Amino acid dipepetide frequency for Burkholderia sp. JS23

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.208AlaAla: 21.208 ± 0.213	1.557AlaCys: 1.557 ± 0.031	7.578AlaAsp: 7.578 ± 0.087	6.561AlaGlu: 6.561 ± 0.066	4.489AlaPhe: 4.489 ± 0.057	11.668AlaGly: 11.668 ± 0.106	2.894AlaHis: 2.894 ± 0.048	5.574AlaIle: 5.574 ± 0.078	2.906AlaLys: 2.906 ± 0.048	16.268AlaLeu: 16.268 ± 0.161	3.337AlaMet: 3.337 ± 0.051	2.943AlaAsn: 2.943 ± 0.05	7.06AlaPro: 7.06 ± 0.092	5.126AlaGln: 5.126 ± 0.068	11.343AlaArg: 11.343 ± 0.119	8.412AlaSer: 8.412 ± 0.088	7.198AlaThr: 7.198 ± 0.087	9.705AlaVal: 9.705 ± 0.101	1.797AlaTrp: 1.797 ± 0.05	2.736AlaTyr: 2.736 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.379CysAla: 1.379 ± 0.036	0.136CysCys: 0.136 ± 0.009	0.598CysAsp: 0.598 ± 0.02	0.501CysGlu: 0.501 ± 0.018	0.33CysPhe: 0.33 ± 0.014	1.007CysGly: 1.007 ± 0.028	0.249CysHis: 0.249 ± 0.014	0.357CysIle: 0.357 ± 0.014	0.168CysLys: 0.168 ± 0.01	0.924CysLeu: 0.924 ± 0.027	0.177CysMet: 0.177 ± 0.011	0.243CysAsn: 0.243 ± 0.013	0.426CysPro: 0.426 ± 0.019	0.243CysGln: 0.243 ± 0.012	0.72CysArg: 0.72 ± 0.025	0.473CysSer: 0.473 ± 0.017	0.465CysThr: 0.465 ± 0.019	0.807CysVal: 0.807 ± 0.025	0.123CysTrp: 0.123 ± 0.011	0.238CysTyr: 0.238 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	9.436AspAla: 9.436 ± 0.123	0.496AspCys: 0.496 ± 0.017	3.516AspAsp: 3.516 ± 0.064	3.339AspGlu: 3.339 ± 0.054	1.973AspPhe: 1.973 ± 0.038	5.426AspGly: 5.426 ± 0.091	1.094AspHis: 1.094 ± 0.029	2.232AspIle: 2.232 ± 0.046	1.224AspLys: 1.224 ± 0.032	5.012AspLeu: 5.012 ± 0.065	1.084AspMet: 1.084 ± 0.031	1.169AspAsn: 1.169 ± 0.038	2.977AspPro: 2.977 ± 0.054	1.47AspGln: 1.47 ± 0.036	4.033AspArg: 4.033 ± 0.066	2.456AspSer: 2.456 ± 0.044	2.813AspThr: 2.813 ± 0.049	4.408AspVal: 4.408 ± 0.057	0.987AspTrp: 0.987 ± 0.024	1.452AspTyr: 1.452 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.976GluAla: 6.976 ± 0.077	0.361GluCys: 0.361 ± 0.016	1.918GluAsp: 1.918 ± 0.037	1.938GluGlu: 1.938 ± 0.042	1.398GluPhe: 1.398 ± 0.034	3.257GluGly: 3.257 ± 0.059	1.262GluHis: 1.262 ± 0.029	2.514GluIle: 2.514 ± 0.045	1.433GluLys: 1.433 ± 0.033	4.686GluLeu: 4.686 ± 0.059	1.148GluMet: 1.148 ± 0.024	1.168GluAsn: 1.168 ± 0.032	2.458GluPro: 2.458 ± 0.039	2.258GluGln: 2.258 ± 0.044	5.194GluArg: 5.194 ± 0.07	2.361GluSer: 2.361 ± 0.039	3.014GluThr: 3.014 ± 0.044	3.442GluVal: 3.442 ± 0.057	0.691GluTrp: 0.691 ± 0.023	0.955GluTyr: 0.955 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.623PheAla: 4.623 ± 0.062	0.419PheCys: 0.419 ± 0.018	2.701PheAsp: 2.701 ± 0.049	2.033PheGlu: 2.033 ± 0.037	1.318PhePhe: 1.318 ± 0.033	3.598PheGly: 3.598 ± 0.048	0.665PheHis: 0.665 ± 0.022	1.349PheIle: 1.349 ± 0.038	0.826PheLys: 0.826 ± 0.026	2.892PheLeu: 2.892 ± 0.052	0.684PheMet: 0.684 ± 0.024	0.928PheAsn: 0.928 ± 0.025	1.542PhePro: 1.542 ± 0.03	0.882PheGln: 0.882 ± 0.026	1.987PheArg: 1.987 ± 0.039	2.11PheSer: 2.11 ± 0.038	1.721PheThr: 1.721 ± 0.043	3.018PheVal: 3.018 ± 0.048	0.462PheTrp: 0.462 ± 0.022	0.845PheTyr: 0.845 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.708GlyAla: 10.708 ± 0.108	0.864GlyCys: 0.864 ± 0.027	4.293GlyAsp: 4.293 ± 0.061	4.373GlyGlu: 4.373 ± 0.065	3.195GlyPhe: 3.195 ± 0.048	7.069GlyGly: 7.069 ± 0.092	1.83GlyHis: 1.83 ± 0.032	4.008GlyIle: 4.008 ± 0.062	2.616GlyLys: 2.616 ± 0.05	8.334GlyLeu: 8.334 ± 0.081	2.187GlyMet: 2.187 ± 0.038	2.21GlyAsn: 2.21 ± 0.056	3.242GlyPro: 3.242 ± 0.054	2.951GlyGln: 2.951 ± 0.049	6.41GlyArg: 6.41 ± 0.071	4.65GlySer: 4.65 ± 0.059	4.668GlyThr: 4.668 ± 0.089	6.788GlyVal: 6.788 ± 0.075	1.379GlyTrp: 1.379 ± 0.037	2.154GlyTyr: 2.154 ± 0.038	0.001GlyXaa: 0.001 ± 0.001
His	3.302HisAla: 3.302 ± 0.046	0.269HisCys: 0.269 ± 0.013	1.323HisAsp: 1.323 ± 0.033	1.014HisGlu: 1.014 ± 0.028	0.879HisPhe: 0.879 ± 0.022	2.173HisGly: 2.173 ± 0.042	0.562HisHis: 0.562 ± 0.022	0.807HisIle: 0.807 ± 0.023	0.356HisLys: 0.356 ± 0.016	2.096HisLeu: 2.096 ± 0.039	0.428HisMet: 0.428 ± 0.018	0.408HisAsn: 0.408 ± 0.016	1.408HisPro: 1.408 ± 0.036	0.603HisGln: 0.603 ± 0.019	1.728HisArg: 1.728 ± 0.032	0.948HisSer: 0.948 ± 0.027	0.927HisThr: 0.927 ± 0.026	1.658HisVal: 1.658 ± 0.032	0.365HisTrp: 0.365 ± 0.014	0.603HisTyr: 0.603 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.819IleAla: 6.819 ± 0.083	0.387IleCys: 0.387 ± 0.016	3.395IleAsp: 3.395 ± 0.044	2.991IleGlu: 2.991 ± 0.047	1.257IlePhe: 1.257 ± 0.032	4.656IleGly: 4.656 ± 0.059	0.759IleHis: 0.759 ± 0.02	1.368IleIle: 1.368 ± 0.038	1.115IleLys: 1.115 ± 0.031	3.102IleLeu: 3.102 ± 0.055	0.653IleMet: 0.653 ± 0.02	1.157IleAsn: 1.157 ± 0.033	1.759IlePro: 1.759 ± 0.032	0.995IleGln: 0.995 ± 0.023	2.615IleArg: 2.615 ± 0.043	2.196IleSer: 2.196 ± 0.042	1.992IleThr: 1.992 ± 0.042	4.06IleVal: 4.06 ± 0.058	0.429IleTrp: 0.429 ± 0.019	0.872IleTyr: 0.872 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.894LysAla: 2.894 ± 0.052	0.145LysCys: 0.145 ± 0.01	1.083LysAsp: 1.083 ± 0.029	1.025LysGlu: 1.025 ± 0.032	0.639LysPhe: 0.639 ± 0.022	1.706LysGly: 1.706 ± 0.031	0.525LysHis: 0.525 ± 0.018	1.106LysIle: 1.106 ± 0.031	0.808LysLys: 0.808 ± 0.028	2.507LysLeu: 2.507 ± 0.039	0.583LysMet: 0.583 ± 0.019	0.568LysAsn: 0.568 ± 0.02	1.533LysPro: 1.533 ± 0.036	1.057LysGln: 1.057 ± 0.026	2.207LysArg: 2.207 ± 0.046	1.323LysSer: 1.323 ± 0.035	1.539LysThr: 1.539 ± 0.037	1.772LysVal: 1.772 ± 0.041	0.285LysTrp: 0.285 ± 0.015	0.502LysTyr: 0.502 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.458LeuAla: 15.458 ± 0.136	1.048LeuCys: 1.048 ± 0.03	6.548LeuAsp: 6.548 ± 0.078	4.445LeuGlu: 4.445 ± 0.064	3.519LeuPhe: 3.519 ± 0.06	8.629LeuGly: 8.629 ± 0.094	2.237LeuHis: 2.237 ± 0.043	4.411LeuIle: 4.411 ± 0.061	2.479LeuLys: 2.479 ± 0.049	11.053LeuLeu: 11.053 ± 0.122	1.989LeuMet: 1.989 ± 0.038	2.401LeuAsn: 2.401 ± 0.035	6.437LeuPro: 6.437 ± 0.084	3.225LeuGln: 3.225 ± 0.042	8.304LeuArg: 8.304 ± 0.096	6.625LeuSer: 6.625 ± 0.071	5.325LeuThr: 5.325 ± 0.06	7.207LeuVal: 7.207 ± 0.085	1.089LeuTrp: 1.089 ± 0.029	2.083LeuTyr: 2.083 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.457MetAla: 2.457 ± 0.043	0.155MetCys: 0.155 ± 0.01	0.822MetAsp: 0.822 ± 0.022	0.75MetGlu: 0.75 ± 0.02	0.692MetPhe: 0.692 ± 0.019	1.354MetGly: 1.354 ± 0.034	0.519MetHis: 0.519 ± 0.021	1.011MetIle: 1.011 ± 0.027	0.772MetLys: 0.772 ± 0.025	2.501MetLeu: 2.501 ± 0.043	0.517MetMet: 0.517 ± 0.019	0.758MetAsn: 0.758 ± 0.022	1.521MetPro: 1.521 ± 0.036	0.926MetGln: 0.926 ± 0.027	1.904MetArg: 1.904 ± 0.038	1.634MetSer: 1.634 ± 0.035	1.461MetThr: 1.461 ± 0.033	1.497MetVal: 1.497 ± 0.029	0.178MetTrp: 0.178 ± 0.011	0.346MetTyr: 0.346 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.361AsnAla: 3.361 ± 0.053	0.234AsnCys: 0.234 ± 0.013	1.39AsnAsp: 1.39 ± 0.035	1.083AsnGlu: 1.083 ± 0.031	0.822AsnPhe: 0.822 ± 0.026	2.357AsnGly: 2.357 ± 0.057	0.437AsnHis: 0.437 ± 0.016	0.975AsnIle: 0.975 ± 0.029	0.568AsnLys: 0.568 ± 0.021	2.295AsnLeu: 2.295 ± 0.041	0.482AsnMet: 0.482 ± 0.018	0.631AsnAsn: 0.631 ± 0.024	1.469AsnPro: 1.469 ± 0.032	0.726AsnGln: 0.726 ± 0.023	1.729AsnArg: 1.729 ± 0.036	1.038AsnSer: 1.038 ± 0.03	1.299AsnThr: 1.299 ± 0.044	1.965AsnVal: 1.965 ± 0.041	0.345AsnTrp: 0.345 ± 0.017	0.601AsnTyr: 0.601 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.757ProAla: 7.757 ± 0.081	0.386ProCys: 0.386 ± 0.019	3.326ProAsp: 3.326 ± 0.06	2.734ProGlu: 2.734 ± 0.048	1.88ProPhe: 1.88 ± 0.038	4.339ProGly: 4.339 ± 0.054	1.162ProHis: 1.162 ± 0.03	2.069ProIle: 2.069 ± 0.041	1.119ProLys: 1.119 ± 0.03	5.5ProLeu: 5.5 ± 0.071	1.095ProMet: 1.095 ± 0.026	1.312ProAsn: 1.312 ± 0.03	2.784ProPro: 2.784 ± 0.052	1.664ProGln: 1.664 ± 0.035	3.619ProArg: 3.619 ± 0.057	3.232ProSer: 3.232 ± 0.051	2.948ProThr: 2.948 ± 0.053	4.34ProVal: 4.34 ± 0.057	0.666ProTrp: 0.666 ± 0.02	1.146ProTyr: 1.146 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	5.186GlnAla: 5.186 ± 0.075	0.302GlnCys: 0.302 ± 0.015	1.373GlnAsp: 1.373 ± 0.031	1.199GlnGlu: 1.199 ± 0.027	1.067GlnPhe: 1.067 ± 0.032	2.281GlnGly: 2.281 ± 0.041	0.822GlnHis: 0.822 ± 0.023	1.702GlnIle: 1.702 ± 0.037	0.774GlnLys: 0.774 ± 0.026	3.525GlnLeu: 3.525 ± 0.057	0.848GlnMet: 0.848 ± 0.028	0.746GlnAsn: 0.746 ± 0.024	1.959GlnPro: 1.959 ± 0.039	1.645GlnGln: 1.645 ± 0.052	3.477GlnArg: 3.477 ± 0.057	1.856GlnSer: 1.856 ± 0.035	1.952GlnThr: 1.952 ± 0.038	2.378GlnVal: 2.378 ± 0.044	0.537GlnTrp: 0.537 ± 0.019	0.768GlnTyr: 0.768 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	10.201ArgAla: 10.201 ± 0.115	0.741ArgCys: 0.741 ± 0.022	4.611ArgAsp: 4.611 ± 0.06	4.278ArgGlu: 4.278 ± 0.058	3.266ArgPhe: 3.266 ± 0.049	5.327ArgGly: 5.327 ± 0.064	2.145ArgHis: 2.145 ± 0.042	3.71ArgIle: 3.71 ± 0.054	1.767ArgLys: 1.767 ± 0.037	8.885ArgLeu: 8.885 ± 0.085	1.886ArgMet: 1.886 ± 0.035	1.87ArgAsn: 1.87 ± 0.04	3.879ArgPro: 3.879 ± 0.055	3.156ArgGln: 3.156 ± 0.052	7.052ArgArg: 7.052 ± 0.09	3.861ArgSer: 3.861 ± 0.061	3.798ArgThr: 3.798 ± 0.055	5.761ArgVal: 5.761 ± 0.067	1.17ArgTrp: 1.17 ± 0.029	2.154ArgTyr: 2.154 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.455SerAla: 7.455 ± 0.081	0.459SerCys: 0.459 ± 0.019	3.071SerAsp: 3.071 ± 0.051	2.497SerGlu: 2.497 ± 0.045	1.973SerPhe: 1.973 ± 0.043	5.404SerGly: 5.404 ± 0.068	1.184SerHis: 1.184 ± 0.027	2.372SerIle: 2.372 ± 0.045	1.309SerLys: 1.309 ± 0.034	5.827SerLeu: 5.827 ± 0.059	1.18SerMet: 1.18 ± 0.027	1.45SerAsn: 1.45 ± 0.036	2.951SerPro: 2.951 ± 0.042	1.817SerGln: 1.817 ± 0.036	4.159SerArg: 4.159 ± 0.06	3.172SerSer: 3.172 ± 0.059	2.977SerThr: 2.977 ± 0.048	4.359SerVal: 4.359 ± 0.056	0.724SerTrp: 0.724 ± 0.024	1.292SerTyr: 1.292 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.62ThrAla: 6.62 ± 0.093	0.404ThrCys: 0.404 ± 0.016	2.703ThrAsp: 2.703 ± 0.068	2.216ThrGlu: 2.216 ± 0.037	1.832ThrPhe: 1.832 ± 0.036	4.833ThrGly: 4.833 ± 0.085	1.14ThrHis: 1.14 ± 0.03	2.356ThrIle: 2.356 ± 0.052	0.885ThrLys: 0.885 ± 0.028	6.664ThrLeu: 6.664 ± 0.075	1.084ThrMet: 1.084 ± 0.032	1.047ThrAsn: 1.047 ± 0.028	3.642ThrPro: 3.642 ± 0.07	1.734ThrGln: 1.734 ± 0.036	3.825ThrArg: 3.825 ± 0.05	2.802ThrSer: 2.802 ± 0.046	2.959ThrThr: 2.959 ± 0.083	4.687ThrVal: 4.687 ± 0.083	0.599ThrTrp: 0.599 ± 0.02	1.12ThrTyr: 1.12 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.598ValAla: 10.598 ± 0.106	0.828ValCys: 0.828 ± 0.026	4.453ValAsp: 4.453 ± 0.06	3.962ValGlu: 3.962 ± 0.051	2.665ValPhe: 2.665 ± 0.044	5.99ValGly: 5.99 ± 0.063	1.477ValHis: 1.477 ± 0.035	3.353ValIle: 3.353 ± 0.055	1.909ValLys: 1.909 ± 0.04	7.969ValLeu: 7.969 ± 0.087	1.695ValMet: 1.695 ± 0.034	1.93ValAsn: 1.93 ± 0.038	4.217ValPro: 4.217 ± 0.055	2.301ValGln: 2.301 ± 0.039	5.573ValArg: 5.573 ± 0.066	4.619ValSer: 4.619 ± 0.057	4.278ValThr: 4.278 ± 0.061	6.344ValVal: 6.344 ± 0.07	0.968ValTrp: 0.968 ± 0.026	1.61ValTyr: 1.61 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.146TrpAla: 1.146 ± 0.029	0.134TrpCys: 0.134 ± 0.008	0.556TrpAsp: 0.556 ± 0.018	0.408TrpGlu: 0.408 ± 0.017	0.525TrpPhe: 0.525 ± 0.019	0.793TrpGly: 0.793 ± 0.025	0.429TrpHis: 0.429 ± 0.018	0.555TrpIle: 0.555 ± 0.02	0.268TrpLys: 0.268 ± 0.014	2.111TrpLeu: 2.111 ± 0.047	0.309TrpMet: 0.309 ± 0.014	0.333TrpAsn: 0.333 ± 0.015	0.713TrpPro: 0.713 ± 0.025	0.799TrpGln: 0.799 ± 0.028	1.536TrpArg: 1.536 ± 0.041	0.742TrpSer: 0.742 ± 0.024	0.678TrpThr: 0.678 ± 0.022	0.817TrpVal: 0.817 ± 0.024	0.199TrpTrp: 0.199 ± 0.012	0.282TrpTyr: 0.282 ± 0.016	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.78TyrAla: 2.78 ± 0.045	0.238TyrCys: 0.238 ± 0.012	1.341TyrAsp: 1.341 ± 0.041	1.086TyrGlu: 1.086 ± 0.03	0.889TyrPhe: 0.889 ± 0.022	2.062TyrGly: 2.062 ± 0.041	0.461TyrHis: 0.461 ± 0.016	0.749TyrIle: 0.749 ± 0.022	0.505TyrLys: 0.505 ± 0.019	2.361TyrLeu: 2.361 ± 0.042	0.407TyrMet: 0.407 ± 0.017	0.536TyrAsn: 0.536 ± 0.022	1.102TyrPro: 1.102 ± 0.027	0.818TyrGln: 0.818 ± 0.027	2.102TyrArg: 2.102 ± 0.04	1.118TyrSer: 1.118 ± 0.032	1.139TyrThr: 1.139 ± 0.03	1.728TyrVal: 1.728 ± 0.039	0.341TyrTrp: 0.341 ± 0.017	0.562TyrTyr: 0.562 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 4543 proteins (1518797 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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