Amino acid dipepetide frequency for Felis domesticus papillomavirus type 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.91AlaAla: 5.91 ± 1.894
1.266AlaCys: 1.266 ± 1.147
4.643AlaAsp: 4.643 ± 1.256
4.221AlaGlu: 4.221 ± 0.938
4.643AlaPhe: 4.643 ± 1.437
2.955AlaGly: 2.955 ± 0.915
0.422AlaHis: 0.422 ± 0.351
1.688AlaIle: 1.688 ± 1.141
4.221AlaLys: 4.221 ± 1.971
5.065AlaLeu: 5.065 ± 1.467
0.844AlaMet: 0.844 ± 0.392
1.266AlaAsn: 1.266 ± 0.698
4.221AlaPro: 4.221 ± 0.843
2.533AlaGln: 2.533 ± 0.761
5.065AlaArg: 5.065 ± 2.712
5.91AlaSer: 5.91 ± 1.106
4.643AlaThr: 4.643 ± 1.144
4.221AlaVal: 4.221 ± 1.696
0.422AlaTrp: 0.422 ± 0.351
2.111AlaTyr: 2.111 ± 1.076
0.0AlaXaa: 0.0 ± 0.0
Cys
2.111CysAla: 2.111 ± 1.712
0.844CysCys: 0.844 ± 1.016
0.844CysAsp: 0.844 ± 0.66
0.422CysGlu: 0.422 ± 0.33
1.688CysPhe: 1.688 ± 0.545
2.111CysGly: 2.111 ± 1.517
0.0CysHis: 0.0 ± 0.0
0.844CysIle: 0.844 ± 0.629
2.111CysLys: 2.111 ± 0.903
2.111CysLeu: 2.111 ± 1.362
0.844CysMet: 0.844 ± 0.629
0.422CysAsn: 0.422 ± 0.351
1.688CysPro: 1.688 ± 0.597
0.844CysGln: 0.844 ± 0.629
0.844CysArg: 0.844 ± 0.629
2.111CysSer: 2.111 ± 1.314
0.0CysThr: 0.0 ± 0.0
1.688CysVal: 1.688 ± 1.255
0.844CysTrp: 0.844 ± 0.413
0.844CysTyr: 0.844 ± 0.732
0.0CysXaa: 0.0 ± 0.0
Asp
4.221AspAla: 4.221 ± 1.243
2.111AspCys: 2.111 ± 1.414
2.111AspAsp: 2.111 ± 0.679
4.221AspGlu: 4.221 ± 1.298
2.533AspPhe: 2.533 ± 0.767
3.799AspGly: 3.799 ± 1.687
0.844AspHis: 0.844 ± 0.424
4.643AspIle: 4.643 ± 1.462
3.377AspLys: 3.377 ± 0.976
10.131AspLeu: 10.131 ± 3.022
1.266AspMet: 1.266 ± 0.758
2.533AspAsn: 2.533 ± 1.08
5.488AspPro: 5.488 ± 1.96
1.688AspGln: 1.688 ± 0.65
2.955AspArg: 2.955 ± 1.143
3.799AspSer: 3.799 ± 1.74
2.111AspThr: 2.111 ± 0.679
1.688AspVal: 1.688 ± 0.664
1.266AspTrp: 1.266 ± 0.99
0.844AspTyr: 0.844 ± 0.504
0.0AspXaa: 0.0 ± 0.0
Glu
3.799GluAla: 3.799 ± 1.329
0.422GluCys: 0.422 ± 0.33
6.332GluAsp: 6.332 ± 2.407
6.754GluGlu: 6.754 ± 1.836
2.533GluPhe: 2.533 ± 1.022
2.111GluGly: 2.111 ± 1.006
1.266GluHis: 1.266 ± 0.409
2.533GluIle: 2.533 ± 0.503
2.533GluLys: 2.533 ± 0.941
2.955GluLeu: 2.955 ± 0.963
0.422GluMet: 0.422 ± 0.33
3.799GluAsn: 3.799 ± 0.967
3.377GluPro: 3.377 ± 0.901
7.176GluGln: 7.176 ± 1.697
3.377GluArg: 3.377 ± 1.652
2.111GluSer: 2.111 ± 0.73
4.221GluThr: 4.221 ± 1.287
5.065GluVal: 5.065 ± 1.197
1.266GluTrp: 1.266 ± 0.617
1.266GluTyr: 1.266 ± 0.667
0.0GluXaa: 0.0 ± 0.0
Phe
2.533PheAla: 2.533 ± 0.901
2.955PheCys: 2.955 ± 1.473
3.799PheAsp: 3.799 ± 0.781
1.688PheGlu: 1.688 ± 1.141
2.533PhePhe: 2.533 ± 0.934
1.688PheGly: 1.688 ± 0.773
0.0PheHis: 0.0 ± 0.0
1.266PheIle: 1.266 ± 0.409
2.111PheLys: 2.111 ± 0.997
4.643PheLeu: 4.643 ± 1.774
0.844PheMet: 0.844 ± 0.504
0.844PheAsn: 0.844 ± 0.703
2.533PhePro: 2.533 ± 1.228
2.533PheGln: 2.533 ± 1.004
2.955PheArg: 2.955 ± 0.575
2.111PheSer: 2.111 ± 1.18
3.799PheThr: 3.799 ± 1.485
2.111PheVal: 2.111 ± 0.949
1.688PheTrp: 1.688 ± 0.931
1.266PheTyr: 1.266 ± 1.054
0.0PheXaa: 0.0 ± 0.0
Gly
3.799GlyAla: 3.799 ± 0.806
1.266GlyCys: 1.266 ± 1.011
4.643GlyAsp: 4.643 ± 0.492
5.91GlyGlu: 5.91 ± 1.02
1.266GlyPhe: 1.266 ± 0.409
5.065GlyGly: 5.065 ± 1.22
0.844GlyHis: 0.844 ± 0.703
2.533GlyIle: 2.533 ± 0.693
3.799GlyLys: 3.799 ± 2.022
5.488GlyLeu: 5.488 ± 2.229
1.266GlyMet: 1.266 ± 0.685
1.688GlyAsn: 1.688 ± 0.597
4.221GlyPro: 4.221 ± 1.239
3.799GlyGln: 3.799 ± 1.004
5.065GlyArg: 5.065 ± 2.038
6.332GlySer: 6.332 ± 2.057
5.91GlyThr: 5.91 ± 2.167
3.377GlyVal: 3.377 ± 0.903
0.422GlyTrp: 0.422 ± 0.424
1.266GlyTyr: 1.266 ± 0.49
0.0GlyXaa: 0.0 ± 0.0
His
1.266HisAla: 1.266 ± 1.054
0.422HisCys: 0.422 ± 0.33
0.422HisAsp: 0.422 ± 0.33
0.422HisGlu: 0.422 ± 0.33
0.422HisPhe: 0.422 ± 0.351
0.422HisGly: 0.422 ± 0.523
0.0HisHis: 0.0 ± 0.0
0.422HisIle: 0.422 ± 0.391
0.844HisLys: 0.844 ± 0.413
2.533HisLeu: 2.533 ± 1.196
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.111HisPro: 2.111 ± 1.391
0.422HisGln: 0.422 ± 0.33
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
0.844HisThr: 0.844 ± 0.703
1.688HisVal: 1.688 ± 0.273
0.844HisTrp: 0.844 ± 0.504
0.844HisTyr: 0.844 ± 0.498
0.0HisXaa: 0.0 ± 0.0
Ile
3.377IleAla: 3.377 ± 1.418
0.422IleCys: 0.422 ± 0.33
1.266IleAsp: 1.266 ± 0.651
3.799IleGlu: 3.799 ± 1.042
1.688IlePhe: 1.688 ± 0.597
4.221IleGly: 4.221 ± 1.566
0.422IleHis: 0.422 ± 0.351
0.844IleIle: 0.844 ± 0.444
0.844IleLys: 0.844 ± 0.703
4.221IleLeu: 4.221 ± 1.245
0.422IleMet: 0.422 ± 0.289
1.266IleAsn: 1.266 ± 0.667
1.266IlePro: 1.266 ± 1.172
2.533IleGln: 2.533 ± 0.454
1.266IleArg: 1.266 ± 1.011
5.488IleSer: 5.488 ± 1.951
0.844IleThr: 0.844 ± 0.504
1.688IleVal: 1.688 ± 0.56
0.0IleTrp: 0.0 ± 0.0
1.266IleTyr: 1.266 ± 0.494
0.0IleXaa: 0.0 ± 0.0
Lys
4.221LysAla: 4.221 ± 0.753
1.688LysCys: 1.688 ± 0.628
2.111LysAsp: 2.111 ± 0.913
3.377LysGlu: 3.377 ± 1.197
2.533LysPhe: 2.533 ± 1.175
3.377LysGly: 3.377 ± 1.654
0.844LysHis: 0.844 ± 0.66
1.266LysIle: 1.266 ± 0.756
4.643LysLys: 4.643 ± 1.369
2.955LysLeu: 2.955 ± 0.992
0.422LysMet: 0.422 ± 0.597
1.688LysAsn: 1.688 ± 0.784
1.688LysPro: 1.688 ± 0.597
2.955LysGln: 2.955 ± 0.966
5.065LysArg: 5.065 ± 1.705
4.643LysSer: 4.643 ± 1.82
3.799LysThr: 3.799 ± 1.286
3.799LysVal: 3.799 ± 1.024
0.0LysTrp: 0.0 ± 0.0
2.533LysTyr: 2.533 ± 0.542
0.0LysXaa: 0.0 ± 0.0
Leu
4.643LeuAla: 4.643 ± 0.933
2.533LeuCys: 2.533 ± 1.29
4.643LeuAsp: 4.643 ± 0.968
5.065LeuGlu: 5.065 ± 1.525
6.332LeuPhe: 6.332 ± 1.943
8.02LeuGly: 8.02 ± 3.589
0.844LeuHis: 0.844 ± 0.444
1.266LeuIle: 1.266 ± 0.867
4.643LeuLys: 4.643 ± 1.422
8.864LeuLeu: 8.864 ± 2.471
1.688LeuMet: 1.688 ± 0.979
2.533LeuAsn: 2.533 ± 1.011
5.065LeuPro: 5.065 ± 2.666
7.598LeuGln: 7.598 ± 1.29
5.91LeuArg: 5.91 ± 1.38
8.02LeuSer: 8.02 ± 3.087
6.332LeuThr: 6.332 ± 2.042
5.488LeuVal: 5.488 ± 1.298
0.422LeuTrp: 0.422 ± 0.424
3.799LeuTyr: 3.799 ± 1.373
0.0LeuXaa: 0.0 ± 0.0
Met
2.111MetAla: 2.111 ± 1.034
0.422MetCys: 0.422 ± 0.33
1.688MetAsp: 1.688 ± 0.64
0.844MetGlu: 0.844 ± 0.498
0.844MetPhe: 0.844 ± 0.392
0.422MetGly: 0.422 ± 0.351
0.0MetHis: 0.0 ± 0.0
0.844MetIle: 0.844 ± 0.683
0.844MetLys: 0.844 ± 0.392
0.844MetLeu: 0.844 ± 0.424
0.0MetMet: 0.0 ± 0.0
0.844MetAsn: 0.844 ± 0.413
0.422MetPro: 0.422 ± 0.523
1.266MetGln: 1.266 ± 0.617
1.266MetArg: 1.266 ± 0.605
1.266MetSer: 1.266 ± 0.651
0.422MetThr: 0.422 ± 0.33
1.688MetVal: 1.688 ± 0.784
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.266AsnAla: 1.266 ± 0.99
0.422AsnCys: 0.422 ± 0.33
2.533AsnAsp: 2.533 ± 0.794
0.844AsnGlu: 0.844 ± 0.444
0.422AsnPhe: 0.422 ± 0.351
1.266AsnGly: 1.266 ± 0.667
0.844AsnHis: 0.844 ± 0.615
0.844AsnIle: 0.844 ± 0.504
2.533AsnLys: 2.533 ± 1.02
1.688AsnLeu: 1.688 ± 0.887
0.844AsnMet: 0.844 ± 0.703
0.844AsnAsn: 0.844 ± 0.703
4.221AsnPro: 4.221 ± 1.325
0.844AsnGln: 0.844 ± 0.703
1.266AsnArg: 1.266 ± 0.759
2.955AsnSer: 2.955 ± 1.031
2.111AsnThr: 2.111 ± 0.536
2.111AsnVal: 2.111 ± 1.33
0.0AsnTrp: 0.0 ± 0.0
0.844AsnTyr: 0.844 ± 0.665
0.0AsnXaa: 0.0 ± 0.0
Pro
5.065ProAla: 5.065 ± 2.535
0.844ProCys: 0.844 ± 0.629
3.799ProAsp: 3.799 ± 1.536
4.643ProGlu: 4.643 ± 1.166
1.266ProPhe: 1.266 ± 0.634
4.221ProGly: 4.221 ± 2.329
0.844ProHis: 0.844 ± 1.313
2.111ProIle: 2.111 ± 0.758
4.221ProLys: 4.221 ± 0.923
6.332ProLeu: 6.332 ± 1.744
0.0ProMet: 0.0 ± 0.0
3.377ProAsn: 3.377 ± 1.132
8.442ProPro: 8.442 ± 3.509
2.111ProGln: 2.111 ± 1.021
5.065ProArg: 5.065 ± 2.241
3.799ProSer: 3.799 ± 1.305
5.488ProThr: 5.488 ± 2.028
4.221ProVal: 4.221 ± 1.672
0.422ProTrp: 0.422 ± 0.424
2.955ProTyr: 2.955 ± 0.865
0.0ProXaa: 0.0 ± 0.0
Gln
2.111GlnAla: 2.111 ± 1.174
2.111GlnCys: 2.111 ± 0.601
2.111GlnAsp: 2.111 ± 0.972
3.377GlnGlu: 3.377 ± 1.317
1.688GlnPhe: 1.688 ± 0.825
5.488GlnGly: 5.488 ± 1.048
0.844GlnHis: 0.844 ± 0.688
1.688GlnIle: 1.688 ± 0.534
2.111GlnLys: 2.111 ± 0.697
5.91GlnLeu: 5.91 ± 1.734
1.266GlnMet: 1.266 ± 0.849
2.111GlnAsn: 2.111 ± 1.116
2.955GlnPro: 2.955 ± 1.043
3.377GlnGln: 3.377 ± 0.858
2.533GlnArg: 2.533 ± 0.467
2.955GlnSer: 2.955 ± 0.815
2.955GlnThr: 2.955 ± 1.365
3.799GlnVal: 3.799 ± 0.9
0.844GlnTrp: 0.844 ± 0.629
1.266GlnTyr: 1.266 ± 0.38
0.0GlnXaa: 0.0 ± 0.0
Arg
3.799ArgAla: 3.799 ± 1.07
1.688ArgCys: 1.688 ± 1.132
3.377ArgAsp: 3.377 ± 1.149
4.643ArgGlu: 4.643 ± 1.355
2.111ArgPhe: 2.111 ± 0.717
7.176ArgGly: 7.176 ± 3.288
1.266ArgHis: 1.266 ± 0.759
2.533ArgIle: 2.533 ± 1.43
3.377ArgLys: 3.377 ± 1.265
8.02ArgLeu: 8.02 ± 1.403
0.844ArgMet: 0.844 ± 0.413
1.266ArgAsn: 1.266 ± 0.637
3.377ArgPro: 3.377 ± 1.592
2.111ArgGln: 2.111 ± 0.913
3.799ArgArg: 3.799 ± 1.693
4.643ArgSer: 4.643 ± 1.276
2.955ArgThr: 2.955 ± 1.387
5.488ArgVal: 5.488 ± 1.426
1.266ArgTrp: 1.266 ± 0.409
2.533ArgTyr: 2.533 ± 0.817
0.0ArgXaa: 0.0 ± 0.0
Ser
6.332SerAla: 6.332 ± 1.38
0.422SerCys: 0.422 ± 0.508
7.176SerAsp: 7.176 ± 2.462
2.111SerGlu: 2.111 ± 0.744
2.955SerPhe: 2.955 ± 1.193
5.91SerGly: 5.91 ± 2.32
1.266SerHis: 1.266 ± 0.854
0.844SerIle: 0.844 ± 0.413
2.533SerLys: 2.533 ± 0.794
10.131SerLeu: 10.131 ± 2.518
0.844SerMet: 0.844 ± 0.413
1.266SerAsn: 1.266 ± 0.745
4.643SerPro: 4.643 ± 0.922
2.955SerGln: 2.955 ± 0.602
6.332SerArg: 6.332 ± 1.627
3.377SerSer: 3.377 ± 0.961
6.754SerThr: 6.754 ± 1.641
4.221SerVal: 4.221 ± 1.782
1.266SerTrp: 1.266 ± 0.409
0.844SerTyr: 0.844 ± 0.444
0.0SerXaa: 0.0 ± 0.0
Thr
2.955ThrAla: 2.955 ± 0.881
1.266ThrCys: 1.266 ± 0.61
2.955ThrAsp: 2.955 ± 0.767
3.377ThrGlu: 3.377 ± 0.731
2.955ThrPhe: 2.955 ± 0.83
3.799ThrGly: 3.799 ± 1.39
0.422ThrHis: 0.422 ± 0.351
3.377ThrIle: 3.377 ± 1.241
2.955ThrLys: 2.955 ± 0.895
3.377ThrLeu: 3.377 ± 1.119
1.688ThrMet: 1.688 ± 0.557
1.266ThrAsn: 1.266 ± 0.667
6.332ThrPro: 6.332 ± 2.336
2.533ThrGln: 2.533 ± 0.977
6.332ThrArg: 6.332 ± 1.607
5.488ThrSer: 5.488 ± 1.81
5.91ThrThr: 5.91 ± 2.3
5.065ThrVal: 5.065 ± 0.907
0.422ThrTrp: 0.422 ± 0.424
3.377ThrTyr: 3.377 ± 0.783
0.0ThrXaa: 0.0 ± 0.0
Val
2.955ValAla: 2.955 ± 0.862
0.844ValCys: 0.844 ± 0.615
5.065ValAsp: 5.065 ± 1.443
5.065ValGlu: 5.065 ± 1.327
3.799ValPhe: 3.799 ± 1.204
3.377ValGly: 3.377 ± 1.487
0.844ValHis: 0.844 ± 0.444
4.221ValIle: 4.221 ± 2.135
2.955ValLys: 2.955 ± 1.204
5.065ValLeu: 5.065 ± 0.996
0.422ValMet: 0.422 ± 0.33
1.688ValAsn: 1.688 ± 0.784
4.643ValPro: 4.643 ± 1.185
2.111ValGln: 2.111 ± 0.717
5.488ValArg: 5.488 ± 1.372
5.065ValSer: 5.065 ± 1.685
5.065ValThr: 5.065 ± 1.242
1.688ValVal: 1.688 ± 0.819
1.266ValTrp: 1.266 ± 0.698
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
1.688TrpAla: 1.688 ± 0.557
0.422TrpCys: 0.422 ± 0.351
0.422TrpAsp: 0.422 ± 0.424
0.844TrpGlu: 0.844 ± 0.703
0.0TrpPhe: 0.0 ± 0.0
0.844TrpGly: 0.844 ± 0.413
1.266TrpHis: 1.266 ± 0.863
1.688TrpIle: 1.688 ± 0.784
0.844TrpLys: 0.844 ± 0.629
0.844TrpLeu: 0.844 ± 0.392
0.422TrpMet: 0.422 ± 0.424
0.0TrpAsn: 0.0 ± 0.0
0.422TrpPro: 0.422 ± 0.33
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.844TrpSer: 0.844 ± 0.413
1.266TrpThr: 1.266 ± 0.77
1.266TrpVal: 1.266 ± 0.617
0.0TrpTrp: 0.0 ± 0.0
0.422TrpTyr: 0.422 ± 0.33
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.111TyrAla: 2.111 ± 0.949
0.844TyrCys: 0.844 ± 0.667
1.688TyrAsp: 1.688 ± 0.273
1.688TyrGlu: 1.688 ± 0.943
2.111TyrPhe: 2.111 ± 0.392
1.688TyrGly: 1.688 ± 0.273
0.844TyrHis: 0.844 ± 0.504
1.688TyrIle: 1.688 ± 0.784
2.111TyrLys: 2.111 ± 1.036
2.533TyrLeu: 2.533 ± 1.378
1.266TyrMet: 1.266 ± 0.695
0.0TyrAsn: 0.0 ± 0.0
2.111TyrPro: 2.111 ± 0.784
2.111TyrGln: 2.111 ± 1.642
1.688TyrArg: 1.688 ± 0.904
1.266TyrSer: 1.266 ± 0.789
0.422TyrThr: 0.422 ± 0.33
1.266TyrVal: 1.266 ± 0.494
0.844TyrTrp: 0.844 ± 0.392
2.111TyrTyr: 2.111 ± 0.839
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski