Amino acid dipepetide frequency for Hydrotalea sandarakina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.008AlaAla: 7.008 ± 0.121	0.772AlaCys: 0.772 ± 0.03	3.649AlaAsp: 3.649 ± 0.062	3.941AlaGlu: 3.941 ± 0.077	3.868AlaPhe: 3.868 ± 0.069	5.257AlaGly: 5.257 ± 0.089	1.429AlaHis: 1.429 ± 0.041	6.553AlaIle: 6.553 ± 0.091	4.653AlaLys: 4.653 ± 0.075	7.699AlaLeu: 7.699 ± 0.105	1.875AlaMet: 1.875 ± 0.053	4.492AlaAsn: 4.492 ± 0.072	2.483AlaPro: 2.483 ± 0.05	3.403AlaGln: 3.403 ± 0.059	2.171AlaArg: 2.171 ± 0.046	4.091AlaSer: 4.091 ± 0.064	4.473AlaThr: 4.473 ± 0.083	4.724AlaVal: 4.724 ± 0.072	0.813AlaTrp: 0.813 ± 0.034	3.108AlaTyr: 3.108 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.557CysAla: 0.557 ± 0.026	0.146CysCys: 0.146 ± 0.013	0.366CysAsp: 0.366 ± 0.02	0.397CysGlu: 0.397 ± 0.022	0.468CysPhe: 0.468 ± 0.024	0.671CysGly: 0.671 ± 0.025	0.221CysHis: 0.221 ± 0.02	0.852CysIle: 0.852 ± 0.033	0.588CysLys: 0.588 ± 0.03	0.822CysLeu: 0.822 ± 0.029	0.226CysMet: 0.226 ± 0.016	0.596CysAsn: 0.596 ± 0.027	0.39CysPro: 0.39 ± 0.021	0.241CysGln: 0.241 ± 0.016	0.277CysArg: 0.277 ± 0.016	0.6CysSer: 0.6 ± 0.027	0.568CysThr: 0.568 ± 0.027	0.504CysVal: 0.504 ± 0.025	0.112CysTrp: 0.112 ± 0.01	0.384CysTyr: 0.384 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.044AspAla: 4.044 ± 0.065	0.394AspCys: 0.394 ± 0.019	2.124AspAsp: 2.124 ± 0.066	2.782AspGlu: 2.782 ± 0.056	2.546AspPhe: 2.546 ± 0.051	3.101AspGly: 3.101 ± 0.078	0.675AspHis: 0.675 ± 0.032	3.575AspIle: 3.575 ± 0.059	3.049AspLys: 3.049 ± 0.064	3.818AspLeu: 3.818 ± 0.067	0.982AspMet: 0.982 ± 0.038	2.472AspAsn: 2.472 ± 0.057	1.628AspPro: 1.628 ± 0.046	1.035AspGln: 1.035 ± 0.03	1.294AspArg: 1.294 ± 0.039	2.846AspSer: 2.846 ± 0.065	2.712AspThr: 2.712 ± 0.056	3.261AspVal: 3.261 ± 0.064	0.646AspTrp: 0.646 ± 0.024	2.289AspTyr: 2.289 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.229GluAla: 4.229 ± 0.085	0.346GluCys: 0.346 ± 0.019	2.004GluAsp: 2.004 ± 0.055	3.06GluGlu: 3.06 ± 0.08	1.985GluPhe: 1.985 ± 0.051	2.9GluGly: 2.9 ± 0.057	1.089GluHis: 1.089 ± 0.036	3.786GluIle: 3.786 ± 0.069	4.912GluLys: 4.912 ± 0.092	4.844GluLeu: 4.844 ± 0.083	1.521GluMet: 1.521 ± 0.043	3.434GluAsn: 3.434 ± 0.057	1.59GluPro: 1.59 ± 0.043	2.754GluGln: 2.754 ± 0.067	2.02GluArg: 2.02 ± 0.048	2.389GluSer: 2.389 ± 0.054	2.73GluThr: 2.73 ± 0.054	3.368GluVal: 3.368 ± 0.059	0.764GluTrp: 0.764 ± 0.029	1.859GluTyr: 1.859 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.362PheAla: 3.362 ± 0.061	0.49PheCys: 0.49 ± 0.022	2.428PheAsp: 2.428 ± 0.054	2.528PheGlu: 2.528 ± 0.054	2.655PhePhe: 2.655 ± 0.06	3.168PheGly: 3.168 ± 0.058	0.96PheHis: 0.96 ± 0.031	4.138PheIle: 4.138 ± 0.072	3.206PheLys: 3.206 ± 0.059	4.609PheLeu: 4.609 ± 0.082	1.085PheMet: 1.085 ± 0.035	3.319PheAsn: 3.319 ± 0.066	1.887PhePro: 1.887 ± 0.045	1.844PheGln: 1.844 ± 0.044	1.502PheArg: 1.502 ± 0.037	3.573PheSer: 3.573 ± 0.066	3.211PheThr: 3.211 ± 0.058	2.963PheVal: 2.963 ± 0.063	0.67PheTrp: 0.67 ± 0.03	2.197PheTyr: 2.197 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	4.452GlyAla: 4.452 ± 0.076	0.703GlyCys: 0.703 ± 0.03	2.727GlyAsp: 2.727 ± 0.065	2.808GlyGlu: 2.808 ± 0.062	3.391GlyPhe: 3.391 ± 0.063	4.648GlyGly: 4.648 ± 0.105	1.259GlyHis: 1.259 ± 0.036	5.867GlyIle: 5.867 ± 0.082	4.856GlyLys: 4.856 ± 0.074	5.739GlyLeu: 5.739 ± 0.082	1.789GlyMet: 1.789 ± 0.038	4.193GlyAsn: 4.193 ± 0.074	1.549GlyPro: 1.549 ± 0.045	1.932GlyGln: 1.932 ± 0.042	2.109GlyArg: 2.109 ± 0.05	3.843GlySer: 3.843 ± 0.075	4.125GlyThr: 4.125 ± 0.076	4.113GlyVal: 4.113 ± 0.074	0.988GlyTrp: 0.988 ± 0.03	3.053GlyTyr: 3.053 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.438HisAla: 1.438 ± 0.043	0.23HisCys: 0.23 ± 0.014	0.794HisAsp: 0.794 ± 0.026	1.111HisGlu: 1.111 ± 0.034	1.467HisPhe: 1.467 ± 0.043	1.1HisGly: 1.1 ± 0.037	0.727HisHis: 0.727 ± 0.032	1.695HisIle: 1.695 ± 0.041	1.16HisLys: 1.16 ± 0.036	2.301HisLeu: 2.301 ± 0.056	0.408HisMet: 0.408 ± 0.023	1.142HisAsn: 1.142 ± 0.039	1.159HisPro: 1.159 ± 0.037	1.117HisGln: 1.117 ± 0.043	0.76HisArg: 0.76 ± 0.032	1.15HisSer: 1.15 ± 0.033	1.225HisThr: 1.225 ± 0.038	1.097HisVal: 1.097 ± 0.037	0.334HisTrp: 0.334 ± 0.018	1.051HisTyr: 1.051 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.637IleAla: 6.637 ± 0.095	0.797IleCys: 0.797 ± 0.032	4.195IleAsp: 4.195 ± 0.059	4.527IleGlu: 4.527 ± 0.074	3.436IlePhe: 3.436 ± 0.069	4.951IleGly: 4.951 ± 0.094	1.815IleHis: 1.815 ± 0.043	6.372IleIle: 6.372 ± 0.109	4.862IleLys: 4.862 ± 0.071	6.82IleLeu: 6.82 ± 0.112	1.503IleMet: 1.503 ± 0.044	4.612IleAsn: 4.612 ± 0.077	3.685IlePro: 3.685 ± 0.067	3.946IleGln: 3.946 ± 0.07	2.596IleArg: 2.596 ± 0.054	4.801IleSer: 4.801 ± 0.078	4.925IleThr: 4.925 ± 0.081	4.897IleVal: 4.897 ± 0.078	0.819IleTrp: 0.819 ± 0.031	2.797IleTyr: 2.797 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	5.236LysAla: 5.236 ± 0.083	0.399LysCys: 0.399 ± 0.023	3.214LysAsp: 3.214 ± 0.056	4.311LysGlu: 4.311 ± 0.09	2.339LysPhe: 2.339 ± 0.052	4.114LysGly: 4.114 ± 0.07	1.406LysHis: 1.406 ± 0.042	5.214LysIle: 5.214 ± 0.084	5.802LysLys: 5.802 ± 0.104	5.63LysLeu: 5.63 ± 0.081	1.935LysMet: 1.935 ± 0.046	5.05LysAsn: 5.05 ± 0.084	2.83LysPro: 2.83 ± 0.059	3.498LysGln: 3.498 ± 0.066	2.369LysArg: 2.369 ± 0.052	3.241LysSer: 3.241 ± 0.061	3.943LysThr: 3.943 ± 0.065	4.081LysVal: 4.081 ± 0.067	0.915LysTrp: 0.915 ± 0.034	2.678LysTyr: 2.678 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	6.691LeuAla: 6.691 ± 0.097	0.872LeuCys: 0.872 ± 0.027	3.704LeuAsp: 3.704 ± 0.066	4.251LeuGlu: 4.251 ± 0.093	5.034LeuPhe: 5.034 ± 0.083	5.607LeuGly: 5.607 ± 0.08	2.304LeuHis: 2.304 ± 0.058	6.627LeuIle: 6.627 ± 0.109	6.627LeuLys: 6.627 ± 0.087	10.293LeuLeu: 10.293 ± 0.14	2.423LeuMet: 2.423 ± 0.051	6.212LeuAsn: 6.212 ± 0.083	4.628LeuPro: 4.628 ± 0.068	5.733LeuGln: 5.733 ± 0.097	3.165LeuArg: 3.165 ± 0.059	6.179LeuSer: 6.179 ± 0.086	5.167LeuThr: 5.167 ± 0.082	5.279LeuVal: 5.279 ± 0.075	0.944LeuTrp: 0.944 ± 0.036	3.601LeuTyr: 3.601 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.963MetAla: 1.963 ± 0.049	0.144MetCys: 0.144 ± 0.011	1.078MetAsp: 1.078 ± 0.035	1.263MetGlu: 1.263 ± 0.04	0.883MetPhe: 0.883 ± 0.036	1.63MetGly: 1.63 ± 0.045	0.672MetHis: 0.672 ± 0.03	1.451MetIle: 1.451 ± 0.038	1.843MetLys: 1.843 ± 0.041	2.291MetLeu: 2.291 ± 0.057	0.641MetMet: 0.641 ± 0.027	1.45MetAsn: 1.45 ± 0.038	1.261MetPro: 1.261 ± 0.034	1.646MetGln: 1.646 ± 0.047	1.013MetArg: 1.013 ± 0.032	1.183MetSer: 1.183 ± 0.04	0.859MetThr: 0.859 ± 0.03	1.581MetVal: 1.581 ± 0.041	0.198MetTrp: 0.198 ± 0.014	0.769MetTyr: 0.769 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	5.078AsnAla: 5.078 ± 0.073	0.56AsnCys: 0.56 ± 0.028	3.132AsnAsp: 3.132 ± 0.065	3.592AsnGlu: 3.592 ± 0.069	3.156AsnPhe: 3.156 ± 0.058	4.479AsnGly: 4.479 ± 0.093	1.291AsnHis: 1.291 ± 0.04	5.214AsnIle: 5.214 ± 0.08	4.18AsnLys: 4.18 ± 0.063	5.218AsnLeu: 5.218 ± 0.072	1.4AsnMet: 1.4 ± 0.037	5.001AsnAsn: 5.001 ± 0.098	2.888AsnPro: 2.888 ± 0.056	2.524AsnGln: 2.524 ± 0.056	2.141AsnArg: 2.141 ± 0.053	3.406AsnSer: 3.406 ± 0.07	3.97AsnThr: 3.97 ± 0.079	3.633AsnVal: 3.633 ± 0.063	0.933AsnTrp: 0.933 ± 0.035	2.99AsnTyr: 2.99 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	3.294ProAla: 3.294 ± 0.058	0.278ProCys: 0.278 ± 0.016	2.239ProAsp: 2.239 ± 0.049	2.5ProGlu: 2.5 ± 0.051	2.165ProPhe: 2.165 ± 0.044	2.665ProGly: 2.665 ± 0.053	0.842ProHis: 0.842 ± 0.035	3.104ProIle: 3.104 ± 0.055	2.374ProLys: 2.374 ± 0.05	3.634ProLeu: 3.634 ± 0.059	0.815ProMet: 0.815 ± 0.031	2.817ProAsn: 2.817 ± 0.063	1.189ProPro: 1.189 ± 0.042	1.554ProGln: 1.554 ± 0.045	0.927ProArg: 0.927 ± 0.03	2.128ProSer: 2.128 ± 0.049	2.296ProThr: 2.296 ± 0.046	2.938ProVal: 2.938 ± 0.049	0.441ProTrp: 0.441 ± 0.024	1.838ProTyr: 1.838 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.928GlnAla: 2.928 ± 0.064	0.313GlnCys: 0.313 ± 0.018	1.322GlnAsp: 1.322 ± 0.039	1.903GlnGlu: 1.903 ± 0.053	2.285GlnPhe: 2.285 ± 0.045	1.965GlnGly: 1.965 ± 0.05	1.303GlnHis: 1.303 ± 0.037	3.316GlnIle: 3.316 ± 0.068	3.421GlnLys: 3.421 ± 0.067	5.574GlnLeu: 5.574 ± 0.084	1.169GlnMet: 1.169 ± 0.037	2.796GlnAsn: 2.796 ± 0.06	2.05GlnPro: 2.05 ± 0.047	4.179GlnGln: 4.179 ± 0.082	1.583GlnArg: 1.583 ± 0.041	2.432GlnSer: 2.432 ± 0.05	2.551GlnThr: 2.551 ± 0.056	2.425GlnVal: 2.425 ± 0.052	0.682GlnTrp: 0.682 ± 0.027	2.176GlnTyr: 2.176 ± 0.056	0.0GlnXaa: 0.0 ± 0.0
Arg	1.913ArgAla: 1.913 ± 0.052	0.252ArgCys: 0.252 ± 0.016	1.445ArgAsp: 1.445 ± 0.042	1.651ArgGlu: 1.651 ± 0.046	1.761ArgPhe: 1.761 ± 0.046	1.816ArgGly: 1.816 ± 0.047	0.62ArgHis: 0.62 ± 0.026	2.757ArgIle: 2.757 ± 0.061	2.64ArgLys: 2.64 ± 0.059	3.214ArgLeu: 3.214 ± 0.061	0.984ArgMet: 0.984 ± 0.029	2.284ArgAsn: 2.284 ± 0.045	1.152ArgPro: 1.152 ± 0.04	1.391ArgGln: 1.391 ± 0.042	1.239ArgArg: 1.239 ± 0.038	1.799ArgSer: 1.799 ± 0.042	1.661ArgThr: 1.661 ± 0.037	1.886ArgVal: 1.886 ± 0.048	0.474ArgTrp: 0.474 ± 0.024	1.557ArgTyr: 1.557 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	4.225SerAla: 4.225 ± 0.073	0.599SerCys: 0.599 ± 0.03	2.457SerAsp: 2.457 ± 0.044	2.452SerGlu: 2.452 ± 0.056	3.448SerPhe: 3.448 ± 0.071	4.233SerGly: 4.233 ± 0.073	0.985SerHis: 0.985 ± 0.034	4.914SerIle: 4.914 ± 0.07	3.581SerLys: 3.581 ± 0.066	5.629SerLeu: 5.629 ± 0.074	1.289SerMet: 1.289 ± 0.04	3.727SerAsn: 3.727 ± 0.071	2.082SerPro: 2.082 ± 0.055	1.797SerGln: 1.797 ± 0.042	1.776SerArg: 1.776 ± 0.04	3.393SerSer: 3.393 ± 0.08	3.452SerThr: 3.452 ± 0.072	3.836SerVal: 3.836 ± 0.079	0.726SerTrp: 0.726 ± 0.029	2.323SerTyr: 2.323 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.724ThrAla: 4.724 ± 0.071	0.443ThrCys: 0.443 ± 0.021	2.888ThrAsp: 2.888 ± 0.059	2.815ThrGlu: 2.815 ± 0.055	2.727ThrPhe: 2.727 ± 0.058	4.419ThrGly: 4.419 ± 0.081	1.261ThrHis: 1.261 ± 0.038	5.111ThrIle: 5.111 ± 0.075	3.175ThrLys: 3.175 ± 0.056	5.505ThrLeu: 5.505 ± 0.073	1.036ThrMet: 1.036 ± 0.034	3.667ThrAsn: 3.667 ± 0.074	2.869ThrPro: 2.869 ± 0.051	2.359ThrGln: 2.359 ± 0.052	1.562ThrArg: 1.562 ± 0.043	3.125ThrSer: 3.125 ± 0.068	3.875ThrThr: 3.875 ± 0.085	3.926ThrVal: 3.926 ± 0.077	0.641ThrTrp: 0.641 ± 0.029	2.414ThrTyr: 2.414 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	4.772ValAla: 4.772 ± 0.073	0.685ValCys: 0.685 ± 0.028	2.919ValAsp: 2.919 ± 0.056	3.085ValGlu: 3.085 ± 0.064	3.095ValPhe: 3.095 ± 0.06	3.868ValGly: 3.868 ± 0.068	1.306ValHis: 1.306 ± 0.041	4.803ValIle: 4.803 ± 0.07	3.884ValLys: 3.884 ± 0.069	6.168ValLeu: 6.168 ± 0.087	1.503ValMet: 1.503 ± 0.042	3.787ValAsn: 3.787 ± 0.074	2.584ValPro: 2.584 ± 0.057	2.679ValGln: 2.679 ± 0.052	1.878ValArg: 1.878 ± 0.046	3.662ValSer: 3.662 ± 0.058	3.756ValThr: 3.756 ± 0.067	4.216ValVal: 4.216 ± 0.069	0.728ValTrp: 0.728 ± 0.028	2.512ValTyr: 2.512 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.795TrpAla: 0.795 ± 0.031	0.134TrpCys: 0.134 ± 0.01	0.638TrpAsp: 0.638 ± 0.028	0.632TrpGlu: 0.632 ± 0.025	0.624TrpPhe: 0.624 ± 0.027	0.824TrpGly: 0.824 ± 0.029	0.331TrpHis: 0.331 ± 0.021	0.889TrpIle: 0.889 ± 0.03	0.823TrpLys: 0.823 ± 0.028	1.39TrpLeu: 1.39 ± 0.039	0.413TrpMet: 0.413 ± 0.022	0.836TrpAsn: 0.836 ± 0.032	0.389TrpPro: 0.389 ± 0.023	0.776TrpGln: 0.776 ± 0.031	0.466TrpArg: 0.466 ± 0.022	0.577TrpSer: 0.577 ± 0.027	0.494TrpThr: 0.494 ± 0.022	0.846TrpVal: 0.846 ± 0.029	0.264TrpTrp: 0.264 ± 0.016	0.552TrpTyr: 0.552 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.115TyrAla: 3.115 ± 0.058	0.43TyrCys: 0.43 ± 0.019	1.953TyrAsp: 1.953 ± 0.045	1.975TyrGlu: 1.975 ± 0.049	2.46TyrPhe: 2.46 ± 0.055	2.728TyrGly: 2.728 ± 0.049	0.97TyrHis: 0.97 ± 0.035	2.756TyrIle: 2.756 ± 0.058	2.569TyrLys: 2.569 ± 0.051	4.139TyrLeu: 4.139 ± 0.066	0.82TyrMet: 0.82 ± 0.032	2.898TyrAsn: 2.898 ± 0.069	1.744TyrPro: 1.744 ± 0.042	1.967TyrGln: 1.967 ± 0.044	1.65TyrArg: 1.65 ± 0.036	2.508TyrSer: 2.508 ± 0.058	2.549TyrThr: 2.549 ± 0.058	2.319TyrVal: 2.319 ± 0.049	0.6TyrTrp: 0.6 ± 0.024	2.038TyrTyr: 2.038 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2813 proteins (986317 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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