Amino acid dipepetide frequency for Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.302AlaAla: 4.302 ± 0.089	0.481AlaCys: 0.481 ± 0.033	2.89AlaAsp: 2.89 ± 0.062	3.889AlaGlu: 3.889 ± 0.084	2.252AlaPhe: 2.252 ± 0.064	5.225AlaGly: 5.225 ± 0.106	0.985AlaHis: 0.985 ± 0.039	4.965AlaIle: 4.965 ± 0.093	2.959AlaLys: 2.959 ± 0.068	6.216AlaLeu: 6.216 ± 0.105	1.436AlaMet: 1.436 ± 0.039	2.1AlaAsn: 2.1 ± 0.061	1.671AlaPro: 1.671 ± 0.047	1.395AlaGln: 1.395 ± 0.049	4.497AlaArg: 4.497 ± 0.077	3.453AlaSer: 3.453 ± 0.09	2.719AlaThr: 2.719 ± 0.069	4.459AlaVal: 4.459 ± 0.092	0.502AlaTrp: 0.502 ± 0.032	1.892AlaTyr: 1.892 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.328CysAla: 0.328 ± 0.024	0.099CysCys: 0.099 ± 0.01	0.392CysAsp: 0.392 ± 0.022	0.398CysGlu: 0.398 ± 0.021	0.223CysPhe: 0.223 ± 0.016	0.759CysGly: 0.759 ± 0.04	0.193CysHis: 0.193 ± 0.017	0.517CysIle: 0.517 ± 0.03	0.478CysLys: 0.478 ± 0.026	0.679CysLeu: 0.679 ± 0.038	0.144CysMet: 0.144 ± 0.014	0.346CysAsn: 0.346 ± 0.021	0.502CysPro: 0.502 ± 0.035	0.318CysGln: 0.318 ± 0.023	0.383CysArg: 0.383 ± 0.023	0.437CysSer: 0.437 ± 0.026	0.337CysThr: 0.337 ± 0.024	0.407CysVal: 0.407 ± 0.026	0.087CysTrp: 0.087 ± 0.011	0.295CysTyr: 0.295 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.245AspAla: 2.245 ± 0.061	0.415AspCys: 0.415 ± 0.026	2.76AspAsp: 2.76 ± 0.064	4.09AspGlu: 4.09 ± 0.085	2.612AspPhe: 2.612 ± 0.061	3.608AspGly: 3.608 ± 0.066	0.863AspHis: 0.863 ± 0.035	5.499AspIle: 5.499 ± 0.101	4.762AspLys: 4.762 ± 0.076	5.759AspLeu: 5.759 ± 0.094	1.298AspMet: 1.298 ± 0.038	3.19AspAsn: 3.19 ± 0.072	1.989AspPro: 1.989 ± 0.049	1.216AspGln: 1.216 ± 0.042	2.94AspArg: 2.94 ± 0.07	2.658AspSer: 2.658 ± 0.075	2.313AspThr: 2.313 ± 0.061	3.509AspVal: 3.509 ± 0.076	0.615AspTrp: 0.615 ± 0.034	2.783AspTyr: 2.783 ± 0.076	0.0AspXaa: 0.0 ± 0.0
Glu	4.621GluAla: 4.621 ± 0.093	0.386GluCys: 0.386 ± 0.025	4.247GluAsp: 4.247 ± 0.085	7.525GluGlu: 7.525 ± 0.119	2.593GluPhe: 2.593 ± 0.064	5.02GluGly: 5.02 ± 0.084	1.04GluHis: 1.04 ± 0.038	6.837GluIle: 6.837 ± 0.099	6.908GluLys: 6.908 ± 0.128	7.373GluLeu: 7.373 ± 0.108	1.971GluMet: 1.971 ± 0.05	3.744GluAsn: 3.744 ± 0.074	1.922GluPro: 1.922 ± 0.056	1.952GluGln: 1.952 ± 0.066	3.35GluArg: 3.35 ± 0.076	2.944GluSer: 2.944 ± 0.061	2.94GluThr: 2.94 ± 0.064	5.989GluVal: 5.989 ± 0.093	0.504GluTrp: 0.504 ± 0.029	2.75GluTyr: 2.75 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.16PheAla: 2.16 ± 0.061	0.32PheCys: 0.32 ± 0.023	2.314PheAsp: 2.314 ± 0.051	2.31PheGlu: 2.31 ± 0.054	2.078PhePhe: 2.078 ± 0.067	2.808PheGly: 2.808 ± 0.069	0.559PheHis: 0.559 ± 0.027	4.067PheIle: 4.067 ± 0.087	3.455PheLys: 3.455 ± 0.069	3.993PheLeu: 3.993 ± 0.102	1.042PheMet: 1.042 ± 0.045	2.549PheAsn: 2.549 ± 0.057	1.444PhePro: 1.444 ± 0.044	0.988PheGln: 0.988 ± 0.032	1.543PheArg: 1.543 ± 0.044	2.833PheSer: 2.833 ± 0.068	2.335PheThr: 2.335 ± 0.055	2.58PheVal: 2.58 ± 0.064	0.402PheTrp: 0.402 ± 0.024	1.655PheTyr: 1.655 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.306GlyAla: 4.306 ± 0.1	0.691GlyCys: 0.691 ± 0.036	3.84GlyAsp: 3.84 ± 0.072	5.081GlyGlu: 5.081 ± 0.097	3.364GlyPhe: 3.364 ± 0.083	5.05GlyGly: 5.05 ± 0.111	1.325GlyHis: 1.325 ± 0.041	6.749GlyIle: 6.749 ± 0.114	5.644GlyLys: 5.644 ± 0.086	7.816GlyLeu: 7.816 ± 0.121	1.868GlyMet: 1.868 ± 0.051	3.292GlyAsn: 3.292 ± 0.08	1.915GlyPro: 1.915 ± 0.053	2.416GlyGln: 2.416 ± 0.052	3.301GlyArg: 3.301 ± 0.07	3.85GlySer: 3.85 ± 0.082	3.427GlyThr: 3.427 ± 0.079	5.675GlyVal: 5.675 ± 0.095	0.749GlyTrp: 0.749 ± 0.033	3.269GlyTyr: 3.269 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	0.755HisAla: 0.755 ± 0.032	0.145HisCys: 0.145 ± 0.015	0.821HisAsp: 0.821 ± 0.034	0.885HisGlu: 0.885 ± 0.035	0.786HisPhe: 0.786 ± 0.033	1.204HisGly: 1.204 ± 0.039	0.381HisHis: 0.381 ± 0.024	1.306HisIle: 1.306 ± 0.044	1.082HisLys: 1.082 ± 0.042	1.667HisLeu: 1.667 ± 0.049	0.277HisMet: 0.277 ± 0.018	0.964HisAsn: 0.964 ± 0.038	0.901HisPro: 0.901 ± 0.035	0.535HisGln: 0.535 ± 0.028	0.812HisArg: 0.812 ± 0.034	0.812HisSer: 0.812 ± 0.034	0.748HisThr: 0.748 ± 0.029	0.827HisVal: 0.827 ± 0.038	0.155HisTrp: 0.155 ± 0.016	0.7HisTyr: 0.7 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.117IleAla: 5.117 ± 0.1	0.6IleCys: 0.6 ± 0.03	5.096IleAsp: 5.096 ± 0.089	6.171IleGlu: 6.171 ± 0.107	3.679IlePhe: 3.679 ± 0.08	5.762IleGly: 5.762 ± 0.103	1.178IleHis: 1.178 ± 0.039	8.702IleIle: 8.702 ± 0.15	8.058IleLys: 8.058 ± 0.123	8.002IleLeu: 8.002 ± 0.127	1.991IleMet: 1.991 ± 0.055	5.469IleAsn: 5.469 ± 0.087	3.818IlePro: 3.818 ± 0.076	1.86IleGln: 1.86 ± 0.048	3.351IleArg: 3.351 ± 0.077	5.211IleSer: 5.211 ± 0.101	4.807IleThr: 4.807 ± 0.09	5.203IleVal: 5.203 ± 0.087	0.631IleTrp: 0.631 ± 0.035	3.231IleTyr: 3.231 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	4.608LysAla: 4.608 ± 0.091	0.483LysCys: 0.483 ± 0.03	4.443LysAsp: 4.443 ± 0.084	7.459LysGlu: 7.459 ± 0.118	2.365LysPhe: 2.365 ± 0.058	5.219LysGly: 5.219 ± 0.087	1.095LysHis: 1.095 ± 0.04	6.9LysIle: 6.9 ± 0.113	7.581LysLys: 7.581 ± 0.112	7.106LysLeu: 7.106 ± 0.108	1.97LysMet: 1.97 ± 0.04	4.38LysAsn: 4.38 ± 0.088	2.627LysPro: 2.627 ± 0.055	2.065LysGln: 2.065 ± 0.062	3.479LysArg: 3.479 ± 0.084	3.467LysSer: 3.467 ± 0.083	3.692LysThr: 3.692 ± 0.072	5.849LysVal: 5.849 ± 0.107	0.605LysTrp: 0.605 ± 0.029	3.25LysTyr: 3.25 ± 0.077	0.0LysXaa: 0.0 ± 0.0
Leu	6.543LeuAla: 6.543 ± 0.111	0.588LeuCys: 0.588 ± 0.032	5.487LeuAsp: 5.487 ± 0.1	6.984LeuGlu: 6.984 ± 0.097	4.0LeuPhe: 4.0 ± 0.094	6.867LeuGly: 6.867 ± 0.118	1.357LeuHis: 1.357 ± 0.044	8.586LeuIle: 8.586 ± 0.126	9.074LeuLys: 9.074 ± 0.131	9.175LeuLeu: 9.175 ± 0.155	2.336LeuMet: 2.336 ± 0.055	5.59LeuAsn: 5.59 ± 0.099	4.044LeuPro: 4.044 ± 0.072	2.461LeuGln: 2.461 ± 0.054	3.71LeuArg: 3.71 ± 0.064	6.017LeuSer: 6.017 ± 0.103	5.374LeuThr: 5.374 ± 0.095	6.852LeuVal: 6.852 ± 0.103	0.711LeuTrp: 0.711 ± 0.031	3.341LeuTyr: 3.341 ± 0.082	0.0LeuXaa: 0.0 ± 0.0
Met	2.097MetAla: 2.097 ± 0.054	0.147MetCys: 0.147 ± 0.014	1.349MetAsp: 1.349 ± 0.045	1.88MetGlu: 1.88 ± 0.05	0.793MetPhe: 0.793 ± 0.035	2.071MetGly: 2.071 ± 0.055	0.25MetHis: 0.25 ± 0.021	1.709MetIle: 1.709 ± 0.043	1.899MetLys: 1.899 ± 0.051	1.974MetLeu: 1.974 ± 0.052	0.582MetMet: 0.582 ± 0.031	1.121MetAsn: 1.121 ± 0.035	0.805MetPro: 0.805 ± 0.033	0.479MetGln: 0.479 ± 0.026	0.839MetArg: 0.839 ± 0.034	1.3MetSer: 1.3 ± 0.043	1.165MetThr: 1.165 ± 0.043	2.241MetVal: 2.241 ± 0.058	0.141MetTrp: 0.141 ± 0.013	0.585MetTyr: 0.585 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.061AsnAla: 2.061 ± 0.064	0.41AsnCys: 0.41 ± 0.026	2.323AsnAsp: 2.323 ± 0.06	3.031AsnGlu: 3.031 ± 0.069	2.192AsnPhe: 2.192 ± 0.055	3.273AsnGly: 3.273 ± 0.067	0.904AsnHis: 0.904 ± 0.036	5.054AsnIle: 5.054 ± 0.092	4.598AsnLys: 4.598 ± 0.093	5.573AsnLeu: 5.573 ± 0.089	1.177AsnMet: 1.177 ± 0.043	3.495AsnAsn: 3.495 ± 0.092	2.522AsnPro: 2.522 ± 0.063	1.644AsnGln: 1.644 ± 0.06	2.694AsnArg: 2.694 ± 0.074	2.817AsnSer: 2.817 ± 0.078	2.407AsnThr: 2.407 ± 0.056	2.818AsnVal: 2.818 ± 0.068	0.552AsnTrp: 0.552 ± 0.027	2.549AsnTyr: 2.549 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.195ProAla: 2.195 ± 0.055	0.32ProCys: 0.32 ± 0.021	2.933ProAsp: 2.933 ± 0.059	3.843ProGlu: 3.843 ± 0.077	1.694ProPhe: 1.694 ± 0.049	3.513ProGly: 3.513 ± 0.072	0.736ProHis: 0.736 ± 0.031	2.046ProIle: 2.046 ± 0.048	1.105ProLys: 1.105 ± 0.041	3.662ProLeu: 3.662 ± 0.084	0.675ProMet: 0.675 ± 0.029	1.068ProAsn: 1.068 ± 0.037	1.258ProPro: 1.258 ± 0.042	0.918ProGln: 0.918 ± 0.036	1.744ProArg: 1.744 ± 0.049	1.727ProSer: 1.727 ± 0.046	1.651ProThr: 1.651 ± 0.05	3.726ProVal: 3.726 ± 0.072	0.365ProTrp: 0.365 ± 0.024	1.431ProTyr: 1.431 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	1.781GlnAla: 1.781 ± 0.054	0.13GlnCys: 0.13 ± 0.015	1.318GlnAsp: 1.318 ± 0.04	2.393GlnGlu: 2.393 ± 0.064	0.973GlnPhe: 0.973 ± 0.038	2.028GlnGly: 2.028 ± 0.051	0.388GlnHis: 0.388 ± 0.025	2.122GlnIle: 2.122 ± 0.056	2.23GlnLys: 2.23 ± 0.058	2.587GlnLeu: 2.587 ± 0.071	0.698GlnMet: 0.698 ± 0.032	1.228GlnAsn: 1.228 ± 0.038	0.858GlnPro: 0.858 ± 0.034	0.924GlnGln: 0.924 ± 0.044	1.166GlnArg: 1.166 ± 0.038	1.169GlnSer: 1.169 ± 0.035	1.14GlnThr: 1.14 ± 0.039	2.255GlnVal: 2.255 ± 0.059	0.231GlnTrp: 0.231 ± 0.019	0.991GlnTyr: 0.991 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	2.799ArgAla: 2.799 ± 0.068	0.343ArgCys: 0.343 ± 0.021	2.738ArgAsp: 2.738 ± 0.061	4.379ArgGlu: 4.379 ± 0.086	1.839ArgPhe: 1.839 ± 0.053	3.453ArgGly: 3.453 ± 0.072	0.729ArgHis: 0.729 ± 0.031	3.795ArgIle: 3.795 ± 0.08	3.782ArgLys: 3.782 ± 0.068	4.717ArgLeu: 4.717 ± 0.085	1.097ArgMet: 1.097 ± 0.038	2.185ArgAsn: 2.185 ± 0.052	1.486ArgPro: 1.486 ± 0.042	1.545ArgGln: 1.545 ± 0.046	2.151ArgArg: 2.151 ± 0.064	2.002ArgSer: 2.002 ± 0.051	1.949ArgThr: 1.949 ± 0.06	3.993ArgVal: 3.993 ± 0.075	0.384ArgTrp: 0.384 ± 0.023	1.918ArgTyr: 1.918 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	2.582SerAla: 2.582 ± 0.068	0.434SerCys: 0.434 ± 0.024	2.686SerAsp: 2.686 ± 0.069	3.228SerGlu: 3.228 ± 0.065	2.766SerPhe: 2.766 ± 0.072	4.617SerGly: 4.617 ± 0.086	0.99SerHis: 0.99 ± 0.037	4.587SerIle: 4.587 ± 0.082	3.486SerLys: 3.486 ± 0.071	6.198SerLeu: 6.198 ± 0.098	1.166SerMet: 1.166 ± 0.038	2.579SerAsn: 2.579 ± 0.067	2.183SerPro: 2.183 ± 0.054	1.585SerGln: 1.585 ± 0.058	2.984SerArg: 2.984 ± 0.066	3.366SerSer: 3.366 ± 0.079	2.503SerThr: 2.503 ± 0.062	3.286SerVal: 3.286 ± 0.068	0.554SerTrp: 0.554 ± 0.026	2.208SerTyr: 2.208 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	3.103ThrAla: 3.103 ± 0.063	0.36ThrCys: 0.36 ± 0.025	2.739ThrAsp: 2.739 ± 0.067	3.081ThrGlu: 3.081 ± 0.065	1.858ThrPhe: 1.858 ± 0.059	5.098ThrGly: 5.098 ± 0.086	0.776ThrHis: 0.776 ± 0.037	3.93ThrIle: 3.93 ± 0.078	2.297ThrLys: 2.297 ± 0.053	4.562ThrLeu: 4.562 ± 0.081	1.047ThrMet: 1.047 ± 0.04	1.944ThrAsn: 1.944 ± 0.052	2.284ThrPro: 2.284 ± 0.06	1.0ThrGln: 1.0 ± 0.039	2.779ThrArg: 2.779 ± 0.067	2.773ThrSer: 2.773 ± 0.055	2.742ThrThr: 2.742 ± 0.064	3.726ThrVal: 3.726 ± 0.07	0.462ThrTrp: 0.462 ± 0.029	1.803ThrTyr: 1.803 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	4.504ValAla: 4.504 ± 0.106	0.543ValCys: 0.543 ± 0.03	4.238ValAsp: 4.238 ± 0.082	5.105ValGlu: 5.105 ± 0.097	3.02ValPhe: 3.02 ± 0.075	4.672ValGly: 4.672 ± 0.084	0.973ValHis: 0.973 ± 0.039	6.893ValIle: 6.893 ± 0.106	5.849ValLys: 5.849 ± 0.092	6.634ValLeu: 6.634 ± 0.106	1.735ValMet: 1.735 ± 0.048	3.936ValAsn: 3.936 ± 0.079	2.418ValPro: 2.418 ± 0.057	1.488ValGln: 1.488 ± 0.046	2.959ValArg: 2.959 ± 0.072	4.401ValSer: 4.401 ± 0.071	3.793ValThr: 3.793 ± 0.072	5.511ValVal: 5.511 ± 0.106	0.532ValTrp: 0.532 ± 0.026	2.453ValTyr: 2.453 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.457TrpAla: 0.457 ± 0.028	0.069TrpCys: 0.069 ± 0.01	0.533TrpAsp: 0.533 ± 0.028	0.683TrpGlu: 0.683 ± 0.027	0.405TrpPhe: 0.405 ± 0.024	0.672TrpGly: 0.672 ± 0.031	0.148TrpHis: 0.148 ± 0.015	0.557TrpIle: 0.557 ± 0.031	0.597TrpLys: 0.597 ± 0.031	0.907TrpLeu: 0.907 ± 0.032	0.19TrpMet: 0.19 ± 0.018	0.433TrpAsn: 0.433 ± 0.024	0.354TrpPro: 0.354 ± 0.025	0.406TrpGln: 0.406 ± 0.024	0.328TrpArg: 0.328 ± 0.021	0.509TrpSer: 0.509 ± 0.027	0.373TrpThr: 0.373 ± 0.024	0.645TrpVal: 0.645 ± 0.029	0.136TrpTrp: 0.136 ± 0.015	0.318TrpTyr: 0.318 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.725TyrAla: 1.725 ± 0.053	0.356TyrCys: 0.356 ± 0.021	1.975TyrAsp: 1.975 ± 0.076	2.2TyrGlu: 2.2 ± 0.058	1.947TyrPhe: 1.947 ± 0.054	2.708TyrGly: 2.708 ± 0.068	0.89TyrHis: 0.89 ± 0.041	3.118TyrIle: 3.118 ± 0.065	2.8TyrLys: 2.8 ± 0.063	4.496TyrLeu: 4.496 ± 0.077	0.728TyrMet: 0.728 ± 0.028	2.479TyrAsn: 2.479 ± 0.059	1.607TyrPro: 1.607 ± 0.048	1.416TyrGln: 1.416 ± 0.042	2.275TyrArg: 2.275 ± 0.058	2.242TyrSer: 2.242 ± 0.061	1.951TyrThr: 1.951 ± 0.055	2.105TyrVal: 2.105 ± 0.056	0.402TyrTrp: 0.402 ± 0.024	1.982TyrTyr: 1.982 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2324 proteins (736705 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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