Amino acid dipepetide frequency for Paludibacter propionicigenes (strain DSM 17365 / JCM 13257 / WB4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.165AlaAla: 5.165 ± 0.102	0.716AlaCys: 0.716 ± 0.029	3.917AlaAsp: 3.917 ± 0.074	4.379AlaGlu: 4.379 ± 0.08	3.219AlaPhe: 3.219 ± 0.057	5.016AlaGly: 5.016 ± 0.09	1.127AlaHis: 1.127 ± 0.037	5.088AlaIle: 5.088 ± 0.08	4.622AlaLys: 4.622 ± 0.077	6.556AlaLeu: 6.556 ± 0.093	1.571AlaMet: 1.571 ± 0.044	3.602AlaAsn: 3.602 ± 0.075	2.127AlaPro: 2.127 ± 0.053	2.653AlaGln: 2.653 ± 0.054	2.443AlaArg: 2.443 ± 0.054	4.425AlaSer: 4.425 ± 0.102	4.037AlaThr: 4.037 ± 0.097	4.495AlaVal: 4.495 ± 0.073	0.679AlaTrp: 0.679 ± 0.025	2.703AlaTyr: 2.703 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.602CysAla: 0.602 ± 0.029	0.142CysCys: 0.142 ± 0.012	0.492CysAsp: 0.492 ± 0.031	0.496CysGlu: 0.496 ± 0.025	0.514CysPhe: 0.514 ± 0.02	0.787CysGly: 0.787 ± 0.032	0.225CysHis: 0.225 ± 0.023	0.693CysIle: 0.693 ± 0.023	0.619CysLys: 0.619 ± 0.029	0.881CysLeu: 0.881 ± 0.034	0.205CysMet: 0.205 ± 0.013	0.523CysAsn: 0.523 ± 0.024	0.405CysPro: 0.405 ± 0.028	0.264CysGln: 0.264 ± 0.029	0.389CysArg: 0.389 ± 0.019	0.719CysSer: 0.719 ± 0.026	0.516CysThr: 0.516 ± 0.023	0.676CysVal: 0.676 ± 0.029	0.126CysTrp: 0.126 ± 0.012	0.4CysTyr: 0.4 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.689AspAla: 3.689 ± 0.065	0.528AspCys: 0.528 ± 0.021	2.306AspAsp: 2.306 ± 0.052	3.543AspGlu: 3.543 ± 0.061	3.113AspPhe: 3.113 ± 0.061	3.562AspGly: 3.562 ± 0.099	0.73AspHis: 0.73 ± 0.024	4.249AspIle: 4.249 ± 0.069	4.351AspLys: 4.351 ± 0.069	4.708AspLeu: 4.708 ± 0.073	1.292AspMet: 1.292 ± 0.033	2.976AspAsn: 2.976 ± 0.061	1.643AspPro: 1.643 ± 0.04	1.351AspGln: 1.351 ± 0.037	1.916AspArg: 1.916 ± 0.046	3.196AspSer: 3.196 ± 0.065	2.407AspThr: 2.407 ± 0.057	3.495AspVal: 3.495 ± 0.061	0.706AspTrp: 0.706 ± 0.028	2.584AspTyr: 2.584 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	3.911GluAla: 3.911 ± 0.076	0.467GluCys: 0.467 ± 0.025	2.525GluAsp: 2.525 ± 0.054	3.606GluGlu: 3.606 ± 0.078	2.684GluPhe: 2.684 ± 0.063	3.099GluGly: 3.099 ± 0.064	0.979GluHis: 0.979 ± 0.034	5.054GluIle: 5.054 ± 0.081	5.308GluLys: 5.308 ± 0.091	6.058GluLeu: 6.058 ± 0.095	1.766GluMet: 1.766 ± 0.044	3.778GluAsn: 3.778 ± 0.068	1.573GluPro: 1.573 ± 0.044	2.256GluGln: 2.256 ± 0.053	2.498GluArg: 2.498 ± 0.06	3.282GluSer: 3.282 ± 0.06	3.286GluThr: 3.286 ± 0.068	3.684GluVal: 3.684 ± 0.069	0.652GluTrp: 0.652 ± 0.028	2.332GluTyr: 2.332 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.172PheAla: 3.172 ± 0.06	0.589PheCys: 0.589 ± 0.023	3.008PheAsp: 3.008 ± 0.062	2.843PheGlu: 2.843 ± 0.064	2.504PhePhe: 2.504 ± 0.053	3.534PheGly: 3.534 ± 0.073	0.834PheHis: 0.834 ± 0.027	3.625PheIle: 3.625 ± 0.066	3.079PheLys: 3.079 ± 0.061	4.295PheLeu: 4.295 ± 0.08	1.191PheMet: 1.191 ± 0.037	2.855PheAsn: 2.855 ± 0.054	1.732PhePro: 1.732 ± 0.043	1.511PheGln: 1.511 ± 0.045	1.897PheArg: 1.897 ± 0.045	4.142PheSer: 4.142 ± 0.062	2.994PheThr: 2.994 ± 0.059	3.283PheVal: 3.283 ± 0.052	0.573PheTrp: 0.573 ± 0.027	2.071PheTyr: 2.071 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.315GlyAla: 4.315 ± 0.078	0.748GlyCys: 0.748 ± 0.04	3.163GlyAsp: 3.163 ± 0.104	3.356GlyGlu: 3.356 ± 0.062	3.489GlyPhe: 3.489 ± 0.058	4.503GlyGly: 4.503 ± 0.1	1.11GlyHis: 1.11 ± 0.037	5.436GlyIle: 5.436 ± 0.086	5.189GlyLys: 5.189 ± 0.073	5.959GlyLeu: 5.959 ± 0.096	1.724GlyMet: 1.724 ± 0.05	3.666GlyAsn: 3.666 ± 0.086	1.185GlyPro: 1.185 ± 0.037	1.908GlyGln: 1.908 ± 0.042	2.362GlyArg: 2.362 ± 0.055	4.308GlySer: 4.308 ± 0.115	4.211GlyThr: 4.211 ± 0.149	4.753GlyVal: 4.753 ± 0.085	0.843GlyTrp: 0.843 ± 0.034	2.968GlyTyr: 2.968 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.073HisAla: 1.073 ± 0.029	0.21HisCys: 0.21 ± 0.018	0.822HisAsp: 0.822 ± 0.03	0.939HisGlu: 0.939 ± 0.032	1.058HisPhe: 1.058 ± 0.037	1.122HisGly: 1.122 ± 0.039	0.39HisHis: 0.39 ± 0.022	1.291HisIle: 1.291 ± 0.038	1.097HisLys: 1.097 ± 0.038	1.66HisLeu: 1.66 ± 0.047	0.315HisMet: 0.315 ± 0.016	0.922HisAsn: 0.922 ± 0.029	0.867HisPro: 0.867 ± 0.028	0.587HisGln: 0.587 ± 0.021	0.686HisArg: 0.686 ± 0.03	1.122HisSer: 1.122 ± 0.033	0.984HisThr: 0.984 ± 0.027	0.976HisVal: 0.976 ± 0.033	0.202HisTrp: 0.202 ± 0.014	0.826HisTyr: 0.826 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.618IleAla: 5.618 ± 0.082	0.877IleCys: 0.877 ± 0.04	4.562IleAsp: 4.562 ± 0.071	4.743IleGlu: 4.743 ± 0.081	3.436IlePhe: 3.436 ± 0.063	5.037IleGly: 5.037 ± 0.068	1.395IleHis: 1.395 ± 0.038	5.655IleIle: 5.655 ± 0.082	5.214IleLys: 5.214 ± 0.07	6.613IleLeu: 6.613 ± 0.091	1.548IleMet: 1.548 ± 0.04	4.321IleAsn: 4.321 ± 0.075	3.358IlePro: 3.358 ± 0.055	2.641IleGln: 2.641 ± 0.056	3.046IleArg: 3.046 ± 0.059	5.647IleSer: 5.647 ± 0.079	4.504IleThr: 4.504 ± 0.11	4.911IleVal: 4.911 ± 0.076	0.682IleTrp: 0.682 ± 0.026	2.921IleTyr: 2.921 