Amino acid dipepetide frequency for Aruac virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.336AlaAla: 2.336 ± 1.317
1.298AlaCys: 1.298 ± 0.534
2.595AlaAsp: 2.595 ± 0.826
2.336AlaGlu: 2.336 ± 1.712
1.817AlaPhe: 1.817 ± 1.333
2.595AlaGly: 2.595 ± 0.72
1.038AlaHis: 1.038 ± 0.353
4.153AlaIle: 4.153 ± 0.687
2.855AlaLys: 2.855 ± 1.084
4.931AlaLeu: 4.931 ± 0.655
0.779AlaMet: 0.779 ± 0.281
2.076AlaAsn: 2.076 ± 0.527
2.336AlaPro: 2.336 ± 1.626
1.038AlaGln: 1.038 ± 0.512
1.557AlaArg: 1.557 ± 1.008
2.336AlaSer: 2.336 ± 0.606
2.076AlaThr: 2.076 ± 0.846
4.412AlaVal: 4.412 ± 2.84
0.26AlaTrp: 0.26 ± 0.158
0.779AlaTyr: 0.779 ± 0.319
0.0AlaXaa: 0.0 ± 0.0
Cys
1.298CysAla: 1.298 ± 0.313
0.0CysCys: 0.0 ± 0.0
0.519CysAsp: 0.519 ± 0.256
1.298CysGlu: 1.298 ± 0.506
0.519CysPhe: 0.519 ± 0.256
1.817CysGly: 1.817 ± 0.807
0.519CysHis: 0.519 ± 0.475
0.779CysIle: 0.779 ± 1.027
2.595CysLys: 2.595 ± 1.066
1.038CysLeu: 1.038 ± 0.413
0.0CysMet: 0.0 ± 0.0
0.26CysAsn: 0.26 ± 0.32
0.779CysPro: 0.779 ± 0.754
1.038CysGln: 1.038 ± 0.518
0.779CysArg: 0.779 ± 0.319
1.557CysSer: 1.557 ± 0.534
1.557CysThr: 1.557 ± 0.741
0.26CysVal: 0.26 ± 0.158
0.0CysTrp: 0.0 ± 0.0
0.26CysTyr: 0.26 ± 0.32
0.0CysXaa: 0.0 ± 0.0
Asp
0.779AspAla: 0.779 ± 0.475
1.298AspCys: 1.298 ± 0.573
2.595AspAsp: 2.595 ± 1.106
2.595AspGlu: 2.595 ± 0.596
1.298AspPhe: 1.298 ± 0.46
3.893AspGly: 3.893 ± 0.927
2.076AspHis: 2.076 ± 1.002
4.153AspIle: 4.153 ± 0.499
4.153AspLys: 4.153 ± 0.664
6.229AspLeu: 6.229 ± 2.552
1.817AspMet: 1.817 ± 1.013
2.336AspAsn: 2.336 ± 0.768
3.634AspPro: 3.634 ± 1.073
2.076AspGln: 2.076 ± 0.8
1.817AspArg: 1.817 ± 0.532
3.634AspSer: 3.634 ± 1.089
2.076AspThr: 2.076 ± 0.595
2.076AspVal: 2.076 ± 1.66
2.595AspTrp: 2.595 ± 1.372
2.855AspTyr: 2.855 ± 0.665
0.0AspXaa: 0.0 ± 0.0
Glu
3.114GluAla: 3.114 ± 2.115
0.26GluCys: 0.26 ± 0.158
3.114GluAsp: 3.114 ± 0.466
5.71GluGlu: 5.71 ± 1.181
2.336GluPhe: 2.336 ± 0.793
3.374GluGly: 3.374 ± 1.866
1.557GluHis: 1.557 ± 0.826
5.71GluIle: 5.71 ± 0.819
4.412GluLys: 4.412 ± 1.219
4.931GluLeu: 4.931 ± 1.522
1.817GluMet: 1.817 ± 0.75
1.817GluAsn: 1.817 ± 0.881
2.076GluPro: 2.076 ± 1.236
1.038GluGln: 1.038 ± 0.633
1.557GluArg: 1.557 ± 0.404
6.748GluSer: 6.748 ± 1.124
5.71GluThr: 5.71 ± 0.572
2.595GluVal: 2.595 ± 0.72
1.038GluTrp: 1.038 ± 0.872
2.076GluTyr: 2.076 ± 0.634
0.0GluXaa: 0.0 ± 0.0
Phe
1.038PheAla: 1.038 ± 0.979
0.779PheCys: 0.779 ± 0.365
3.114PheAsp: 3.114 ± 0.604
1.298PheGlu: 1.298 ± 0.46
2.595PhePhe: 2.595 ± 0.541
1.298PheGly: 1.298 ± 0.939
0.26PheHis: 0.26 ± 0.158
2.855PheIle: 2.855 ± 1.298
3.634PheLys: 3.634 ± 0.407
2.855PheLeu: 2.855 ± 0.775
0.26PheMet: 0.26 ± 0.158
1.298PheAsn: 1.298 ± 0.633
1.817PhePro: 1.817 ± 0.567
2.336PheGln: 2.336 ± 0.947
2.076PheArg: 2.076 ± 1.119
3.634PheSer: 3.634 ± 1.236
1.557PheThr: 1.557 ± 1.602
3.893PheVal: 3.893 ± 0.784
0.519PheTrp: 0.519 ± 0.317
1.557PheTyr: 1.557 ± 0.678
0.0PheXaa: 0.0 ± 0.0
Gly
1.557GlyAla: 1.557 ± 0.467
0.779GlyCys: 0.779 ± 0.319
2.595GlyAsp: 2.595 ± 1.135
3.374GlyGlu: 3.374 ± 1.483
2.336GlyPhe: 2.336 ± 1.101
3.374GlyGly: 3.374 ± 1.201
0.779GlyHis: 0.779 ± 0.475
6.748GlyIle: 6.748 ± 1.769
2.336GlyLys: 2.336 ± 0.805
8.046GlyLeu: 8.046 ± 1.833
2.336GlyMet: 2.336 ± 0.844
3.114GlyAsn: 3.114 ± 1.83
1.298GlyPro: 1.298 ± 0.889
2.855GlyGln: 2.855 ± 1.324
2.336GlyArg: 2.336 ± 0.878
3.893GlySer: 3.893 ± 1.25
4.672GlyThr: 4.672 ± 1.917
3.114GlyVal: 3.114 ± 1.014
0.779GlyTrp: 0.779 ± 0.557
3.114GlyTyr: 3.114 ± 0.919
0.0GlyXaa: 0.0 ± 0.0
His
1.557HisAla: 1.557 ± 0.73
0.0HisCys: 0.0 ± 0.0
0.519HisAsp: 0.519 ± 0.513
0.519HisGlu: 0.519 ± 0.256
1.038HisPhe: 1.038 ± 0.377
1.038HisGly: 1.038 ± 0.518
0.519HisHis: 0.519 ± 0.256
1.557HisIle: 1.557 ± 0.579
1.298HisLys: 1.298 ± 0.641
2.855HisLeu: 2.855 ± 1.084
0.779HisMet: 0.779 ± 0.281
0.779HisAsn: 0.779 ± 0.478
2.076HisPro: 2.076 ± 0.521
1.038HisGln: 1.038 ± 0.802
1.298HisArg: 1.298 ± 0.71
1.817HisSer: 1.817 ± 1.134
1.557HisThr: 1.557 ± 1.688
0.26HisVal: 0.26 ± 0.158
0.26HisTrp: 0.26 ± 0.158
0.519HisTyr: 0.519 ± 0.385
0.0HisXaa: 0.0 ± 0.0
Ile
2.595IleAla: 2.595 ± 0.88
1.817IleCys: 1.817 ± 0.921
4.931IleAsp: 4.931 ± 1.835
4.153IleGlu: 4.153 ± 1.123
3.374IlePhe: 3.374 ± 0.711
5.191IleGly: 5.191 ± 1.271
1.557IleHis: 1.557 ± 0.372
6.229IleIle: 6.229 ± 1.395
6.748IleLys: 6.748 ± 1.412
6.488IleLeu: 6.488 ± 1.042
1.557IleMet: 1.557 ± 0.648
4.931IleAsn: 4.931 ± 1.9
4.672IlePro: 4.672 ± 0.611
2.595IleGln: 2.595 ± 0.428
7.008IleArg: 7.008 ± 1.063
7.008IleSer: 7.008 ± 1.915
2.855IleThr: 2.855 ± 1.435
3.114IleVal: 3.114 ± 0.966
1.557IleTrp: 1.557 ± 0.433
3.634IleTyr: 3.634 ± 1.976
0.0IleXaa: 0.0 ± 0.0
Lys
2.336LysAla: 2.336 ± 1.133
0.779LysCys: 0.779 ± 0.959
4.412LysAsp: 4.412 ± 0.66
4.931LysGlu: 4.931 ± 0.655
1.557LysPhe: 1.557 ± 0.633
4.931LysGly: 4.931 ± 0.883
0.519LysHis: 0.519 ± 0.287
5.45LysIle: 5.45 ± 1.475
5.45LysLys: 5.45 ± 1.206
5.969LysLeu: 5.969 ± 1.09
1.817LysMet: 1.817 ± 0.97
3.374LysAsn: 3.374 ± 1.233
3.114LysPro: 3.114 ± 1.704
2.595LysGln: 2.595 ± 1.088
4.931LysArg: 4.931 ± 1.092
4.412LysSer: 4.412 ± 1.138
2.855LysThr: 2.855 ± 0.473
3.893LysVal: 3.893 ± 0.732
1.038LysTrp: 1.038 ± 0.301
1.298LysTyr: 1.298 ± 0.791
0.0LysXaa: 0.0 ± 0.0
Leu
4.672LeuAla: 4.672 ± 0.773
1.817LeuCys: 1.817 ± 0.623
4.672LeuAsp: 4.672 ± 1.081
8.046LeuGlu: 8.046 ± 1.951
3.634LeuPhe: 3.634 ± 0.858
5.191LeuGly: 5.191 ± 1.18
1.557LeuHis: 1.557 ± 0.394
10.122LeuIle: 10.122 ± 3.741
5.191LeuLys: 5.191 ± 1.3
6.748LeuLeu: 6.748 ± 1.09
2.855LeuMet: 2.855 ± 0.684
5.71LeuAsn: 5.71 ± 1.573
4.412LeuPro: 4.412 ± 0.869
3.374LeuGln: 3.374 ± 1.181
4.931LeuArg: 4.931 ± 1.36
9.343LeuSer: 9.343 ± 2.071
5.191LeuThr: 5.191 ± 1.27
4.412LeuVal: 4.412 ± 0.71
1.038LeuTrp: 1.038 ± 0.623
2.595LeuTyr: 2.595 ± 0.918
0.0LeuXaa: 0.0 ± 0.0
Met
0.519MetAla: 0.519 ± 0.287
0.779MetCys: 0.779 ± 0.281
1.298MetAsp: 1.298 ± 1.086
1.817MetGlu: 1.817 ± 0.444
1.817MetPhe: 1.817 ± 0.83
1.298MetGly: 1.298 ± 0.573
0.519MetHis: 0.519 ± 0.489
1.038MetIle: 1.038 ± 0.301
1.557MetLys: 1.557 ± 0.394
3.374MetLeu: 3.374 ± 1.039
0.779MetMet: 0.779 ± 0.555
0.779MetAsn: 0.779 ± 0.475
0.519MetPro: 0.519 ± 0.625
0.779MetGln: 0.779 ± 0.864
1.557MetArg: 1.557 ± 0.515
3.114MetSer: 3.114 ± 1.589
1.038MetThr: 1.038 ± 0.529
2.076MetVal: 2.076 ± 0.527
0.779MetTrp: 0.779 ± 0.319
1.298MetTyr: 1.298 ± 0.71
0.0MetXaa: 0.0 ± 0.0
Asn
2.855AsnAla: 2.855 ± 1.558
0.779AsnCys: 0.779 ± 0.565
3.114AsnAsp: 3.114 ± 0.796
2.336AsnGlu: 2.336 ± 0.843
1.817AsnPhe: 1.817 ± 0.513
2.595AsnGly: 2.595 ± 0.96
1.298AsnHis: 1.298 ± 0.791
2.336AsnIle: 2.336 ± 0.59
2.595AsnLys: 2.595 ± 0.717
6.488AsnLeu: 6.488 ± 2.415
1.298AsnMet: 1.298 ± 0.981
3.114AsnAsn: 3.114 ± 1.005
3.114AsnPro: 3.114 ± 0.993
1.038AsnGln: 1.038 ± 0.7
1.038AsnArg: 1.038 ± 0.633
3.114AsnSer: 3.114 ± 0.978
2.855AsnThr: 2.855 ± 1.097
1.817AsnVal: 1.817 ± 0.592
1.038AsnTrp: 1.038 ± 0.377
3.114AsnTyr: 3.114 ± 0.585
0.0AsnXaa: 0.0 ± 0.0
Pro
2.855ProAla: 2.855 ± 2.416
1.038ProCys: 1.038 ± 0.633
3.374ProAsp: 3.374 ± 1.155
3.114ProGlu: 3.114 ± 1.569
1.298ProPhe: 1.298 ± 0.897
3.374ProGly: 3.374 ± 1.876
1.298ProHis: 1.298 ± 1.063
4.672ProIle: 4.672 ± 1.277
2.855ProLys: 2.855 ± 1.325
3.893ProLeu: 3.893 ± 0.771
0.779ProMet: 0.779 ± 0.446
1.817ProAsn: 1.817 ± 1.374
3.374ProPro: 3.374 ± 2.237
1.298ProGln: 1.298 ± 0.313
2.076ProArg: 2.076 ± 0.477
5.45ProSer: 5.45 ± 1.188
3.374ProThr: 3.374 ± 0.877
2.595ProVal: 2.595 ± 0.778
0.779ProTrp: 0.779 ± 0.475
2.076ProTyr: 2.076 ± 0.527
0.0ProXaa: 0.0 ± 0.0
Gln
1.038GlnAla: 1.038 ± 0.523
1.298GlnCys: 1.298 ± 0.313
1.817GlnAsp: 1.817 ± 0.513
2.076GlnGlu: 2.076 ± 0.351
1.038GlnPhe: 1.038 ± 0.633
2.076GlnGly: 2.076 ± 0.595
0.26GlnHis: 0.26 ± 0.337
3.114GlnIle: 3.114 ± 0.701
2.076GlnLys: 2.076 ± 1.196
3.114GlnLeu: 3.114 ± 1.013
1.298GlnMet: 1.298 ± 0.573
2.076GlnAsn: 2.076 ± 0.688
1.298GlnPro: 1.298 ± 0.897
0.779GlnGln: 0.779 ± 0.555
2.076GlnArg: 2.076 ± 0.8
3.634GlnSer: 3.634 ± 0.732
2.855GlnThr: 2.855 ± 1.509
1.298GlnVal: 1.298 ± 0.684
0.519GlnTrp: 0.519 ± 0.64
1.038GlnTyr: 1.038 ± 0.79
0.0GlnXaa: 0.0 ± 0.0
Arg
3.114ArgAla: 3.114 ± 0.764
0.779ArgCys: 0.779 ± 0.281
1.817ArgAsp: 1.817 ± 0.65
1.817ArgGlu: 1.817 ± 1.108
3.114ArgPhe: 3.114 ± 0.812
3.893ArgGly: 3.893 ± 0.93
1.557ArgHis: 1.557 ± 0.857
2.855ArgIle: 2.855 ± 0.815
3.114ArgLys: 3.114 ± 1.235
3.114ArgLeu: 3.114 ± 1.199
1.298ArgMet: 1.298 ± 0.955
4.153ArgAsn: 4.153 ± 1.069
2.336ArgPro: 2.336 ± 0.797
2.076ArgGln: 2.076 ± 0.755
3.114ArgArg: 3.114 ± 1.326
4.672ArgSer: 4.672 ± 1.112
2.336ArgThr: 2.336 ± 0.793
1.298ArgVal: 1.298 ± 0.48
1.038ArgTrp: 1.038 ± 0.523
2.076ArgTyr: 2.076 ± 0.46
0.0ArgXaa: 0.0 ± 0.0
Ser
4.412SerAla: 4.412 ± 1.347
2.076SerCys: 2.076 ± 0.611
6.229SerAsp: 6.229 ± 0.576
5.71SerGlu: 5.71 ± 0.932
2.855SerPhe: 2.855 ± 1.664
3.634SerGly: 3.634 ± 0.716
2.595SerHis: 2.595 ± 1.297
7.008SerIle: 7.008 ± 2.043
4.672SerLys: 4.672 ± 0.611
9.603SerLeu: 9.603 ± 2.884
1.298SerMet: 1.298 ± 0.556
2.595SerAsn: 2.595 ± 0.626
4.412SerPro: 4.412 ± 0.75
1.817SerGln: 1.817 ± 0.513
4.153SerArg: 4.153 ± 0.742
7.008SerSer: 7.008 ± 2.658
3.893SerThr: 3.893 ± 0.794
3.893SerVal: 3.893 ± 1.432
2.855SerTrp: 2.855 ± 0.683
3.893SerTyr: 3.893 ± 0.51
0.0SerXaa: 0.0 ± 0.0
Thr
2.855ThrAla: 2.855 ± 1.558
0.26ThrCys: 0.26 ± 0.337
3.374ThrAsp: 3.374 ± 1.291
2.595ThrGlu: 2.595 ± 0.689
2.076ThrPhe: 2.076 ± 0.755
3.634ThrGly: 3.634 ± 0.64
0.519ThrHis: 0.519 ± 0.489
5.191ThrIle: 5.191 ± 0.637
4.153ThrLys: 4.153 ± 0.609
4.412ThrLeu: 4.412 ± 1.608
2.076ThrMet: 2.076 ± 0.382
2.595ThrAsn: 2.595 ± 0.646
3.374ThrPro: 3.374 ± 0.727
2.336ThrGln: 2.336 ± 1.333
2.336ThrArg: 2.336 ± 0.966
4.931ThrSer: 4.931 ± 1.148
4.672ThrThr: 4.672 ± 1.015
4.931ThrVal: 4.931 ± 1.4
1.817ThrTrp: 1.817 ± 0.435
1.298ThrTyr: 1.298 ± 0.791
0.0ThrXaa: 0.0 ± 0.0
Val
1.557ValAla: 1.557 ± 0.984
0.779ValCys: 0.779 ± 0.565
3.114ValAsp: 3.114 ± 0.743
1.817ValGlu: 1.817 ± 1.018
2.336ValPhe: 2.336 ± 0.688
2.855ValGly: 2.855 ± 0.596
1.298ValHis: 1.298 ± 1.2
2.855ValIle: 2.855 ± 0.452
3.114ValLys: 3.114 ± 1.529
6.748ValLeu: 6.748 ± 1.748
2.336ValMet: 2.336 ± 1.604
1.817ValAsn: 1.817 ± 0.513
2.855ValPro: 2.855 ± 0.613
2.336ValGln: 2.336 ± 1.126
2.336ValArg: 2.336 ± 0.849
3.893ValSer: 3.893 ± 0.589
5.191ValThr: 5.191 ± 1.277
2.076ValVal: 2.076 ± 2.086
0.26ValTrp: 0.26 ± 0.158
2.076ValTyr: 2.076 ± 1.144
0.0ValXaa: 0.0 ± 0.0
Trp
1.817TrpAla: 1.817 ± 0.44
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.076TrpGlu: 2.076 ± 1.059
0.519TrpPhe: 0.519 ± 0.287
1.298TrpGly: 1.298 ± 0.791
0.519TrpHis: 0.519 ± 0.317
3.374TrpIle: 3.374 ± 0.482
0.779TrpLys: 0.779 ± 0.475
0.26TrpLeu: 0.26 ± 0.337
0.519TrpMet: 0.519 ± 0.475
1.038TrpAsn: 1.038 ± 0.377
0.779TrpPro: 0.779 ± 0.425
0.519TrpGln: 0.519 ± 0.317
0.519TrpArg: 0.519 ± 0.64
1.817TrpSer: 1.817 ± 0.701
1.298TrpThr: 1.298 ± 0.806
1.557TrpVal: 1.557 ± 0.857
0.26TrpTrp: 0.26 ± 0.32
0.26TrpTyr: 0.26 ± 0.32
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.298TyrAla: 1.298 ± 0.679
0.26TyrCys: 0.26 ± 0.337
0.779TyrAsp: 0.779 ± 0.431
3.374TyrGlu: 3.374 ± 0.512
1.298TyrPhe: 1.298 ± 0.648
2.076TyrGly: 2.076 ± 0.617
1.038TyrHis: 1.038 ± 0.377
1.817TyrIle: 1.817 ± 0.851
2.076TyrLys: 2.076 ± 0.649
4.412TyrLeu: 4.412 ± 1.441
0.779TyrMet: 0.779 ± 0.475
2.076TyrAsn: 2.076 ± 0.974
3.114TyrPro: 3.114 ± 0.749
1.817TyrGln: 1.817 ± 0.44
2.076TyrArg: 2.076 ± 0.478
2.595TyrSer: 2.595 ± 0.702
1.817TyrThr: 1.817 ± 0.65
2.336TyrVal: 2.336 ± 0.363
0.779TyrTrp: 0.779 ± 0.425
1.038TyrTyr: 1.038 ± 0.7
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (3854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski