Amino acid dipepetide frequency for Tetrasphaera jenkinsii Ben 74

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.966AlaAla: 20.966 ± 0.188
0.977AlaCys: 0.977 ± 0.031
8.599AlaAsp: 8.599 ± 0.096
7.487AlaGlu: 7.487 ± 0.103
3.603AlaPhe: 3.603 ± 0.054
12.554AlaGly: 12.554 ± 0.127
2.639AlaHis: 2.639 ± 0.051
5.652AlaIle: 5.652 ± 0.069
3.136AlaLys: 3.136 ± 0.063
13.654AlaLeu: 13.654 ± 0.144
3.017AlaMet: 3.017 ± 0.051
2.493AlaAsn: 2.493 ± 0.053
6.381AlaPro: 6.381 ± 0.092
3.94AlaGln: 3.94 ± 0.055
10.082AlaArg: 10.082 ± 0.116
6.898AlaSer: 6.898 ± 0.098
8.274AlaThr: 8.274 ± 0.097
10.751AlaVal: 10.751 ± 0.126
2.009AlaTrp: 2.009 ± 0.042
3.013AlaTyr: 3.013 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.987CysAla: 0.987 ± 0.034
0.101CysCys: 0.101 ± 0.009
0.451CysAsp: 0.451 ± 0.022
0.319CysGlu: 0.319 ± 0.016
0.244CysPhe: 0.244 ± 0.015
0.904CysGly: 0.904 ± 0.034
0.201CysHis: 0.201 ± 0.013
0.227CysIle: 0.227 ± 0.015
0.114CysLys: 0.114 ± 0.01
0.631CysLeu: 0.631 ± 0.023
0.118CysMet: 0.118 ± 0.011
0.124CysAsn: 0.124 ± 0.01
0.545CysPro: 0.545 ± 0.026
0.213CysGln: 0.213 ± 0.013
0.644CysArg: 0.644 ± 0.027
0.475CysSer: 0.475 ± 0.022
0.448CysThr: 0.448 ± 0.023
0.588CysVal: 0.588 ± 0.021
0.121CysTrp: 0.121 ± 0.012
0.148CysTyr: 0.148 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
8.001AspAla: 8.001 ± 0.094
0.39AspCys: 0.39 ± 0.02
3.997AspAsp: 3.997 ± 0.069
3.689AspGlu: 3.689 ± 0.07
1.789AspPhe: 1.789 ± 0.045
5.953AspGly: 5.953 ± 0.087
1.371AspHis: 1.371 ± 0.034
2.337AspIle: 2.337 ± 0.039
1.258AspLys: 1.258 ± 0.041
7.134AspLeu: 7.134 ± 0.086
0.862AspMet: 0.862 ± 0.028
1.2AspAsn: 1.2 ± 0.035
4.508AspPro: 4.508 ± 0.071
1.716AspGln: 1.716 ± 0.04
4.784AspArg: 4.784 ± 0.069
2.714AspSer: 2.714 ± 0.056
2.676AspThr: 2.676 ± 0.054
5.329AspVal: 5.329 ± 0.076
0.999AspTrp: 0.999 ± 0.027
1.315AspTyr: 1.315 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
6.723GluAla: 6.723 ± 0.091
0.349GluCys: 0.349 ± 0.017
2.609GluAsp: 2.609 ± 0.048
2.635GluGlu: 2.635 ± 0.059
1.577GluPhe: 1.577 ± 0.045
3.683GluGly: 3.683 ± 0.067
1.412GluHis: 1.412 ± 0.038
2.455GluIle: 2.455 ± 0.049
1.249GluLys: 1.249 ± 0.04
5.366GluLeu: 5.366 ± 0.079
0.977GluMet: 0.977 ± 0.031
0.898GluAsn: 0.898 ± 0.029
2.948GluPro: 2.948 ± 0.058
1.887GluGln: 1.887 ± 0.041
4.889GluArg: 4.889 ± 0.086
2.926GluSer: 2.926 ± 0.052
2.593GluThr: 2.593 ± 0.055
4.798GluVal: 4.798 ± 0.075
0.813GluTrp: 0.813 ± 0.033
0.833GluTyr: 0.833 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
3.905PheAla: 3.905 ± 0.068
0.227PheCys: 0.227 ± 0.014
2.071PheAsp: 2.071 ± 0.044
1.428PheGlu: 1.428 ± 0.041
0.912PhePhe: 0.912 ± 0.034
3.193PheGly: 3.193 ± 0.064
0.617PheHis: 0.617 ± 0.025
0.973PheIle: 0.973 ± 0.038
0.538PheLys: 0.538 ± 0.023
2.565PheLeu: 2.565 ± 0.053
0.408PheMet: 0.408 ± 0.022
0.608PheAsn: 0.608 ± 0.024
1.376PhePro: 1.376 ± 0.037
0.621PheGln: 0.621 ± 0.024
1.711PheArg: 1.711 ± 0.038
1.475PheSer: 1.475 ± 0.033
1.903PheThr: 1.903 ± 0.047
2.637PheVal: 2.637 ± 0.046
0.407PheTrp: 0.407 ± 0.019
0.608PheTyr: 0.608 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
10.768GlyAla: 10.768 ± 0.121
0.834GlyCys: 0.834 ± 0.027
5.287GlyAsp: 5.287 ± 0.068
4.824GlyGlu: 4.824 ± 0.07
2.828GlyPhe: 2.828 ± 0.05
8.104GlyGly: 8.104 ± 0.122
2.131GlyHis: 2.131 ± 0.044
4.204GlyIle: 4.204 ± 0.056
2.448GlyLys: 2.448 ± 0.054
9.18GlyLeu: 9.18 ± 0.103
2.214GlyMet: 2.214 ± 0.049
1.847GlyAsn: 1.847 ± 0.045
4.548GlyPro: 4.548 ± 0.074
2.757GlyGln: 2.757 ± 0.056
7.089GlyArg: 7.089 ± 0.091
5.611GlySer: 5.611 ± 0.086
5.547GlyThr: 5.547 ± 0.082
7.548GlyVal: 7.548 ± 0.089
1.695GlyTrp: 1.695 ± 0.041
2.115GlyTyr: 2.115 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.472HisAla: 2.472 ± 0.051
0.191HisCys: 0.191 ± 0.012
1.472HisAsp: 1.472 ± 0.038
1.169HisGlu: 1.169 ± 0.031
0.593HisPhe: 0.593 ± 0.024
2.041HisGly: 2.041 ± 0.044
0.624HisHis: 0.624 ± 0.024
0.759HisIle: 0.759 ± 0.027
0.314HisLys: 0.314 ± 0.016
2.374HisLeu: 2.374 ± 0.056
0.304HisMet: 0.304 ± 0.016
0.436HisAsn: 0.436 ± 0.02
1.653HisPro: 1.653 ± 0.039
0.596HisGln: 0.596 ± 0.024
1.884HisArg: 1.884 ± 0.046
0.976HisSer: 0.976 ± 0.031
1.219HisThr: 1.219 ± 0.032
1.717HisVal: 1.717 ± 0.039
0.34HisTrp: 0.34 ± 0.013
0.426HisTyr: 0.426 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.052IleAla: 6.052 ± 0.077
0.329IleCys: 0.329 ± 0.018
3.135IleAsp: 3.135 ± 0.053
2.667IleGlu: 2.667 ± 0.054
1.068IlePhe: 1.068 ± 0.032
4.125IleGly: 4.125 ± 0.071
0.843IleHis: 0.843 ± 0.026
1.372IleIle: 1.372 ± 0.039
0.915IleLys: 0.915 ± 0.034
3.391IleLeu: 3.391 ± 0.062
0.545IleMet: 0.545 ± 0.022
0.92IleAsn: 0.92 ± 0.031
2.451IlePro: 2.451 ± 0.048
0.932IleGln: 0.932 ± 0.029
2.725IleArg: 2.725 ± 0.056
2.132IleSer: 2.132 ± 0.052
2.49IleThr: 2.49 ± 0.049
3.834IleVal: 3.834 ± 0.063
0.511IleTrp: 0.511 ± 0.02
0.702IleTyr: 0.702 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
2.97LysAla: 2.97 ± 0.065
0.122LysCys: 0.122 ± 0.012
1.243LysAsp: 1.243 ± 0.042
1.027LysGlu: 1.027 ± 0.036
0.577LysPhe: 0.577 ± 0.021
1.767LysGly: 1.767 ± 0.048
0.394LysHis: 0.394 ± 0.019
0.922LysIle: 0.922 ± 0.03
0.742LysLys: 0.742 ± 0.034
1.837LysLeu: 1.837 ± 0.051
0.41LysMet: 0.41 ± 0.019
0.476LysAsn: 0.476 ± 0.022
1.337LysPro: 1.337 ± 0.033
0.676LysGln: 0.676 ± 0.024
1.532LysArg: 1.532 ± 0.039
1.254LysSer: 1.254 ± 0.039
1.393LysThr: 1.393 ± 0.041
2.024LysVal: 2.024 ± 0.046
0.281LysTrp: 0.281 ± 0.015
0.462LysTyr: 0.462 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
15.594LeuAla: 15.594 ± 0.162
0.662LeuCys: 0.662 ± 0.027
6.904LeuAsp: 6.904 ± 0.093
4.239LeuGlu: 4.239 ± 0.074
2.328LeuPhe: 2.328 ± 0.051
9.497LeuGly: 9.497 ± 0.104
1.935LeuHis: 1.935 ± 0.043
4.066LeuIle: 4.066 ± 0.068
1.738LeuLys: 1.738 ± 0.042
10.018LeuLeu: 10.018 ± 0.141
1.708LeuMet: 1.708 ± 0.036
1.705LeuAsn: 1.705 ± 0.042
5.838LeuPro: 5.838 ± 0.072
2.171LeuGln: 2.171 ± 0.044
7.714LeuArg: 7.714 ± 0.094
5.38LeuSer: 5.38 ± 0.075
6.785LeuThr: 6.785 ± 0.083
8.91LeuVal: 8.91 ± 0.107
1.196LeuTrp: 1.196 ± 0.032
1.476LeuTyr: 1.476 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
2.503MetAla: 2.503 ± 0.047
0.165MetCys: 0.165 ± 0.011
0.918MetAsp: 0.918 ± 0.034
0.736MetGlu: 0.736 ± 0.027
0.519MetPhe: 0.519 ± 0.025
1.488MetGly: 1.488 ± 0.036
0.351MetHis: 0.351 ± 0.018
0.843MetIle: 0.843 ± 0.029
0.461MetLys: 0.461 ± 0.022
1.881MetLeu: 1.881 ± 0.044
0.372MetMet: 0.372 ± 0.021
0.446MetAsn: 0.446 ± 0.022
1.345MetPro: 1.345 ± 0.035
0.467MetGln: 0.467 ± 0.021
1.502MetArg: 1.502 ± 0.036
1.6MetSer: 1.6 ± 0.036
1.91MetThr: 1.91 ± 0.034
1.435MetVal: 1.435 ± 0.041
0.256MetTrp: 0.256 ± 0.014
0.306MetTyr: 0.306 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.507AsnAla: 2.507 ± 0.048
0.16AsnCys: 0.16 ± 0.01
1.052AsnAsp: 1.052 ± 0.039
0.864AsnGlu: 0.864 ± 0.026
0.55AsnPhe: 0.55 ± 0.023
1.843AsnGly: 1.843 ± 0.044
0.446AsnHis: 0.446 ± 0.022
0.715AsnIle: 0.715 ± 0.028
0.418AsnLys: 0.418 ± 0.021
1.99AsnLeu: 1.99 ± 0.044
0.321AsnMet: 0.321 ± 0.018
0.471AsnAsn: 0.471 ± 0.024
1.575AsnPro: 1.575 ± 0.045
0.544AsnGln: 0.544 ± 0.023
1.4AsnArg: 1.4 ± 0.039
1.029AsnSer: 1.029 ± 0.035
1.091AsnThr: 1.091 ± 0.034
1.628AsnVal: 1.628 ± 0.039
0.335AsnTrp: 0.335 ± 0.017
0.482AsnTyr: 0.482 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
7.854ProAla: 7.854 ± 0.096
0.353ProCys: 0.353 ± 0.018
4.272ProAsp: 4.272 ± 0.064
3.568ProGlu: 3.568 ± 0.072
1.498ProPhe: 1.498 ± 0.039
5.88ProGly: 5.88 ± 0.081
1.187ProHis: 1.187 ± 0.034
2.143ProIle: 2.143 ± 0.049
1.209ProLys: 1.209 ± 0.037
4.834ProLeu: 4.834 ± 0.064
1.218ProMet: 1.218 ± 0.036
1.143ProAsn: 1.143 ± 0.036
3.144ProPro: 3.144 ± 0.068
1.544ProGln: 1.544 ± 0.037
3.932ProArg: 3.932 ± 0.062
3.32ProSer: 3.32 ± 0.061
3.772ProThr: 3.772 ± 0.054
4.923ProVal: 4.923 ± 0.073
0.937ProTrp: 0.937 ± 0.026
1.07ProTyr: 1.07 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.58GlnAla: 3.58 ± 0.063
0.189GlnCys: 0.189 ± 0.013
1.355GlnAsp: 1.355 ± 0.034
1.323GlnGlu: 1.323 ± 0.034
0.769GlnPhe: 0.769 ± 0.028
2.13GlnGly: 2.13 ± 0.05
0.644GlnHis: 0.644 ± 0.022
1.313GlnIle: 1.313 ± 0.038
0.581GlnLys: 0.581 ± 0.024
2.86GlnLeu: 2.86 ± 0.046
0.523GlnMet: 0.523 ± 0.023
0.483GlnAsn: 0.483 ± 0.024
1.667GlnPro: 1.667 ± 0.038
1.028GlnGln: 1.028 ± 0.036
2.529GlnArg: 2.529 ± 0.053
1.411GlnSer: 1.411 ± 0.039
1.347GlnThr: 1.347 ± 0.034
2.614GlnVal: 2.614 ± 0.05
0.49GlnTrp: 0.49 ± 0.02
0.46GlnTyr: 0.46 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
9.408ArgAla: 9.408 ± 0.102
0.587ArgCys: 0.587 ± 0.024
4.57ArgAsp: 4.57 ± 0.07
4.175ArgGlu: 4.175 ± 0.067
2.337ArgPhe: 2.337 ± 0.048
5.932ArgGly: 5.932 ± 0.083
2.071ArgHis: 2.071 ± 0.051
3.403ArgIle: 3.403 ± 0.057
1.439ArgLys: 1.439 ± 0.039
8.317ArgLeu: 8.317 ± 0.096
1.806ArgMet: 1.806 ± 0.035
1.377ArgAsn: 1.377 ± 0.039
4.377ArgPro: 4.377 ± 0.08
2.179ArgGln: 2.179 ± 0.046
7.361ArgArg: 7.361 ± 0.113
4.2ArgSer: 4.2 ± 0.071
4.347ArgThr: 4.347 ± 0.067
5.961ArgVal: 5.961 ± 0.073
1.423ArgTrp: 1.423 ± 0.036
1.596ArgTyr: 1.596 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
7.425SerAla: 7.425 ± 0.093
0.426SerCys: 0.426 ± 0.021
2.85SerAsp: 2.85 ± 0.045
2.439SerGlu: 2.439 ± 0.046
1.652SerPhe: 1.652 ± 0.039
6.025SerGly: 6.025 ± 0.09
1.017SerHis: 1.017 ± 0.029
2.107SerIle: 2.107 ± 0.043
1.075SerLys: 1.075 ± 0.036
5.263SerLeu: 5.263 ± 0.068
1.405SerMet: 1.405 ± 0.037
1.056SerAsn: 1.056 ± 0.039
3.426SerPro: 3.426 ± 0.062
1.456SerGln: 1.456 ± 0.04
4.005SerArg: 4.005 ± 0.064
3.447SerSer: 3.447 ± 0.084
3.626SerThr: 3.626 ± 0.067
4.422SerVal: 4.422 ± 0.067
0.959SerTrp: 0.959 ± 0.028
1.156SerTyr: 1.156 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
7.583ThrAla: 7.583 ± 0.1
0.477ThrCys: 0.477 ± 0.024
3.673ThrAsp: 3.673 ± 0.062
2.811ThrGlu: 2.811 ± 0.056
1.885ThrPhe: 1.885 ± 0.042
5.956ThrGly: 5.956 ± 0.085
1.22ThrHis: 1.22 ± 0.032
2.725ThrIle: 2.725 ± 0.046
1.431ThrLys: 1.431 ± 0.039
5.728ThrLeu: 5.728 ± 0.083
1.229ThrMet: 1.229 ± 0.036
1.312ThrAsn: 1.312 ± 0.043
4.149ThrPro: 4.149 ± 0.069
1.503ThrGln: 1.503 ± 0.033
4.065ThrArg: 4.065 ± 0.075
3.908ThrSer: 3.908 ± 0.07
4.361ThrThr: 4.361 ± 0.077
5.101ThrVal: 5.101 ± 0.069
1.043ThrTrp: 1.043 ± 0.032
1.416ThrTyr: 1.416 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
11.962ValAla: 11.962 ± 0.119
0.722ValCys: 0.722 ± 0.027
5.383ValAsp: 5.383 ± 0.083
4.581ValGlu: 4.581 ± 0.066
2.253ValPhe: 2.253 ± 0.051
7.505ValGly: 7.505 ± 0.09
1.758ValHis: 1.758 ± 0.044
3.735ValIle: 3.735 ± 0.062
1.744ValLys: 1.744 ± 0.046
8.864ValLeu: 8.864 ± 0.1
1.55ValMet: 1.55 ± 0.036
1.664ValAsn: 1.664 ± 0.041
4.638ValPro: 4.638 ± 0.059
1.968ValGln: 1.968 ± 0.044
6.043ValArg: 6.043 ± 0.076
4.479ValSer: 4.479 ± 0.066
5.862ValThr: 5.862 ± 0.077
8.687ValVal: 8.687 ± 0.092
1.156ValTrp: 1.156 ± 0.037
1.308ValTyr: 1.308 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.749TrpAla: 1.749 ± 0.044
0.164TrpCys: 0.164 ± 0.012
0.789TrpAsp: 0.789 ± 0.025
0.631TrpGlu: 0.631 ± 0.03
0.56TrpPhe: 0.56 ± 0.024
1.121TrpGly: 1.121 ± 0.03
0.349TrpHis: 0.349 ± 0.019
0.645TrpIle: 0.645 ± 0.024
0.297TrpLys: 0.297 ± 0.016
1.871TrpLeu: 1.871 ± 0.045
0.318TrpMet: 0.318 ± 0.019
0.373TrpAsn: 0.373 ± 0.019
0.832TrpPro: 0.832 ± 0.031
0.567TrpGln: 0.567 ± 0.025
1.426TrpArg: 1.426 ± 0.037
1.126TrpSer: 1.126 ± 0.036
0.962TrpThr: 0.962 ± 0.034
1.236TrpVal: 1.236 ± 0.032
0.395TrpTrp: 0.395 ± 0.02
0.29TrpTyr: 0.29 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.115TyrAla: 3.115 ± 0.051
0.178TyrCys: 0.178 ± 0.014
1.394TyrAsp: 1.394 ± 0.036
1.006TyrGlu: 1.006 ± 0.031
0.638TyrPhe: 0.638 ± 0.023
1.877TyrGly: 1.877 ± 0.039
0.352TyrHis: 0.352 ± 0.017
0.545TyrIle: 0.545 ± 0.023
0.339TyrLys: 0.339 ± 0.017
2.107TyrLeu: 2.107 ± 0.042
0.199TyrMet: 0.199 ± 0.014
0.386TyrAsn: 0.386 ± 0.021
1.067TyrPro: 1.067 ± 0.032
0.531TyrGln: 0.531 ± 0.023
1.548TyrArg: 1.548 ± 0.037
0.876TyrSer: 0.876 ± 0.031
0.97TyrThr: 0.97 ± 0.035
1.718TyrVal: 1.718 ± 0.041
0.337TyrTrp: 0.337 ± 0.019
0.409TyrTyr: 0.409 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3715 proteins (1123227 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski