Amino acid dipepetide frequency for Kineothrix alysoides

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.082AlaAla: 7.082 ± 0.111	0.995AlaCys: 0.995 ± 0.028	4.348AlaAsp: 4.348 ± 0.059	5.233AlaGlu: 5.233 ± 0.067	3.038AlaPhe: 3.038 ± 0.058	6.246AlaGly: 6.246 ± 0.092	1.02AlaHis: 1.02 ± 0.028	5.184AlaIle: 5.184 ± 0.073	4.571AlaLys: 4.571 ± 0.059	6.694AlaLeu: 6.694 ± 0.087	2.182AlaMet: 2.182 ± 0.043	2.502AlaAsn: 2.502 ± 0.044	1.884AlaPro: 1.884 ± 0.048	2.365AlaGln: 2.365 ± 0.047	2.63AlaArg: 2.63 ± 0.051	4.12AlaSer: 4.12 ± 0.07	3.158AlaThr: 3.158 ± 0.078	6.126AlaVal: 6.126 ± 0.081	0.58AlaTrp: 0.58 ± 0.021	2.844AlaTyr: 2.844 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.899CysAla: 0.899 ± 0.026	0.238CysCys: 0.238 ± 0.013	0.765CysAsp: 0.765 ± 0.024	0.897CysGlu: 0.897 ± 0.03	0.646CysPhe: 0.646 ± 0.025	1.38CysGly: 1.38 ± 0.036	0.269CysHis: 0.269 ± 0.015	1.104CysIle: 1.104 ± 0.028	0.782CysLys: 0.782 ± 0.026	1.155CysLeu: 1.155 ± 0.031	0.438CysMet: 0.438 ± 0.017	0.589CysAsn: 0.589 ± 0.021	0.534CysPro: 0.534 ± 0.038	0.323CysGln: 0.323 ± 0.014	0.617CysArg: 0.617 ± 0.024	0.83CysSer: 0.83 ± 0.024	0.688CysThr: 0.688 ± 0.02	0.9CysVal: 0.9 ± 0.025	0.112CysTrp: 0.112 ± 0.01	0.594CysTyr: 0.594 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.777AspAla: 3.777 ± 0.057	0.713AspCys: 0.713 ± 0.027	2.49AspAsp: 2.49 ± 0.053	4.364AspGlu: 4.364 ± 0.07	2.624AspPhe: 2.624 ± 0.05	4.249AspGly: 4.249 ± 0.08	0.677AspHis: 0.677 ± 0.025	5.001AspIle: 5.001 ± 0.069	3.923AspLys: 3.923 ± 0.053	4.148AspLeu: 4.148 ± 0.056	1.96AspMet: 1.96 ± 0.038	2.492AspAsn: 2.492 ± 0.053	1.395AspPro: 1.395 ± 0.033	0.971AspGln: 0.971 ± 0.027	2.209AspArg: 2.209 ± 0.044	3.225AspSer: 3.225 ± 0.049	2.999AspThr: 2.999 ± 0.053	3.576AspVal: 3.576 ± 0.052	0.58AspTrp: 0.58 ± 0.025	2.934AspTyr: 2.934 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.668GluAla: 5.668 ± 0.073	0.829GluCys: 0.829 ± 0.028	4.169GluAsp: 4.169 ± 0.061	8.188GluGlu: 8.188 ± 0.116	2.63GluPhe: 2.63 ± 0.048	4.825GluGly: 4.825 ± 0.075	1.261GluHis: 1.261 ± 0.033	5.97GluIle: 5.97 ± 0.079	6.859GluLys: 6.859 ± 0.085	6.665GluLeu: 6.665 ± 0.075	2.365GluMet: 2.365 ± 0.043	4.226GluAsn: 4.226 ± 0.056	1.785GluPro: 1.785 ± 0.037	2.761GluGln: 2.761 ± 0.05	3.493GluArg: 3.493 ± 0.061	3.777GluSer: 3.777 ± 0.063	3.73GluThr: 3.73 ± 0.052	4.622GluVal: 4.622 ± 0.056	0.747GluTrp: 0.747 ± 0.024	3.302GluTyr: 3.302 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.04PheAla: 3.04 ± 0.052	0.716PheCys: 0.716 ± 0.025	2.506PheAsp: 2.506 ± 0.048	2.818PheGlu: 2.818 ± 0.049	2.068PhePhe: 2.068 ± 0.042	3.049PheGly: 3.049 ± 0.053	0.859PheHis: 0.859 ± 0.027	3.378PheIle: 3.378 ± 0.054	2.217PheLys: 2.217 ± 0.041	3.997PheLeu: 3.997 ± 0.077	1.268PheMet: 1.268 ± 0.031	1.639PheAsn: 1.639 ± 0.035	1.374PhePro: 1.374 ± 0.036	1.348PheGln: 1.348 ± 0.035	1.642PheArg: 1.642 ± 0.035	3.145PheSer: 3.145 ± 0.054	2.382PheThr: 2.382 ± 0.047	2.8PheVal: 2.8 ± 0.049	0.459PheTrp: 0.459 ± 0.018	1.911PheTyr: 1.911 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.973GlyAla: 4.973 ± 0.101	1.139GlyCys: 1.139 ± 0.031	3.504GlyAsp: 3.504 ± 0.063	5.165GlyGlu: 5.165 ± 0.072	3.224GlyPhe: 3.224 ± 0.054	4.965GlyGly: 4.965 ± 0.087	1.132GlyHis: 1.132 ± 0.025	6.62GlyIle: 6.62 ± 0.09	5.397GlyLys: 5.397 ± 0.067	5.749GlyLeu: 5.749 ± 0.071	2.522GlyMet: 2.522 ± 0.048	3.338GlyAsn: 3.338 ± 0.066	1.515GlyPro: 1.515 ± 0.109	2.054GlyGln: 2.054 ± 0.037	3.12GlyArg: 3.12 ± 0.057	4.221GlySer: 4.221 ± 0.059	4.157GlyThr: 4.157 ± 0.079	4.756GlyVal: 4.756 ± 0.072	0.689GlyTrp: 0.689 ± 0.024	3.486GlyTyr: 3.486 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	0.956HisAla: 0.956 ± 0.024	0.263HisCys: 0.263 ± 0.014	0.804HisAsp: 0.804 ± 0.029	1.057HisGlu: 1.057 ± 0.032	0.822HisPhe: 0.822 ± 0.026	1.153HisGly: 1.153 ± 0.031	0.366HisHis: 0.366 ± 0.024	1.462HisIle: 1.462 ± 0.033	0.967HisLys: 0.967 ± 0.029	1.391HisLeu: 1.391 ± 0.041	0.525HisMet: 0.525 ± 0.02	0.782HisAsn: 0.782 ± 0.025	0.726HisPro: 0.726 ± 0.024	0.44HisGln: 0.44 ± 0.018	0.73HisArg: 0.73 ± 0.026	0.989HisSer: 0.989 ± 0.028	0.863HisThr: 0.863 ± 0.025	0.982HisVal: 0.982 ± 0.03	0.179HisTrp: 0.179 ± 0.013	0.756HisTyr: 0.756 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.024IleAla: 6.024 ± 0.069	1.316IleCys: 1.316 ± 0.033	4.288IleAsp: 4.288 ± 0.062	5.298IleGlu: 5.298 ± 0.068	3.328IlePhe: 3.328 ± 0.056	5.561IleGly: 5.561 ± 0.064	1.391IleHis: 1.391 ± 0.032	6.234IleIle: 6.234 ± 0.083	4.733IleLys: 4.733 ± 0.072	7.341IleLeu: 7.341 ± 0.078	2.311IleMet: 2.311 ± 0.047	3.51IleAsn: 3.51 ± 0.053	3.145IlePro: 3.145 ± 0.055	2.201IleGln: 2.201 ± 0.046	3.49IleArg: 3.49 ± 0.056	5.531IleSer: 5.531 ± 0.062	4.363IleThr: 4.363 ± 0.065	5.23IleVal: 5.23 ± 0.07	0.728IleTrp: 0.728 ± 0.023	3.235IleTyr: 3.235 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.932LysAla: 4.932 ± 0.065	0.664LysCys: 0.664 ± 0.024	3.993LysAsp: 3.993 ± 0.055	7.255LysGlu: 7.255 ± 0.095	1.872LysPhe: 1.872 ± 0.037	4.339LysGly: 4.339 ± 0.066	0.951LysHis: 0.951 ± 0.024	5.088LysIle: 5.088 ± 0.064	5.928LysLys: 5.928 ± 0.089	5.55LysLeu: 5.55 ± 0.071	2.129LysMet: 2.129 ± 0.037	3.746LysAsn: 3.746 ± 0.058	1.757LysPro: 1.757 ± 0.039	2.368LysGln: 2.368 ± 0.047	3.151LysArg: 3.151 ± 0.051	3.558LysSer: 3.558 ± 0.055	3.569LysThr: 3.569 ± 0.054	4.287LysVal: 4.287 ± 0.061	0.656LysTrp: 0.656 ± 0.024	2.97LysTyr: 2.97 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	6.389LeuAla: 6.389 ± 0.075	1.465LeuCys: 1.465 ± 0.038	4.609LeuAsp: 4.609 ± 0.057	6.204LeuGlu: 6.204 ± 0.064	4.171LeuPhe: 4.171 ± 0.076	5.656LeuGly: 5.656 ± 0.08	1.474LeuHis: 1.474 ± 0.034	6.339LeuIle: 6.339 ± 0.077	6.015LeuLys: 6.015 ± 0.069	8.987LeuLeu: 8.987 ± 0.1	2.584LeuMet: 2.584 ± 0.045	4.014LeuAsn: 4.014 ± 0.063	3.311LeuPro: 3.311 ± 0.057	2.909LeuGln: 2.909 ± 0.051	3.669LeuArg: 3.669 ± 0.055	6.71LeuSer: 6.71 ± 0.077	5.045LeuThr: 5.045 ± 0.063	5.094LeuVal: 5.094 ± 0.067	0.867LeuTrp: 0.867 ± 0.029	3.531LeuTyr: 3.531 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.292MetAla: 2.292 ± 0.036	0.341MetCys: 0.341 ± 0.016	1.92MetAsp: 1.92 ± 0.033	2.807MetGlu: 2.807 ± 0.045	1.067MetPhe: 1.067 ± 0.027	2.136MetGly: 2.136 ± 0.042	0.429MetHis: 0.429 ± 0.019	2.19MetIle: 2.19 ± 0.044	2.624MetLys: 2.624 ± 0.041	2.877MetLeu: 2.877 ± 0.05	0.908MetMet: 0.908 ± 0.03	1.64MetAsn: 1.64 ± 0.039	1.127MetPro: 1.127 ± 0.033	1.077MetGln: 1.077 ± 0.027	1.289MetArg: 1.289 ± 0.03	1.833MetSer: 1.833 ± 0.039	1.631MetThr: 1.631 ± 0.034	1.876MetVal: 1.876 ± 0.04	0.24MetTrp: 0.24 ± 0.013	0.92MetTyr: 0.92 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.167AsnAla: 3.167 ± 0.05	0.61AsnCys: 0.61 ± 0.022	2.223AsnAsp: 2.223 ± 0.042	3.174AsnGlu: 3.174 ± 0.053	1.77AsnPhe: 1.77 ± 0.038	3.543AsnGly: 3.543 ± 0.059	0.785AsnHis: 0.785 ± 0.028	4.035AsnIle: 4.035 ± 0.057	3.044AsnLys: 3.044 ± 0.048	3.814AsnLeu: 3.814 ± 0.061	1.481AsnMet: 1.481 ± 0.031	2.251AsnAsn: 2.251 ± 0.064	1.858AsnPro: 1.858 ± 0.038	1.423AsnGln: 1.423 ± 0.032	1.984AsnArg: 1.984 ± 0.048	2.696AsnSer: 2.696 ± 0.047	2.568AsnThr: 2.568 ± 0.061	2.961AsnVal: 2.961 ± 0.043	0.455AsnTrp: 0.455 ± 0.018	2.058AsnTyr: 2.058 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.357ProAla: 2.357 ± 0.041	0.435ProCys: 0.435 ± 0.02	2.124ProAsp: 2.124 ± 0.041	2.988ProGlu: 2.988 ± 0.05	1.517ProPhe: 1.517 ± 0.035	2.041ProGly: 2.041 ± 0.05	0.559ProHis: 0.559 ± 0.024	2.176ProIle: 2.176 ± 0.044	1.716ProLys: 1.716 ± 0.039	2.71ProLeu: 2.71 ± 0.048	0.881ProMet: 0.881 ± 0.023	1.149ProAsn: 1.149 ± 0.032	0.713ProPro: 0.713 ± 0.023	1.059ProGln: 1.059 ± 0.04	0.91ProArg: 0.91 ± 0.024	1.801ProSer: 1.801 ± 0.036	1.461ProThr: 1.461 ± 0.073	2.656ProVal: 2.656 ± 0.061	0.331ProTrp: 0.331 ± 0.016	1.479ProTyr: 1.479 ± 0.036	0.001ProXaa: 0.001 ± 0.001
Gln	2.229GlnAla: 2.229 ± 0.041	0.323GlnCys: 0.323 ± 0.017	1.47GlnAsp: 1.47 ± 0.033	2.59GlnGlu: 2.59 ± 0.052	1.221GlnPhe: 1.221 ± 0.029	2.055GlnGly: 2.055 ± 0.054	0.431GlnHis: 0.431 ± 0.019	2.587GlnIle: 2.587 ± 0.045	2.364GlnLys: 2.364 ± 0.044	2.627GlnLeu: 2.627 ± 0.041	1.144GlnMet: 1.144 ± 0.026	1.579GlnAsn: 1.579 ± 0.037	0.858GlnPro: 0.858 ± 0.028	1.005GlnGln: 1.005 ± 0.034	1.255GlnArg: 1.255 ± 0.03	1.71GlnSer: 1.71 ± 0.038	1.644GlnThr: 1.644 ± 0.037	1.884GlnVal: 1.884 ± 0.039	0.295GlnTrp: 0.295 ± 0.014	1.355GlnTyr: 1.355 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.485ArgAla: 2.485 ± 0.049	0.477ArgCys: 0.477 ± 0.02	2.001ArgAsp: 2.001 ± 0.043	3.575ArgGlu: 3.575 ± 0.054	1.921ArgPhe: 1.921 ± 0.044	2.485ArgGly: 2.485 ± 0.048	0.733ArgHis: 0.733 ± 0.023	3.618ArgIle: 3.618 ± 0.05	3.265ArgLys: 3.265 ± 0.057	3.847ArgLeu: 3.847 ± 0.054	1.555ArgMet: 1.555 ± 0.034	2.12ArgAsn: 2.12 ± 0.046	1.152ArgPro: 1.152 ± 0.03	1.457ArgGln: 1.457 ± 0.03	2.034ArgArg: 2.034 ± 0.041	2.112ArgSer: 2.112 ± 0.037	2.106ArgThr: 2.106 ± 0.043	2.461ArgVal: 2.461 ± 0.042	0.325ArgTrp: 0.325 ± 0.016	1.83ArgTyr: 1.83 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.347SerAla: 4.347 ± 0.069	0.785SerCys: 0.785 ± 0.027	3.382SerAsp: 3.382 ± 0.058	4.154SerGlu: 4.154 ± 0.069	2.938SerPhe: 2.938 ± 0.049	5.259SerGly: 5.259 ± 0.087	1.021SerHis: 1.021 ± 0.027	4.842SerIle: 4.842 ± 0.066	3.613SerLys: 3.613 ± 0.057	5.581SerLeu: 5.581 ± 0.066	1.912SerMet: 1.912 ± 0.033	2.446SerAsn: 2.446 ± 0.05	1.87SerPro: 1.87 ± 0.038	1.791SerGln: 1.791 ± 0.039	2.505SerArg: 2.505 ± 0.044	3.909SerSer: 3.909 ± 0.067	2.909SerThr: 2.909 ± 0.064	4.458SerVal: 4.458 ± 0.061	0.538SerTrp: 0.538 ± 0.019	2.856SerTyr: 2.856 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	4.42ThrAla: 4.42 ± 0.083	0.585ThrCys: 0.585 ± 0.022	3.127ThrAsp: 3.127 ± 0.054	3.656ThrGlu: 3.656 ± 0.053	2.175ThrPhe: 2.175 ± 0.042	4.811ThrGly: 4.811 ± 0.149	0.802ThrHis: 0.802 ± 0.023	4.058ThrIle: 4.058 ± 0.067	3.019ThrLys: 3.019 ± 0.056	4.632ThrLeu: 4.632 ± 0.063	1.439ThrMet: 1.439 ± 0.034	2.162ThrAsn: 2.162 ± 0.045	1.926ThrPro: 1.926 ± 0.039	1.519ThrGln: 1.519 ± 0.034	1.725ThrArg: 1.725 ± 0.037	3.05ThrSer: 3.05 ± 0.055	2.652ThrThr: 2.652 ± 0.066	4.346ThrVal: 4.346 ± 0.086	0.459ThrTrp: 0.459 ± 0.021	2.091ThrTyr: 2.091 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.391ValAla: 4.391 ± 0.069	1.087ValCys: 1.087 ± 0.032	3.493ValAsp: 3.493 ± 0.051	4.438ValGlu: 4.438 ± 0.066	3.067ValPhe: 3.067 ± 0.052	4.185ValGly: 4.185 ± 0.062	1.047ValHis: 1.047 ± 0.029	5.394ValIle: 5.394 ± 0.07	4.409ValLys: 4.409 ± 0.06	6.485ValLeu: 6.485 ± 0.075	2.023ValMet: 2.023 ± 0.039	3.089ValAsn: 3.089 ± 0.052	2.379ValPro: 2.379 ± 0.041	1.812ValGln: 1.812 ± 0.041	2.727ValArg: 2.727 ± 0.043	4.791ValSer: 4.791 ± 0.071	4.044ValThr: 4.044 ± 0.086	4.494ValVal: 4.494 ± 0.071	0.621ValTrp: 0.621 ± 0.023	2.721ValTyr: 2.721 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.498TrpAla: 0.498 ± 0.019	0.146TrpCys: 0.146 ± 0.011	0.534TrpAsp: 0.534 ± 0.023	0.688TrpGlu: 0.688 ± 0.024	0.443TrpPhe: 0.443 ± 0.02	0.671TrpGly: 0.671 ± 0.021	0.178TrpHis: 0.178 ± 0.011	0.693TrpIle: 0.693 ± 0.023	0.724TrpLys: 0.724 ± 0.023	0.895TrpLeu: 0.895 ± 0.025	0.355TrpMet: 0.355 ± 0.018	0.574TrpAsn: 0.574 ± 0.021	0.235TrpPro: 0.235 ± 0.013	0.363TrpGln: 0.363 ± 0.016	0.372TrpArg: 0.372 ± 0.017	0.499TrpSer: 0.499 ± 0.02	0.463TrpThr: 0.463 ± 0.019	0.509TrpVal: 0.509 ± 0.019	0.135TrpTrp: 0.135 ± 0.01	0.409TrpTyr: 0.409 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.878TyrAla: 2.878 ± 0.048	0.634TyrCys: 0.634 ± 0.023	2.555TyrAsp: 2.555 ± 0.049	3.322TyrGlu: 3.322 ± 0.061	2.073TyrPhe: 2.073 ± 0.044	3.115TyrGly: 3.115 ± 0.053	0.827TyrHis: 0.827 ± 0.027	3.281TyrIle: 3.281 ± 0.059	2.594TyrLys: 2.594 ± 0.049	3.898TyrLeu: 3.898 ± 0.067	1.243TyrMet: 1.243 ± 0.031	2.054TyrAsn: 2.054 ± 0.041	1.519TyrPro: 1.519 ± 0.031	1.379TyrGln: 1.379 ± 0.039	2.008TyrArg: 2.008 ± 0.043	2.611TyrSer: 2.611 ± 0.045	2.22TyrThr: 2.22 ± 0.043	2.678TyrVal: 2.678 ± 0.04	0.391TyrTrp: 0.391 ± 0.019	2.137TyrTyr: 2.137 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.002

Statistics based on 4121 proteins (1351134 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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