Amino acid dipepetide frequency for Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.612AlaAla: 10.612 ± 0.142	1.213AlaCys: 1.213 ± 0.042	5.01AlaAsp: 5.01 ± 0.071	6.336AlaGlu: 6.336 ± 0.101	3.577AlaPhe: 3.577 ± 0.062	8.177AlaGly: 8.177 ± 0.112	1.582AlaHis: 1.582 ± 0.039	5.646AlaIle: 5.646 ± 0.067	4.606AlaLys: 4.606 ± 0.074	9.012AlaLeu: 9.012 ± 0.091	2.596AlaMet: 2.596 ± 0.05	2.94AlaAsn: 2.94 ± 0.075	3.342AlaPro: 3.342 ± 0.065	2.634AlaGln: 2.634 ± 0.048	4.808AlaArg: 4.808 ± 0.077	5.064AlaSer: 5.064 ± 0.082	5.001AlaThr: 5.001 ± 0.109	7.145AlaVal: 7.145 ± 0.09	0.857AlaTrp: 0.857 ± 0.028	2.32AlaTyr: 2.32 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.937CysAla: 0.937 ± 0.027	0.244CysCys: 0.244 ± 0.018	0.618CysAsp: 0.618 ± 0.025	0.574CysGlu: 0.574 ± 0.022	0.468CysPhe: 0.468 ± 0.018	1.307CysGly: 1.307 ± 0.037	0.978CysHis: 0.978 ± 0.106	0.667CysIle: 0.667 ± 0.022	0.461CysLys: 0.461 ± 0.021	1.136CysLeu: 1.136 ± 0.029	0.281CysMet: 0.281 ± 0.013	0.497CysAsn: 0.497 ± 0.025	0.697CysPro: 0.697 ± 0.03	0.367CysGln: 0.367 ± 0.018	0.849CysArg: 0.849 ± 0.029	0.935CysSer: 0.935 ± 0.037	0.679CysThr: 0.679 ± 0.027	0.665CysVal: 0.665 ± 0.025	0.129CysTrp: 0.129 ± 0.01	0.399CysTyr: 0.399 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.365AspAla: 4.365 ± 0.068	0.727AspCys: 0.727 ± 0.033	2.489AspAsp: 2.489 ± 0.06	3.357AspGlu: 3.357 ± 0.072	2.349AspPhe: 2.349 ± 0.051	4.22AspGly: 4.22 ± 0.079	1.038AspHis: 1.038 ± 0.03	3.472AspIle: 3.472 ± 0.057	2.624AspLys: 2.624 ± 0.045	5.526AspLeu: 5.526 ± 0.078	1.348AspMet: 1.348 ± 0.035	1.921AspAsn: 1.921 ± 0.038	2.577AspPro: 2.577 ± 0.057	1.551AspGln: 1.551 ± 0.037	3.151AspArg: 3.151 ± 0.053	2.782AspSer: 2.782 ± 0.048	2.575AspThr: 2.575 ± 0.053	3.432AspVal: 3.432 ± 0.051	0.583AspTrp: 0.583 ± 0.02	1.882AspTyr: 1.882 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.638GluAla: 5.638 ± 0.088	0.548GluCys: 0.548 ± 0.021	2.787GluAsp: 2.787 ± 0.057	4.947GluGlu: 4.947 ± 0.096	2.174GluPhe: 2.174 ± 0.044	4.322GluGly: 4.322 ± 0.075	1.149GluHis: 1.149 ± 0.031	4.432GluIle: 4.432 ± 0.08	4.816GluLys: 4.816 ± 0.09	6.606GluLeu: 6.606 ± 0.094	1.945GluMet: 1.945 ± 0.044	2.414GluAsn: 2.414 ± 0.048	2.146GluPro: 2.146 ± 0.042	2.545GluGln: 2.545 ± 0.051	4.043GluArg: 4.043 ± 0.078	3.099GluSer: 3.099 ± 0.049	3.346GluThr: 3.346 ± 0.054	4.433GluVal: 4.433 ± 0.07	0.601GluTrp: 0.601 ± 0.026	1.687GluTyr: 1.687 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.708PheAla: 3.708 ± 0.054	0.615PheCys: 0.615 ± 0.024	2.292PheAsp: 2.292 ± 0.041	2.016PheGlu: 2.016 ± 0.046	2.052PhePhe: 2.052 ± 0.045	3.184PheGly: 3.184 ± 0.06	0.904PheHis: 0.904 ± 0.028	2.602PheIle: 2.602 ± 0.054	1.753PheLys: 1.753 ± 0.041	4.016PheLeu: 4.016 ± 0.066	0.961PheMet: 0.961 ± 0.031	1.654PheAsn: 1.654 ± 0.042	1.799PhePro: 1.799 ± 0.046	1.181PheGln: 1.181 ± 0.029	2.287PheArg: 2.287 ± 0.053	3.23PheSer: 3.23 ± 0.052	2.529PheThr: 2.529 ± 0.043	2.595PheVal: 2.595 ± 0.049	0.447PheTrp: 0.447 ± 0.02	1.3PheTyr: 1.3 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.57GlyAla: 6.57 ± 0.096	1.289GlyCys: 1.289 ± 0.037	3.945GlyAsp: 3.945 ± 0.077	4.99GlyGlu: 4.99 ± 0.075	3.362GlyPhe: 3.362 ± 0.049	6.34GlyGly: 6.34 ± 0.1	1.551GlyHis: 1.551 ± 0.037	5.73GlyIle: 5.73 ± 0.07	5.364GlyLys: 5.364 ± 0.067	7.191GlyLeu: 7.191 ± 0.079	2.301GlyMet: 2.301 ± 0.041	3.38GlyAsn: 3.38 ± 0.086	2.194GlyPro: 2.194 ± 0.042	2.343GlyGln: 2.343 ± 0.04	4.428GlyArg: 4.428 ± 0.071	4.977GlySer: 4.977 ± 0.099	5.057GlyThr: 5.057 ± 0.127	5.451GlyVal: 5.451 ± 0.068	0.925GlyTrp: 0.925 ± 0.031	2.775GlyTyr: 2.775 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.66HisAla: 1.66 ± 0.045	0.316HisCys: 0.316 ± 0.015	1.184HisAsp: 1.184 ± 0.034	1.152HisGlu: 1.152 ± 0.026	0.923HisPhe: 0.923 ± 0.031	1.857HisGly: 1.857 ± 0.047	0.549HisHis: 0.549 ± 0.025	1.134HisIle: 1.134 ± 0.035	0.846HisLys: 0.846 ± 0.03	2.191HisLeu: 2.191 ± 0.049	0.51HisMet: 0.51 ± 0.02	0.769HisAsn: 0.769 ± 0.031	1.155HisPro: 1.155 ± 0.034	0.684HisGln: 0.684 ± 0.024	1.233HisArg: 1.233 ± 0.034	1.16HisSer: 1.16 ± 0.039	0.959HisThr: 0.959 ± 0.032	1.262HisVal: 1.262 ± 0.038	0.239HisTrp: 0.239 ± 0.016	0.669HisTyr: 0.669 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.106IleAla: 6.106 ± 0.073	0.832IleCys: 0.832 ± 0.028	3.66IleAsp: 3.66 ± 0.055	3.714IleGlu: 3.714 ± 0.064	2.674IlePhe: 2.674 ± 0.053	4.907IleGly: 4.907 ± 0.068	1.261IleHis: 1.261 ± 0.038	4.175IleIle: 4.175 ± 0.058	3.263IleLys: 3.263 ± 0.06	5.645IleLeu: 5.645 ± 0.074	1.41IleMet: 1.41 ± 0.035	2.576IleAsn: 2.576 ± 0.049	3.072IlePro: 3.072 ± 0.052	1.64IleGln: 1.64 ± 0.04	3.47IleArg: 3.47 ± 0.055	4.294IleSer: 4.294 ± 0.07	3.897IleThr: 3.897 ± 0.065	4.206IleVal: 4.206 ± 0.057	0.525IleTrp: 0.525 ± 0.023	1.848IleTyr: 1.848 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.911LysAla: 4.911 ± 0.087	0.567LysCys: 0.567 ± 0.028	2.804LysAsp: 2.804 ± 0.056	4.17LysGlu: 4.17 ± 0.081	1.584LysPhe: 1.584 ± 0.037	4.479LysGly: 4.479 ± 0.064	0.965LysHis: 0.965 ± 0.032	3.54LysIle: 3.54 ± 0.064	3.999LysLys: 3.999 ± 0.086	4.759LysLeu: 4.759 ± 0.079	1.53LysMet: 1.53 ± 0.037	2.168LysAsn: 2.168 ± 0.047	2.283LysPro: 2.283 ± 0.043	1.731LysGln: 1.731 ± 0.043	2.83LysArg: 2.83 ± 0.052	2.953LysSer: 2.953 ± 0.055	2.964LysThr: 2.964 ± 0.05	4.01LysVal: 4.01 ± 0.07	0.493LysTrp: 0.493 ± 0.022	1.41LysTyr: 1.41 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	10.044LeuAla: 10.044 ± 0.116	1.21LeuCys: 1.21 ± 0.036	5.23LeuAsp: 5.23 ± 0.073	6.107LeuGlu: 6.107 ± 0.093	4.22LeuPhe: 4.22 ± 0.074	7.018LeuGly: 7.018 ± 0.098	2.021LeuHis: 2.021 ± 0.043	5.463LeuIle: 5.463 ± 0.069	5.912LeuLys: 5.912 ± 0.076	10.466LeuLeu: 10.466 ± 0.129	2.315LeuMet: 2.315 ± 0.044	3.383LeuAsn: 3.383 ± 0.048	4.915LeuPro: 4.915 ± 0.071	3.594LeuGln: 3.594 ± 0.065	5.288LeuArg: 5.288 ± 0.073	6.594LeuSer: 6.594 ± 0.073	5.416LeuThr: 5.416 ± 0.088	6.904LeuVal: 6.904 ± 0.081	0.864LeuTrp: 0.864 ± 0.026	2.578LeuTyr: 2.578 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.745MetAla: 2.745 ± 0.045	0.19MetCys: 0.19 ± 0.012	1.397MetAsp: 1.397 ± 0.032	1.922MetGlu: 1.922 ± 0.045	0.719MetPhe: 0.719 ± 0.023	2.055MetGly: 2.055 ± 0.045	0.467MetHis: 0.467 ± 0.019	1.399MetIle: 1.399 ± 0.037	1.72MetLys: 1.72 ± 0.042	2.416MetLeu: 2.416 ± 0.048	0.588MetMet: 0.588 ± 0.024	1.014MetAsn: 1.014 ± 0.031	1.238MetPro: 1.238 ± 0.029	0.91MetGln: 0.91 ± 0.026	1.25MetArg: 1.25 ± 0.029	1.442MetSer: 1.442 ± 0.034	1.509MetThr: 1.509 ± 0.032	1.965MetVal: 1.965 ± 0.038	0.157MetTrp: 0.157 ± 0.011	0.438MetTyr: 0.438 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.033AsnAla: 3.033 ± 0.063	0.548AsnCys: 0.548 ± 0.025	1.793AsnAsp: 1.793 ± 0.058	1.824AsnGlu: 1.824 ± 0.035	1.417AsnPhe: 1.417 ± 0.03	3.298AsnGly: 3.298 ± 0.087	0.735AsnHis: 0.735 ± 0.026	2.51AsnIle: 2.51 ± 0.043	1.602AsnLys: 1.602 ± 0.04	3.902AsnLeu: 3.902 ± 0.048	0.86AsnMet: 0.86 ± 0.025	1.472AsnAsn: 1.472 ± 0.05	2.196AsnPro: 2.196 ± 0.047	1.087AsnGln: 1.087 ± 0.03	2.342AsnArg: 2.342 ± 0.045	2.152AsnSer: 2.152 ± 0.064	1.879AsnThr: 1.879 ± 0.077	2.429AsnVal: 2.429 ± 0.05	0.444AsnTrp: 0.444 ± 0.019	1.252AsnTyr: 1.252 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	4.402ProAla: 4.402 ± 0.073	0.441ProCys: 0.441 ± 0.019	2.579ProAsp: 2.579 ± 0.051	3.374ProGlu: 3.374 ± 0.06	2.073ProPhe: 2.073 ± 0.044	3.622ProGly: 3.622 ± 0.065	0.928ProHis: 0.928 ± 0.03	2.183ProIle: 2.183 ± 0.043	1.816ProLys: 1.816 ± 0.04	4.451ProLeu: 4.451 ± 0.06	0.966ProMet: 0.966 ± 0.026	1.207ProAsn: 1.207 ± 0.034	1.968ProPro: 1.968 ± 0.046	1.507ProGln: 1.507 ± 0.036	1.883ProArg: 1.883 ± 0.041	2.341ProSer: 2.341 ± 0.045	2.166ProThr: 2.166 ± 0.059	3.833ProVal: 3.833 ± 0.058	0.5ProTrp: 0.5 ± 0.02	1.297ProTyr: 1.297 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.114GlnAla: 3.114 ± 0.055	0.325GlnCys: 0.325 ± 0.02	1.417GlnAsp: 1.417 ± 0.034	2.253GlnGlu: 2.253 ± 0.05	1.151GlnPhe: 1.151 ± 0.03	2.368GlnGly: 2.368 ± 0.046	0.609GlnHis: 0.609 ± 0.024	2.053GlnIle: 2.053 ± 0.045	1.906GlnLys: 1.906 ± 0.047	3.336GlnLeu: 3.336 ± 0.055	0.958GlnMet: 0.958 ± 0.029	1.134GlnAsn: 1.134 ± 0.031	1.345GlnPro: 1.345 ± 0.033	1.357GlnGln: 1.357 ± 0.039	1.89GlnArg: 1.89 ± 0.042	1.769GlnSer: 1.769 ± 0.036	1.637GlnThr: 1.637 ± 0.033	2.685GlnVal: 2.685 ± 0.05	0.375GlnTrp: 0.375 ± 0.018	0.831GlnTyr: 0.831 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.916ArgAla: 3.916 ± 0.062	0.686ArgCys: 0.686 ± 0.024	2.84ArgAsp: 2.84 ± 0.054	4.244ArgGlu: 4.244 ± 0.073	2.547ArgPhe: 2.547 ± 0.05	3.53ArgGly: 3.53 ± 0.054	1.341ArgHis: 1.341 ± 0.035	3.967ArgIle: 3.967 ± 0.061	3.161ArgLys: 3.161 ± 0.057	6.263ArgLeu: 6.263 ± 0.088	1.548ArgMet: 1.548 ± 0.037	2.099ArgAsn: 2.099 ± 0.037	2.076ArgPro: 2.076 ± 0.043	2.385ArgGln: 2.385 ± 0.045	3.349ArgArg: 3.349 ± 0.062	2.969ArgSer: 2.969 ± 0.055	2.636ArgThr: 2.636 ± 0.039	3.703ArgVal: 3.703 ± 0.055	0.637ArgTrp: 0.637 ± 0.024	1.825ArgTyr: 1.825 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.288SerAla: 5.288 ± 0.083	0.954SerCys: 0.954 ± 0.042	2.902SerAsp: 2.902 ± 0.05	3.077SerGlu: 3.077 ± 0.053	2.898SerPhe: 2.898 ± 0.049	5.775SerGly: 5.775 ± 0.095	1.359SerHis: 1.359 ± 0.037	3.767SerIle: 3.767 ± 0.06	2.38SerLys: 2.38 ± 0.049	6.284SerLeu: 6.284 ± 0.087	1.478SerMet: 1.478 ± 0.037	1.934SerAsn: 1.934 ± 0.061	2.872SerPro: 2.872 ± 0.055	1.917SerGln: 1.917 ± 0.039	3.509SerArg: 3.509 ± 0.055	4.179SerSer: 4.179 ± 0.072	3.295SerThr: 3.295 ± 0.086	3.891SerVal: 3.891 ± 0.062	0.674SerTrp: 0.674 ± 0.025	1.893SerTyr: 1.893 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.549ThrAla: 5.549 ± 0.118	0.707ThrCys: 0.707 ± 0.035	2.884ThrAsp: 2.884 ± 0.055	2.894ThrGlu: 2.894 ± 0.049	2.397ThrPhe: 2.397 ± 0.049	5.541ThrGly: 5.541 ± 0.124	0.911ThrHis: 0.911 ± 0.024	3.843ThrIle: 3.843 ± 0.071	2.119ThrLys: 2.119 ± 0.045	5.409ThrLeu: 5.409 ± 0.074	1.268ThrMet: 1.268 ± 0.033	1.853ThrAsn: 1.853 ± 0.063	2.775ThrPro: 2.775 ± 0.069	1.334ThrGln: 1.334 ± 0.04	2.607ThrArg: 2.607 ± 0.045	3.424ThrSer: 3.424 ± 0.083	3.39ThrThr: 3.39 ± 0.119	4.488ThrVal: 4.488 ± 0.098	0.554ThrTrp: 0.554 ± 0.029	1.661ThrTyr: 1.661 ± 0.073	0.0ThrXaa: 0.0 ± 0.0
Val	6.94ValAla: 6.94 ± 0.088	0.862ValCys: 0.862 ± 0.029	3.916ValAsp: 3.916 ± 0.055	4.606ValGlu: 4.606 ± 0.069	2.788ValPhe: 2.788 ± 0.052	4.863ValGly: 4.863 ± 0.065	1.229ValHis: 1.229 ± 0.035	4.629ValIle: 4.629 ± 0.061	4.021ValLys: 4.021 ± 0.063	6.535ValLeu: 6.535 ± 0.081	1.834ValMet: 1.834 ± 0.044	2.77ValAsn: 2.77 ± 0.058	3.048ValPro: 3.048 ± 0.048	2.08ValGln: 2.08 ± 0.044	3.813ValArg: 3.813 ± 0.056	4.473ValSer: 4.473 ± 0.065	4.609ValThr: 4.609 ± 0.108	5.599ValVal: 5.599 ± 0.079	0.647ValTrp: 0.647 ± 0.027	1.802ValTyr: 1.802 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.643TrpAla: 0.643 ± 0.025	0.118TrpCys: 0.118 ± 0.011	0.524TrpAsp: 0.524 ± 0.022	0.621TrpGlu: 0.621 ± 0.024	0.466TrpPhe: 0.466 ± 0.022	0.838TrpGly: 0.838 ± 0.032	0.237TrpHis: 0.237 ± 0.012	0.541TrpIle: 0.541 ± 0.023	0.554TrpLys: 0.554 ± 0.02	1.141TrpLeu: 1.141 ± 0.034	0.243TrpMet: 0.243 ± 0.015	0.422TrpAsn: 0.422 ± 0.022	0.41TrpPro: 0.41 ± 0.021	0.552TrpGln: 0.552 ± 0.024	0.607TrpArg: 0.607 ± 0.022	0.65TrpSer: 0.65 ± 0.029	0.507TrpThr: 0.507 ± 0.03	0.61TrpVal: 0.61 ± 0.022	0.134TrpTrp: 0.134 ± 0.011	0.299TrpTyr: 0.299 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.297TyrAla: 2.297 ± 0.043	0.493TyrCys: 0.493 ± 0.032	1.695TyrAsp: 1.695 ± 0.053	1.5TyrGlu: 1.5 ± 0.037	1.288TyrPhe: 1.288 ± 0.032	2.462TyrGly: 2.462 ± 0.056	0.641TyrHis: 0.641 ± 0.021	1.422TyrIle: 1.422 ± 0.036	1.229TyrLys: 1.229 ± 0.034	3.254TyrLeu: 3.254 ± 0.051	0.599TyrMet: 0.599 ± 0.024	1.17TyrAsn: 1.17 ± 0.035	1.433TyrPro: 1.433 ± 0.033	1.115TyrGln: 1.115 ± 0.029	2.088TyrArg: 2.088 ± 0.036	1.838TyrSer: 1.838 ± 0.051	1.556TyrThr: 1.556 ± 0.053	1.755TyrVal: 1.755 ± 0.048	0.334TyrTrp: 0.334 ± 0.016	1.01TyrTyr: 1.01 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3798 proteins (1289234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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