Amino acid dipepetide frequency for Yersinia phage JC221

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.259AlaAla: 4.259 ± 0.339
0.71AlaCys: 0.71 ± 0.105
4.132AlaAsp: 4.132 ± 0.29
4.587AlaGlu: 4.587 ± 0.302
2.53AlaPhe: 2.53 ± 0.211
4.223AlaGly: 4.223 ± 0.322
1.019AlaHis: 1.019 ± 0.162
4.787AlaIle: 4.787 ± 0.299
5.46AlaLys: 5.46 ± 0.347
5.57AlaLeu: 5.57 ± 0.388
1.984AlaMet: 1.984 ± 0.217
4.022AlaAsn: 4.022 ± 0.314
2.13AlaPro: 2.13 ± 0.225
1.766AlaGln: 1.766 ± 0.19
2.93AlaArg: 2.93 ± 0.249
3.95AlaSer: 3.95 ± 0.296
4.186AlaThr: 4.186 ± 0.484
4.787AlaVal: 4.787 ± 0.254
0.783AlaTrp: 0.783 ± 0.138
2.767AlaTyr: 2.767 ± 0.263
0.0AlaXaa: 0.0 ± 0.0
Cys
0.874CysAla: 0.874 ± 0.123
0.073CysCys: 0.073 ± 0.033
0.764CysAsp: 0.764 ± 0.121
0.91CysGlu: 0.91 ± 0.133
0.528CysPhe: 0.528 ± 0.102
0.746CysGly: 0.746 ± 0.119
0.291CysHis: 0.291 ± 0.069
0.801CysIle: 0.801 ± 0.121
1.074CysLys: 1.074 ± 0.147
0.819CysLeu: 0.819 ± 0.156
0.255CysMet: 0.255 ± 0.063
0.728CysAsn: 0.728 ± 0.131
0.491CysPro: 0.491 ± 0.105
0.291CysGln: 0.291 ± 0.073
0.51CysArg: 0.51 ± 0.076
1.056CysSer: 1.056 ± 0.153
0.51CysThr: 0.51 ± 0.094
0.855CysVal: 0.855 ± 0.142
0.109CysTrp: 0.109 ± 0.044
0.4CysTyr: 0.4 ± 0.091
0.0CysXaa: 0.0 ± 0.0
Asp
4.605AspAla: 4.605 ± 0.26
0.673AspCys: 0.673 ± 0.125
3.622AspAsp: 3.622 ± 0.251
4.459AspGlu: 4.459 ± 0.284
3.495AspPhe: 3.495 ± 0.264
4.077AspGly: 4.077 ± 0.292
1.019AspHis: 1.019 ± 0.155
5.042AspIle: 5.042 ± 0.331
4.059AspLys: 4.059 ± 0.287
5.661AspLeu: 5.661 ± 0.404
1.638AspMet: 1.638 ± 0.169
3.95AspAsn: 3.95 ± 0.295
2.421AspPro: 2.421 ± 0.21
1.747AspGln: 1.747 ± 0.182
2.712AspArg: 2.712 ± 0.216
4.022AspSer: 4.022 ± 0.223
3.458AspThr: 3.458 ± 0.264
4.332AspVal: 4.332 ± 0.31
1.056AspTrp: 1.056 ± 0.165
3.604AspTyr: 3.604 ± 0.272
0.0AspXaa: 0.0 ± 0.0
Glu
4.459GluAla: 4.459 ± 0.353
1.037GluCys: 1.037 ± 0.163
3.531GluAsp: 3.531 ± 0.245
4.787GluGlu: 4.787 ± 0.365
3.131GluPhe: 3.131 ± 0.212
3.222GluGly: 3.222 ± 0.214
1.292GluHis: 1.292 ± 0.152
5.351GluIle: 5.351 ± 0.335
5.533GluLys: 5.533 ± 0.378
6.243GluLeu: 6.243 ± 0.334
2.621GluMet: 2.621 ± 0.234
3.768GluAsn: 3.768 ± 0.205
1.747GluPro: 1.747 ± 0.171
2.439GluGln: 2.439 ± 0.208
2.912GluArg: 2.912 ± 0.224
4.314GluSer: 4.314 ± 0.287
4.205GluThr: 4.205 ± 0.284
4.259GluVal: 4.259 ± 0.34
1.256GluTrp: 1.256 ± 0.127
3.167GluTyr: 3.167 ± 0.289
0.0GluXaa: 0.0 ± 0.0
Phe
2.475PheAla: 2.475 ± 0.229
0.564PheCys: 0.564 ± 0.103
3.531PheAsp: 3.531 ± 0.305
3.076PheGlu: 3.076 ± 0.261
1.493PhePhe: 1.493 ± 0.177
3.076PheGly: 3.076 ± 0.265
0.71PheHis: 0.71 ± 0.104
3.021PheIle: 3.021 ± 0.255
3.385PheLys: 3.385 ± 0.269
2.748PheLeu: 2.748 ± 0.193
1.547PheMet: 1.547 ± 0.157
2.439PheAsn: 2.439 ± 0.184
1.511PhePro: 1.511 ± 0.19
1.256PheGln: 1.256 ± 0.161
1.857PheArg: 1.857 ± 0.174
2.839PheSer: 2.839 ± 0.269
2.494PheThr: 2.494 ± 0.214
2.439PheVal: 2.439 ± 0.223
0.582PheTrp: 0.582 ± 0.097
1.729PheTyr: 1.729 ± 0.183
0.0PheXaa: 0.0 ± 0.0
Gly
3.768GlyAla: 3.768 ± 0.383
0.892GlyCys: 0.892 ± 0.123
4.405GlyAsp: 4.405 ± 0.329
3.913GlyGlu: 3.913 ± 0.315
3.131GlyPhe: 3.131 ± 0.259
3.95GlyGly: 3.95 ± 0.428
0.965GlyHis: 0.965 ± 0.126
4.114GlyIle: 4.114 ± 0.253
4.66GlyLys: 4.66 ± 0.231
4.423GlyLeu: 4.423 ± 0.308
1.857GlyMet: 1.857 ± 0.195
3.604GlyAsn: 3.604 ± 0.313
0.983GlyPro: 0.983 ± 0.111
1.438GlyGln: 1.438 ± 0.166
2.839GlyArg: 2.839 ± 0.267
4.241GlySer: 4.241 ± 0.312
3.476GlyThr: 3.476 ± 0.432
4.441GlyVal: 4.441 ± 0.308
0.855GlyTrp: 0.855 ± 0.137
3.313GlyTyr: 3.313 ± 0.226
0.0GlyXaa: 0.0 ± 0.0
His
1.165HisAla: 1.165 ± 0.146
0.328HisCys: 0.328 ± 0.086
1.219HisAsp: 1.219 ± 0.157
1.274HisGlu: 1.274 ± 0.147
0.819HisPhe: 0.819 ± 0.113
1.019HisGly: 1.019 ± 0.15
0.346HisHis: 0.346 ± 0.077
1.347HisIle: 1.347 ± 0.163
1.256HisLys: 1.256 ± 0.143
1.565HisLeu: 1.565 ± 0.162
0.4HisMet: 0.4 ± 0.079
0.983HisAsn: 0.983 ± 0.126
0.874HisPro: 0.874 ± 0.12
0.673HisGln: 0.673 ± 0.102
0.746HisArg: 0.746 ± 0.096
0.892HisSer: 0.892 ± 0.13
0.728HisThr: 0.728 ± 0.113
1.256HisVal: 1.256 ± 0.145
0.346HisTrp: 0.346 ± 0.07
0.728HisTyr: 0.728 ± 0.119
0.0HisXaa: 0.0 ± 0.0
Ile
4.714IleAla: 4.714 ± 0.363
0.801IleCys: 0.801 ± 0.116
5.424IleAsp: 5.424 ± 0.322
4.987IleGlu: 4.987 ± 0.277
2.621IlePhe: 2.621 ± 0.191
3.695IleGly: 3.695 ± 0.293
1.128IleHis: 1.128 ± 0.142
4.022IleIle: 4.022 ± 0.309
5.588IleLys: 5.588 ± 0.317
4.66IleLeu: 4.66 ± 0.296
1.838IleMet: 1.838 ± 0.19
3.968IleAsn: 3.968 ± 0.272
3.149IlePro: 3.149 ± 0.236
2.239IleGln: 2.239 ± 0.176
4.114IleArg: 4.114 ± 0.275
4.168IleSer: 4.168 ± 0.277
4.387IleThr: 4.387 ± 0.27
4.35IleVal: 4.35 ± 0.321
0.619IleTrp: 0.619 ± 0.091
2.512IleTyr: 2.512 ± 0.227
0.0IleXaa: 0.0 ± 0.0
Lys
5.57LysAla: 5.57 ± 0.3
0.728LysCys: 0.728 ± 0.12
4.35LysAsp: 4.35 ± 0.331
5.606LysGlu: 5.606 ± 0.408
3.331LysPhe: 3.331 ± 0.244
4.077LysGly: 4.077 ± 0.322
1.729LysHis: 1.729 ± 0.214
4.478LysIle: 4.478 ± 0.26
5.46LysLys: 5.46 ± 0.373
6.079LysLeu: 6.079 ± 0.413
2.257LysMet: 2.257 ± 0.19
4.041LysAsn: 4.041 ± 0.234
2.73LysPro: 2.73 ± 0.223
3.094LysGln: 3.094 ± 0.222
3.367LysArg: 3.367 ± 0.308
4.223LysSer: 4.223 ± 0.258
4.605LysThr: 4.605 ± 0.325
5.133LysVal: 5.133 ± 0.313
1.056LysTrp: 1.056 ± 0.109
3.349LysTyr: 3.349 ± 0.284
0.0LysXaa: 0.0 ± 0.0
Leu
4.896LeuAla: 4.896 ± 0.362
1.11LeuCys: 1.11 ± 0.139
4.66LeuAsp: 4.66 ± 0.343
5.369LeuGlu: 5.369 ± 0.368
2.967LeuPhe: 2.967 ± 0.224
3.95LeuGly: 3.95 ± 0.28
1.474LeuHis: 1.474 ± 0.173
5.26LeuIle: 5.26 ± 0.332
6.243LeuLys: 6.243 ± 0.331
4.205LeuLeu: 4.205 ± 0.292
2.239LeuMet: 2.239 ± 0.233
4.66LeuAsn: 4.66 ± 0.296
3.349LeuPro: 3.349 ± 0.242
2.293LeuGln: 2.293 ± 0.217
3.877LeuArg: 3.877 ± 0.257
4.842LeuSer: 4.842 ± 0.328
4.623LeuThr: 4.623 ± 0.369
4.277LeuVal: 4.277 ± 0.292
0.874LeuTrp: 0.874 ± 0.13
3.058LeuTyr: 3.058 ± 0.256
0.0LeuXaa: 0.0 ± 0.0
Met
2.075MetAla: 2.075 ± 0.199
0.273MetCys: 0.273 ± 0.078
1.893MetAsp: 1.893 ± 0.204
1.948MetGlu: 1.948 ± 0.211
1.347MetPhe: 1.347 ± 0.141
1.365MetGly: 1.365 ± 0.147
0.437MetHis: 0.437 ± 0.088
2.13MetIle: 2.13 ± 0.169
2.657MetLys: 2.657 ± 0.21
1.784MetLeu: 1.784 ± 0.155
0.965MetMet: 0.965 ± 0.138
2.057MetAsn: 2.057 ± 0.179
0.673MetPro: 0.673 ± 0.1
1.037MetGln: 1.037 ± 0.147
1.511MetArg: 1.511 ± 0.177
2.02MetSer: 2.02 ± 0.192
1.693MetThr: 1.693 ± 0.177
1.638MetVal: 1.638 ± 0.172
0.346MetTrp: 0.346 ± 0.086
1.201MetTyr: 1.201 ± 0.147
0.0MetXaa: 0.0 ± 0.0
Asn
4.114AsnAla: 4.114 ± 0.352
0.637AsnCys: 0.637 ± 0.102
3.167AsnAsp: 3.167 ± 0.214
4.095AsnGlu: 4.095 ± 0.267
2.02AsnPhe: 2.02 ± 0.175
4.496AsnGly: 4.496 ± 0.314
1.274AsnHis: 1.274 ± 0.164
3.695AsnIle: 3.695 ± 0.266
3.913AsnLys: 3.913 ± 0.284
3.968AsnLeu: 3.968 ± 0.273
1.602AsnMet: 1.602 ± 0.153
3.24AsnAsn: 3.24 ± 0.262
2.876AsnPro: 2.876 ± 0.204
1.456AsnGln: 1.456 ± 0.162
2.748AsnArg: 2.748 ± 0.21
3.695AsnSer: 3.695 ± 0.299
3.422AsnThr: 3.422 ± 0.308
3.804AsnVal: 3.804 ± 0.255
0.564AsnTrp: 0.564 ± 0.087
2.039AsnTyr: 2.039 ± 0.208
0.0AsnXaa: 0.0 ± 0.0
Pro
2.676ProAla: 2.676 ± 0.211
0.4ProCys: 0.4 ± 0.092
3.003ProAsp: 3.003 ± 0.227
3.276ProGlu: 3.276 ± 0.269
1.711ProPhe: 1.711 ± 0.161
2.002ProGly: 2.002 ± 0.22
0.746ProHis: 0.746 ± 0.127
1.693ProIle: 1.693 ± 0.145
2.239ProLys: 2.239 ± 0.19
2.748ProLeu: 2.748 ± 0.218
0.692ProMet: 0.692 ± 0.113
1.474ProAsn: 1.474 ± 0.155
0.928ProPro: 0.928 ± 0.124
0.764ProGln: 0.764 ± 0.116
1.602ProArg: 1.602 ± 0.17
2.366ProSer: 2.366 ± 0.198
2.057ProThr: 2.057 ± 0.186
3.385ProVal: 3.385 ± 0.243
0.346ProTrp: 0.346 ± 0.084
1.565ProTyr: 1.565 ± 0.15
0.0ProXaa: 0.0 ± 0.0
Gln
2.221GlnAla: 2.221 ± 0.237
0.309GlnCys: 0.309 ± 0.07
1.547GlnAsp: 1.547 ± 0.18
2.184GlnGlu: 2.184 ± 0.163
1.42GlnPhe: 1.42 ± 0.145
1.383GlnGly: 1.383 ± 0.176
0.437GlnHis: 0.437 ± 0.092
2.494GlnIle: 2.494 ± 0.208
2.366GlnLys: 2.366 ± 0.213
2.348GlnLeu: 2.348 ± 0.208
0.946GlnMet: 0.946 ± 0.136
1.456GlnAsn: 1.456 ± 0.151
0.928GlnPro: 0.928 ± 0.142
1.292GlnGln: 1.292 ± 0.191
1.219GlnArg: 1.219 ± 0.161
1.82GlnSer: 1.82 ± 0.189
1.911GlnThr: 1.911 ± 0.205
2.002GlnVal: 2.002 ± 0.185
0.419GlnTrp: 0.419 ± 0.084
1.62GlnTyr: 1.62 ± 0.17
0.0GlnXaa: 0.0 ± 0.0
Arg
2.803ArgAla: 2.803 ± 0.233
0.582ArgCys: 0.582 ± 0.1
3.385ArgAsp: 3.385 ± 0.204
2.894ArgGlu: 2.894 ± 0.272
1.911ArgPhe: 1.911 ± 0.222
3.003ArgGly: 3.003 ± 0.24
0.564ArgHis: 0.564 ± 0.113
3.731ArgIle: 3.731 ± 0.232
3.495ArgLys: 3.495 ± 0.285
3.513ArgLeu: 3.513 ± 0.248
1.42ArgMet: 1.42 ± 0.162
2.639ArgAsn: 2.639 ± 0.207
1.547ArgPro: 1.547 ± 0.18
1.456ArgGln: 1.456 ± 0.143
2.439ArgArg: 2.439 ± 0.236
2.912ArgSer: 2.912 ± 0.191
2.73ArgThr: 2.73 ± 0.226
3.112ArgVal: 3.112 ± 0.271
0.855ArgTrp: 0.855 ± 0.098
2.093ArgTyr: 2.093 ± 0.219
0.0ArgXaa: 0.0 ± 0.0
Ser
3.786SerAla: 3.786 ± 0.233
0.601SerCys: 0.601 ± 0.093
3.859SerAsp: 3.859 ± 0.27
3.731SerGlu: 3.731 ± 0.223
2.93SerPhe: 2.93 ± 0.232
5.133SerGly: 5.133 ± 0.372
1.292SerHis: 1.292 ± 0.163
4.35SerIle: 4.35 ± 0.28
4.423SerLys: 4.423 ± 0.283
4.987SerLeu: 4.987 ± 0.317
1.474SerMet: 1.474 ± 0.158
3.385SerAsn: 3.385 ± 0.214
2.457SerPro: 2.457 ± 0.196
1.766SerGln: 1.766 ± 0.159
3.185SerArg: 3.185 ± 0.233
3.458SerSer: 3.458 ± 0.26
3.495SerThr: 3.495 ± 0.34
4.569SerVal: 4.569 ± 0.221
0.619SerTrp: 0.619 ± 0.097
2.53SerTyr: 2.53 ± 0.182
0.0SerXaa: 0.0 ± 0.0
Thr
3.731ThrAla: 3.731 ± 0.319
0.601ThrCys: 0.601 ± 0.1
3.986ThrAsp: 3.986 ± 0.27
3.331ThrGlu: 3.331 ± 0.276
2.384ThrPhe: 2.384 ± 0.231
4.678ThrGly: 4.678 ± 0.335
1.056ThrHis: 1.056 ± 0.109
4.368ThrIle: 4.368 ± 0.265
4.059ThrLys: 4.059 ± 0.283
4.732ThrLeu: 4.732 ± 0.29
1.201ThrMet: 1.201 ± 0.155
2.821ThrAsn: 2.821 ± 0.262
2.657ThrPro: 2.657 ± 0.285
1.529ThrGln: 1.529 ± 0.166
2.494ThrArg: 2.494 ± 0.205
3.44ThrSer: 3.44 ± 0.414
3.64ThrThr: 3.64 ± 0.413
4.969ThrVal: 4.969 ± 0.427
0.673ThrTrp: 0.673 ± 0.109
2.53ThrTyr: 2.53 ± 0.254
0.0ThrXaa: 0.0 ± 0.0
Val
4.569ValAla: 4.569 ± 0.291
1.11ValCys: 1.11 ± 0.159
4.823ValAsp: 4.823 ± 0.279
5.133ValGlu: 5.133 ± 0.309
2.548ValPhe: 2.548 ± 0.222
3.986ValGly: 3.986 ± 0.299
1.019ValHis: 1.019 ± 0.125
4.459ValIle: 4.459 ± 0.295
5.278ValLys: 5.278 ± 0.307
4.478ValLeu: 4.478 ± 0.267
2.111ValMet: 2.111 ± 0.158
3.768ValAsn: 3.768 ± 0.265
2.239ValPro: 2.239 ± 0.189
1.875ValGln: 1.875 ± 0.203
2.967ValArg: 2.967 ± 0.312
4.296ValSer: 4.296 ± 0.326
4.241ValThr: 4.241 ± 0.42
4.914ValVal: 4.914 ± 0.32
1.092ValTrp: 1.092 ± 0.155
3.64ValTyr: 3.64 ± 0.262
0.0ValXaa: 0.0 ± 0.0
Trp
0.783TrpAla: 0.783 ± 0.107
0.2TrpCys: 0.2 ± 0.069
0.928TrpAsp: 0.928 ± 0.133
0.783TrpGlu: 0.783 ± 0.131
0.582TrpPhe: 0.582 ± 0.103
0.692TrpGly: 0.692 ± 0.113
0.237TrpHis: 0.237 ± 0.062
0.837TrpIle: 0.837 ± 0.138
1.292TrpLys: 1.292 ± 0.168
0.928TrpLeu: 0.928 ± 0.118
0.619TrpMet: 0.619 ± 0.132
0.819TrpAsn: 0.819 ± 0.111
0.273TrpPro: 0.273 ± 0.078
0.51TrpGln: 0.51 ± 0.095
0.619TrpArg: 0.619 ± 0.093
0.655TrpSer: 0.655 ± 0.121
0.582TrpThr: 0.582 ± 0.093
0.928TrpVal: 0.928 ± 0.128
0.2TrpTrp: 0.2 ± 0.062
0.637TrpTyr: 0.637 ± 0.095
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.04TyrAla: 3.04 ± 0.209
0.455TyrCys: 0.455 ± 0.081
3.422TyrAsp: 3.422 ± 0.24
2.93TyrGlu: 2.93 ± 0.22
1.875TyrPhe: 1.875 ± 0.171
2.494TyrGly: 2.494 ± 0.21
0.928TyrHis: 0.928 ± 0.117
3.003TyrIle: 3.003 ± 0.215
2.821TyrLys: 2.821 ± 0.234
2.767TyrLeu: 2.767 ± 0.214
1.365TyrMet: 1.365 ± 0.158
3.021TyrAsn: 3.021 ± 0.273
1.711TyrPro: 1.711 ± 0.152
1.402TyrGln: 1.402 ± 0.186
2.439TyrArg: 2.439 ± 0.218
2.821TyrSer: 2.821 ± 0.231
2.439TyrThr: 2.439 ± 0.255
3.094TyrVal: 3.094 ± 0.256
0.455TyrTrp: 0.455 ± 0.088
1.929TyrTyr: 1.929 ± 0.202
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 274 proteins (54942 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski