Amino acid dipepetide frequency for Apis mellifera associated microvirus 33

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.766AlaAla: 8.766 ± 4.936
0.0AlaCys: 0.0 ± 0.0
5.113AlaAsp: 5.113 ± 2.361
3.652AlaGlu: 3.652 ± 1.493
2.191AlaPhe: 2.191 ± 0.596
4.383AlaGly: 4.383 ± 1.971
3.652AlaHis: 3.652 ± 0.54
3.652AlaIle: 3.652 ± 1.461
5.844AlaLys: 5.844 ± 1.561
4.383AlaLeu: 4.383 ± 1.41
1.461AlaMet: 1.461 ± 0.522
6.574AlaAsn: 6.574 ± 1.621
2.922AlaPro: 2.922 ± 0.981
5.113AlaGln: 5.113 ± 1.565
5.844AlaArg: 5.844 ± 1.399
5.844AlaSer: 5.844 ± 0.863
7.305AlaThr: 7.305 ± 2.071
2.922AlaVal: 2.922 ± 1.763
1.461AlaTrp: 1.461 ± 0.882
2.922AlaTyr: 2.922 ± 1.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.461CysPhe: 1.461 ± 1.163
0.73CysGly: 0.73 ± 0.581
0.73CysHis: 0.73 ± 0.581
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.73CysLeu: 0.73 ± 0.581
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.73CysPro: 0.73 ± 0.74
0.0CysGln: 0.0 ± 0.0
0.73CysArg: 0.73 ± 0.581
0.0CysSer: 0.0 ± 0.0
0.73CysThr: 0.73 ± 0.581
0.73CysVal: 0.73 ± 0.581
0.0CysTrp: 0.0 ± 0.0
0.73CysTyr: 0.73 ± 0.581
0.0CysXaa: 0.0 ± 0.0
Asp
2.922AspAla: 2.922 ± 0.972
0.73AspCys: 0.73 ± 0.581
2.191AspAsp: 2.191 ± 0.871
4.383AspGlu: 4.383 ± 1.188
5.113AspPhe: 5.113 ± 1.607
2.191AspGly: 2.191 ± 1.323
0.73AspHis: 0.73 ± 0.826
0.73AspIle: 0.73 ± 0.441
2.191AspLys: 2.191 ± 1.06
8.766AspLeu: 8.766 ± 1.134
0.0AspMet: 0.0 ± 0.0
2.922AspAsn: 2.922 ± 1.069
2.922AspPro: 2.922 ± 1.247
2.191AspGln: 2.191 ± 1.414
0.73AspArg: 0.73 ± 0.441
2.922AspSer: 2.922 ± 1.247
2.922AspThr: 2.922 ± 1.763
2.922AspVal: 2.922 ± 1.247
0.73AspTrp: 0.73 ± 0.441
2.922AspTyr: 2.922 ± 1.412
0.0AspXaa: 0.0 ± 0.0
Glu
5.113GluAla: 5.113 ± 2.635
0.0GluCys: 0.0 ± 0.0
1.461GluAsp: 1.461 ± 0.993
2.191GluGlu: 2.191 ± 1.822
2.922GluPhe: 2.922 ± 1.033
1.461GluGly: 1.461 ± 0.879
1.461GluHis: 1.461 ± 0.522
7.305GluIle: 7.305 ± 2.337
5.844GluLys: 5.844 ± 3.134
5.844GluLeu: 5.844 ± 1.738
2.922GluMet: 2.922 ± 0.869
0.73GluAsn: 0.73 ± 0.441
0.73GluPro: 0.73 ± 0.74
4.383GluGln: 4.383 ± 2.761
2.922GluArg: 2.922 ± 3.304
2.191GluSer: 2.191 ± 1.073
0.73GluThr: 0.73 ± 0.74
2.922GluVal: 2.922 ± 0.97
0.73GluTrp: 0.73 ± 0.581
2.922GluTyr: 2.922 ± 1.143
0.0GluXaa: 0.0 ± 0.0
Phe
2.191PheAla: 2.191 ± 1.573
0.73PheCys: 0.73 ± 0.581
3.652PheAsp: 3.652 ± 1.502
1.461PheGlu: 1.461 ± 0.817
0.0PhePhe: 0.0 ± 0.0
2.922PheGly: 2.922 ± 0.981
0.0PheHis: 0.0 ± 0.0
1.461PheIle: 1.461 ± 0.817
5.113PheLys: 5.113 ± 2.728
5.113PheLeu: 5.113 ± 2.423
1.461PheMet: 1.461 ± 0.845
5.113PheAsn: 5.113 ± 2.574
0.73PhePro: 0.73 ± 0.441
2.191PheGln: 2.191 ± 0.596
4.383PheArg: 4.383 ± 1.565
2.922PheSer: 2.922 ± 1.143
3.652PheThr: 3.652 ± 1.027
2.191PheVal: 2.191 ± 0.771
0.0PheTrp: 0.0 ± 0.0
0.73PheTyr: 0.73 ± 0.797
0.0PheXaa: 0.0 ± 0.0
Gly
3.652GlyAla: 3.652 ± 1.461
0.0GlyCys: 0.0 ± 0.0
1.461GlyAsp: 1.461 ± 0.522
2.191GlyGlu: 2.191 ± 1.573
3.652GlyPhe: 3.652 ± 1.502
8.035GlyGly: 8.035 ± 4.346
2.191GlyHis: 2.191 ± 0.94
2.191GlyIle: 2.191 ± 0.888
7.305GlyLys: 7.305 ± 2.482
5.113GlyLeu: 5.113 ± 1.007
2.191GlyMet: 2.191 ± 1.49
1.461GlyAsn: 1.461 ± 0.879
3.652GlyPro: 3.652 ± 0.829
1.461GlyGln: 1.461 ± 0.725
1.461GlyArg: 1.461 ± 0.522
5.844GlySer: 5.844 ± 1.895
5.113GlyThr: 5.113 ± 1.841
2.191GlyVal: 2.191 ± 0.871
0.0GlyTrp: 0.0 ± 0.0
2.191GlyTyr: 2.191 ± 0.596
0.0GlyXaa: 0.0 ± 0.0
His
2.191HisAla: 2.191 ± 0.888
0.0HisCys: 0.0 ± 0.0
1.461HisAsp: 1.461 ± 0.741
1.461HisGlu: 1.461 ± 0.993
4.383HisPhe: 4.383 ± 1.328
2.922HisGly: 2.922 ± 1.043
0.0HisHis: 0.0 ± 0.0
0.73HisIle: 0.73 ± 0.441
1.461HisLys: 1.461 ± 0.817
3.652HisLeu: 3.652 ± 0.901
1.461HisMet: 1.461 ± 0.741
2.191HisAsn: 2.191 ± 0.596
0.73HisPro: 0.73 ± 0.797
0.73HisGln: 0.73 ± 0.826
0.0HisArg: 0.0 ± 0.0
2.922HisSer: 2.922 ± 0.972
0.0HisThr: 0.0 ± 0.0
2.922HisVal: 2.922 ± 0.733
0.0HisTrp: 0.0 ± 0.0
2.191HisTyr: 2.191 ± 1.744
0.0HisXaa: 0.0 ± 0.0
Ile
3.652IleAla: 3.652 ± 1.17
0.0IleCys: 0.0 ± 0.0
2.191IleAsp: 2.191 ± 1.709
2.191IleGlu: 2.191 ± 0.596
2.191IlePhe: 2.191 ± 1.418
5.113IleGly: 5.113 ± 1.565
0.73IleHis: 0.73 ± 0.441
2.191IleIle: 2.191 ± 1.577
2.922IleLys: 2.922 ± 2.132
2.191IleLeu: 2.191 ± 1.013
0.0IleMet: 0.0 ± 0.0
3.652IleAsn: 3.652 ± 1.205
2.922IlePro: 2.922 ± 1.567
1.461IleGln: 1.461 ± 0.522
0.73IleArg: 0.73 ± 0.441
3.652IleSer: 3.652 ± 1.54
1.461IleThr: 1.461 ± 0.882
2.922IleVal: 2.922 ± 1.55
0.73IleTrp: 0.73 ± 0.441
3.652IleTyr: 3.652 ± 1.205
