Amino acid dipepetide frequency for Mucilaginibacter polytrichastri

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.91AlaAla: 6.91 ± 0.084	0.666AlaCys: 0.666 ± 0.023	4.844AlaAsp: 4.844 ± 0.057	4.418AlaGlu: 4.418 ± 0.058	3.552AlaPhe: 3.552 ± 0.054	6.164AlaGly: 6.164 ± 0.087	1.379AlaHis: 1.379 ± 0.032	5.841AlaIle: 5.841 ± 0.066	4.884AlaLys: 4.884 ± 0.062	7.162AlaLeu: 7.162 ± 0.07	1.825AlaMet: 1.825 ± 0.037	4.091AlaAsn: 4.091 ± 0.053	2.54AlaPro: 2.54 ± 0.046	3.278AlaGln: 3.278 ± 0.042	2.569AlaArg: 2.569 ± 0.045	4.554AlaSer: 4.554 ± 0.059	4.493AlaThr: 4.493 ± 0.072	5.052AlaVal: 5.052 ± 0.061	0.822AlaTrp: 0.822 ± 0.026	3.157AlaTyr: 3.157 ± 0.046	0.003AlaXaa: 0.003 ± 0.001
Cys	0.523CysAla: 0.523 ± 0.02	0.14CysCys: 0.14 ± 0.01	0.359CysAsp: 0.359 ± 0.014	0.346CysGlu: 0.346 ± 0.015	0.411CysPhe: 0.411 ± 0.015	0.55CysGly: 0.55 ± 0.02	0.172CysHis: 0.172 ± 0.01	0.6CysIle: 0.6 ± 0.02	0.474CysLys: 0.474 ± 0.018	0.779CysLeu: 0.779 ± 0.023	0.184CysMet: 0.184 ± 0.011	0.395CysAsn: 0.395 ± 0.015	0.289CysPro: 0.289 ± 0.014	0.217CysGln: 0.217 ± 0.011	0.304CysArg: 0.304 ± 0.013	0.491CysSer: 0.491 ± 0.016	0.474CysThr: 0.474 ± 0.016	0.457CysVal: 0.457 ± 0.015	0.082CysTrp: 0.082 ± 0.007	0.331CysTyr: 0.331 ± 0.015	0.001CysXaa: 0.001 ± 0.001
Asp	4.243AspAla: 4.243 ± 0.056	0.375AspCys: 0.375 ± 0.015	2.785AspAsp: 2.785 ± 0.05	3.308AspGlu: 3.308 ± 0.053	2.974AspPhe: 2.974 ± 0.043	3.739AspGly: 3.739 ± 0.064	1.087AspHis: 1.087 ± 0.024	3.964AspIle: 3.964 ± 0.054	3.907AspLys: 3.907 ± 0.057	4.996AspLeu: 4.996 ± 0.062	1.227AspMet: 1.227 ± 0.029	2.893AspAsn: 2.893 ± 0.042	2.094AspPro: 2.094 ± 0.038	1.964AspGln: 1.964 ± 0.035	2.037AspArg: 2.037 ± 0.034	2.851AspSer: 2.851 ± 0.049	2.805AspThr: 2.805 ± 0.048	3.5AspVal: 3.5 ± 0.054	0.714AspTrp: 0.714 ± 0.021	2.63AspTyr: 2.63 ± 0.04	0.004AspXaa: 0.004 ± 0.001
Glu	4.234GluAla: 4.234 ± 0.06	0.269GluCys: 0.269 ± 0.013	2.556GluAsp: 2.556 ± 0.046	3.163GluGlu: 3.163 ± 0.052	2.218GluPhe: 2.218 ± 0.04	3.052GluGly: 3.052 ± 0.046	1.192GluHis: 1.192 ± 0.027	3.967GluIle: 3.967 ± 0.062	4.025GluLys: 4.025 ± 0.056	5.44GluLeu: 5.44 ± 0.07	1.327GluMet: 1.327 ± 0.029	2.841GluAsn: 2.841 ± 0.041	1.667GluPro: 1.667 ± 0.035	2.486GluGln: 2.486 ± 0.041	2.268GluArg: 2.268 ± 0.037	2.601GluSer: 2.601 ± 0.041	2.818GluThr: 2.818 ± 0.043	3.473GluVal: 3.473 ± 0.052	0.59GluTrp: 0.59 ± 0.019	1.989GluTyr: 1.989 ± 0.037	0.002GluXaa: 0.002 ± 0.001
Phe	3.439PheAla: 3.439 ± 0.048	0.431PheCys: 0.431 ± 0.019	2.938PheAsp: 2.938 ± 0.042	2.502PheGlu: 2.502 ± 0.041	2.341PhePhe: 2.341 ± 0.043	3.362PheGly: 3.362 ± 0.05	0.819PheHis: 0.819 ± 0.023	3.627PheIle: 3.627 ± 0.053	3.376PheLys: 3.376 ± 0.048	4.066PheLeu: 4.066 ± 0.06	1.083PheMet: 1.083 ± 0.028	3.136PheAsn: 3.136 ± 0.052	1.593PhePro: 1.593 ± 0.029	1.307PheGln: 1.307 ± 0.029	1.694PheArg: 1.694 ± 0.035	3.428PheSer: 3.428 ± 0.049	3.265PheThr: 3.265 ± 0.045	2.715PheVal: 2.715 ± 0.036	0.513PheTrp: 0.513 ± 0.018	2.187PheTyr: 2.187 ± 0.036	0.004PheXaa: 0.004 ± 0.002
Gly	4.64GlyAla: 4.64 ± 0.061	0.572GlyCys: 0.572 ± 0.02	3.332GlyAsp: 3.332 ± 0.049	3.132GlyGlu: 3.132 ± 0.046	3.607GlyPhe: 3.607 ± 0.048	4.918GlyGly: 4.918 ± 0.082	1.357GlyHis: 1.357 ± 0.031	5.503GlyIle: 5.503 ± 0.059	5.155GlyLys: 5.155 ± 0.057	6.4GlyLeu: 6.4 ± 0.067	1.67GlyMet: 1.67 ± 0.035	3.779GlyAsn: 3.779 ± 0.073	1.663GlyPro: 1.663 ± 0.03	2.323GlyGln: 2.323 ± 0.041	2.514GlyArg: 2.514 ± 0.041	4.448GlySer: 4.448 ± 0.066	4.477GlyThr: 4.477 ± 0.081	4.363GlyVal: 4.363 ± 0.061	0.915GlyTrp: 0.915 ± 0.024	3.31GlyTyr: 3.31 ± 0.048	0.006GlyXaa: 0.006 ± 0.002
His	1.308HisAla: 1.308 ± 0.029	0.181HisCys: 0.181 ± 0.011	0.998HisAsp: 0.998 ± 0.025	1.063HisGlu: 1.063 ± 0.024	1.121HisPhe: 1.121 ± 0.024	1.222HisGly: 1.222 ± 0.028	0.618HisHis: 0.618 ± 0.02	1.486HisIle: 1.486 ± 0.025	1.14HisLys: 1.14 ± 0.029	1.961HisLeu: 1.961 ± 0.037	0.408HisMet: 0.408 ± 0.016	1.08HisAsn: 1.08 ± 0.021	1.016HisPro: 1.016 ± 0.029	0.877HisGln: 0.877 ± 0.024	0.746HisArg: 0.746 ± 0.025	1.074HisSer: 1.074 ± 0.026	1.1HisThr: 1.1 ± 0.026	1.093HisVal: 1.093 ± 0.025	0.258HisTrp: 0.258 ± 0.013	0.952HisTyr: 0.952 ± 0.024	0.002HisXaa: 0.002 ± 0.001
Ile	6.283IleAla: 6.283 ± 0.072	0.732IleCys: 0.732 ± 0.021	4.275IleAsp: 4.275 ± 0.054	3.936IleGlu: 3.936 ± 0.056	3.098IlePhe: 3.098 ± 0.048	4.905IleGly: 4.905 ± 0.061	1.317IleHis: 1.317 ± 0.031	5.469IleIle: 5.469 ± 0.058	5.366IleLys: 5.366 ± 0.057	6.167IleLeu: 6.167 ± 0.078	1.409IleMet: 1.409 ± 0.03	4.644IleAsn: 4.644 ± 0.055	3.084IlePro: 3.084 ± 0.048	2.243IleGln: 2.243 ± 0.037	2.863IleArg: 2.863 ± 0.044	5.026IleSer: 5.026 ± 0.051	5.115IleThr: 5.115 ± 0.07	4.284IleVal: 4.284 ± 0.053	0.715IleTrp: 0.715 ± 0.021	2.785IleTyr: 2.785 ± 0.042	0.004IleXaa: 0.004 ± 0.001
Lys	5.612LysAla: 5.612 ± 0.075	0.336LysCys: 0.336 ± 0.015	4.011LysAsp: 4.011 ± 0.056	4.005LysGlu: 4.005 ± 0.058	2.614LysPhe: 2.614 ± 0.038	4.419LysGly: 4.419 ± 0.055	1.364LysHis: 1.364 ± 0.031	4.892LysIle: 4.892 ± 0.057	4.978LysLys: 4.978 ± 0.059	6.345LysLeu: 6.345 ± 0.066	1.771LysMet: 1.771 ± 0.035	3.978LysAsn: 3.978 ± 0.048	2.917LysPro: 2.917 ± 0.044	3.06LysGln: 3.06 ± 0.046	2.675LysArg: 2.675 ± 0.041	3.854LysSer: 3.854 ± 0.05	4.141LysThr: 4.141 ± 0.046	4.353LysVal: 4.353 ± 0.065	0.751LysTrp: 0.751 ± 0.022	2.896LysTyr: 2.896 ± 0.038	0.001LysXaa: 0.001 ± 0.001
Leu	6.984LeuAla: 6.984 ± 0.075	0.779LeuCys: 0.779 ± 0.022	4.673LeuAsp: 4.673 ± 0.058	4.427LeuGlu: 4.427 ± 0.063	4.622LeuPhe: 4.622 ± 0.068	5.831LeuGly: 5.831 ± 0.061	1.798LeuHis: 1.798 ± 0.031	6.847LeuIle: 6.847 ± 0.085	7.351LeuLys: 7.351 ± 0.08	9.539LeuLeu: 9.539 ± 0.114	2.246LeuMet: 2.246 ± 0.041	5.778LeuAsn: 5.778 ± 0.061	4.165LeuPro: 4.165 ± 0.044	3.858LeuGln: 3.858 ± 0.049	3.493LeuArg: 3.493 ± 0.052	6.758LeuSer: 6.758 ± 0.07	5.77LeuThr: 5.77 ± 0.059	5.506LeuVal: 5.506 ± 0.055	0.909LeuTrp: 0.909 ± 0.027	3.395LeuTyr: 3.395 ± 0.049	0.004LeuXaa: 0.004 ± 0.002
Met	1.963MetAla: 1.963 ± 0.036	0.144MetCys: 0.144 ± 0.009	1.242MetAsp: 1.242 ± 0.027	1.216MetGlu: 1.216 ± 0.034	0.858MetPhe: 0.858 ± 0.024	1.519MetGly: 1.519 ± 0.03	0.494MetHis: 0.494 ± 0.015	1.576MetIle: 1.576 ± 0.032	1.787MetLys: 1.787 ± 0.032	2.337MetLeu: 2.337 ± 0.041	0.633MetMet: 0.633 ± 0.018	1.16MetAsn: 1.16 ± 0.027	1.141MetPro: 1.141 ± 0.025	1.043MetGln: 1.043 ± 0.024	0.911MetArg: 0.911 ± 0.023	1.32MetSer: 1.32 ± 0.023	1.05MetThr: 1.05 ± 0.024	1.529MetVal: 1.529 ± 0.033	0.18MetTrp: 0.18 ± 0.011	0.703MetTyr: 0.703 ± 0.021	0.003MetXaa: 0.003 ± 0.001
Asn	4.252AsnAla: 4.252 ± 0.06	0.41AsnCys: 0.41 ± 0.014	2.852AsnAsp: 2.852 ± 0.047	2.855AsnGlu: 2.855 ± 0.046	2.733AsnPhe: 2.733 ± 0.034	4.111AsnGly: 4.111 ± 0.061	1.117AsnHis: 1.117 ± 0.03	4.39AsnIle: 4.39 ± 0.053	3.74AsnLys: 3.74 ± 0.053	5.134AsnLeu: 5.134 ± 0.061	1.257AsnMet: 1.257 ± 0.027	3.634AsnAsn: 3.634 ± 0.061	2.693AsnPro: 2.693 ± 0.042	2.28AsnGln: 2.28 ± 0.038	2.225AsnArg: 2.225 ± 0.03	3.374AsnSer: 3.374 ± 0.054	3.582AsnThr: 3.582 ± 0.056	3.324AsnVal: 3.324 ± 0.044	0.737AsnTrp: 0.737 ± 0.024	2.812AsnTyr: 2.812 ± 0.042	0.002AsnXaa: 0.002 ± 0.001
Pro	3.595ProAla: 3.595 ± 0.057	0.208ProCys: 0.208 ± 0.012	2.631ProAsp: 2.631 ± 0.042	2.644ProGlu: 2.644 ± 0.046	1.831ProPhe: 1.831 ± 0.033	2.893ProGly: 2.893 ± 0.048	0.737ProHis: 0.737 ± 0.021	2.452ProIle: 2.452 ± 0.039	2.159ProLys: 2.159 ± 0.035	3.45ProLeu: 3.45 ± 0.051	0.734ProMet: 0.734 ± 0.022	2.031ProAsn: 2.031 ± 0.039	1.097ProPro: 1.097 ± 0.031	1.636ProGln: 1.636 ± 0.036	1.005ProArg: 1.005 ± 0.025	2.115ProSer: 2.115 ± 0.04	2.027ProThr: 2.027 ± 0.038	3.362ProVal: 3.362 ± 0.054	0.407ProTrp: 0.407 ± 0.018	1.649ProTyr: 1.649 ± 0.034	0.005ProXaa: 0.005 ± 0.001
Gln	2.954GlnAla: 2.954 ± 0.042	0.203GlnCys: 0.203 ± 0.011	1.689GlnAsp: 1.689 ± 0.036	1.879GlnGlu: 1.879 ± 0.034	1.752GlnPhe: 1.752 ± 0.035	2.119GlnGly: 2.119 ± 0.037	0.898GlnHis: 0.898 ± 0.026	2.734GlnIle: 2.734 ± 0.04	2.684GlnLys: 2.684 ± 0.043	4.232GlnLeu: 4.232 ± 0.058	0.986GlnMet: 0.986 ± 0.024	2.256GlnAsn: 2.256 ± 0.038	1.67GlnPro: 1.67 ± 0.032	2.468GlnGln: 2.468 ± 0.071	1.539GlnArg: 1.539 ± 0.039	2.357GlnSer: 2.357 ± 0.042	2.26GlnThr: 2.26 ± 0.031	2.468GlnVal: 2.468 ± 0.041	0.464GlnTrp: 0.464 ± 0.017	1.679GlnTyr: 1.679 ± 0.032	0.002GlnXaa: 0.002 ± 0.001
Arg	2.414ArgAla: 2.414 ± 0.041	0.224ArgCys: 0.224 ± 0.012	1.964ArgAsp: 1.964 ± 0.037	2.023ArgGlu: 2.023 ± 0.035	2.004ArgPhe: 2.004 ± 0.036	2.08ArgGly: 2.08 ± 0.038	0.708ArgHis: 0.708 ± 0.022	2.912ArgIle: 2.912 ± 0.04	2.769ArgLys: 2.769 ± 0.043	3.821ArgLeu: 3.821 ± 0.048	1.002ArgMet: 1.002 ± 0.024	2.176ArgAsn: 2.176 ± 0.038	1.336ArgPro: 1.336 ± 0.026	1.509ArgGln: 1.509 ± 0.034	1.498ArgArg: 1.498 ± 0.036	2.1ArgSer: 2.1 ± 0.034	1.97ArgThr: 1.97 ± 0.035	2.323ArgVal: 2.323 ± 0.038	0.494ArgTrp: 0.494 ± 0.015	1.767ArgTyr: 1.767 ± 0.034	0.004ArgXaa: 0.004 ± 0.001
Ser	4.82SerAla: 4.82 ± 0.059	0.518SerCys: 0.518 ± 0.019	3.064SerAsp: 3.064 ± 0.043	2.751SerGlu: 2.751 ± 0.041	3.446SerPhe: 3.446 ± 0.046	4.827SerGly: 4.827 ± 0.067	1.181SerHis: 1.181 ± 0.029	4.569SerIle: 4.569 ± 0.061	3.75SerLys: 3.75 ± 0.052	5.993SerLeu: 5.993 ± 0.056	1.285SerMet: 1.285 ± 0.03	3.278SerAsn: 3.278 ± 0.058	2.354SerPro: 2.354 ± 0.045	2.146SerGln: 2.146 ± 0.044	2.33SerArg: 2.33 ± 0.044	3.959SerSer: 3.959 ± 0.06	3.732SerThr: 3.732 ± 0.062	4.149SerVal: 4.149 ± 0.051	0.74SerTrp: 0.74 ± 0.022	2.732SerTyr: 2.732 ± 0.043	0.004SerXaa: 0.004 ± 0.001
Thr	5.273ThrAla: 5.273 ± 0.071	0.377ThrCys: 0.377 ± 0.015	3.627ThrAsp: 3.627 ± 0.047	3.02ThrGlu: 3.02 ± 0.044	2.735ThrPhe: 2.735 ± 0.041	5.093ThrGly: 5.093 ± 0.069	1.104ThrHis: 1.104 ± 0.029	4.461ThrIle: 4.461 ± 0.056	3.24ThrLys: 3.24 ± 0.049	5.64ThrLeu: 5.64 ± 0.063	1.086ThrMet: 1.086 ± 0.027	3.13ThrAsn: 3.13 ± 0.053	2.806ThrPro: 2.806 ± 0.05	2.051ThrGln: 2.051 ± 0.039	1.952ThrArg: 1.952 ± 0.034	3.621ThrSer: 3.621 ± 0.051	3.854ThrThr: 3.854 ± 0.077	4.08ThrVal: 4.08 ± 0.067	0.631ThrTrp: 0.631 ± 0.021	2.621ThrTyr: 2.621 ± 0.053	0.002ThrXaa: 0.002 ± 0.001
Val	4.938ValAla: 4.938 ± 0.068	0.528ValCys: 0.528 ± 0.02	3.299ValAsp: 3.299 ± 0.042	3.035ValGlu: 3.035 ± 0.049	3.071ValPhe: 3.071 ± 0.049	3.679ValGly: 3.679 ± 0.054	1.077ValHis: 1.077 ± 0.024	4.972ValIle: 4.972 ± 0.055	4.665ValLys: 4.665 ± 0.057	5.995ValLeu: 5.995 ± 0.073	1.508ValMet: 1.508 ± 0.033	3.838ValAsn: 3.838 ± 0.053	2.371ValPro: 2.371 ± 0.046	2.083ValGln: 2.083 ± 0.039	2.165ValArg: 2.165 ± 0.036	4.403ValSer: 4.403 ± 0.055	4.146ValThr: 4.146 ± 0.075	4.176ValVal: 4.176 ± 0.051	0.661ValTrp: 0.661 ± 0.02	2.574ValTyr: 2.574 ± 0.042	0.005ValXaa: 0.005 ± 0.002
Trp	0.781TrpAla: 0.781 ± 0.021	0.109TrpCys: 0.109 ± 0.008	0.635TrpAsp: 0.635 ± 0.019	0.52TrpGlu: 0.52 ± 0.018	0.561TrpPhe: 0.561 ± 0.018	0.818TrpGly: 0.818 ± 0.024	0.279TrpHis: 0.279 ± 0.013	0.719TrpIle: 0.719 ± 0.021	0.767TrpLys: 0.767 ± 0.02	1.181TrpLeu: 1.181 ± 0.027	0.342TrpMet: 0.342 ± 0.013	0.62TrpAsn: 0.62 ± 0.021	0.364TrpPro: 0.364 ± 0.015	0.529TrpGln: 0.529 ± 0.018	0.478TrpArg: 0.478 ± 0.019	0.655TrpSer: 0.655 ± 0.021	0.572TrpThr: 0.572 ± 0.019	0.716TrpVal: 0.716 ± 0.02	0.203TrpTrp: 0.203 ± 0.011	0.453TrpTyr: 0.453 ± 0.022	0.002TrpXaa: 0.002 ± 0.001
Tyr	3.034TyrAla: 3.034 ± 0.042	0.378TyrCys: 0.378 ± 0.015	2.317TyrAsp: 2.317 ± 0.039	1.935TyrGlu: 1.935 ± 0.033	2.272TyrPhe: 2.272 ± 0.039	2.778TyrGly: 2.778 ± 0.043	1.003TyrHis: 1.003 ± 0.026	2.737TyrIle: 2.737 ± 0.036	2.753TyrLys: 2.753 ± 0.044	4.086TyrLeu: 4.086 ± 0.06	0.823TyrMet: 0.823 ± 0.022	2.775TyrAsn: 2.775 ± 0.043	1.803TyrPro: 1.803 ± 0.033	1.926TyrGln: 1.926 ± 0.033	1.829TyrArg: 1.829 ± 0.035	2.637TyrSer: 2.637 ± 0.046	2.754TyrThr: 2.754 ± 0.052	2.264TyrVal: 2.264 ± 0.044	0.52TyrTrp: 0.52 ± 0.018	2.041TyrTyr: 2.041 ± 0.041	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.004XaaAla: 0.004 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.004XaaAsp: 0.004 ± 0.002	0.002XaaGlu: 0.002 ± 0.001	0.004XaaPhe: 0.004 ± 0.001	0.004XaaGly: 0.004 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.003XaaIle: 0.003 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.006XaaLeu: 0.006 ± 0.002	0.004XaaMet: 0.004 ± 0.002	0.003XaaAsn: 0.003 ± 0.001	0.007XaaPro: 0.007 ± 0.002	0.005XaaGln: 0.005 ± 0.002	0.003XaaArg: 0.003 ± 0.001	0.002XaaSer: 0.002 ± 0.001	0.004XaaThr: 0.004 ± 0.002	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.268XaaXaa: 0.268 ± 0.042

Statistics based on 5195 proteins (1703259 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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