Amino acid dipepetide frequency for Flavobacterium tangerina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.547AlaAla: 3.547 ± 0.091	0.565AlaCys: 0.565 ± 0.023	2.963AlaAsp: 2.963 ± 0.06	3.678AlaGlu: 3.678 ± 0.072	3.37AlaPhe: 3.37 ± 0.058	3.494AlaGly: 3.494 ± 0.076	0.903AlaHis: 0.903 ± 0.034	5.058AlaIle: 5.058 ± 0.083	4.622AlaLys: 4.622 ± 0.076	5.758AlaLeu: 5.758 ± 0.092	1.346AlaMet: 1.346 ± 0.037	3.548AlaAsn: 3.548 ± 0.068	1.658AlaPro: 1.658 ± 0.045	2.421AlaGln: 2.421 ± 0.054	1.601AlaArg: 1.601 ± 0.045	3.591AlaSer: 3.591 ± 0.062	3.56AlaThr: 3.56 ± 0.092	3.605AlaVal: 3.605 ± 0.068	0.485AlaTrp: 0.485 ± 0.026	2.256AlaTyr: 2.256 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.439CysAla: 0.439 ± 0.024	0.114CysCys: 0.114 ± 0.01	0.393CysAsp: 0.393 ± 0.019	0.535CysGlu: 0.535 ± 0.027	0.478CysPhe: 0.478 ± 0.022	0.582CysGly: 0.582 ± 0.03	0.156CysHis: 0.156 ± 0.015	0.608CysIle: 0.608 ± 0.028	0.539CysLys: 0.539 ± 0.023	0.663CysLeu: 0.663 ± 0.025	0.128CysMet: 0.128 ± 0.013	0.497CysAsn: 0.497 ± 0.021	0.335CysPro: 0.335 ± 0.023	0.214CysGln: 0.214 ± 0.015	0.188CysArg: 0.188 ± 0.016	0.563CysSer: 0.563 ± 0.024	0.434CysThr: 0.434 ± 0.022	0.487CysVal: 0.487 ± 0.02	0.07CysTrp: 0.07 ± 0.01	0.303CysTyr: 0.303 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.171AspAla: 3.171 ± 0.058	0.434AspCys: 0.434 ± 0.024	2.71AspAsp: 2.71 ± 0.053	4.002AspGlu: 4.002 ± 0.071	4.026AspPhe: 4.026 ± 0.067	3.169AspGly: 3.169 ± 0.067	0.731AspHis: 0.731 ± 0.026	4.235AspIle: 4.235 ± 0.078	4.418AspLys: 4.418 ± 0.069	5.532AspLeu: 5.532 ± 0.085	0.964AspMet: 0.964 ± 0.034	3.244AspAsn: 3.244 ± 0.066	1.376AspPro: 1.376 ± 0.043	1.405AspGln: 1.405 ± 0.039	1.709AspArg: 1.709 ± 0.041	3.269AspSer: 3.269 ± 0.066	2.375AspThr: 2.375 ± 0.056	3.572AspVal: 3.572 ± 0.069	0.675AspTrp: 0.675 ± 0.026	2.821AspTyr: 2.821 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	3.885GluAla: 3.885 ± 0.074	0.316GluCys: 0.316 ± 0.022	3.32GluAsp: 3.32 ± 0.065	4.695GluGlu: 4.695 ± 0.089	3.315GluPhe: 3.315 ± 0.058	3.287GluGly: 3.287 ± 0.061	1.067GluHis: 1.067 ± 0.033	6.924GluIle: 6.924 ± 0.086	6.291GluLys: 6.291 ± 0.106	6.239GluLeu: 6.239 ± 0.076	1.759GluMet: 1.759 ± 0.045	5.921GluAsn: 5.921 ± 0.086	1.542GluPro: 1.542 ± 0.041	2.512GluGln: 2.512 ± 0.064	2.393GluArg: 2.393 ± 0.059	3.477GluSer: 3.477 ± 0.071	3.898GluThr: 3.898 ± 0.073	4.436GluVal: 4.436 ± 0.081	0.584GluTrp: 0.584 ± 0.023	2.575GluTyr: 2.575 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.184PheAla: 3.184 ± 0.062	0.527PheCys: 0.527 ± 0.031	3.618PheAsp: 3.618 ± 0.066	4.049PheGlu: 4.049 ± 0.07	3.1PhePhe: 3.1 ± 0.071	3.712PheGly: 3.712 ± 0.075	0.872PheHis: 0.872 ± 0.029	4.568PheIle: 4.568 ± 0.075	4.091PheLys: 4.091 ± 0.062	5.094PheLeu: 5.094 ± 0.082	1.139PheMet: 1.139 ± 0.037	3.744PheAsn: 3.744 ± 0.071	1.744PhePro: 1.744 ± 0.046	1.8PheGln: 1.8 ± 0.041	1.623PheArg: 1.623 ± 0.043	4.207PheSer: 4.207 ± 0.079	3.244PheThr: 3.244 ± 0.06	3.465PheVal: 3.465 ± 0.062	0.535PheTrp: 0.535 ± 0.026	2.665PheTyr: 2.665 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	3.511GlyAla: 3.511 ± 0.075	0.579GlyCys: 0.579 ± 0.032	2.776GlyAsp: 2.776 ± 0.059	3.187GlyGlu: 3.187 ± 0.061	3.598GlyPhe: 3.598 ± 0.06	3.716GlyGly: 3.716 ± 0.071	0.897GlyHis: 0.897 ± 0.035	5.273GlyIle: 5.273 ± 0.074	4.772GlyLys: 4.772 ± 0.083	5.184GlyLeu: 5.184 ± 0.083	1.392GlyMet: 1.392 ± 0.046	3.818GlyAsn: 3.818 ± 0.074	1.121GlyPro: 1.121 ± 0.043	1.766GlyGln: 1.766 ± 0.047	1.761GlyArg: 1.761 ± 0.045	3.628GlySer: 3.628 ± 0.069	3.708GlyThr: 3.708 ± 0.083	3.793GlyVal: 3.793 ± 0.079	0.621GlyTrp: 0.621 ± 0.03	2.637GlyTyr: 2.637 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	0.809HisAla: 0.809 ± 0.034	0.164HisCys: 0.164 ± 0.014	0.725HisAsp: 0.725 ± 0.028	0.899HisGlu: 0.899 ± 0.034	1.192HisPhe: 1.192 ± 0.037	0.883HisGly: 0.883 ± 0.03	0.394HisHis: 0.394 ± 0.021	1.385HisIle: 1.385 ± 0.038	1.173HisLys: 1.173 ± 0.031	1.721HisLeu: 1.721 ± 0.045	0.282HisMet: 0.282 ± 0.019	0.941HisAsn: 0.941 ± 0.03	0.699HisPro: 0.699 ± 0.03	0.657HisGln: 0.657 ± 0.03	0.543HisArg: 0.543 ± 0.024	1.058HisSer: 1.058 ± 0.038	0.825HisThr: 0.825 ± 0.029	0.79HisVal: 0.79 ± 0.032	0.167HisTrp: 0.167 ± 0.013	0.73HisTyr: 0.73 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.341IleAla: 5.341 ± 0.082	0.745IleCys: 0.745 ± 0.025	5.234IleAsp: 5.234 ± 0.079	6.478IleGlu: 6.478 ± 0.1	4.203IlePhe: 4.203 ± 0.078	5.071IleGly: 5.071 ± 0.091	1.349IleHis: 1.349 ± 0.044	6.837IleIle: 6.837 ± 0.13	6.45IleLys: 6.45 ± 0.092	7.727IleLeu: 7.727 ± 0.102	1.376IleMet: 1.376 ± 0.036	5.457IleAsn: 5.457 ± 0.087	3.343IlePro: 3.343 ± 0.06	3.137IleGln: 3.137 ± 0.065	2.532IleArg: 2.532 ± 0.043	6.371IleSer: 6.371 ± 0.077	4.869IleThr: 4.869 ± 0.078	5.123IleVal: 5.123 ± 0.089	0.704IleTrp: 0.704 ± 0.029	3.439IleTyr: 3.439 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	4.672LysAla: 4.672 ± 0.084	0.39LysCys: 0.39 ± 0.021	4.507LysAsp: 4.507 ± 0.076	6.18LysGlu: 6.18 ± 0.094	3.586LysPhe: 3.586 ± 0.067	4.028LysGly: 4.028 ± 0.073	1.315LysHis: 1.315 ± 0.036	7.358LysIle: 7.358 ± 0.115	7.254LysLys: 7.254 ± 0.11	6.87LysLeu: 6.87 ± 0.101	2.347LysMet: 2.347 ± 0.045	6.348LysAsn: 6.348 ± 0.102	2.454LysPro: 2.454 ± 0.055	3.073LysGln: 3.073 ± 0.069	2.619LysArg: 2.619 ± 0.057	5.052LysSer: 5.052 ± 0.075	4.749LysThr: 4.749 ± 0.078	4.606LysVal: 4.606 ± 0.076	0.807LysTrp: 0.807 ± 0.032	3.474LysTyr: 3.474 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	5.512LeuAla: 5.512 ± 0.089	0.637LeuCys: 0.637 ± 0.026	4.972LeuAsp: 4.972 ± 0.068	6.134LeuGlu: 6.134 ± 0.096	5.308LeuPhe: 5.308 ± 0.084	5.397LeuGly: 5.397 ± 0.079	1.418LeuHis: 1.418 ± 0.04	7.77LeuIle: 7.77 ± 0.101	7.979LeuLys: 7.979 ± 0.113	8.191LeuLeu: 8.191 ± 0.108	2.083LeuMet: 2.083 ± 0.044	6.571LeuAsn: 6.571 ± 0.101	3.376LeuPro: 3.376 ± 0.059	3.204LeuGln: 3.204 ± 0.065	2.831LeuArg: 2.831 ± 0.057	6.334LeuSer: 6.334 ± 0.091	4.947LeuThr: 4.947 ± 0.077	5.237LeuVal: 5.237 ± 0.076	0.686LeuTrp: 0.686 ± 0.026	3.215LeuTyr: 3.215 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	1.371MetAla: 1.371 ± 0.044	0.131MetCys: 0.131 ± 0.012	0.998MetAsp: 0.998 ± 0.035	1.325MetGlu: 1.325 ± 0.036	1.061MetPhe: 1.061 ± 0.034	1.228MetGly: 1.228 ± 0.04	0.368MetHis: 0.368 ± 0.02	1.747MetIle: 1.747 ± 0.042	2.531MetLys: 2.531 ± 0.05	1.878MetLeu: 1.878 ± 0.054	0.618MetMet: 0.618 ± 0.028	1.541MetAsn: 1.541 ± 0.042	0.715MetPro: 0.715 ± 0.028	0.806MetGln: 0.806 ± 0.03	0.767MetArg: 0.767 ± 0.026	1.283MetSer: 1.283 ± 0.041	1.088MetThr: 1.088 ± 0.033	1.182MetVal: 1.182 ± 0.034	0.167MetTrp: 0.167 ± 0.013	0.775MetTyr: 0.775 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	4.01AsnAla: 4.01 ± 0.076	0.532AsnCys: 0.532 ± 0.031	3.769AsnAsp: 3.769 ± 0.076	5.044AsnGlu: 5.044 ± 0.082	3.779AsnPhe: 3.779 ± 0.079	4.179AsnGly: 4.179 ± 0.087	1.23AsnHis: 1.23 ± 0.035	5.513AsnIle: 5.513 ± 0.094	5.412AsnLys: 5.412 ± 0.096	6.238AsnLeu: 6.238 ± 0.086	1.273AsnMet: 1.273 ± 0.031	4.655AsnAsn: 4.655 ± 0.098	2.919AsnPro: 2.919 ± 0.059	3.08AsnGln: 3.08 ± 0.069	2.196AsnArg: 2.196 ± 0.047	4.476AsnSer: 4.476 ± 0.096	3.627AsnThr: 3.627 ± 0.063	3.871AsnVal: 3.871 ± 0.076	0.755AsnTrp: 0.755 ± 0.026	3.291AsnTyr: 3.291 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	1.713ProAla: 1.713 ± 0.047	0.216ProCys: 0.216 ± 0.015	1.687ProAsp: 1.687 ± 0.044	2.604ProGlu: 2.604 ± 0.061	1.885ProPhe: 1.885 ± 0.05	1.591ProGly: 1.591 ± 0.044	0.476ProHis: 0.476 ± 0.02	2.904ProIle: 2.904 ± 0.051	2.47ProLys: 2.47 ± 0.06	2.687ProLeu: 2.687 ± 0.052	0.729ProMet: 0.729 ± 0.029	2.411ProAsn: 2.411 ± 0.054	0.651ProPro: 0.651 ± 0.029	1.032ProGln: 1.032 ± 0.033	0.791ProArg: 0.791 ± 0.028	1.947ProSer: 1.947 ± 0.043	2.034ProThr: 2.034 ± 0.056	2.118ProVal: 2.118 ± 0.056	0.281ProTrp: 0.281 ± 0.018	1.281ProTyr: 1.281 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.978GlnAla: 1.978 ± 0.053	0.161GlnCys: 0.161 ± 0.014	1.579GlnAsp: 1.579 ± 0.05	2.387GlnGlu: 2.387 ± 0.05	1.936GlnPhe: 1.936 ± 0.046	1.716GlnGly: 1.716 ± 0.046	0.585GlnHis: 0.585 ± 0.024	3.467GlnIle: 3.467 ± 0.066	3.063GlnLys: 3.063 ± 0.06	3.411GlnLeu: 3.411 ± 0.065	0.876GlnMet: 0.876 ± 0.031	2.85GlnAsn: 2.85 ± 0.065	1.073GlnPro: 1.073 ± 0.033	1.426GlnGln: 1.426 ± 0.046	1.109GlnArg: 1.109 ± 0.035	2.0GlnSer: 2.0 ± 0.052	2.217GlnThr: 2.217 ± 0.057	2.044GlnVal: 2.044 ± 0.048	0.334GlnTrp: 0.334 ± 0.018	1.43GlnTyr: 1.43 ± 0.051	0.0GlnXaa: 0.0 ± 0.0
Arg	1.693ArgAla: 1.693 ± 0.045	0.163ArgCys: 0.163 ± 0.013	1.519ArgAsp: 1.519 ± 0.043	2.032ArgGlu: 2.032 ± 0.053	1.837ArgPhe: 1.837 ± 0.045	1.559ArgGly: 1.559 ± 0.043	0.515ArgHis: 0.515 ± 0.025	2.835ArgIle: 2.835 ± 0.055	2.745ArgLys: 2.745 ± 0.059	2.879ArgLeu: 2.879 ± 0.061	0.841ArgMet: 0.841 ± 0.026	2.201ArgAsn: 2.201 ± 0.044	0.903ArgPro: 0.903 ± 0.032	0.894ArgGln: 0.894 ± 0.03	1.06ArgArg: 1.06 ± 0.034	1.666ArgSer: 1.666 ± 0.045	1.712ArgThr: 1.712 ± 0.046	1.884ArgVal: 1.884 ± 0.044	0.319ArgTrp: 0.319 ± 0.018	1.361ArgTyr: 1.361 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.363SerAla: 3.363 ± 0.065	0.681SerCys: 0.681 ± 0.028	3.569SerAsp: 3.569 ± 0.059	4.394SerGlu: 4.394 ± 0.077	4.181SerPhe: 4.181 ± 0.07	4.05SerGly: 4.05 ± 0.076	0.961SerHis: 0.961 ± 0.032	5.445SerIle: 5.445 ± 0.08	5.27SerLys: 5.27 ± 0.076	5.853SerLeu: 5.853 ± 0.088	1.254SerMet: 1.254 ± 0.035	4.624SerAsn: 4.624 ± 0.098	1.794SerPro: 1.794 ± 0.043	2.189SerGln: 2.189 ± 0.048	1.847SerArg: 1.847 ± 0.046	4.105SerSer: 4.105 ± 0.085	3.556SerThr: 3.556 ± 0.072	3.837SerVal: 3.837 ± 0.065	0.606SerTrp: 0.606 ± 0.028	2.748SerTyr: 2.748 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.325ThrAla: 3.325 ± 0.077	0.372ThrCys: 0.372 ± 0.022	3.198ThrAsp: 3.198 ± 0.065	3.725ThrGlu: 3.725 ± 0.055	3.213ThrPhe: 3.213 ± 0.061	3.511ThrGly: 3.511 ± 0.08	0.941ThrHis: 0.941 ± 0.03	4.958ThrIle: 4.958 ± 0.078	4.103ThrLys: 4.103 ± 0.061	5.144ThrLeu: 5.144 ± 0.071	0.934ThrMet: 0.934 ± 0.034	3.827ThrAsn: 3.827 ± 0.084	2.259ThrPro: 2.259 ± 0.059	2.002ThrGln: 2.002 ± 0.053	1.413ThrArg: 1.413 ± 0.043	3.626ThrSer: 3.626 ± 0.078	3.414ThrThr: 3.414 ± 0.101	3.445ThrVal: 3.445 ± 0.072	0.496ThrTrp: 0.496 ± 0.022	2.352ThrTyr: 2.352 ± 0.061	0.001ThrXaa: 0.001 ± 0.001
Val	3.72ValAla: 3.72 ± 0.074	0.544ValCys: 0.544 ± 0.024	3.393ValAsp: 3.393 ± 0.061	3.952ValGlu: 3.952 ± 0.077	3.477ValPhe: 3.477 ± 0.06	3.578ValGly: 3.578 ± 0.075	0.885ValHis: 0.885 ± 0.033	4.917ValIle: 4.917 ± 0.081	4.317ValLys: 4.317 ± 0.067	5.825ValLeu: 5.825 ± 0.08	1.207ValMet: 1.207 ± 0.041	3.968ValAsn: 3.968 ± 0.061	1.99ValPro: 1.99 ± 0.048	1.889ValGln: 1.889 ± 0.041	1.934ValArg: 1.934 ± 0.054	4.284ValSer: 4.284 ± 0.079	3.425ValThr: 3.425 ± 0.075	4.082ValVal: 4.082 ± 0.075	0.527ValTrp: 0.527 ± 0.019	2.465ValTyr: 2.465 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.488TrpAla: 0.488 ± 0.026	0.102TrpCys: 0.102 ± 0.011	0.491TrpAsp: 0.491 ± 0.025	0.539TrpGlu: 0.539 ± 0.026	0.609TrpPhe: 0.609 ± 0.027	0.518TrpGly: 0.518 ± 0.023	0.186TrpHis: 0.186 ± 0.014	0.821TrpIle: 0.821 ± 0.027	0.792TrpLys: 0.792 ± 0.028	0.819TrpLeu: 0.819 ± 0.03	0.28TrpMet: 0.28 ± 0.015	0.785TrpAsn: 0.785 ± 0.031	0.176TrpPro: 0.176 ± 0.016	0.4TrpGln: 0.4 ± 0.021	0.304TrpArg: 0.304 ± 0.018	0.562TrpSer: 0.562 ± 0.026	0.434TrpThr: 0.434 ± 0.024	0.51TrpVal: 0.51 ± 0.024	0.103TrpTrp: 0.103 ± 0.011	0.428TrpTyr: 0.428 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.298TyrAla: 2.298 ± 0.046	0.352TyrCys: 0.352 ± 0.02	2.418TyrAsp: 2.418 ± 0.051	2.593TyrGlu: 2.593 ± 0.048	2.828TyrPhe: 2.828 ± 0.059	2.47TyrGly: 2.47 ± 0.05	0.789TyrHis: 0.789 ± 0.025	3.16TyrIle: 3.16 ± 0.066	3.397TyrLys: 3.397 ± 0.07	4.089TyrLeu: 4.089 ± 0.071	0.749TyrMet: 0.749 ± 0.031	2.898TyrAsn: 2.898 ± 0.065	1.381TyrPro: 1.381 ± 0.039	1.734TyrGln: 1.734 ± 0.04	1.396TyrArg: 1.396 ± 0.039	2.83TyrSer: 2.83 ± 0.06	2.145TyrThr: 2.145 ± 0.055	2.294TyrVal: 2.294 ± 0.054	0.427TyrTrp: 0.427 ± 0.02	2.17TyrTyr: 2.17 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 3128 proteins (991835 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---