0.0IleXaa: 0.0 ± 0.0
Lys
2.922LysAla: 2.922 ± 1.726
1.461LysCys: 1.461 ± 1.163
3.652LysAsp: 3.652 ± 1.927
5.113LysGlu: 5.113 ± 2.698
2.191LysPhe: 2.191 ± 1.21
2.922LysGly: 2.922 ± 0.572
5.113LysHis: 5.113 ± 1.538
2.922LysIle: 2.922 ± 1.247
8.035LysLys: 8.035 ± 3.408
2.922LysLeu: 2.922 ± 1.604
1.461LysMet: 1.461 ± 1.119
5.113LysAsn: 5.113 ± 1.845
1.461LysPro: 1.461 ± 1.007
5.113LysGln: 5.113 ± 1.989
4.383LysArg: 4.383 ± 2.026
2.922LysSer: 2.922 ± 0.717
5.113LysThr: 5.113 ± 2.717
2.191LysVal: 2.191 ± 1.738
0.0LysTrp: 0.0 ± 0.0
2.191LysTyr: 2.191 ± 0.596
0.0LysXaa: 0.0 ± 0.0
Leu
8.035LeuAla: 8.035 ± 2.175
0.73LeuCys: 0.73 ± 0.581
2.922LeuAsp: 2.922 ± 0.733
5.113LeuGlu: 5.113 ± 1.216
1.461LeuPhe: 1.461 ± 0.522
8.766LeuGly: 8.766 ± 2.527
1.461LeuHis: 1.461 ± 0.522
2.922LeuIle: 2.922 ± 0.869
5.113LeuLys: 5.113 ± 2.292
6.574LeuLeu: 6.574 ± 1.782
2.922LeuMet: 2.922 ± 0.984
4.383LeuAsn: 4.383 ± 1.985
5.113LeuPro: 5.113 ± 1.011
4.383LeuGln: 4.383 ± 1.199
7.305LeuArg: 7.305 ± 0.934
4.383LeuSer: 4.383 ± 1.197
10.226LeuThr: 10.226 ± 1.348
0.0LeuVal: 0.0 ± 0.0
0.0LeuTrp: 0.0 ± 0.0
6.574LeuTyr: 6.574 ± 2.249
0.0LeuXaa: 0.0 ± 0.0
Met
2.922MetAla: 2.922 ± 0.572
0.0MetCys: 0.0 ± 0.0
3.652MetAsp: 3.652 ± 2.388
1.461MetGlu: 1.461 ± 1.163
2.191MetPhe: 2.191 ± 2.391
0.73MetGly: 0.73 ± 0.74
0.73MetHis: 0.73 ± 0.797
1.461MetIle: 1.461 ± 0.741
2.191MetLys: 2.191 ± 1.709
0.73MetLeu: 0.73 ± 0.826
0.0MetMet: 0.0 ± 0.0
1.461MetAsn: 1.461 ± 0.725
0.73MetPro: 0.73 ± 0.826
1.461MetGln: 1.461 ± 1.652
1.461MetArg: 1.461 ± 0.882
2.922MetSer: 2.922 ± 1.342
0.73MetThr: 0.73 ± 0.441
1.461MetVal: 1.461 ± 0.725
0.0MetTrp: 0.0 ± 0.0
2.191MetTyr: 2.191 ± 1.013
0.0MetXaa: 0.0 ± 0.0
Asn
5.113AsnAla: 5.113 ± 1.399
1.461AsnCys: 1.461 ± 0.817
0.73AsnAsp: 0.73 ± 0.581
2.922AsnGlu: 2.922 ± 0.733
2.191AsnPhe: 2.191 ± 1.24
3.652AsnGly: 3.652 ± 1.702
0.73AsnHis: 0.73 ± 0.441
2.191AsnIle: 2.191 ± 1.323
5.113AsnLys: 5.113 ± 1.428
5.844AsnLeu: 5.844 ± 1.428
2.191AsnMet: 2.191 ± 1.697
4.383AsnAsn: 4.383 ± 1.222
3.652AsnPro: 3.652 ± 1.519
3.652AsnGln: 3.652 ± 0.831
3.652AsnArg: 3.652 ± 0.737
3.652AsnSer: 3.652 ± 2.148
2.191AsnThr: 2.191 ± 0.871
3.652AsnVal: 3.652 ± 2.136
0.73AsnTrp: 0.73 ± 0.441
4.383AsnTyr: 4.383 ± 1.4
0.0AsnXaa: 0.0 ± 0.0
Pro
2.922ProAla: 2.922 ± 1.069
0.0ProCys: 0.0 ± 0.0
4.383ProAsp: 4.383 ± 0.581
3.652ProGlu: 3.652 ± 1.493
2.191ProPhe: 2.191 ± 1.013
1.461ProGly: 1.461 ± 0.882
0.0ProHis: 0.0 ± 0.0
1.461ProIle: 1.461 ± 0.882
0.73ProLys: 0.73 ± 0.441
5.113ProLeu: 5.113 ± 1.078
2.191ProMet: 2.191 ± 1.369
2.922ProAsn: 2.922 ± 1.033
1.461ProPro: 1.461 ± 0.993
1.461ProGln: 1.461 ± 0.882
0.73ProArg: 0.73 ± 0.581
3.652ProSer: 3.652 ± 0.895
5.113ProThr: 5.113 ± 0.612
1.461ProVal: 1.461 ± 0.522
0.0ProTrp: 0.0 ± 0.0
1.461ProTyr: 1.461 ± 1.163
0.0ProXaa: 0.0 ± 0.0
Gln
5.113GlnAla: 5.113 ± 1.939
0.0GlnCys: 0.0 ± 0.0
2.922GlnAsp: 2.922 ± 1.033
5.844GlnGlu: 5.844 ± 2.032
2.922GlnPhe: 2.922 ± 1.31
1.461GlnGly: 1.461 ± 0.882
3.652GlnHis: 3.652 ± 0.901
2.922GlnIle: 2.922 ± 0.928
4.383GlnLys: 4.383 ± 1.41
2.922GlnLeu: 2.922 ± 0.717
1.461GlnMet: 1.461 ± 0.992
2.922GlnAsn: 2.922 ± 1.069
1.461GlnPro: 1.461 ± 0.882
2.922GlnGln: 2.922 ± 0.572
1.461GlnArg: 1.461 ± 0.725
2.922GlnSer: 2.922 ± 1.31
2.922GlnThr: 2.922 ± 1.763
1.461GlnVal: 1.461 ± 0.817
0.0GlnTrp: 0.0 ± 0.0
2.922GlnTyr: 2.922 ± 1.247
0.0GlnXaa: 0.0 ± 0.0
Arg
2.922ArgAla: 2.922 ± 1.45
1.461ArgCys: 1.461 ± 1.163
2.922ArgAsp: 2.922 ± 0.991
3.652ArgGlu: 3.652 ± 2.029
1.461ArgPhe: 1.461 ± 0.725
2.922ArgGly: 2.922 ± 1.143
2.191ArgHis: 2.191 ± 0.888
1.461ArgIle: 1.461 ± 0.879
2.191ArgLys: 2.191 ± 1.013
3.652ArgLeu: 3.652 ± 1.551
0.73ArgMet: 0.73 ± 0.826
2.922ArgAsn: 2.922 ± 0.572
2.922ArgPro: 2.922 ± 1.281
1.461ArgGln: 1.461 ± 0.522
2.191ArgArg: 2.191 ± 1.447
2.922ArgSer: 2.922 ± 1.174
3.652ArgThr: 3.652 ± 1.338
1.461ArgVal: 1.461 ± 0.882
2.922ArgTrp: 2.922 ± 1.567
2.922ArgTyr: 2.922 ± 1.143
0.0ArgXaa: 0.0 ± 0.0
Ser
10.226SerAla: 10.226 ± 2.117
0.0SerCys: 0.0 ± 0.0
2.922SerAsp: 2.922 ± 1.763
1.461SerGlu: 1.461 ± 0.817
0.73SerPhe: 0.73 ± 0.441
3.652SerGly: 3.652 ± 2.148
2.922SerHis: 2.922 ± 1.713
0.73SerIle: 0.73 ± 0.826
4.383SerLys: 4.383 ± 0.995
6.574SerLeu: 6.574 ± 1.354
2.191SerMet: 2.191 ± 0.596
6.574SerAsn: 6.574 ± 1.208
0.73SerPro: 0.73 ± 0.441
5.113SerGln: 5.113 ± 1.899
5.113SerArg: 5.113 ± 1.31
4.383SerSer: 4.383 ± 2.175
1.461SerThr: 1.461 ± 0.725
3.652SerVal: 3.652 ± 1.205
0.73SerTrp: 0.73 ± 0.441
2.922SerTyr: 2.922 ± 2.298
0.0SerXaa: 0.0 ± 0.0
Thr
5.844ThrAla: 5.844 ± 2.784
0.0ThrCys: 0.0 ± 0.0
2.191ThrAsp: 2.191 ± 0.639
2.191ThrGlu: 2.191 ± 0.871
2.922ThrPhe: 2.922 ± 1.412
3.652ThrGly: 3.652 ± 0.831
1.461ThrHis: 1.461 ± 0.882
5.113ThrIle: 5.113 ± 1.107
1.461ThrLys: 1.461 ± 1.163
7.305ThrLeu: 7.305 ± 1.59
2.191ThrMet: 2.191 ± 0.867
2.922ThrAsn: 2.922 ± 1.043
3.652ThrPro: 3.652 ± 0.737
3.652ThrGln: 3.652 ± 1.027
3.652ThrArg: 3.652 ± 1.493
7.305ThrSer: 7.305 ± 2.885
4.383ThrThr: 4.383 ± 2.828
2.922ThrVal: 2.922 ± 1.412
0.0ThrTrp: 0.0 ± 0.0
1.461ThrTyr: 1.461 ± 0.522
0.0ThrXaa: 0.0 ± 0.0
Val
4.383ValAla: 4.383 ± 1.672
0.0ValCys: 0.0 ± 0.0
2.191ValAsp: 2.191 ± 0.771
2.922ValGlu: 2.922 ± 1.482
1.461ValPhe: 1.461 ± 1.163
1.461ValGly: 1.461 ± 0.836
0.73ValHis: 0.73 ± 0.581
2.191ValIle: 2.191 ± 1.07
0.73ValLys: 0.73 ± 0.581
4.383ValLeu: 4.383 ± 0.82
0.73ValMet: 0.73 ± 0.826
2.922ValAsn: 2.922 ± 1.069
4.383ValPro: 4.383 ± 1.974
2.922ValGln: 2.922 ± 1.043
0.73ValArg: 0.73 ± 0.826
1.461ValSer: 1.461 ± 0.522
3.652ValThr: 3.652 ± 0.829
2.922ValVal: 2.922 ± 1.412
0.0ValTrp: 0.0 ± 0.0
2.191ValTyr: 2.191 ± 0.95
0.0ValXaa: 0.0 ± 0.0
Trp
0.73TrpAla: 0.73 ± 0.441
0.73TrpCys: 0.73 ± 0.581
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
1.461TrpPhe: 1.461 ± 0.882
0.73TrpGly: 0.73 ± 0.441
0.0TrpHis: 0.0 ± 0.0
0.73TrpIle: 0.73 ± 0.441
1.461TrpLys: 1.461 ± 0.522
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.73TrpAsn: 0.73 ± 0.441
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.73TrpSer: 0.73 ± 0.581
0.73TrpThr: 0.73 ± 0.441
0.73TrpVal: 0.73 ± 0.581
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.383TyrAla: 4.383 ± 1.741
0.0TyrCys: 0.0 ± 0.0
5.113TyrAsp: 5.113 ± 1.652
2.922TyrGlu: 2.922 ± 0.928
2.922TyrPhe: 2.922 ± 1.247
2.191TyrGly: 2.191 ± 1.603
2.922TyrHis: 2.922 ± 1.713
2.191TyrIle: 2.191 ± 1.073
0.73TyrLys: 0.73 ± 0.581
6.574TyrLeu: 6.574 ± 1.887
2.191TyrMet: 2.191 ± 0.771
2.191TyrAsn: 2.191 ± 0.596
1.461TyrPro: 1.461 ± 0.882
3.652TyrGln: 3.652 ± 1.25
1.461TyrArg: 1.461 ± 0.882
2.922TyrSer: 2.922 ± 1.043
2.191TyrThr: 2.191 ± 1.744
0.73TyrVal: 0.73 ± 0.441
0.73TyrTrp: 0.73 ± 0.441
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski