Amino acid dipepetide frequency for Sulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 11577 / YK-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.434AlaAla: 6.434 ± 0.156
0.754AlaCys: 0.754 ± 0.032
3.94AlaAsp: 3.94 ± 0.073
4.554AlaGlu: 4.554 ± 0.1
3.327AlaPhe: 3.327 ± 0.061
4.594AlaGly: 4.594 ± 0.098
1.804AlaHis: 1.804 ± 0.045
6.064AlaIle: 6.064 ± 0.087
5.257AlaLys: 5.257 ± 0.091
9.446AlaLeu: 9.446 ± 0.117
2.476AlaMet: 2.476 ± 0.063
2.997AlaAsn: 2.997 ± 0.063
2.336AlaPro: 2.336 ± 0.059
2.994AlaGln: 2.994 ± 0.086
3.002AlaArg: 3.002 ± 0.062
5.075AlaSer: 5.075 ± 0.079
3.885AlaThr: 3.885 ± 0.12
5.019AlaVal: 5.019 ± 0.087
0.535AlaTrp: 0.535 ± 0.022
2.799AlaTyr: 2.799 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.738CysAla: 0.738 ± 0.031
0.084CysCys: 0.084 ± 0.011
0.753CysAsp: 0.753 ± 0.029
0.737CysGlu: 0.737 ± 0.032
0.319CysPhe: 0.319 ± 0.018
0.787CysGly: 0.787 ± 0.036
0.289CysHis: 0.289 ± 0.018
0.575CysIle: 0.575 ± 0.029
0.458CysLys: 0.458 ± 0.024
0.513CysLeu: 0.513 ± 0.026
0.208CysMet: 0.208 ± 0.015
0.429CysAsn: 0.429 ± 0.026
0.433CysPro: 0.433 ± 0.028
0.227CysGln: 0.227 ± 0.015
0.44CysArg: 0.44 ± 0.022
0.65CysSer: 0.65 ± 0.031
0.5CysThr: 0.5 ± 0.022
0.552CysVal: 0.552 ± 0.028
0.063CysTrp: 0.063 ± 0.009
0.281CysTyr: 0.281 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.581AspAla: 4.581 ± 0.074
0.408AspCys: 0.408 ± 0.022
3.002AspAsp: 3.002 ± 0.082
4.891AspGlu: 4.891 ± 0.08
2.812AspPhe: 2.812 ± 0.065
3.412AspGly: 3.412 ± 0.076
1.172AspHis: 1.172 ± 0.042
4.526AspIle: 4.526 ± 0.076
3.435AspLys: 3.435 ± 0.067
5.039AspLeu: 5.039 ± 0.087
1.518AspMet: 1.518 ± 0.042
2.195AspAsn: 2.195 ± 0.059
2.114AspPro: 2.114 ± 0.056
1.725AspGln: 1.725 ± 0.045
2.374AspArg: 2.374 ± 0.059
2.964AspSer: 2.964 ± 0.053
3.335AspThr: 3.335 ± 0.088
3.477AspVal: 3.477 ± 0.073
0.459AspTrp: 0.459 ± 0.024
2.064AspTyr: 2.064 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.778GluAla: 5.778 ± 0.097
0.699GluCys: 0.699 ± 0.032
2.914GluAsp: 2.914 ± 0.057
5.373GluGlu: 5.373 ± 0.108
2.857GluPhe: 2.857 ± 0.062
4.473GluGly: 4.473 ± 0.079
1.873GluHis: 1.873 ± 0.045
5.63GluIle: 5.63 ± 0.094
5.362GluLys: 5.362 ± 0.086
6.916GluLeu: 6.916 ± 0.096
2.125GluMet: 2.125 ± 0.045
3.568GluAsn: 3.568 ± 0.062
1.893GluPro: 1.893 ± 0.051
2.371GluGln: 2.371 ± 0.058
3.758GluArg: 3.758 ± 0.068
4.382GluSer: 4.382 ± 0.072
3.49GluThr: 3.49 ± 0.071
4.097GluVal: 4.097 ± 0.069
0.663GluTrp: 0.663 ± 0.03
2.587GluTyr: 2.587 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.373PheAla: 3.373 ± 0.073
0.45PheCys: 0.45 ± 0.025
3.143PheAsp: 3.143 ± 0.069
3.458PheGlu: 3.458 ± 0.065
2.293PhePhe: 2.293 ± 0.066
3.476PheGly: 3.476 ± 0.079
0.933PheHis: 0.933 ± 0.035
3.472PheIle: 3.472 ± 0.068
2.653PheLys: 2.653 ± 0.053
4.248PheLeu: 4.248 ± 0.09
1.16PheMet: 1.16 ± 0.035
2.105PheAsn: 2.105 ± 0.047
1.307PhePro: 1.307 ± 0.039
1.123PheGln: 1.123 ± 0.036
1.673PheArg: 1.673 ± 0.044
3.399PheSer: 3.399 ± 0.064
2.479PheThr: 2.479 ± 0.058
2.894PheVal: 2.894 ± 0.065
0.503PheTrp: 0.503 ± 0.028
1.696PheTyr: 1.696 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.746GlyAla: 4.746 ± 0.119
0.825GlyCys: 0.825 ± 0.035
3.488GlyAsp: 3.488 ± 0.088
4.444GlyGlu: 4.444 ± 0.079
3.326GlyPhe: 3.326 ± 0.07
4.531GlyGly: 4.531 ± 0.111
1.318GlyHis: 1.318 ± 0.036
5.436GlyIle: 5.436 ± 0.079
4.377GlyLys: 4.377 ± 0.077
5.449GlyLeu: 5.449 ± 0.088
1.989GlyMet: 1.989 ± 0.048
2.6GlyAsn: 2.6 ± 0.087
1.001GlyPro: 1.001 ± 0.042
1.591GlyGln: 1.591 ± 0.041
2.638GlyArg: 2.638 ± 0.06
4.23GlySer: 4.23 ± 0.082
3.49GlyThr: 3.49 ± 0.101
4.606GlyVal: 4.606 ± 0.078
0.77GlyTrp: 0.77 ± 0.029
3.005GlyTyr: 3.005 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.651HisAla: 1.651 ± 0.043
0.256HisCys: 0.256 ± 0.015
1.25HisAsp: 1.25 ± 0.043
1.553HisGlu: 1.553 ± 0.04
1.314HisPhe: 1.314 ± 0.042
1.355HisGly: 1.355 ± 0.042
0.791HisHis: 0.791 ± 0.032
1.711HisIle: 1.711 ± 0.047
1.234HisLys: 1.234 ± 0.033
2.269HisLeu: 2.269 ± 0.057
0.51HisMet: 0.51 ± 0.026
1.023HisAsn: 1.023 ± 0.037
1.254HisPro: 1.254 ± 0.04
0.807HisGln: 0.807 ± 0.036
1.009HisArg: 1.009 ± 0.036
1.443HisSer: 1.443 ± 0.042
1.323HisThr: 1.323 ± 0.034
1.144HisVal: 1.144 ± 0.033
0.198HisTrp: 0.198 ± 0.015
1.039HisTyr: 1.039 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
7.282IleAla: 7.282 ± 0.102
0.664IleCys: 0.664 ± 0.027
5.603IleAsp: 5.603 ± 0.091
6.371IleGlu: 6.371 ± 0.09
3.118IlePhe: 3.118 ± 0.067
5.566IleGly: 5.566 ± 0.097
1.632IleHis: 1.632 ± 0.044
5.628IleIle: 5.628 ± 0.106
4.654IleLys: 4.654 ± 0.078
6.783IleLeu: 6.783 ± 0.106
1.614IleMet: 1.614 ± 0.045
3.539IleAsn: 3.539 ± 0.064
2.921IlePro: 2.921 ± 0.064
2.257IleGln: 2.257 ± 0.054
3.529IleArg: 3.529 ± 0.067
5.24IleSer: 5.24 ± 0.09
4.599IleThr: 4.599 ± 0.08
5.176IleVal: 5.176 ± 0.089
0.52IleTrp: 0.52 ± 0.026
2.431IleTyr: 2.431 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.972LysAla: 4.972 ± 0.093
0.447LysCys: 0.447 ± 0.026
2.913LysAsp: 2.913 ± 0.073
5.754LysGlu: 5.754 ± 0.1
2.065LysPhe: 2.065 ± 0.052
3.631LysGly: 3.631 ± 0.066
1.388LysHis: 1.388 ± 0.041
5.399LysIle: 5.399 ± 0.088
4.829LysLys: 4.829 ± 0.084
5.712LysLeu: 5.712 ± 0.089
2.089LysMet: 2.089 ± 0.05
3.736LysAsn: 3.736 ± 0.075
2.23LysPro: 2.23 ± 0.056
2.036LysGln: 2.036 ± 0.05
3.208LysArg: 3.208 ± 0.061
4.176LysSer: 4.176 ± 0.077
3.861LysThr: 3.861 ± 0.068
3.695LysVal: 3.695 ± 0.071
0.463LysTrp: 0.463 ± 0.024
2.069LysTyr: 2.069 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
6.764LeuAla: 6.764 ± 0.089
0.912LeuCys: 0.912 ± 0.034
5.199LeuAsp: 5.199 ± 0.07
6.669LeuGlu: 6.669 ± 0.095
4.939LeuPhe: 4.939 ± 0.091
6.005LeuGly: 6.005 ± 0.09
2.275LeuHis: 2.275 ± 0.052
7.486LeuIle: 7.486 ± 0.097
6.905LeuLys: 6.905 ± 0.101
9.528LeuLeu: 9.528 ± 0.149
2.616LeuMet: 2.616 ± 0.059
4.553LeuAsn: 4.553 ± 0.069
3.554LeuPro: 3.554 ± 0.065
3.182LeuGln: 3.182 ± 0.063
4.398LeuArg: 4.398 ± 0.086
8.605LeuSer: 8.605 ± 0.124
5.014LeuThr: 5.014 ± 0.088
5.121LeuVal: 5.121 ± 0.078
0.835LeuTrp: 0.835 ± 0.034
3.633LeuTyr: 3.633 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
2.165MetAla: 2.165 ± 0.049
0.188MetCys: 0.188 ± 0.013
1.454MetAsp: 1.454 ± 0.04
1.82MetGlu: 1.82 ± 0.043
1.031MetPhe: 1.031 ± 0.039
1.924MetGly: 1.924 ± 0.05
0.632MetHis: 0.632 ± 0.028
2.315MetIle: 2.315 ± 0.058
2.11MetLys: 2.11 ± 0.05
2.565MetLeu: 2.565 ± 0.061
0.995MetMet: 0.995 ± 0.032
1.408MetAsn: 1.408 ± 0.036
0.93MetPro: 0.93 ± 0.032
0.986MetGln: 0.986 ± 0.033
1.293MetArg: 1.293 ± 0.041
1.948MetSer: 1.948 ± 0.048
1.368MetThr: 1.368 ± 0.045
1.791MetVal: 1.791 ± 0.043
0.195MetTrp: 0.195 ± 0.015
0.646MetTyr: 0.646 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.765AsnAla: 3.765 ± 0.069
0.342AsnCys: 0.342 ± 0.022
2.939AsnAsp: 2.939 ± 0.082
3.196AsnGlu: 3.196 ± 0.068
1.884AsnPhe: 1.884 ± 0.056
3.147AsnGly: 3.147 ± 0.075
1.01AsnHis: 1.01 ± 0.035
3.682AsnIle: 3.682 ± 0.061
2.45AsnLys: 2.45 ± 0.059
4.202AsnLeu: 4.202 ± 0.064
0.975AsnMet: 0.975 ± 0.037
1.967AsnAsn: 1.967 ± 0.058
2.181AsnPro: 2.181 ± 0.05
1.466AsnGln: 1.466 ± 0.041
2.328AsnArg: 2.328 ± 0.056
2.583AsnSer: 2.583 ± 0.058
2.637AsnThr: 2.637 ± 0.058
2.838AsnVal: 2.838 ± 0.059
0.295AsnTrp: 0.295 ± 0.02
1.501AsnTyr: 1.501 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
2.069ProAla: 2.069 ± 0.053
0.265ProCys: 0.265 ± 0.018
1.941ProAsp: 1.941 ± 0.052
2.343ProGlu: 2.343 ± 0.055
1.952ProPhe: 1.952 ± 0.044
1.518ProGly: 1.518 ± 0.045
0.907ProHis: 0.907 ± 0.035
2.859ProIle: 2.859 ± 0.059
2.377ProLys: 2.377 ± 0.058
3.58ProLeu: 3.58 ± 0.066
0.975ProMet: 0.975 ± 0.032
1.484ProAsn: 1.484 ± 0.047
1.076ProPro: 1.076 ± 0.039
1.123ProGln: 1.123 ± 0.035
1.178ProArg: 1.178 ± 0.035
2.543ProSer: 2.543 ± 0.058
1.926ProThr: 1.926 ± 0.05
2.085ProVal: 2.085 ± 0.055
0.303ProTrp: 0.303 ± 0.021
1.555ProTyr: 1.555 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.06GlnAla: 2.06 ± 0.067
0.295GlnCys: 0.295 ± 0.018
1.317GlnAsp: 1.317 ± 0.041
2.281GlnGlu: 2.281 ± 0.061
1.292GlnPhe: 1.292 ± 0.041
1.797GlnGly: 1.797 ± 0.044
0.659GlnHis: 0.659 ± 0.031
2.788GlnIle: 2.788 ± 0.057
2.811GlnLys: 2.811 ± 0.061
2.791GlnLeu: 2.791 ± 0.06
1.091GlnMet: 1.091 ± 0.038
2.06GlnAsn: 2.06 ± 0.055
0.973GlnPro: 0.973 ± 0.034
1.112GlnGln: 1.112 ± 0.037
1.45GlnArg: 1.45 ± 0.041
2.482GlnSer: 2.482 ± 0.057
1.937GlnThr: 1.937 ± 0.051
1.572GlnVal: 1.572 ± 0.042
0.35GlnTrp: 0.35 ± 0.02
1.127GlnTyr: 1.127 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.995ArgAla: 2.995 ± 0.064
0.389ArgCys: 0.389 ± 0.02
2.31ArgAsp: 2.31 ± 0.05
3.163ArgGlu: 3.163 ± 0.069
2.628ArgPhe: 2.628 ± 0.054
2.453ArgGly: 2.453 ± 0.056
1.183ArgHis: 1.183 ± 0.045
3.605ArgIle: 3.605 ± 0.071
2.277ArgLys: 2.277 ± 0.054
4.677ArgLeu: 4.677 ± 0.08
1.146ArgMet: 1.146 ± 0.035
1.931ArgAsn: 1.931 ± 0.056
1.237ArgPro: 1.237 ± 0.042
1.447ArgGln: 1.447 ± 0.039
2.038ArgArg: 2.038 ± 0.062
2.986ArgSer: 2.986 ± 0.066
1.978ArgThr: 1.978 ± 0.046
2.707ArgVal: 2.707 ± 0.064
0.423ArgTrp: 0.423 ± 0.021
2.197ArgTyr: 2.197 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
5.415SerAla: 5.415 ± 0.096
0.59SerCys: 0.59 ± 0.028
4.124SerAsp: 4.124 ± 0.068
4.209SerGlu: 4.209 ± 0.063
3.153SerPhe: 3.153 ± 0.064
4.913SerGly: 4.913 ± 0.1
1.571SerHis: 1.571 ± 0.041
5.451SerIle: 5.451 ± 0.078
3.883SerLys: 3.883 ± 0.073
7.054SerLeu: 7.054 ± 0.102
1.888SerMet: 1.888 ± 0.048
2.837SerAsn: 2.837 ± 0.061
2.303SerPro: 2.303 ± 0.054
2.212SerGln: 2.212 ± 0.057
2.709SerArg: 2.709 ± 0.054
4.648SerSer: 4.648 ± 0.095
3.49SerThr: 3.49 ± 0.076
4.504SerVal: 4.504 ± 0.082
0.484SerTrp: 0.484 ± 0.023
2.458SerTyr: 2.458 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
4.24ThrAla: 4.24 ± 0.092
0.387ThrCys: 0.387 ± 0.022
2.809ThrAsp: 2.809 ± 0.064
2.711ThrGlu: 2.711 ± 0.057
2.506ThrPhe: 2.506 ± 0.06
3.234ThrGly: 3.234 ± 0.098
1.28ThrHis: 1.28 ± 0.039
4.448ThrIle: 4.448 ± 0.063
3.156ThrLys: 3.156 ± 0.064
6.736ThrLeu: 6.736 ± 0.12
1.326ThrMet: 1.326 ± 0.042
2.081ThrAsn: 2.081 ± 0.064
2.664ThrPro: 2.664 ± 0.054
2.11ThrGln: 2.11 ± 0.054
1.893ThrArg: 1.893 ± 0.049
3.322ThrSer: 3.322 ± 0.089
2.932ThrThr: 2.932 ± 0.084
3.724ThrVal: 3.724 ± 0.08
0.371ThrTrp: 0.371 ± 0.022
2.1ThrTyr: 2.1 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
4.895ValAla: 4.895 ± 0.087
0.644ValCys: 0.644 ± 0.031
3.543ValAsp: 3.543 ± 0.067
4.139ValGlu: 4.139 ± 0.081
2.662ValPhe: 2.662 ± 0.069
3.892ValGly: 3.892 ± 0.077
1.295ValHis: 1.295 ± 0.04
5.038ValIle: 5.038 ± 0.089
3.689ValLys: 3.689 ± 0.074
6.156ValLeu: 6.156 ± 0.082
1.86ValMet: 1.86 ± 0.05
2.756ValAsn: 2.756 ± 0.062
2.051ValPro: 2.051 ± 0.056
1.896ValGln: 1.896 ± 0.056
2.587ValArg: 2.587 ± 0.059
4.468ValSer: 4.468 ± 0.072
3.327ValThr: 3.327 ± 0.079
4.313ValVal: 4.313 ± 0.082
0.543ValTrp: 0.543 ± 0.026
2.107ValTyr: 2.107 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.486TrpAla: 0.486 ± 0.026
0.101TrpCys: 0.101 ± 0.01
0.463TrpAsp: 0.463 ± 0.027
0.507TrpGlu: 0.507 ± 0.025
0.429TrpPhe: 0.429 ± 0.023
0.597TrpGly: 0.597 ± 0.029
0.225TrpHis: 0.225 ± 0.018
0.721TrpIle: 0.721 ± 0.029
0.491TrpLys: 0.491 ± 0.024
0.913TrpLeu: 0.913 ± 0.038
0.354TrpMet: 0.354 ± 0.019
0.445TrpAsn: 0.445 ± 0.023
0.193TrpPro: 0.193 ± 0.015
0.304TrpGln: 0.304 ± 0.02
0.367TrpArg: 0.367 ± 0.019
0.491TrpSer: 0.491 ± 0.023
0.325TrpThr: 0.325 ± 0.02
0.604TrpVal: 0.604 ± 0.026
0.103TrpTrp: 0.103 ± 0.011
0.346TrpTyr: 0.346 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.882TyrAla: 2.882 ± 0.064
0.337TyrCys: 0.337 ± 0.019
2.4TyrAsp: 2.4 ± 0.055
2.635TyrGlu: 2.635 ± 0.061
1.929TyrPhe: 1.929 ± 0.056
2.552TyrGly: 2.552 ± 0.05
0.895TyrHis: 0.895 ± 0.035
2.295TyrIle: 2.295 ± 0.054
2.266TyrLys: 2.266 ± 0.047
3.613TyrLeu: 3.613 ± 0.07
0.85TyrMet: 0.85 ± 0.028
1.675TyrAsn: 1.675 ± 0.045
1.409TyrPro: 1.409 ± 0.047
1.277TyrGln: 1.277 ± 0.039
1.899TyrArg: 1.899 ± 0.046
2.262TyrSer: 2.262 ± 0.047
2.136TyrThr: 2.136 ± 0.058
1.941TyrVal: 1.941 ± 0.051
0.389TyrTrp: 0.389 ± 0.023
1.411TyrTyr: 1.411 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2794 proteins (867431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski