.451
4.486ThrLys: 4.486 ± 1.347
4.486ThrLeu: 4.486 ± 1.536
1.631ThrMet: 1.631 ± 0.803
3.67ThrAsn: 3.67 ± 0.658
0.816ThrPro: 0.816 ± 0.513
1.223ThrGln: 1.223 ± 0.79
2.855ThrArg: 2.855 ± 0.732
2.447ThrSer: 2.447 ± 0.905
2.855ThrThr: 2.855 ± 1.64
3.67ThrVal: 3.67 ± 1.281
0.408ThrTrp: 0.408 ± 0.433
2.447ThrTyr: 2.447 ± 0.983
0.0ThrXaa: 0.0 ± 0.0
Val
2.447ValAla: 2.447 ± 1.438
0.0ValCys: 0.0 ± 0.0
3.263ValAsp: 3.263 ± 0.989
2.855ValGlu: 2.855 ± 1.282
1.631ValPhe: 1.631 ± 1.073
0.408ValGly: 0.408 ± 0.433
0.408ValHis: 0.408 ± 0.339
4.894ValIle: 4.894 ± 1.368
4.078ValLys: 4.078 ± 1.664
4.486ValLeu: 4.486 ± 1.756
1.223ValMet: 1.223 ± 0.7
1.223ValAsn: 1.223 ± 0.574
1.631ValPro: 1.631 ± 0.782
3.263ValGln: 3.263 ± 0.902
2.447ValArg: 2.447 ± 0.912
5.302ValSer: 5.302 ± 1.279
3.67ValThr: 3.67 ± 1.079
2.855ValVal: 2.855 ± 1.39
0.408ValTrp: 0.408 ± 0.339
4.078ValTyr: 4.078 ± 1.12
0.0ValXaa: 0.0 ± 0.0
Trp
1.223TrpAla: 1.223 ± 0.567
0.0TrpCys: 0.0 ± 0.0
0.408TrpAsp: 0.408 ± 0.339
0.408TrpGlu: 0.408 ± 0.448
0.816TrpPhe: 0.816 ± 0.621
0.408TrpGly: 0.408 ± 0.433
0.816TrpHis: 0.816 ± 0.47
1.223TrpIle: 1.223 ± 0.639
0.816TrpLys: 0.816 ± 0.656
2.039TrpLeu: 2.039 ± 1.15
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.223TrpGln: 1.223 ± 0.527
0.408TrpArg: 0.408 ± 0.345
0.816TrpSer: 0.816 ± 0.533
0.0TrpThr: 0.0 ± 0.0
0.408TrpVal: 0.408 ± 0.4
0.408TrpTrp: 0.408 ± 0.339
0.408TrpTyr: 0.408 ± 0.407
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.67TyrAla: 3.67 ± 1.199
0.408TyrCys: 0.408 ± 0.4
2.039TyrAsp: 2.039 ± 0.951
3.67TyrGlu: 3.67 ± 1.214
4.486TyrPhe: 4.486 ± 1.292
1.223TyrGly: 1.223 ± 0.699
0.408TyrHis: 0.408 ± 0.407
4.078TyrIle: 4.078 ± 1.342
4.486TyrLys: 4.486 ± 1.266
6.117TyrLeu: 6.117 ± 1.206
1.631TyrMet: 1.631 ± 0.793
2.855TyrAsn: 2.855 ± 0.991
0.816TyrPro: 0.816 ± 0.886
2.447TyrGln: 2.447 ± 0.794
2.855TyrArg: 2.855 ± 1.09
2.855TyrSer: 2.855 ± 1.09
1.631TyrThr: 1.631 ± 0.629
1.631TyrVal: 1.631 ± 0.998
0.408TyrTrp: 0.408 ± 0.339
2.039TyrTyr: 2.039 ± 0.81
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 16 proteins (2453 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski