Amino acid dipepetide frequency for Thermobifida halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.498AlaAla: 19.498 ± 0.189	0.929AlaCys: 0.929 ± 0.027	8.493AlaAsp: 8.493 ± 0.097	9.89AlaGlu: 9.89 ± 0.103	3.427AlaPhe: 3.427 ± 0.05	10.55AlaGly: 10.55 ± 0.098	2.782AlaHis: 2.782 ± 0.05	3.461AlaIle: 3.461 ± 0.052	2.049AlaLys: 2.049 ± 0.05	13.871AlaLeu: 13.871 ± 0.147	2.225AlaMet: 2.225 ± 0.041	2.002AlaAsn: 2.002 ± 0.045	6.26AlaPro: 6.26 ± 0.084	3.331AlaGln: 3.331 ± 0.062	10.432AlaArg: 10.432 ± 0.114	5.455AlaSer: 5.455 ± 0.067	6.308AlaThr: 6.308 ± 0.072	12.425AlaVal: 12.425 ± 0.131	1.76AlaTrp: 1.76 ± 0.04	2.36AlaTyr: 2.36 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.0CysAla: 1.0 ± 0.028	0.097CysCys: 0.097 ± 0.009	0.478CysAsp: 0.478 ± 0.019	0.431CysGlu: 0.431 ± 0.018	0.233CysPhe: 0.233 ± 0.013	0.895CysGly: 0.895 ± 0.027	0.203CysHis: 0.203 ± 0.013	0.121CysIle: 0.121 ± 0.01	0.07CysLys: 0.07 ± 0.007	0.682CysLeu: 0.682 ± 0.024	0.123CysMet: 0.123 ± 0.009	0.099CysAsn: 0.099 ± 0.009	0.491CysPro: 0.491 ± 0.023	0.156CysGln: 0.156 ± 0.01	0.616CysArg: 0.616 ± 0.022	0.435CysSer: 0.435 ± 0.021	0.394CysThr: 0.394 ± 0.017	0.733CysVal: 0.733 ± 0.024	0.108CysTrp: 0.108 ± 0.009	0.175CysTyr: 0.175 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.348AspAla: 7.348 ± 0.091	0.403AspCys: 0.403 ± 0.02	4.044AspAsp: 4.044 ± 0.073	4.046AspGlu: 4.046 ± 0.065	1.655AspPhe: 1.655 ± 0.04	5.992AspGly: 5.992 ± 0.084	1.588AspHis: 1.588 ± 0.038	2.058AspIle: 2.058 ± 0.044	0.836AspLys: 0.836 ± 0.03	6.898AspLeu: 6.898 ± 0.07	0.943AspMet: 0.943 ± 0.03	1.109AspAsn: 1.109 ± 0.03	4.787AspPro: 4.787 ± 0.07	1.526AspGln: 1.526 ± 0.037	5.519AspArg: 5.519 ± 0.071	3.044AspSer: 3.044 ± 0.055	3.542AspThr: 3.542 ± 0.067	5.049AspVal: 5.049 ± 0.065	0.99AspTrp: 0.99 ± 0.029	1.473AspTyr: 1.473 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.902GluAla: 7.902 ± 0.09	0.398GluCys: 0.398 ± 0.021	3.184GluAsp: 3.184 ± 0.056	5.074GluGlu: 5.074 ± 0.07	1.874GluPhe: 1.874 ± 0.04	4.497GluGly: 4.497 ± 0.067	1.781GluHis: 1.781 ± 0.035	2.716GluIle: 2.716 ± 0.056	1.288GluLys: 1.288 ± 0.038	7.192GluLeu: 7.192 ± 0.088	1.053GluMet: 1.053 ± 0.028	1.224GluAsn: 1.224 ± 0.034	3.508GluPro: 3.508 ± 0.068	2.469GluGln: 2.469 ± 0.055	6.73GluArg: 6.73 ± 0.093	2.84GluSer: 2.84 ± 0.049	3.461GluThr: 3.461 ± 0.057	5.316GluVal: 5.316 ± 0.074	0.956GluTrp: 0.956 ± 0.03	1.32GluTyr: 1.32 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.642PheAla: 3.642 ± 0.058	0.275PheCys: 0.275 ± 0.013	2.157PheAsp: 2.157 ± 0.042	1.474PheGlu: 1.474 ± 0.034	0.932PhePhe: 0.932 ± 0.031	2.999PheGly: 2.999 ± 0.05	0.652PheHis: 0.652 ± 0.024	0.618PheIle: 0.618 ± 0.022	0.371PheLys: 0.371 ± 0.019	2.783PheLeu: 2.783 ± 0.05	0.409PheMet: 0.409 ± 0.019	0.593PheAsn: 0.593 ± 0.021	1.468PhePro: 1.468 ± 0.033	0.647PheGln: 0.647 ± 0.025	1.882PheArg: 1.882 ± 0.047	1.487PheSer: 1.487 ± 0.037	2.103PheThr: 2.103 ± 0.042	2.56PheVal: 2.56 ± 0.046	0.428PheTrp: 0.428 ± 0.02	0.614PheTyr: 0.614 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.065GlyAla: 10.065 ± 0.108	0.808GlyCys: 0.808 ± 0.024	5.214GlyAsp: 5.214 ± 0.076	5.583GlyGlu: 5.583 ± 0.072	2.774GlyPhe: 2.774 ± 0.054	8.383GlyGly: 8.383 ± 0.106	2.124GlyHis: 2.124 ± 0.04	3.197GlyIle: 3.197 ± 0.058	1.679GlyLys: 1.679 ± 0.041	8.77GlyLeu: 8.77 ± 0.114	2.024GlyMet: 2.024 ± 0.034	1.647GlyAsn: 1.647 ± 0.037	4.514GlyPro: 4.514 ± 0.071	2.536GlyGln: 2.536 ± 0.047	7.861GlyArg: 7.861 ± 0.09	4.769GlySer: 4.769 ± 0.076	5.385GlyThr: 5.385 ± 0.078	8.068GlyVal: 8.068 ± 0.084	1.556GlyTrp: 1.556 ± 0.038	2.355GlyTyr: 2.355 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.623HisAla: 2.623 ± 0.051	0.2HisCys: 0.2 ± 0.013	1.377HisAsp: 1.377 ± 0.032	1.235HisGlu: 1.235 ± 0.033	0.612HisPhe: 0.612 ± 0.023	2.353HisGly: 2.353 ± 0.044	0.713HisHis: 0.713 ± 0.027	0.676HisIle: 0.676 ± 0.026	0.28HisLys: 0.28 ± 0.015	2.422HisLeu: 2.422 ± 0.049	0.325HisMet: 0.325 ± 0.015	0.445HisAsn: 0.445 ± 0.019	1.754HisPro: 1.754 ± 0.037	0.605HisGln: 0.605 ± 0.024	2.29HisArg: 2.29 ± 0.05	1.118HisSer: 1.118 ± 0.028	1.349HisThr: 1.349 ± 0.037	1.792HisVal: 1.792 ± 0.038	0.339HisTrp: 0.339 ± 0.018	0.528HisTyr: 0.528 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	4.553IleAla: 4.553 ± 0.072	0.261IleCys: 0.261 ± 0.015	2.391IleAsp: 2.391 ± 0.046	2.006IleGlu: 2.006 ± 0.041	0.707IlePhe: 0.707 ± 0.025	3.247IleGly: 3.247 ± 0.06	0.573IleHis: 0.573 ± 0.021	1.008IleIle: 1.008 ± 0.031	0.539IleLys: 0.539 ± 0.02	2.45IleLeu: 2.45 ± 0.052	0.519IleMet: 0.519 ± 0.02	0.763IleAsn: 0.763 ± 0.026	1.794IlePro: 1.794 ± 0.038	0.74IleGln: 0.74 ± 0.025	2.482IleArg: 2.482 ± 0.048	1.749IleSer: 1.749 ± 0.041	2.314IleThr: 2.314 ± 0.04	2.91IleVal: 2.91 ± 0.053	0.32IleTrp: 0.32 ± 0.017	0.531IleTyr: 0.531 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	1.929LysAla: 1.929 ± 0.044	0.079LysCys: 0.079 ± 0.008	0.849LysAsp: 0.849 ± 0.029	1.017LysGlu: 1.017 ± 0.033	0.353LysPhe: 0.353 ± 0.019	1.246LysGly: 1.246 ± 0.035	0.349LysHis: 0.349 ± 0.016	0.729LysIle: 0.729 ± 0.026	0.57LysLys: 0.57 ± 0.031	1.544LysLeu: 1.544 ± 0.041	0.306LysMet: 0.306 ± 0.017	0.397LysAsn: 0.397 ± 0.017	0.94LysPro: 0.94 ± 0.029	0.519LysGln: 0.519 ± 0.023	1.432LysArg: 1.432 ± 0.035	0.83LysSer: 0.83 ± 0.027	1.029LysThr: 1.029 ± 0.032	1.366LysVal: 1.366 ± 0.038	0.202LysTrp: 0.202 ± 0.014	0.35LysTyr: 0.35 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.545LeuAla: 14.545 ± 0.147	0.81LeuCys: 0.81 ± 0.027	6.942LeuAsp: 6.942 ± 0.085	5.378LeuGlu: 5.378 ± 0.07	2.836LeuPhe: 2.836 ± 0.056	9.073LeuGly: 9.073 ± 0.094	2.15LeuHis: 2.15 ± 0.043	2.895LeuIle: 2.895 ± 0.053	1.478LeuLys: 1.478 ± 0.042	11.54LeuLeu: 11.54 ± 0.129	1.578LeuMet: 1.578 ± 0.039	1.79LeuAsn: 1.79 ± 0.039	6.358LeuPro: 6.358 ± 0.079	1.864LeuGln: 1.864 ± 0.037	9.654LeuArg: 9.654 ± 0.103	5.542LeuSer: 5.542 ± 0.07	6.344LeuThr: 6.344 ± 0.076	9.846LeuVal: 9.846 ± 0.108	1.333LeuTrp: 1.333 ± 0.037	1.853LeuTyr: 1.853 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.254MetAla: 2.254 ± 0.044	0.114MetCys: 0.114 ± 0.009	0.947MetAsp: 0.947 ± 0.025	0.861MetGlu: 0.861 ± 0.026	0.491MetPhe: 0.491 ± 0.021	1.431MetGly: 1.431 ± 0.036	0.306MetHis: 0.306 ± 0.017	0.614MetIle: 0.614 ± 0.023	0.313MetLys: 0.313 ± 0.015	1.782MetLeu: 1.782 ± 0.041	0.287MetMet: 0.287 ± 0.015	0.426MetAsn: 0.426 ± 0.018	1.034MetPro: 1.034 ± 0.032	0.381MetGln: 0.381 ± 0.02	1.581MetArg: 1.581 ± 0.037	1.364MetSer: 1.364 ± 0.036	1.411MetThr: 1.411 ± 0.034	1.577MetVal: 1.577 ± 0.038	0.216MetTrp: 0.216 ± 0.013	0.28MetTyr: 0.28 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.172AsnAla: 2.172 ± 0.047	0.16AsnCys: 0.16 ± 0.013	0.966AsnAsp: 0.966 ± 0.031	0.982AsnGlu: 0.982 ± 0.032	0.506AsnPhe: 0.506 ± 0.023	1.826AsnGly: 1.826 ± 0.043	0.418AsnHis: 0.418 ± 0.021	0.708AsnIle: 0.708 ± 0.025	0.303AsnLys: 0.303 ± 0.016	1.825AsnLeu: 1.825 ± 0.041	0.322AsnMet: 0.322 ± 0.017	0.473AsnAsn: 0.473 ± 0.023	1.5AsnPro: 1.5 ± 0.035	0.567AsnGln: 0.567 ± 0.021	1.555AsnArg: 1.555 ± 0.041	0.958AsnSer: 0.958 ± 0.03	1.164AsnThr: 1.164 ± 0.031	1.414AsnVal: 1.414 ± 0.038	0.299AsnTrp: 0.299 ± 0.016	0.472AsnTyr: 0.472 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.886ProAla: 6.886 ± 0.088	0.312ProCys: 0.312 ± 0.016	4.757ProAsp: 4.757 ± 0.077	5.077ProGlu: 5.077 ± 0.081	1.518ProPhe: 1.518 ± 0.038	6.065ProGly: 6.065 ± 0.072	1.406ProHis: 1.406 ± 0.035	1.362ProIle: 1.362 ± 0.031	0.917ProLys: 0.917 ± 0.028	5.374ProLeu: 5.374 ± 0.081	1.02ProMet: 1.02 ± 0.024	1.023ProAsn: 1.023 ± 0.026	3.763ProPro: 3.763 ± 0.074	1.498ProGln: 1.498 ± 0.036	4.327ProArg: 4.327 ± 0.062	3.053ProSer: 3.053 ± 0.054	3.18ProThr: 3.18 ± 0.061	5.502ProVal: 5.502 ± 0.07	0.89ProTrp: 0.89 ± 0.032	1.26ProTyr: 1.26 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.306GlnAla: 3.306 ± 0.068	0.158GlnCys: 0.158 ± 0.012	1.129GlnAsp: 1.129 ± 0.032	1.638GlnGlu: 1.638 ± 0.044	0.589GlnPhe: 0.589 ± 0.02	1.92GlnGly: 1.92 ± 0.043	0.647GlnHis: 0.647 ± 0.023	1.181GlnIle: 1.181 ± 0.029	0.474GlnLys: 0.474 ± 0.021	2.632GlnLeu: 2.632 ± 0.055	0.543GlnMet: 0.543 ± 0.022	0.487GlnAsn: 0.487 ± 0.022	1.55GlnPro: 1.55 ± 0.04	1.085GlnGln: 1.085 ± 0.04	2.665GlnArg: 2.665 ± 0.047	1.165GlnSer: 1.165 ± 0.033	1.429GlnThr: 1.429 ± 0.035	2.396GlnVal: 2.396 ± 0.043	0.395GlnTrp: 0.395 ± 0.017	0.49GlnTyr: 0.49 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	10.084ArgAla: 10.084 ± 0.116	0.651ArgCys: 0.651 ± 0.025	4.963ArgAsp: 4.963 ± 0.069	5.434ArgGlu: 5.434 ± 0.076	2.634ArgPhe: 2.634 ± 0.043	6.585ArgGly: 6.585 ± 0.08	2.16ArgHis: 2.16 ± 0.035	3.484ArgIle: 3.484 ± 0.055	1.42ArgLys: 1.42 ± 0.037	9.546ArgLeu: 9.546 ± 0.098	2.019ArgMet: 2.019 ± 0.045	1.534ArgAsn: 1.534 ± 0.038	5.056ArgPro: 5.056 ± 0.065	2.304ArgGln: 2.304 ± 0.043	9.019ArgArg: 9.019 ± 0.119	4.664ArgSer: 4.664 ± 0.061	5.17ArgThr: 5.17 ± 0.072	7.427ArgVal: 7.427 ± 0.091	1.491ArgTrp: 1.491 ± 0.042	1.987ArgTyr: 1.987 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.315SerAla: 6.315 ± 0.075	0.375SerCys: 0.375 ± 0.019	3.016SerAsp: 3.016 ± 0.054	2.885SerGlu: 2.885 ± 0.056	1.487SerPhe: 1.487 ± 0.039	5.926SerGly: 5.926 ± 0.085	1.071SerHis: 1.071 ± 0.034	1.409SerIle: 1.409 ± 0.034	0.708SerLys: 0.708 ± 0.027	4.865SerLeu: 4.865 ± 0.067	1.012SerMet: 1.012 ± 0.03	0.848SerAsn: 0.848 ± 0.024	3.328SerPro: 3.328 ± 0.058	1.28SerGln: 1.28 ± 0.036	3.991SerArg: 3.991 ± 0.054	2.746SerSer: 2.746 ± 0.059	2.954SerThr: 2.954 ± 0.06	4.379SerVal: 4.379 ± 0.064	0.877SerTrp: 0.877 ± 0.029	1.238SerTyr: 1.238 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.957ThrAla: 7.957 ± 0.104	0.384ThrCys: 0.384 ± 0.018	3.746ThrAsp: 3.746 ± 0.059	3.726ThrGlu: 3.726 ± 0.063	1.534ThrPhe: 1.534 ± 0.035	6.222ThrGly: 6.222 ± 0.082	1.216ThrHis: 1.216 ± 0.033	1.683ThrIle: 1.683 ± 0.042	0.873ThrLys: 0.873 ± 0.025	5.544ThrLeu: 5.544 ± 0.078	0.984ThrMet: 0.984 ± 0.03	0.945ThrAsn: 0.945 ± 0.028	3.99ThrPro: 3.99 ± 0.073	1.299ThrGln: 1.299 ± 0.035	4.192ThrArg: 4.192 ± 0.057	2.791ThrSer: 2.791 ± 0.05	3.493ThrThr: 3.493 ± 0.064	6.325ThrVal: 6.325 ± 0.068	0.821ThrTrp: 0.821 ± 0.022	1.056ThrTyr: 1.056 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	11.41ValAla: 11.41 ± 0.118	0.824ValCys: 0.824 ± 0.023	5.989ValAsp: 5.989 ± 0.081	5.93ValGlu: 5.93 ± 0.075	2.805ValPhe: 2.805 ± 0.05	7.102ValGly: 7.102 ± 0.088	2.097ValHis: 2.097 ± 0.044	2.885ValIle: 2.885 ± 0.054	1.286ValLys: 1.286 ± 0.034	9.886ValLeu: 9.886 ± 0.104	1.432ValMet: 1.432 ± 0.04	1.98ValAsn: 1.98 ± 0.043	5.2ValPro: 5.2 ± 0.073	1.898ValGln: 1.898 ± 0.042	7.935ValArg: 7.935 ± 0.077	4.746ValSer: 4.746 ± 0.066	5.457ValThr: 5.457 ± 0.075	9.14ValVal: 9.14 ± 0.127	1.266ValTrp: 1.266 ± 0.035	1.701ValTyr: 1.701 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.555TrpAla: 1.555 ± 0.041	0.136TrpCys: 0.136 ± 0.01	0.809TrpAsp: 0.809 ± 0.027	0.851TrpGlu: 0.851 ± 0.025	0.481TrpPhe: 0.481 ± 0.022	1.004TrpGly: 1.004 ± 0.031	0.363TrpHis: 0.363 ± 0.02	0.527TrpIle: 0.527 ± 0.024	0.287TrpLys: 0.287 ± 0.015	1.818TrpLeu: 1.818 ± 0.044	0.279TrpMet: 0.279 ± 0.014	0.416TrpAsn: 0.416 ± 0.021	0.771TrpPro: 0.771 ± 0.027	0.532TrpGln: 0.532 ± 0.02	1.47TrpArg: 1.47 ± 0.033	0.922TrpSer: 0.922 ± 0.032	0.994TrpThr: 0.994 ± 0.031	1.048TrpVal: 1.048 ± 0.033	0.354TrpTrp: 0.354 ± 0.019	0.306TrpTyr: 0.306 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.463TyrAla: 2.463 ± 0.045	0.167TyrCys: 0.167 ± 0.012	1.396TyrAsp: 1.396 ± 0.038	1.263TyrGlu: 1.263 ± 0.034	0.646TyrPhe: 0.646 ± 0.024	1.995TyrGly: 1.995 ± 0.044	0.44TyrHis: 0.44 ± 0.02	0.524TyrIle: 0.524 ± 0.022	0.294TyrLys: 0.294 ± 0.014	2.389TyrLeu: 2.389 ± 0.052	0.262TyrMet: 0.262 ± 0.015	0.387TyrAsn: 0.387 ± 0.019	1.124TyrPro: 1.124 ± 0.033	0.643TyrGln: 0.643 ± 0.024	2.002TyrArg: 2.002 ± 0.042	1.031TyrSer: 1.031 ± 0.03	1.302TyrThr: 1.302 ± 0.035	1.696TyrVal: 1.696 ± 0.041	0.327TyrTrp: 0.327 ± 0.016	0.483TyrTyr: 0.483 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4067 proteins (1241983 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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