Amino acid dipepetide frequency for Bittarella massiliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.241AlaAla: 13.241 ± 0.207	1.585AlaCys: 1.585 ± 0.05	5.311AlaAsp: 5.311 ± 0.087	6.388AlaGlu: 6.388 ± 0.106	4.015AlaPhe: 4.015 ± 0.065	8.793AlaGly: 8.793 ± 0.119	1.521AlaHis: 1.521 ± 0.05	5.138AlaIle: 5.138 ± 0.078	4.231AlaLys: 4.231 ± 0.079	12.057AlaLeu: 12.057 ± 0.163	2.289AlaMet: 2.289 ± 0.051	2.204AlaAsn: 2.204 ± 0.061	4.023AlaPro: 4.023 ± 0.093	3.947AlaGln: 3.947 ± 0.086	5.428AlaArg: 5.428 ± 0.105	4.131AlaSer: 4.131 ± 0.079	3.876AlaThr: 3.876 ± 0.078	8.566AlaVal: 8.566 ± 0.128	0.675AlaTrp: 0.675 ± 0.026	2.771AlaTyr: 2.771 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.723CysAla: 1.723 ± 0.048	0.388CysCys: 0.388 ± 0.021	1.082CysAsp: 1.082 ± 0.032	1.019CysGlu: 1.019 ± 0.038	0.64CysPhe: 0.64 ± 0.028	1.968CysGly: 1.968 ± 0.062	0.36CysHis: 0.36 ± 0.022	0.812CysIle: 0.812 ± 0.032	0.782CysLys: 0.782 ± 0.031	1.562CysLeu: 1.562 ± 0.053	0.317CysMet: 0.317 ± 0.019	0.478CysAsn: 0.478 ± 0.027	0.961CysPro: 0.961 ± 0.037	0.597CysGln: 0.597 ± 0.025	1.307CysArg: 1.307 ± 0.038	0.894CysSer: 0.894 ± 0.035	0.9CysThr: 0.9 ± 0.032	1.043CysVal: 1.043 ± 0.036	0.178CysTrp: 0.178 ± 0.015	0.617CysTyr: 0.617 ± 0.041	0.0CysXaa: 0.0 ± 0.0
Asp	4.442AspAla: 4.442 ± 0.071	1.143AspCys: 1.143 ± 0.045	2.576AspAsp: 2.576 ± 0.063	4.057AspGlu: 4.057 ± 0.084	2.522AspPhe: 2.522 ± 0.059	4.962AspGly: 4.962 ± 0.096	0.821AspHis: 0.821 ± 0.033	3.19AspIle: 3.19 ± 0.069	2.374AspLys: 2.374 ± 0.066	5.24AspLeu: 5.24 ± 0.087	1.245AspMet: 1.245 ± 0.045	1.39AspAsn: 1.39 ± 0.041	2.656AspPro: 2.656 ± 0.062	1.442AspGln: 1.442 ± 0.04	3.556AspArg: 3.556 ± 0.068	2.593AspSer: 2.593 ± 0.064	2.752AspThr: 2.752 ± 0.064	3.192AspVal: 3.192 ± 0.062	0.733AspTrp: 0.733 ± 0.03	2.152AspTyr: 2.152 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.087GluAla: 6.087 ± 0.104	0.715GluCys: 0.715 ± 0.029	3.391GluAsp: 3.391 ± 0.076	6.689GluGlu: 6.689 ± 0.103	1.897GluPhe: 1.897 ± 0.051	6.409GluGly: 6.409 ± 0.099	1.274GluHis: 1.274 ± 0.044	4.098GluIle: 4.098 ± 0.087	4.441GluLys: 4.441 ± 0.096	6.413GluLeu: 6.413 ± 0.102	2.194GluMet: 2.194 ± 0.05	2.688GluAsn: 2.688 ± 0.062	2.231GluPro: 2.231 ± 0.053	2.934GluGln: 2.934 ± 0.073	4.887GluArg: 4.887 ± 0.09	2.942GluSer: 2.942 ± 0.055	3.309GluThr: 3.309 ± 0.065	4.372GluVal: 4.372 ± 0.083	0.655GluTrp: 0.655 ± 0.028	2.057GluTyr: 2.057 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	4.151PheAla: 4.151 ± 0.081	0.961PheCys: 0.961 ± 0.038	2.467PheAsp: 2.467 ± 0.052	2.153PheGlu: 2.153 ± 0.049	1.783PhePhe: 1.783 ± 0.051	3.288PheGly: 3.288 ± 0.07	0.664PheHis: 0.664 ± 0.028	1.92PheIle: 1.92 ± 0.056	1.36PheLys: 1.36 ± 0.041	4.184PheLeu: 4.184 ± 0.078	0.74PheMet: 0.74 ± 0.031	0.978PheAsn: 0.978 ± 0.033	1.517PhePro: 1.517 ± 0.041	1.166PheGln: 1.166 ± 0.04	1.698PheArg: 1.698 ± 0.049	3.07PheSer: 3.07 ± 0.063	2.36PheThr: 2.36 ± 0.053	2.81PheVal: 2.81 ± 0.071	0.529PheTrp: 0.529 ± 0.027	1.41PheTyr: 1.41 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	7.737GlyAla: 7.737 ± 0.117	1.741GlyCys: 1.741 ± 0.055	4.543GlyAsp: 4.543 ± 0.093	7.279GlyGlu: 7.279 ± 0.1	3.237GlyPhe: 3.237 ± 0.061	7.753GlyGly: 7.753 ± 0.155	1.432GlyHis: 1.432 ± 0.048	4.583GlyIle: 4.583 ± 0.079	4.443GlyLys: 4.443 ± 0.084	7.664GlyLeu: 7.664 ± 0.11	2.339GlyMet: 2.339 ± 0.052	2.349GlyAsn: 2.349 ± 0.059	2.405GlyPro: 2.405 ± 0.057	3.092GlyGln: 3.092 ± 0.061	5.439GlyArg: 5.439 ± 0.095	4.585GlySer: 4.585 ± 0.096	4.009GlyThr: 4.009 ± 0.085	6.401GlyVal: 6.401 ± 0.104	0.999GlyTrp: 0.999 ± 0.039	3.215GlyTyr: 3.215 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.159HisAla: 1.159 ± 0.041	0.419HisCys: 0.419 ± 0.023	0.787HisAsp: 0.787 ± 0.037	0.684HisGlu: 0.684 ± 0.032	0.913HisPhe: 0.913 ± 0.034	1.313HisGly: 1.313 ± 0.043	0.385HisHis: 0.385 ± 0.02	1.09HisIle: 1.09 ± 0.036	0.655HisLys: 0.655 ± 0.028	1.949HisLeu: 1.949 ± 0.045	0.322HisMet: 0.322 ± 0.019	0.53HisAsn: 0.53 ± 0.022	1.076HisPro: 1.076 ± 0.039	0.679HisGln: 0.679 ± 0.027	1.27HisArg: 1.27 ± 0.035	0.992HisSer: 0.992 ± 0.034	0.997HisThr: 0.997 ± 0.034	0.8HisVal: 0.8 ± 0.033	0.238HisTrp: 0.238 ± 0.018	0.708HisTyr: 0.708 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.603IleAla: 5.603 ± 0.091	1.006IleCys: 1.006 ± 0.034	3.361IleAsp: 3.361 ± 0.066	3.374IleGlu: 3.374 ± 0.073	1.897IlePhe: 1.897 ± 0.053	4.078IleGly: 4.078 ± 0.085	0.929IleHis: 0.929 ± 0.032	2.559IleIle: 2.559 ± 0.064	2.329IleLys: 2.329 ± 0.065	5.189IleLeu: 5.189 ± 0.093	1.019IleMet: 1.019 ± 0.04	1.565IleAsn: 1.565 ± 0.046	2.744IlePro: 2.744 ± 0.057	1.577IleGln: 1.577 ± 0.041	3.044IleArg: 3.044 ± 0.062	3.41IleSer: 3.41 ± 0.072	3.092IleThr: 3.092 ± 0.072	3.767IleVal: 3.767 ± 0.082	0.516IleTrp: 0.516 ± 0.025	1.664IleTyr: 1.664 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.416LysAla: 4.416 ± 0.089	0.443LysCys: 0.443 ± 0.025	2.443LysAsp: 2.443 ± 0.058	3.924LysGlu: 3.924 ± 0.087	1.148LysPhe: 1.148 ± 0.035	3.728LysGly: 3.728 ± 0.075	0.631LysHis: 0.631 ± 0.029	2.834LysIle: 2.834 ± 0.06	3.619LysLys: 3.619 ± 0.07	4.178LysLeu: 4.178 ± 0.077	1.432LysMet: 1.432 ± 0.042	2.075LysAsn: 2.075 ± 0.05	1.741LysPro: 1.741 ± 0.054	1.732LysGln: 1.732 ± 0.052	2.864LysArg: 2.864 ± 0.062	2.405LysSer: 2.405 ± 0.064	2.825LysThr: 2.825 ± 0.062	3.223LysVal: 3.223 ± 0.072	0.421LysTrp: 0.421 ± 0.022	1.474LysTyr: 1.474 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	11.035LeuAla: 11.035 ± 0.158	2.538LeuCys: 2.538 ± 0.063	5.426LeuAsp: 5.426 ± 0.091	6.31LeuGlu: 6.31 ± 0.107	4.488LeuPhe: 4.488 ± 0.098	7.937LeuGly: 7.937 ± 0.109	1.778LeuHis: 1.778 ± 0.041	4.597LeuIle: 4.597 ± 0.078	4.404LeuLys: 4.404 ± 0.082	11.514LeuLeu: 11.514 ± 0.167	2.237LeuMet: 2.237 ± 0.052	2.583LeuAsn: 2.583 ± 0.053	5.436LeuPro: 5.436 ± 0.098	3.801LeuGln: 3.801 ± 0.076	5.963LeuArg: 5.963 ± 0.097	6.783LeuSer: 6.783 ± 0.101	5.718LeuThr: 5.718 ± 0.083	6.563LeuVal: 6.563 ± 0.096	1.09LeuTrp: 1.09 ± 0.044	3.496LeuTyr: 3.496 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.616MetAla: 2.616 ± 0.064	0.251MetCys: 0.251 ± 0.017	1.371MetAsp: 1.371 ± 0.046	2.071MetGlu: 2.071 ± 0.047	0.696MetPhe: 0.696 ± 0.028	2.228MetGly: 2.228 ± 0.056	0.342MetHis: 0.342 ± 0.02	1.066MetIle: 1.066 ± 0.036	1.554MetLys: 1.554 ± 0.047	2.21MetLeu: 2.21 ± 0.064	0.651MetMet: 0.651 ± 0.031	0.804MetAsn: 0.804 ± 0.03	0.952MetPro: 0.952 ± 0.038	0.905MetGln: 0.905 ± 0.032	1.287MetArg: 1.287 ± 0.041	1.335MetSer: 1.335 ± 0.038	1.266MetThr: 1.266 ± 0.04	1.667MetVal: 1.667 ± 0.044	0.144MetTrp: 0.144 ± 0.013	0.544MetTyr: 0.544 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.576AsnAla: 2.576 ± 0.056	0.527AsnCys: 0.527 ± 0.024	1.303AsnAsp: 1.303 ± 0.046	1.414AsnGlu: 1.414 ± 0.043	1.11AsnPhe: 1.11 ± 0.037	2.484AsnGly: 2.484 ± 0.066	0.51AsnHis: 0.51 ± 0.027	1.975AsnIle: 1.975 ± 0.05	1.24AsnLys: 1.24 ± 0.035	3.087AsnLeu: 3.087 ± 0.068	0.734AsnMet: 0.734 ± 0.033	0.814AsnAsn: 0.814 ± 0.032	1.727AsnPro: 1.727 ± 0.054	0.979AsnGln: 0.979 ± 0.031	1.889AsnArg: 1.889 ± 0.05	1.444AsnSer: 1.444 ± 0.051	1.716AsnThr: 1.716 ± 0.047	1.839AsnVal: 1.839 ± 0.055	0.331AsnTrp: 0.331 ± 0.018	1.081AsnTyr: 1.081 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.795ProAla: 4.795 ± 0.1	0.66ProCys: 0.66 ± 0.026	2.727ProAsp: 2.727 ± 0.069	3.532ProGlu: 3.532 ± 0.064	1.819ProPhe: 1.819 ± 0.053	3.483ProGly: 3.483 ± 0.073	0.825ProHis: 0.825 ± 0.032	2.052ProIle: 2.052 ± 0.05	1.68ProLys: 1.68 ± 0.05	4.552ProLeu: 4.552 ± 0.082	0.844ProMet: 0.844 ± 0.033	1.087ProAsn: 1.087 ± 0.031	1.921ProPro: 1.921 ± 0.07	1.926ProGln: 1.926 ± 0.054	2.012ProArg: 2.012 ± 0.053	2.273ProSer: 2.273 ± 0.058	2.097ProThr: 2.097 ± 0.05	3.638ProVal: 3.638 ± 0.074	0.354ProTrp: 0.354 ± 0.02	1.49ProTyr: 1.49 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	3.408GlnAla: 3.408 ± 0.077	0.395GlnCys: 0.395 ± 0.026	1.42GlnAsp: 1.42 ± 0.046	2.271GlnGlu: 2.271 ± 0.058	1.238GlnPhe: 1.238 ± 0.04	2.964GlnGly: 2.964 ± 0.058	0.47GlnHis: 0.47 ± 0.023	2.257GlnIle: 2.257 ± 0.053	2.416GlnLys: 2.416 ± 0.056	3.835GlnLeu: 3.835 ± 0.078	1.182GlnMet: 1.182 ± 0.036	1.719GlnAsn: 1.719 ± 0.043	1.463GlnPro: 1.463 ± 0.041	1.515GlnGln: 1.515 ± 0.053	2.372GlnArg: 2.372 ± 0.061	1.946GlnSer: 1.946 ± 0.051	1.82GlnThr: 1.82 ± 0.05	2.966GlnVal: 2.966 ± 0.07	0.355GlnTrp: 0.355 ± 0.02	1.276GlnTyr: 1.276 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	5.782ArgAla: 5.782 ± 0.109	1.034ArgCys: 1.034 ± 0.038	2.947ArgAsp: 2.947 ± 0.06	5.12ArgGlu: 5.12 ± 0.098	2.457ArgPhe: 2.457 ± 0.06	4.317ArgGly: 4.317 ± 0.08	1.124ArgHis: 1.124 ± 0.032	2.913ArgIle: 2.913 ± 0.067	2.467ArgLys: 2.467 ± 0.062	6.084ArgLeu: 6.084 ± 0.096	1.683ArgMet: 1.683 ± 0.049	1.43ArgAsn: 1.43 ± 0.045	2.631ArgPro: 2.631 ± 0.061	3.069ArgGln: 3.069 ± 0.061	4.731ArgArg: 4.731 ± 0.102	2.714ArgSer: 2.714 ± 0.055	2.51ArgThr: 2.51 ± 0.05	4.114ArgVal: 4.114 ± 0.08	0.855ArgTrp: 0.855 ± 0.038	2.309ArgTyr: 2.309 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.336SerAla: 5.336 ± 0.093	0.826SerCys: 0.826 ± 0.034	2.693SerAsp: 2.693 ± 0.064	3.034SerGlu: 3.034 ± 0.071	2.494SerPhe: 2.494 ± 0.055	5.248SerGly: 5.248 ± 0.099	1.04SerHis: 1.04 ± 0.035	2.923SerIle: 2.923 ± 0.064	2.185SerLys: 2.185 ± 0.053	5.699SerLeu: 5.699 ± 0.085	1.188SerMet: 1.188 ± 0.041	1.262SerAsn: 1.262 ± 0.047	2.522SerPro: 2.522 ± 0.054	2.052SerGln: 2.052 ± 0.052	3.077SerArg: 3.077 ± 0.062	3.103SerSer: 3.103 ± 0.093	2.603SerThr: 2.603 ± 0.062	3.85SerVal: 3.85 ± 0.073	0.546SerTrp: 0.546 ± 0.024	2.005SerTyr: 2.005 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.733ThrAla: 5.733 ± 0.097	0.722ThrCys: 0.722 ± 0.03	2.668ThrAsp: 2.668 ± 0.062	2.732ThrGlu: 2.732 ± 0.055	2.077ThrPhe: 2.077 ± 0.049	5.06ThrGly: 5.06 ± 0.091	0.923ThrHis: 0.923 ± 0.033	2.725ThrIle: 2.725 ± 0.059	1.845ThrLys: 1.845 ± 0.045	5.62ThrLeu: 5.62 ± 0.085	0.98ThrMet: 0.98 ± 0.04	1.221ThrAsn: 1.221 ± 0.047	2.946ThrPro: 2.946 ± 0.066	1.624ThrGln: 1.624 ± 0.044	2.333ThrArg: 2.333 ± 0.059	2.423ThrSer: 2.423 ± 0.066	2.6ThrThr: 2.6 ± 0.059	4.653ThrVal: 4.653 ± 0.106	0.399ThrTrp: 0.399 ± 0.019	1.64ThrTyr: 1.64 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	6.729ValAla: 6.729 ± 0.095	1.443ValCys: 1.443 ± 0.047	4.009ValAsp: 4.009 ± 0.081	5.053ValGlu: 5.053 ± 0.077	2.826ValPhe: 2.826 ± 0.069	5.516ValGly: 5.516 ± 0.097	1.126ValHis: 1.126 ± 0.035	3.864ValIle: 3.864 ± 0.071	3.586ValLys: 3.586 ± 0.073	7.524ValLeu: 7.524 ± 0.106	1.638ValMet: 1.638 ± 0.051	2.146ValAsn: 2.146 ± 0.044	3.013ValPro: 3.013 ± 0.06	2.251ValGln: 2.251 ± 0.049	3.943ValArg: 3.943 ± 0.075	4.433ValSer: 4.433 ± 0.083	3.875ValThr: 3.875 ± 0.086	5.221ValVal: 5.221 ± 0.101	0.731ValTrp: 0.731 ± 0.029	2.358ValTyr: 2.358 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.847TrpAla: 0.847 ± 0.034	0.183TrpCys: 0.183 ± 0.016	0.563TrpAsp: 0.563 ± 0.026	0.721TrpGlu: 0.721 ± 0.03	0.433TrpPhe: 0.433 ± 0.022	0.941TrpGly: 0.941 ± 0.034	0.181TrpHis: 0.181 ± 0.014	0.411TrpIle: 0.411 ± 0.023	0.498TrpLys: 0.498 ± 0.024	1.143TrpLeu: 1.143 ± 0.043	0.284TrpMet: 0.284 ± 0.021	0.342TrpAsn: 0.342 ± 0.023	0.355TrpPro: 0.355 ± 0.021	0.535TrpGln: 0.535 ± 0.031	0.634TrpArg: 0.634 ± 0.032	0.496TrpSer: 0.496 ± 0.025	0.418TrpThr: 0.418 ± 0.021	0.731TrpVal: 0.731 ± 0.027	0.124TrpTrp: 0.124 ± 0.013	0.367TrpTyr: 0.367 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.774TyrAla: 2.774 ± 0.06	0.646TyrCys: 0.646 ± 0.025	1.951TyrAsp: 1.951 ± 0.047	1.858TyrGlu: 1.858 ± 0.051	1.516TyrPhe: 1.516 ± 0.041	2.776TyrGly: 2.776 ± 0.054	0.628TyrHis: 0.628 ± 0.026	1.716TyrIle: 1.716 ± 0.055	1.445TyrLys: 1.445 ± 0.044	3.992TyrLeu: 3.992 ± 0.072	0.639TyrMet: 0.639 ± 0.027	1.119TyrAsn: 1.119 ± 0.039	1.446TyrPro: 1.446 ± 0.038	1.466TyrGln: 1.466 ± 0.046	2.558TyrArg: 2.558 ± 0.057	1.715TyrSer: 1.715 ± 0.049	2.18TyrThr: 2.18 ± 0.067	1.868TyrVal: 1.868 ± 0.052	0.337TyrTrp: 0.337 ± 0.021	1.243TyrTyr: 1.243 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2773 proteins (844879 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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