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	5.018LysAla: 5.018 ± 0.08	0.461LysCys: 0.461 ± 0.021	3.946LysAsp: 3.946 ± 0.071	4.843LysGlu: 4.843 ± 0.088	2.735LysPhe: 2.735 ± 0.057	4.3LysGly: 4.3 ± 0.071	1.212LysHis: 1.212 ± 0.035	5.673LysIle: 5.673 ± 0.081	5.709LysLys: 5.709 ± 0.094	6.643LysLeu: 6.643 ± 0.083	2.226LysMet: 2.226 ± 0.046	4.492LysAsn: 4.492 ± 0.071	2.579LysPro: 2.579 ± 0.049	2.865LysGln: 2.865 ± 0.059	2.863LysArg: 2.863 ± 0.054	4.608LysSer: 4.608 ± 0.07	4.777LysThr: 4.777 ± 0.069	4.613LysVal: 4.613 ± 0.07	0.741LysTrp: 0.741 ± 0.03	3.138LysTyr: 3.138 ± 0.055	0.0LysXaa: 0.0 ± 0.0
Leu	6.089LeuAla: 6.089 ± 0.095	0.908LeuCys: 0.908 ± 0.031	4.569LeuAsp: 4.569 ± 0.061	4.828LeuGlu: 4.828 ± 0.086	4.911LeuPhe: 4.911 ± 0.084	5.523LeuGly: 5.523 ± 0.098	1.6LeuHis: 1.6 ± 0.044	6.972LeuIle: 6.972 ± 0.091	7.279LeuLys: 7.279 ± 0.097	9.033LeuLeu: 9.033 ± 0.123	2.196LeuMet: 2.196 ± 0.052	5.557LeuAsn: 5.557 ± 0.078	3.774LeuPro: 3.774 ± 0.057	3.21LeuGln: 3.21 ± 0.064	3.563LeuArg: 3.563 ± 0.07	7.294LeuSer: 7.294 ± 0.1	5.55LeuThr: 5.55 ± 0.089	5.497LeuVal: 5.497 ± 0.079	0.833LeuTrp: 0.833 ± 0.026	3.431LeuTyr: 3.431 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.666MetAla: 1.666 ± 0.046	0.184MetCys: 0.184 ± 0.015	1.183MetAsp: 1.183 ± 0.034	1.386MetGlu: 1.386 ± 0.041	0.975MetPhe: 0.975 ± 0.034	1.521MetGly: 1.521 ± 0.041	0.441MetHis: 0.441 ± 0.022	1.701MetIle: 1.701 ± 0.04	2.274MetLys: 2.274 ± 0.044	2.233MetLeu: 2.233 ± 0.056	0.601MetMet: 0.601 ± 0.023	1.515MetAsn: 1.515 ± 0.035	0.977MetPro: 0.977 ± 0.029	0.885MetGln: 0.885 ± 0.03	0.987MetArg: 0.987 ± 0.03	1.653MetSer: 1.653 ± 0.042	1.35MetThr: 1.35 ± 0.033	1.386MetVal: 1.386 ± 0.038	0.209MetTrp: 0.209 ± 0.014	0.762MetTyr: 0.762 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.928AsnAla: 3.928 ± 0.084	0.52AsnCys: 0.52 ± 0.028	2.876AsnAsp: 2.876 ± 0.05	3.407AsnGlu: 3.407 ± 0.066	2.752AsnPhe: 2.752 ± 0.055	3.972AsnGly: 3.972 ± 0.08	0.993AsnHis: 0.993 ± 0.032	4.485AsnIle: 4.485 ± 0.082	4.213AsnLys: 4.213 ± 0.076	4.944AsnLeu: 4.944 ± 0.087	1.319AsnMet: 1.319 ± 0.041	3.525AsnAsn: 3.525 ± 0.101	2.747AsnPro: 2.747 ± 0.055	2.012AsnGln: 2.012 ± 0.052	2.269AsnArg: 2.269 ± 0.054	3.872AsnSer: 3.872 ± 0.081	3.337AsnThr: 3.337 ± 0.097	3.546AsnVal: 3.546 ± 0.072	0.714AsnTrp: 0.714 ± 0.025	2.786AsnTyr: 2.786 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.684ProAla: 2.684 ± 0.055	0.265ProCys: 0.265 ± 0.015	2.284ProAsp: 2.284 ± 0.049	2.79ProGlu: 2.79 ± 0.064	1.79ProPhe: 1.79 ± 0.048	2.139ProGly: 2.139 ± 0.043	0.628ProHis: 0.628 ± 0.026	2.521ProIle: 2.521 ± 0.051	2.219ProLys: 2.219 ± 0.045	3.081ProLeu: 3.081 ± 0.059	0.783ProMet: 0.783 ± 0.027	1.945ProAsn: 1.945 ± 0.045	0.768ProPro: 0.768 ± 0.028	1.297ProGln: 1.297 ± 0.034	1.115ProArg: 1.115 ± 0.036	2.091ProSer: 2.091 ± 0.051	2.353ProThr: 2.353 ± 0.054	2.856ProVal: 2.856 ± 0.048	0.38ProTrp: 0.38 ± 0.02	1.49ProTyr: 1.49 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.304GlnAla: 2.304 ± 0.046	0.229GlnCys: 0.229 ± 0.016	1.359GlnAsp: 1.359 ± 0.034	1.808GlnGlu: 1.808 ± 0.047	1.614GlnPhe: 1.614 ± 0.041	1.845GlnGly: 1.845 ± 0.051	0.655GlnHis: 0.655 ± 0.024	2.701GlnIle: 2.701 ± 0.056	2.718GlnLys: 2.718 ± 0.055	3.522GlnLeu: 3.522 ± 0.075	0.84GlnMet: 0.84 ± 0.026	2.089GlnAsn: 2.089 ± 0.046	1.228GlnPro: 1.228 ± 0.038	1.602GlnGln: 1.602 ± 0.049	1.372GlnArg: 1.372 ± 0.037	2.294GlnSer: 2.294 ± 0.048	2.193GlnThr: 2.193 ± 0.046	2.053GlnVal: 2.053 ± 0.051	0.369GlnTrp: 0.369 ± 0.022	1.458GlnTyr: 1.458 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.297ArgAla: 2.297 ± 0.045	0.291ArgCys: 0.291 ± 0.019	1.811ArgAsp: 1.811 ± 0.047	2.273ArgGlu: 2.273 ± 0.049	2.115ArgPhe: 2.115 ± 0.058	2.017ArgGly: 2.017 ± 0.046	0.648ArgHis: 0.648 ± 0.026	3.28ArgIle: 3.28 ± 0.066	3.101ArgLys: 3.101 ± 0.061	3.689ArgLeu: 3.689 ± 0.064	1.094ArgMet: 1.094 ± 0.029	2.297ArgAsn: 2.297 ± 0.056	1.265ArgPro: 1.265 ± 0.039	1.304ArgGln: 1.304 ± 0.037	1.607ArgArg: 1.607 ± 0.047	2.072ArgSer: 2.072 ± 0.05	2.079ArgThr: 2.079 ± 0.045	2.422ArgVal: 2.422 ± 0.055	0.474ArgTrp: 0.474 ± 0.021	1.758ArgTyr: 1.758 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.662SerAla: 4.662 ± 0.093	0.702SerCys: 0.702 ± 0.025	3.532SerAsp: 3.532 ± 0.057	3.703SerGlu: 3.703 ± 0.061	3.708SerPhe: 3.708 ± 0.063	4.974SerGly: 4.974 ± 0.124	1.1SerHis: 1.1 ± 0.037	5.453SerIle: 5.453 ± 0.083	4.539SerLys: 4.539 ± 0.066	6.261SerLeu: 6.261 ± 0.079	1.483SerMet: 1.483 ± 0.042	3.742SerAsn: 3.742 ± 0.087	2.434SerPro: 2.434 ± 0.055	2.14SerGln: 2.14 ± 0.046	2.234SerArg: 2.234 ± 0.05	4.768SerSer: 4.768 ± 0.116	4.232SerThr: 4.232 ± 0.109	4.864SerVal: 4.864 ± 0.076	0.785SerTrp: 0.785 ± 0.033	3.016SerTyr: 3.016 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	4.395ThrAla: 4.395 ± 0.133	0.467ThrCys: 0.467 ± 0.02	3.472ThrAsp: 3.472 ± 0.065	3.372ThrGlu: 3.372 ± 0.058	2.858ThrPhe: 2.858 ± 0.059	4.45ThrGly: 4.45 ± 0.123	0.991ThrHis: 0.991 ± 0.029	4.488ThrIle: 4.488 ± 0.095	3.697ThrLys: 3.697 ± 0.066	5.457ThrLeu: 5.457 ± 0.077	1.085ThrMet: 1.085 ± 0.035	3.361ThrAsn: 3.361 ± 0.099	2.671ThrPro: 2.671 ± 0.06	1.808ThrGln: 1.808 ± 0.046	1.945ThrArg: 1.945 ± 0.045	3.879ThrSer: 3.879 ± 0.093	3.719ThrThr: 3.719 ± 0.121	4.191ThrVal: 4.191 ± 0.089	0.609ThrTrp: 0.609 ± 0.029	2.386ThrTyr: 2.386 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	4.577ValAla: 4.577 ± 0.071	0.746ValCys: 0.746 ± 0.028	3.691ValAsp: 3.691 ± 0.063	3.847ValGlu: 3.847 ± 0.068	3.33ValPhe: 3.33 ± 0.059	4.251ValGly: 4.251 ± 0.079	1.08ValHis: 1.08 ± 0.031	4.775ValIle: 4.775 ± 0.078	4.379ValLys: 4.379 ± 0.071	6.107ValLeu: 6.107 ± 0.097	1.427ValMet: 1.427 ± 0.043	3.702ValAsn: 3.702 ± 0.073	2.249ValPro: 2.249 ± 0.045	2.003ValGln: 2.003 ± 0.039	2.511ValArg: 2.511 ± 0.055	5.089ValSer: 5.089 ± 0.087	3.719ValThr: 3.719 ± 0.092	4.708ValVal: 4.708 ± 0.073	0.688ValTrp: 0.688 ± 0.028	2.575ValTyr: 2.575 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.659TrpAla: 0.659 ± 0.027	0.134TrpCys: 0.134 ± 0.011	0.629TrpAsp: 0.629 ± 0.027	0.569TrpGlu: 0.569 ± 0.023	0.546TrpPhe: 0.546 ± 0.025	0.801TrpGly: 0.801 ± 0.032	0.235TrpHis: 0.235 ± 0.022	0.772TrpIle: 0.772 ± 0.029	0.862TrpLys: 0.862 ± 0.033	0.995TrpLeu: 0.995 ± 0.033	0.347TrpMet: 0.347 ± 0.019	0.721TrpAsn: 0.721 ± 0.027	0.208TrpPro: 0.208 ± 0.015	0.412TrpGln: 0.412 ± 0.021	0.441TrpArg: 0.441 ± 0.02	0.689TrpSer: 0.689 ± 0.026	0.637TrpThr: 0.637 ± 0.03	0.657TrpVal: 0.657 ± 0.03	0.166TrpTrp: 0.166 ± 0.014	0.448TrpTyr: 0.448 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.719TyrAla: 2.719 ± 0.057	0.488TyrCys: 0.488 ± 0.023	2.199TyrAsp: 2.199 ± 0.047	2.066TyrGlu: 2.066 ± 0.046	2.381TyrPhe: 2.381 ± 0.052	2.741TyrGly: 2.741 ± 0.062	0.776TyrHis: 0.776 ± 0.031	2.818TyrIle: 2.818 ± 0.056	2.974TyrLys: 2.974 ± 0.055	3.921TyrLeu: 3.921 ± 0.072	0.874TyrMet: 0.874 ± 0.027	2.629TyrAsn: 2.629 ± 0.066	1.692TyrPro: 1.692 ± 0.044	1.543TyrGln: 1.543 ± 0.04	1.752TyrArg: 1.752 ± 0.046	3.185TyrSer: 3.185 ± 0.059	2.412TyrThr: 2.412 ± 0.065	2.386TyrVal: 2.386 ± 0.046	0.496TyrTrp: 0.496 ± 0.025	1.973TyrTyr: 1.973 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3020 proteins (1067089 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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