Amino acid dipepetide frequency for Aquicella lusitana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.058AlaAla: 8.058 ± 0.139
1.099AlaCys: 1.099 ± 0.039
4.033AlaAsp: 4.033 ± 0.071
5.143AlaGlu: 5.143 ± 0.102
3.696AlaPhe: 3.696 ± 0.076
5.821AlaGly: 5.821 ± 0.119
1.868AlaHis: 1.868 ± 0.048
6.458AlaIle: 6.458 ± 0.099
5.107AlaLys: 5.107 ± 0.086
9.333AlaLeu: 9.333 ± 0.145
2.322AlaMet: 2.322 ± 0.055
3.491AlaAsn: 3.491 ± 0.079
2.772AlaPro: 2.772 ± 0.065
3.333AlaGln: 3.333 ± 0.063
3.973AlaArg: 3.973 ± 0.078
5.002AlaSer: 5.002 ± 0.078
4.087AlaThr: 4.087 ± 0.082
5.434AlaVal: 5.434 ± 0.092
1.059AlaTrp: 1.059 ± 0.042
2.78AlaTyr: 2.78 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.847CysAla: 0.847 ± 0.038
0.182CysCys: 0.182 ± 0.017
0.525CysAsp: 0.525 ± 0.025
0.597CysGlu: 0.597 ± 0.03
0.584CysPhe: 0.584 ± 0.031
0.842CysGly: 0.842 ± 0.037
0.378CysHis: 0.378 ± 0.023
0.671CysIle: 0.671 ± 0.031
0.517CysLys: 0.517 ± 0.031
1.204CysLeu: 1.204 ± 0.04
0.27CysMet: 0.27 ± 0.02
0.419CysAsn: 0.419 ± 0.025
0.46CysPro: 0.46 ± 0.029
0.446CysGln: 0.446 ± 0.025
0.536CysArg: 0.536 ± 0.03
0.631CysSer: 0.631 ± 0.032
0.506CysThr: 0.506 ± 0.027
0.676CysVal: 0.676 ± 0.03
0.127CysTrp: 0.127 ± 0.012
0.429CysTyr: 0.429 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.801AspAla: 3.801 ± 0.087
0.461AspCys: 0.461 ± 0.023
2.091AspAsp: 2.091 ± 0.059
3.25AspGlu: 3.25 ± 0.071
2.288AspPhe: 2.288 ± 0.056
2.489AspGly: 2.489 ± 0.06
1.166AspHis: 1.166 ± 0.04
3.775AspIle: 3.775 ± 0.078
3.282AspLys: 3.282 ± 0.072
4.947AspLeu: 4.947 ± 0.091
1.218AspMet: 1.218 ± 0.04
1.884AspAsn: 1.884 ± 0.05
2.296AspPro: 2.296 ± 0.051
2.028AspGln: 2.028 ± 0.051
2.422AspArg: 2.422 ± 0.064
2.32AspSer: 2.32 ± 0.063
2.365AspThr: 2.365 ± 0.052
3.074AspVal: 3.074 ± 0.065
0.665AspTrp: 0.665 ± 0.031
2.047AspTyr: 2.047 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
5.106GluAla: 5.106 ± 0.094
0.478GluCys: 0.478 ± 0.024
2.447GluAsp: 2.447 ± 0.062
3.854GluGlu: 3.854 ± 0.098
2.057GluPhe: 2.057 ± 0.05
3.091GluGly: 3.091 ± 0.073
1.345GluHis: 1.345 ± 0.044
4.533GluIle: 4.533 ± 0.075
5.246GluLys: 5.246 ± 0.107
5.716GluLeu: 5.716 ± 0.106
1.733GluMet: 1.733 ± 0.05
2.927GluAsn: 2.927 ± 0.068
1.828GluPro: 1.828 ± 0.047
2.835GluGln: 2.835 ± 0.068
3.236GluArg: 3.236 ± 0.074
3.126GluSer: 3.126 ± 0.07
3.276GluThr: 3.276 ± 0.07
3.562GluVal: 3.562 ± 0.074
0.691GluTrp: 0.691 ± 0.028
1.663GluTyr: 1.663 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.699PheAla: 3.699 ± 0.074
0.631PheCys: 0.631 ± 0.031
2.343PheAsp: 2.343 ± 0.061
2.059PheGlu: 2.059 ± 0.049
2.343PhePhe: 2.343 ± 0.062
2.76PheGly: 2.76 ± 0.06
1.081PheHis: 1.081 ± 0.042
3.487PheIle: 3.487 ± 0.075
2.132PheLys: 2.132 ± 0.061
4.583PheLeu: 4.583 ± 0.104
1.003PheMet: 1.003 ± 0.039
2.061PheAsn: 2.061 ± 0.048
1.779PhePro: 1.779 ± 0.051
1.49PheGln: 1.49 ± 0.044
1.677PheArg: 1.677 ± 0.047
3.448PheSer: 3.448 ± 0.074
2.445PheThr: 2.445 ± 0.063
2.569PheVal: 2.569 ± 0.068
0.558PheTrp: 0.558 ± 0.034
1.798PheTyr: 1.798 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.773GlyAla: 4.773 ± 0.103
0.848GlyCys: 0.848 ± 0.04
2.827GlyAsp: 2.827 ± 0.073
3.532GlyGlu: 3.532 ± 0.071
3.174GlyPhe: 3.174 ± 0.066
4.259GlyGly: 4.259 ± 0.108
1.503GlyHis: 1.503 ± 0.048
5.137GlyIle: 5.137 ± 0.094
4.247GlyLys: 4.247 ± 0.079
6.388GlyLeu: 6.388 ± 0.112
1.985GlyMet: 1.985 ± 0.052
2.398GlyAsn: 2.398 ± 0.066
1.869GlyPro: 1.869 ± 0.056
2.271GlyGln: 2.271 ± 0.054
2.825GlyArg: 2.825 ± 0.073
3.683GlySer: 3.683 ± 0.091
3.374GlyThr: 3.374 ± 0.098
4.187GlyVal: 4.187 ± 0.087
0.924GlyTrp: 0.924 ± 0.037
2.381GlyTyr: 2.381 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
2.152HisAla: 2.152 ± 0.06
0.37HisCys: 0.37 ± 0.024
1.178HisAsp: 1.178 ± 0.039
1.482HisGlu: 1.482 ± 0.05
1.23HisPhe: 1.23 ± 0.041
1.586HisGly: 1.586 ± 0.05
0.969HisHis: 0.969 ± 0.041
1.686HisIle: 1.686 ± 0.043
1.13HisLys: 1.13 ± 0.04
2.662HisLeu: 2.662 ± 0.065
0.513HisMet: 0.513 ± 0.025
0.832HisAsn: 0.832 ± 0.035
1.476HisPro: 1.476 ± 0.043
1.21HisGln: 1.21 ± 0.034
1.216HisArg: 1.216 ± 0.043
1.383HisSer: 1.383 ± 0.043
1.154HisThr: 1.154 ± 0.039
1.494HisVal: 1.494 ± 0.046
0.369HisTrp: 0.369 ± 0.021
1.099HisTyr: 1.099 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.86IleAla: 6.86 ± 0.105
0.818IleCys: 0.818 ± 0.037
4.026IleAsp: 4.026 ± 0.077
4.502IleGlu: 4.502 ± 0.075
3.119IlePhe: 3.119 ± 0.069
4.781IleGly: 4.781 ± 0.104
1.815IleHis: 1.815 ± 0.05
5.175IleIle: 5.175 ± 0.1
4.509IleLys: 4.509 ± 0.097
6.997IleLeu: 6.997 ± 0.122
1.532IleMet: 1.532 ± 0.044
3.381IleAsn: 3.381 ± 0.072
3.178IlePro: 3.178 ± 0.06
2.876IleGln: 2.876 ± 0.062
3.408IleArg: 3.408 ± 0.07
4.676IleSer: 4.676 ± 0.084
4.205IleThr: 4.205 ± 0.091
4.481IleVal: 4.481 ± 0.087
0.637IleTrp: 0.637 ± 0.029
2.382IleTyr: 2.382 ± 0.06
0.0IleXaa: 0.0 ± 0.0
Lys
4.725LysAla: 4.725 ± 0.093
0.41LysCys: 0.41 ± 0.026
2.735LysAsp: 2.735 ± 0.068
4.069LysGlu: 4.069 ± 0.091
1.701LysPhe: 1.701 ± 0.062
3.178LysGly: 3.178 ± 0.075
1.42LysHis: 1.42 ± 0.046
4.563LysIle: 4.563 ± 0.096
5.03LysLys: 5.03 ± 0.113
5.965LysLeu: 5.965 ± 0.099
1.745LysMet: 1.745 ± 0.046
3.305LysAsn: 3.305 ± 0.072
2.661LysPro: 2.661 ± 0.063
3.173LysGln: 3.173 ± 0.079
3.159LysArg: 3.159 ± 0.067
3.624LysSer: 3.624 ± 0.082
3.646LysThr: 3.646 ± 0.081
3.218LysVal: 3.218 ± 0.071
0.616LysTrp: 0.616 ± 0.033
1.709LysTyr: 1.709 ± 0.05
0.0LysXaa: 0.0 ± 0.0
Leu
9.582LeuAla: 9.582 ± 0.133
1.181LeuCys: 1.181 ± 0.044
4.943LeuAsp: 4.943 ± 0.083
5.544LeuGlu: 5.544 ± 0.096
5.059LeuPhe: 5.059 ± 0.098
6.638LeuGly: 6.638 ± 0.096
2.462LeuHis: 2.462 ± 0.057
7.648LeuIle: 7.648 ± 0.107
6.076LeuLys: 6.076 ± 0.101
11.832LeuLeu: 11.832 ± 0.182
2.6LeuMet: 2.6 ± 0.06
4.634LeuAsn: 4.634 ± 0.081
5.35LeuPro: 5.35 ± 0.097
4.426LeuGln: 4.426 ± 0.084
5.262LeuArg: 5.262 ± 0.084
7.68LeuSer: 7.68 ± 0.121
5.87LeuThr: 5.87 ± 0.107
6.097LeuVal: 6.097 ± 0.108
1.091LeuTrp: 1.091 ± 0.039
3.075LeuTyr: 3.075 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.244MetAla: 2.244 ± 0.054
0.203MetCys: 0.203 ± 0.015
1.205MetAsp: 1.205 ± 0.045
1.36MetGlu: 1.36 ± 0.047
0.701MetPhe: 0.701 ± 0.028
1.546MetGly: 1.546 ± 0.053
0.623MetHis: 0.623 ± 0.03
1.689MetIle: 1.689 ± 0.052
1.61MetLys: 1.61 ± 0.051
2.821MetLeu: 2.821 ± 0.071
0.735MetMet: 0.735 ± 0.035
1.146MetAsn: 1.146 ± 0.043
1.319MetPro: 1.319 ± 0.039
1.38MetGln: 1.38 ± 0.043
1.449MetArg: 1.449 ± 0.044
1.474MetSer: 1.474 ± 0.044
1.635MetThr: 1.635 ± 0.046
1.486MetVal: 1.486 ± 0.04
0.186MetTrp: 0.186 ± 0.018
0.534MetTyr: 0.534 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.413AsnAla: 3.413 ± 0.074
0.407AsnCys: 0.407 ± 0.025
2.071AsnAsp: 2.071 ± 0.054
2.657AsnGlu: 2.657 ± 0.07
1.731AsnPhe: 1.731 ± 0.051
2.433AsnGly: 2.433 ± 0.075
1.095AsnHis: 1.095 ± 0.047
3.269AsnIle: 3.269 ± 0.064
2.78AsnLys: 2.78 ± 0.067
4.252AsnLeu: 4.252 ± 0.082
0.973AsnMet: 0.973 ± 0.035
2.081AsnAsn: 2.081 ± 0.065
2.45AsnPro: 2.45 ± 0.048
2.075AsnGln: 2.075 ± 0.06
2.121AsnArg: 2.121 ± 0.061
2.075AsnSer: 2.075 ± 0.062
2.311AsnThr: 2.311 ± 0.06
2.414AsnVal: 2.414 ± 0.055
0.581AsnTrp: 0.581 ± 0.028
1.532AsnTyr: 1.532 ± 0.053
0.0AsnXaa: 0.0 ± 0.0
Pro
3.829ProAla: 3.829 ± 0.079
0.37ProCys: 0.37 ± 0.022
2.649ProAsp: 2.649 ± 0.06
3.083ProGlu: 3.083 ± 0.062
1.977ProPhe: 1.977 ± 0.054
2.744ProGly: 2.744 ± 0.062
1.117ProHis: 1.117 ± 0.039
2.735ProIle: 2.735 ± 0.069
2.059ProLys: 2.059 ± 0.055
4.539ProLeu: 4.539 ± 0.078
0.878ProMet: 0.878 ± 0.033
1.65ProAsn: 1.65 ± 0.049
1.842ProPro: 1.842 ± 0.059
1.771ProGln: 1.771 ± 0.053
1.725ProArg: 1.725 ± 0.058
2.665ProSer: 2.665 ± 0.067
2.116ProThr: 2.116 ± 0.054
3.459ProVal: 3.459 ± 0.066
0.485ProTrp: 0.485 ± 0.029
1.594ProTyr: 1.594 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
4.03GlnAla: 4.03 ± 0.088
0.387GlnCys: 0.387 ± 0.024
1.897GlnAsp: 1.897 ± 0.049
2.462GlnGlu: 2.462 ± 0.055
1.896GlnPhe: 1.896 ± 0.053
2.534GlnGly: 2.534 ± 0.053
1.296GlnHis: 1.296 ± 0.042
2.784GlnIle: 2.784 ± 0.06
2.804GlnLys: 2.804 ± 0.069
4.956GlnLeu: 4.956 ± 0.093
0.959GlnMet: 0.959 ± 0.038
1.845GlnAsn: 1.845 ± 0.052
1.934GlnPro: 1.934 ± 0.058
2.584GlnGln: 2.584 ± 0.064
2.191GlnArg: 2.191 ± 0.059
2.546GlnSer: 2.546 ± 0.056
2.243GlnThr: 2.243 ± 0.051
2.546GlnVal: 2.546 ± 0.06
0.509GlnTrp: 0.509 ± 0.03
1.457GlnTyr: 1.457 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
3.508ArgAla: 3.508 ± 0.066
0.49ArgCys: 0.49 ± 0.03
2.385ArgAsp: 2.385 ± 0.063
3.409ArgGlu: 3.409 ± 0.075
2.336ArgPhe: 2.336 ± 0.052
2.609ArgGly: 2.609 ± 0.066
1.421ArgHis: 1.421 ± 0.044
3.658ArgIle: 3.658 ± 0.075
2.791ArgLys: 2.791 ± 0.064
5.588ArgLeu: 5.588 ± 0.089
1.324ArgMet: 1.324 ± 0.04
1.878ArgAsn: 1.878 ± 0.05
1.765ArgPro: 1.765 ± 0.048
2.379ArgGln: 2.379 ± 0.059
2.458ArgArg: 2.458 ± 0.065
2.625ArgSer: 2.625 ± 0.071
2.222ArgThr: 2.222 ± 0.052
2.84ArgVal: 2.84 ± 0.068
0.661ArgTrp: 0.661 ± 0.036
2.027ArgTyr: 2.027 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
4.992SerAla: 4.992 ± 0.082
0.648SerCys: 0.648 ± 0.033
2.88SerAsp: 2.88 ± 0.074
3.174SerGlu: 3.174 ± 0.075
2.812SerPhe: 2.812 ± 0.067
4.382SerGly: 4.382 ± 0.098
1.703SerHis: 1.703 ± 0.047
4.299SerIle: 4.299 ± 0.082
3.174SerLys: 3.174 ± 0.084
6.997SerLeu: 6.997 ± 0.119
1.578SerMet: 1.578 ± 0.041
2.381SerAsn: 2.381 ± 0.065
2.712SerPro: 2.712 ± 0.06
2.64SerGln: 2.64 ± 0.068
2.975SerArg: 2.975 ± 0.062
4.092SerSer: 4.092 ± 0.101
3.133SerThr: 3.133 ± 0.068
3.75SerVal: 3.75 ± 0.07
0.708SerTrp: 0.708 ± 0.036
2.023SerTyr: 2.023 ± 0.053
0.0SerXaa: 0.0 ± 0.0
Thr
4.563ThrAla: 4.563 ± 0.093
0.549ThrCys: 0.549 ± 0.031
2.441ThrAsp: 2.441 ± 0.053
2.857ThrGlu: 2.857 ± 0.058
2.176ThrPhe: 2.176 ± 0.062
3.976ThrGly: 3.976 ± 0.09
1.428ThrHis: 1.428 ± 0.037
3.858ThrIle: 3.858 ± 0.077
2.529ThrLys: 2.529 ± 0.063
6.362ThrLeu: 6.362 ± 0.112
1.178ThrMet: 1.178 ± 0.042
1.984ThrAsn: 1.984 ± 0.058
2.804ThrPro: 2.804 ± 0.067
2.338ThrGln: 2.338 ± 0.06
2.429ThrArg: 2.429 ± 0.06
3.237ThrSer: 3.237 ± 0.078
2.825ThrThr: 2.825 ± 0.085
3.444ThrVal: 3.444 ± 0.071
0.59ThrTrp: 0.59 ± 0.028
1.657ThrTyr: 1.657 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
5.189ValAla: 5.189 ± 0.085
0.699ValCys: 0.699 ± 0.032
3.012ValAsp: 3.012 ± 0.072
3.372ValGlu: 3.372 ± 0.077
2.724ValPhe: 2.724 ± 0.057
3.92ValGly: 3.92 ± 0.086
1.224ValHis: 1.224 ± 0.039
5.09ValIle: 5.09 ± 0.1
3.483ValLys: 3.483 ± 0.072
6.287ValLeu: 6.287 ± 0.112
1.789ValMet: 1.789 ± 0.044
2.743ValAsn: 2.743 ± 0.069
2.751ValPro: 2.751 ± 0.066
2.003ValGln: 2.003 ± 0.055
2.839ValArg: 2.839 ± 0.072
4.105ValSer: 4.105 ± 0.077
3.635ValThr: 3.635 ± 0.08
4.132ValVal: 4.132 ± 0.101
0.608ValTrp: 0.608 ± 0.029
1.91ValTyr: 1.91 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.681TrpAla: 0.681 ± 0.032
0.128TrpCys: 0.128 ± 0.013
0.576TrpAsp: 0.576 ± 0.029
0.604TrpGlu: 0.604 ± 0.03
0.548TrpPhe: 0.548 ± 0.027
0.704TrpGly: 0.704 ± 0.033
0.361TrpHis: 0.361 ± 0.021
0.838TrpIle: 0.838 ± 0.033
0.602TrpLys: 0.602 ± 0.036
1.582TrpLeu: 1.582 ± 0.052
0.357TrpMet: 0.357 ± 0.02
0.474TrpAsn: 0.474 ± 0.029
0.456TrpPro: 0.456 ± 0.027
0.739TrpGln: 0.739 ± 0.039
0.657TrpArg: 0.657 ± 0.03
0.627TrpSer: 0.627 ± 0.028
0.518TrpThr: 0.518 ± 0.028
0.708TrpVal: 0.708 ± 0.035
0.166TrpTrp: 0.166 ± 0.015
0.354TrpTyr: 0.354 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.815TyrAla: 2.815 ± 0.055
0.485TyrCys: 0.485 ± 0.024
1.606TyrAsp: 1.606 ± 0.049
1.738TyrGlu: 1.738 ± 0.05
1.791TyrPhe: 1.791 ± 0.052
2.295TyrGly: 2.295 ± 0.066
0.916TyrHis: 0.916 ± 0.041
2.009TyrIle: 2.009 ± 0.051
1.544TyrLys: 1.544 ± 0.05
4.04TyrLeu: 4.04 ± 0.078
0.653TyrMet: 0.653 ± 0.028
1.208TyrAsn: 1.208 ± 0.049
1.584TyrPro: 1.584 ± 0.048
1.866TyrGln: 1.866 ± 0.052
1.817TyrArg: 1.817 ± 0.054
2.035TyrSer: 2.035 ± 0.063
1.659TyrThr: 1.659 ± 0.048
1.942TyrVal: 1.942 ± 0.047
0.446TyrTrp: 0.446 ± 0.03
1.376TyrTyr: 1.376 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2370 proteins (748558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski