Amino acid dipepetide frequency for Cellulomonas composti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.263AlaAla: 23.263 ± 0.268
0.903AlaCys: 0.903 ± 0.031
9.293AlaAsp: 9.293 ± 0.114
6.968AlaGlu: 6.968 ± 0.104
3.502AlaPhe: 3.502 ± 0.069
13.657AlaGly: 13.657 ± 0.136
2.765AlaHis: 2.765 ± 0.064
4.317AlaIle: 4.317 ± 0.082
2.108AlaLys: 2.108 ± 0.071
14.973AlaLeu: 14.973 ± 0.172
2.478AlaMet: 2.478 ± 0.044
2.008AlaAsn: 2.008 ± 0.053
7.877AlaPro: 7.877 ± 0.134
4.328AlaGln: 4.328 ± 0.075
11.063AlaArg: 11.063 ± 0.139
6.752AlaSer: 6.752 ± 0.092
9.037AlaThr: 9.037 ± 0.116
13.286AlaVal: 13.286 ± 0.137
2.161AlaTrp: 2.161 ± 0.051
2.49AlaTyr: 2.49 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.808CysAla: 0.808 ± 0.031
0.066CysCys: 0.066 ± 0.008
0.376CysAsp: 0.376 ± 0.019
0.314CysGlu: 0.314 ± 0.021
0.171CysPhe: 0.171 ± 0.014
0.685CysGly: 0.685 ± 0.024
0.141CysHis: 0.141 ± 0.014
0.15CysIle: 0.15 ± 0.013
0.07CysLys: 0.07 ± 0.009
0.512CysLeu: 0.512 ± 0.023
0.078CysMet: 0.078 ± 0.007
0.108CysAsn: 0.108 ± 0.01
0.388CysPro: 0.388 ± 0.022
0.123CysGln: 0.123 ± 0.011
0.357CysArg: 0.357 ± 0.02
0.349CysSer: 0.349 ± 0.018
0.431CysThr: 0.431 ± 0.025
0.516CysVal: 0.516 ± 0.027
0.089CysTrp: 0.089 ± 0.009
0.108CysTyr: 0.108 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
9.523AspAla: 9.523 ± 0.122
0.285AspCys: 0.285 ± 0.017
5.65AspAsp: 5.65 ± 0.102
6.067AspGlu: 6.067 ± 0.097
1.382AspPhe: 1.382 ± 0.038
6.948AspGly: 6.948 ± 0.103
1.189AspHis: 1.189 ± 0.03
1.454AspIle: 1.454 ± 0.045
0.849AspLys: 0.849 ± 0.034
7.147AspLeu: 7.147 ± 0.091
0.673AspMet: 0.673 ± 0.022
0.748AspAsn: 0.748 ± 0.03
4.785AspPro: 4.785 ± 0.081
1.446AspGln: 1.446 ± 0.037
4.472AspArg: 4.472 ± 0.085
2.248AspSer: 2.248 ± 0.052
2.779AspThr: 2.779 ± 0.063
7.053AspVal: 7.053 ± 0.083
0.936AspTrp: 0.936 ± 0.028
1.017AspTyr: 1.017 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
6.704GluAla: 6.704 ± 0.115
0.281GluCys: 0.281 ± 0.016
2.598GluAsp: 2.598 ± 0.052
2.101GluGlu: 2.101 ± 0.055
1.232GluPhe: 1.232 ± 0.041
3.731GluGly: 3.731 ± 0.072
1.728GluHis: 1.728 ± 0.047
2.04GluIle: 2.04 ± 0.056
0.885GluLys: 0.885 ± 0.038
6.417GluLeu: 6.417 ± 0.092
0.71GluMet: 0.71 ± 0.023
0.859GluAsn: 0.859 ± 0.03
3.797GluPro: 3.797 ± 0.095
2.305GluGln: 2.305 ± 0.052
5.246GluArg: 5.246 ± 0.088
2.466GluSer: 2.466 ± 0.059
2.608GluThr: 2.608 ± 0.057
4.987GluVal: 4.987 ± 0.073
0.612GluTrp: 0.612 ± 0.023
0.953GluTyr: 0.953 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.531PheAla: 3.531 ± 0.06
0.175PheCys: 0.175 ± 0.012
1.954PheAsp: 1.954 ± 0.044
1.437PheGlu: 1.437 ± 0.04
0.739PhePhe: 0.739 ± 0.03
2.697PheGly: 2.697 ± 0.057
0.492PheHis: 0.492 ± 0.02
0.596PheIle: 0.596 ± 0.028
0.354PheLys: 0.354 ± 0.02
2.185PheLeu: 2.185 ± 0.046
0.321PheMet: 0.321 ± 0.016
0.402PheAsn: 0.402 ± 0.02
1.183PhePro: 1.183 ± 0.035
0.587PheGln: 0.587 ± 0.026
1.509PheArg: 1.509 ± 0.037
1.283PheSer: 1.283 ± 0.04
1.759PheThr: 1.759 ± 0.048
2.934PheVal: 2.934 ± 0.059
0.43PheTrp: 0.43 ± 0.023
0.523PheTyr: 0.523 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
12.11GlyAla: 12.11 ± 0.126
0.592GlyCys: 0.592 ± 0.023
5.422GlyAsp: 5.422 ± 0.086
4.565GlyGlu: 4.565 ± 0.076
2.598GlyPhe: 2.598 ± 0.055
8.072GlyGly: 8.072 ± 0.109
1.957GlyHis: 1.957 ± 0.043
3.256GlyIle: 3.256 ± 0.062
1.796GlyLys: 1.796 ± 0.053
9.376GlyLeu: 9.376 ± 0.124
1.675GlyMet: 1.675 ± 0.039
1.441GlyAsn: 1.441 ± 0.056
5.018GlyPro: 5.018 ± 0.076
2.351GlyGln: 2.351 ± 0.044
7.178GlyArg: 7.178 ± 0.106
5.486GlySer: 5.486 ± 0.094
6.79GlyThr: 6.79 ± 0.121
8.83GlyVal: 8.83 ± 0.111
1.779GlyTrp: 1.779 ± 0.043
2.053GlyTyr: 2.053 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
2.771HisAla: 2.771 ± 0.061
0.122HisCys: 0.122 ± 0.01
1.503HisAsp: 1.503 ± 0.04
1.181HisGlu: 1.181 ± 0.035
0.423HisPhe: 0.423 ± 0.019
2.096HisGly: 2.096 ± 0.045
0.598HisHis: 0.598 ± 0.028
0.426HisIle: 0.426 ± 0.02
0.232HisLys: 0.232 ± 0.015
2.34HisLeu: 2.34 ± 0.051
0.236HisMet: 0.236 ± 0.015
0.296HisAsn: 0.296 ± 0.016
1.496HisPro: 1.496 ± 0.038
0.492HisGln: 0.492 ± 0.019
1.728HisArg: 1.728 ± 0.041
0.75HisSer: 0.75 ± 0.027
1.045HisThr: 1.045 ± 0.032
2.203HisVal: 2.203 ± 0.053
0.301HisTrp: 0.301 ± 0.017
0.374HisTyr: 0.374 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.763IleAla: 4.763 ± 0.085
0.191IleCys: 0.191 ± 0.015
2.512IleAsp: 2.512 ± 0.052
1.947IleGlu: 1.947 ± 0.049
0.679IlePhe: 0.679 ± 0.03
3.411IleGly: 3.411 ± 0.074
0.43IleHis: 0.43 ± 0.021
0.762IleIle: 0.762 ± 0.032
0.557IleLys: 0.557 ± 0.031
2.171IleLeu: 2.171 ± 0.055
0.379IleMet: 0.379 ± 0.021
0.531IleAsn: 0.531 ± 0.024
1.579IlePro: 1.579 ± 0.039
0.629IleGln: 0.629 ± 0.026
1.764IleArg: 1.764 ± 0.049
1.524IleSer: 1.524 ± 0.044
2.013IleThr: 2.013 ± 0.046
3.166IleVal: 3.166 ± 0.067
0.344IleTrp: 0.344 ± 0.02
0.473IleTyr: 0.473 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
1.962LysAla: 1.962 ± 0.064
0.072LysCys: 0.072 ± 0.009
0.914LysAsp: 0.914 ± 0.037
0.706LysGlu: 0.706 ± 0.033
0.357LysPhe: 0.357 ± 0.02
1.276LysGly: 1.276 ± 0.042
0.336LysHis: 0.336 ± 0.018
0.628LysIle: 0.628 ± 0.032
0.456LysLys: 0.456 ± 0.029
1.386LysLeu: 1.386 ± 0.045
0.205LysMet: 0.205 ± 0.014
0.355LysAsn: 0.355 ± 0.022
0.884LysPro: 0.884 ± 0.036
0.445LysGln: 0.445 ± 0.021
1.055LysArg: 1.055 ± 0.037
0.843LysSer: 0.843 ± 0.034
0.882LysThr: 0.882 ± 0.033
1.612LysVal: 1.612 ± 0.052
0.167LysTrp: 0.167 ± 0.013
0.346LysTyr: 0.346 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
16.152LeuAla: 16.152 ± 0.188
0.555LeuCys: 0.555 ± 0.024
7.42LeuAsp: 7.42 ± 0.101
5.117LeuGlu: 5.117 ± 0.086
2.189LeuPhe: 2.189 ± 0.053
9.284LeuGly: 9.284 ± 0.113
1.986LeuHis: 1.986 ± 0.05
2.307LeuIle: 2.307 ± 0.061
1.245LeuLys: 1.245 ± 0.044
10.18LeuLeu: 10.18 ± 0.161
1.307LeuMet: 1.307 ± 0.037
1.243LeuAsn: 1.243 ± 0.039
5.958LeuPro: 5.958 ± 0.074
2.234LeuGln: 2.234 ± 0.044
8.018LeuArg: 8.018 ± 0.109
4.612LeuSer: 4.612 ± 0.069
6.788LeuThr: 6.788 ± 0.102
12.221LeuVal: 12.221 ± 0.169
1.268LeuTrp: 1.268 ± 0.043
1.443LeuTyr: 1.443 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
1.864MetAla: 1.864 ± 0.049
0.099MetCys: 0.099 ± 0.009
0.692MetAsp: 0.692 ± 0.026
0.461MetGlu: 0.461 ± 0.022
0.437MetPhe: 0.437 ± 0.022
1.101MetGly: 1.101 ± 0.034
0.329MetHis: 0.329 ± 0.018
0.536MetIle: 0.536 ± 0.023
0.233MetLys: 0.233 ± 0.016
1.578MetLeu: 1.578 ± 0.039
0.176MetMet: 0.176 ± 0.015
0.295MetAsn: 0.295 ± 0.016
1.011MetPro: 1.011 ± 0.026
0.384MetGln: 0.384 ± 0.018
1.263MetArg: 1.263 ± 0.037
1.345MetSer: 1.345 ± 0.031
1.564MetThr: 1.564 ± 0.039
1.216MetVal: 1.216 ± 0.035
0.167MetTrp: 0.167 ± 0.014
0.213MetTyr: 0.213 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
1.972AsnAla: 1.972 ± 0.06
0.111AsnCys: 0.111 ± 0.01
0.959AsnAsp: 0.959 ± 0.039
0.661AsnGlu: 0.661 ± 0.029
0.438AsnPhe: 0.438 ± 0.023
1.58AsnGly: 1.58 ± 0.052
0.338AsnHis: 0.338 ± 0.019
0.493AsnIle: 0.493 ± 0.021
0.284AsnLys: 0.284 ± 0.017
1.59AsnLeu: 1.59 ± 0.041
0.226AsnMet: 0.226 ± 0.013
0.351AsnAsn: 0.351 ± 0.023
1.275AsnPro: 1.275 ± 0.039
0.428AsnGln: 0.428 ± 0.022
1.027AsnArg: 1.027 ± 0.035
0.663AsnSer: 0.663 ± 0.032
0.849AsnThr: 0.849 ± 0.038
1.425AsnVal: 1.425 ± 0.044
0.233AsnTrp: 0.233 ± 0.014
0.335AsnTyr: 0.335 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
9.07ProAla: 9.07 ± 0.121
0.239ProCys: 0.239 ± 0.015
5.145ProAsp: 5.145 ± 0.082
3.236ProGlu: 3.236 ± 0.059
1.481ProPhe: 1.481 ± 0.037
6.102ProGly: 6.102 ± 0.077
1.206ProHis: 1.206 ± 0.034
1.396ProIle: 1.396 ± 0.038
0.737ProLys: 0.737 ± 0.035
4.868ProLeu: 4.868 ± 0.072
0.914ProMet: 0.914 ± 0.034
0.804ProAsn: 0.804 ± 0.029
3.193ProPro: 3.193 ± 0.081
1.603ProGln: 1.603 ± 0.045
3.854ProArg: 3.854 ± 0.077
3.326ProSer: 3.326 ± 0.063
4.58ProThr: 4.58 ± 0.112
5.995ProVal: 5.995 ± 0.084
0.972ProTrp: 0.972 ± 0.034
1.053ProTyr: 1.053 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.568GlnAla: 3.568 ± 0.064
0.132GlnCys: 0.132 ± 0.01
1.55GlnAsp: 1.55 ± 0.039
1.22GlnGlu: 1.22 ± 0.036
0.709GlnPhe: 0.709 ± 0.025
2.019GlnGly: 2.019 ± 0.047
0.626GlnHis: 0.626 ± 0.024
1.072GlnIle: 1.072 ± 0.034
0.373GlnLys: 0.373 ± 0.021
2.667GlnLeu: 2.667 ± 0.057
0.418GlnMet: 0.418 ± 0.019
0.411GlnAsn: 0.411 ± 0.021
1.578GlnPro: 1.578 ± 0.051
0.992GlnGln: 0.992 ± 0.038
2.394GlnArg: 2.394 ± 0.051
1.219GlnSer: 1.219 ± 0.037
1.397GlnThr: 1.397 ± 0.042
3.208GlnVal: 3.208 ± 0.054
0.495GlnTrp: 0.495 ± 0.023
0.607GlnTyr: 0.607 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
10.66ArgAla: 10.66 ± 0.135
0.44ArgCys: 0.44 ± 0.021
4.406ArgAsp: 4.406 ± 0.074
4.231ArgGlu: 4.231 ± 0.078
2.012ArgPhe: 2.012 ± 0.046
5.705ArgGly: 5.705 ± 0.083
1.689ArgHis: 1.689 ± 0.045
2.69ArgIle: 2.69 ± 0.05
1.077ArgLys: 1.077 ± 0.036
8.223ArgLeu: 8.223 ± 0.111
1.453ArgMet: 1.453 ± 0.039
1.088ArgAsn: 1.088 ± 0.032
4.421ArgPro: 4.421 ± 0.071
1.892ArgGln: 1.892 ± 0.047
7.792ArgArg: 7.792 ± 0.137
4.062ArgSer: 4.062 ± 0.063
5.381ArgThr: 5.381 ± 0.078
6.855ArgVal: 6.855 ± 0.084
1.514ArgTrp: 1.514 ± 0.043
1.608ArgTyr: 1.608 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
6.888SerAla: 6.888 ± 0.093
0.326SerCys: 0.326 ± 0.02
3.358SerAsp: 3.358 ± 0.062
2.127SerGlu: 2.127 ± 0.048
1.496SerPhe: 1.496 ± 0.04
5.678SerGly: 5.678 ± 0.086
0.879SerHis: 0.879 ± 0.03
1.676SerIle: 1.676 ± 0.044
0.72SerLys: 0.72 ± 0.029
4.546SerLeu: 4.546 ± 0.078
1.002SerMet: 1.002 ± 0.033
0.878SerAsn: 0.878 ± 0.039
2.904SerPro: 2.904 ± 0.055
1.23SerGln: 1.23 ± 0.035
3.484SerArg: 3.484 ± 0.054
3.606SerSer: 3.606 ± 0.07
3.842SerThr: 3.842 ± 0.082
4.506SerVal: 4.506 ± 0.071
0.967SerTrp: 0.967 ± 0.031
1.075SerTyr: 1.075 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
8.711ThrAla: 8.711 ± 0.117
0.418ThrCys: 0.418 ± 0.029
3.819ThrAsp: 3.819 ± 0.078
2.615ThrGlu: 2.615 ± 0.061
1.984ThrPhe: 1.984 ± 0.05
6.601ThrGly: 6.601 ± 0.093
1.185ThrHis: 1.185 ± 0.036
2.366ThrIle: 2.366 ± 0.061
1.056ThrLys: 1.056 ± 0.036
6.314ThrLeu: 6.314 ± 0.095
0.931ThrMet: 0.931 ± 0.03
1.194ThrAsn: 1.194 ± 0.047
4.552ThrPro: 4.552 ± 0.091
1.658ThrGln: 1.658 ± 0.042
4.091ThrArg: 4.091 ± 0.074
4.017ThrSer: 4.017 ± 0.085
5.117ThrThr: 5.117 ± 0.104
6.662ThrVal: 6.662 ± 0.126
1.165ThrTrp: 1.165 ± 0.033
1.449ThrTyr: 1.449 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
14.794ValAla: 14.794 ± 0.149
0.568ValCys: 0.568 ± 0.023
6.819ValAsp: 6.819 ± 0.082
5.67ValGlu: 5.67 ± 0.086
2.197ValPhe: 2.197 ± 0.051
8.734ValGly: 8.734 ± 0.121
2.068ValHis: 2.068 ± 0.04
2.76ValIle: 2.76 ± 0.065
1.356ValLys: 1.356 ± 0.048
11.333ValLeu: 11.333 ± 0.156
1.346ValMet: 1.346 ± 0.04
1.541ValAsn: 1.541 ± 0.04
6.066ValPro: 6.066 ± 0.081
2.422ValGln: 2.422 ± 0.051
7.956ValArg: 7.956 ± 0.11
4.659ValSer: 4.659 ± 0.061
6.806ValThr: 6.806 ± 0.128
12.916ValVal: 12.916 ± 0.158
1.292ValTrp: 1.292 ± 0.038
1.513ValTyr: 1.513 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.756TrpAla: 1.756 ± 0.045
0.133TrpCys: 0.133 ± 0.012
0.917TrpAsp: 0.917 ± 0.032
0.613TrpGlu: 0.613 ± 0.023
0.549TrpPhe: 0.549 ± 0.022
1.126TrpGly: 1.126 ± 0.036
0.338TrpHis: 0.338 ± 0.018
0.498TrpIle: 0.498 ± 0.024
0.226TrpLys: 0.226 ± 0.014
1.72TrpLeu: 1.72 ± 0.046
0.251TrpMet: 0.251 ± 0.015
0.361TrpAsn: 0.361 ± 0.021
0.784TrpPro: 0.784 ± 0.024
0.574TrpGln: 0.574 ± 0.024
1.389TrpArg: 1.389 ± 0.038
1.093TrpSer: 1.093 ± 0.04
1.16TrpThr: 1.16 ± 0.036
1.393TrpVal: 1.393 ± 0.037
0.437TrpTrp: 0.437 ± 0.023
0.32TrpTyr: 0.32 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.36TyrAla: 2.36 ± 0.053
0.133TyrCys: 0.133 ± 0.011
1.345TyrAsp: 1.345 ± 0.042
1.024TyrGlu: 1.024 ± 0.034
0.517TyrPhe: 0.517 ± 0.021
1.841TyrGly: 1.841 ± 0.042
0.332TyrHis: 0.332 ± 0.016
0.402TyrIle: 0.402 ± 0.02
0.273TyrLys: 0.273 ± 0.017
2.002TyrLeu: 2.002 ± 0.046
0.182TyrMet: 0.182 ± 0.012
0.324TyrAsn: 0.324 ± 0.019
1.025TyrPro: 1.025 ± 0.036
0.531TyrGln: 0.531 ± 0.027
1.556TyrArg: 1.556 ± 0.042
0.887TyrSer: 0.887 ± 0.035
1.075TyrThr: 1.075 ± 0.042
1.833TyrVal: 1.833 ± 0.045
0.311TyrTrp: 0.311 ± 0.018
0.395TyrTyr: 0.395 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3111 proteins (1071251 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski