Amino acid dipepetide frequency for Xenorhabdus doucetiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.622AlaAla: 7.622 ± 0.118
0.959AlaCys: 0.959 ± 0.034
4.38AlaAsp: 4.38 ± 0.064
5.571AlaGlu: 5.571 ± 0.077
3.236AlaPhe: 3.236 ± 0.056
6.682AlaGly: 6.682 ± 0.118
1.753AlaHis: 1.753 ± 0.051
5.963AlaIle: 5.963 ± 0.093
4.194AlaLys: 4.194 ± 0.078
9.974AlaLeu: 9.974 ± 0.135
2.331AlaMet: 2.331 ± 0.046
3.348AlaAsn: 3.348 ± 0.061
2.929AlaPro: 2.929 ± 0.073
3.923AlaGln: 3.923 ± 0.099
4.264AlaArg: 4.264 ± 0.076
4.596AlaSer: 4.596 ± 0.069
4.114AlaThr: 4.114 ± 0.062
5.61AlaVal: 5.61 ± 0.092
1.041AlaTrp: 1.041 ± 0.034
2.413AlaTyr: 2.413 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.81CysAla: 0.81 ± 0.026
0.198CysCys: 0.198 ± 0.014
0.546CysAsp: 0.546 ± 0.025
0.558CysGlu: 0.558 ± 0.023
0.452CysPhe: 0.452 ± 0.02
0.932CysGly: 0.932 ± 0.028
0.413CysHis: 0.413 ± 0.022
0.632CysIle: 0.632 ± 0.023
0.346CysLys: 0.346 ± 0.017
1.13CysLeu: 1.13 ± 0.038
0.226CysMet: 0.226 ± 0.016
0.374CysAsn: 0.374 ± 0.02
0.49CysPro: 0.49 ± 0.022
0.594CysGln: 0.594 ± 0.023
0.589CysArg: 0.589 ± 0.025
0.709CysSer: 0.709 ± 0.027
0.486CysThr: 0.486 ± 0.022
0.665CysVal: 0.665 ± 0.024
0.174CysTrp: 0.174 ± 0.012
0.386CysTyr: 0.386 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.141AspAla: 4.141 ± 0.073
0.514AspCys: 0.514 ± 0.024
2.656AspAsp: 2.656 ± 0.053
3.383AspGlu: 3.383 ± 0.064
2.318AspPhe: 2.318 ± 0.05
3.415AspGly: 3.415 ± 0.071
1.154AspHis: 1.154 ± 0.038
4.15AspIle: 4.15 ± 0.063
2.97AspLys: 2.97 ± 0.066
4.739AspLeu: 4.739 ± 0.064
1.24AspMet: 1.24 ± 0.033
2.586AspAsn: 2.586 ± 0.056
2.199AspPro: 2.199 ± 0.065
1.755AspGln: 1.755 ± 0.037
2.488AspArg: 2.488 ± 0.053
2.894AspSer: 2.894 ± 0.057
2.469AspThr: 2.469 ± 0.049
3.212AspVal: 3.212 ± 0.054
0.867AspTrp: 0.867 ± 0.027
2.041AspTyr: 2.041 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
4.6GluAla: 4.6 ± 0.083
0.547GluCys: 0.547 ± 0.024
2.375GluAsp: 2.375 ± 0.053
3.467GluGlu: 3.467 ± 0.078
1.974GluPhe: 1.974 ± 0.051
3.346GluGly: 3.346 ± 0.064
1.64GluHis: 1.64 ± 0.038
4.102GluIle: 4.102 ± 0.075
4.011GluLys: 4.011 ± 0.07
6.451GluLeu: 6.451 ± 0.091
1.676GluMet: 1.676 ± 0.04
2.941GluAsn: 2.941 ± 0.053
2.063GluPro: 2.063 ± 0.045
3.765GluGln: 3.765 ± 0.067
3.621GluArg: 3.621 ± 0.068
3.117GluSer: 3.117 ± 0.058
3.187GluThr: 3.187 ± 0.054
3.295GluVal: 3.295 ± 0.067
0.759GluTrp: 0.759 ± 0.025
1.802GluTyr: 1.802 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.199PheAla: 3.199 ± 0.06
0.534PheCys: 0.534 ± 0.022
2.499PheAsp: 2.499 ± 0.049
1.95PheGlu: 1.95 ± 0.049
1.875PhePhe: 1.875 ± 0.045
2.928PheGly: 2.928 ± 0.058
0.936PheHis: 0.936 ± 0.031
2.969PheIle: 2.969 ± 0.062
1.588PheLys: 1.588 ± 0.042
3.522PheLeu: 3.522 ± 0.063
1.045PheMet: 1.045 ± 0.033
1.996PheAsn: 1.996 ± 0.05
1.587PhePro: 1.587 ± 0.04
1.275PheGln: 1.275 ± 0.031
1.779PheArg: 1.779 ± 0.039
3.446PheSer: 3.446 ± 0.056
2.317PheThr: 2.317 ± 0.05
2.437PheVal: 2.437 ± 0.058
0.583PheTrp: 0.583 ± 0.019
1.391PheTyr: 1.391 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.243GlyAla: 5.243 ± 0.073
0.903GlyCys: 0.903 ± 0.028
3.377GlyAsp: 3.377 ± 0.082
4.248GlyGlu: 4.248 ± 0.069
3.073GlyPhe: 3.073 ± 0.05
4.89GlyGly: 4.89 ± 0.09
1.726GlyHis: 1.726 ± 0.042
5.257GlyIle: 5.257 ± 0.102
4.211GlyLys: 4.211 ± 0.085
6.924GlyLeu: 6.924 ± 0.093
2.015GlyMet: 2.015 ± 0.038
2.935GlyAsn: 2.935 ± 0.075
1.566GlyPro: 1.566 ± 0.038
3.032GlyGln: 3.032 ± 0.065
3.521GlyArg: 3.521 ± 0.074
3.893GlySer: 3.893 ± 0.058
3.466GlyThr: 3.466 ± 0.064
4.835GlyVal: 4.835 ± 0.076
1.102GlyTrp: 1.102 ± 0.033
2.774GlyTyr: 2.774 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.823HisAla: 1.823 ± 0.039
0.41HisCys: 0.41 ± 0.02
1.262HisAsp: 1.262 ± 0.038
1.274HisGlu: 1.274 ± 0.033
1.194HisPhe: 1.194 ± 0.037
1.68HisGly: 1.68 ± 0.039
0.98HisHis: 0.98 ± 0.041
1.594HisIle: 1.594 ± 0.038
0.99HisLys: 0.99 ± 0.03
2.66HisLeu: 2.66 ± 0.062
0.518HisMet: 0.518 ± 0.022
0.948HisAsn: 0.948 ± 0.027
1.385HisPro: 1.385 ± 0.036
1.441HisGln: 1.441 ± 0.03
1.351HisArg: 1.351 ± 0.035
1.536HisSer: 1.536 ± 0.04
1.141HisThr: 1.141 ± 0.031
1.395HisVal: 1.395 ± 0.032
0.45HisTrp: 0.45 ± 0.019
1.116HisTyr: 1.116 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.417IleAla: 6.417 ± 0.089
0.777IleCys: 0.777 ± 0.026
3.918IleAsp: 3.918 ± 0.057
4.143IleGlu: 4.143 ± 0.067
2.513IlePhe: 2.513 ± 0.054
4.844IleGly: 4.844 ± 0.073
1.514IleHis: 1.514 ± 0.036
4.188IleIle: 4.188 ± 0.076
3.335IleLys: 3.335 ± 0.065
6.014IleLeu: 6.014 ± 0.091
1.444IleMet: 1.444 ± 0.042
3.354IleAsn: 3.354 ± 0.059
3.088IlePro: 3.088 ± 0.049
2.381IleGln: 2.381 ± 0.046
3.437IleArg: 3.437 ± 0.058
4.755IleSer: 4.755 ± 0.075
4.043IleThr: 4.043 ± 0.056
3.95IleVal: 3.95 ± 0.058
0.846IleTrp: 0.846 ± 0.031
2.012IleTyr: 2.012 ± 0.046
0.0IleXaa: 0.0 ± 0.0
Lys
4.287LysAla: 4.287 ± 0.071
0.315LysCys: 0.315 ± 0.016
2.255LysAsp: 2.255 ± 0.064
3.064LysGlu: 3.064 ± 0.065
1.437LysPhe: 1.437 ± 0.039
3.2LysGly: 3.2 ± 0.061
1.091LysHis: 1.091 ± 0.03
3.444LysIle: 3.444 ± 0.062
3.089LysLys: 3.089 ± 0.07
5.056LysLeu: 5.056 ± 0.077
1.417LysMet: 1.417 ± 0.037
2.613LysAsn: 2.613 ± 0.052
2.27LysPro: 2.27 ± 0.049
2.611LysGln: 2.611 ± 0.057
2.677LysArg: 2.677 ± 0.054
2.879LysSer: 2.879 ± 0.061
2.992LysThr: 2.992 ± 0.058
3.18LysVal: 3.18 ± 0.07
0.573LysTrp: 0.573 ± 0.024
1.411LysTyr: 1.411 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
10.202LeuAla: 10.202 ± 0.16
1.171LeuCys: 1.171 ± 0.036
5.485LeuAsp: 5.485 ± 0.087
5.608LeuGlu: 5.608 ± 0.082
4.534LeuPhe: 4.534 ± 0.069
6.961LeuGly: 6.961 ± 0.097
2.395LeuHis: 2.395 ± 0.044
6.662LeuIle: 6.662 ± 0.085
5.156LeuLys: 5.156 ± 0.071
11.497LeuLeu: 11.497 ± 0.132
2.706LeuMet: 2.706 ± 0.06
4.864LeuAsn: 4.864 ± 0.065
5.765LeuPro: 5.765 ± 0.108
4.39LeuGln: 4.39 ± 0.075
5.615LeuArg: 5.615 ± 0.087
8.007LeuSer: 8.007 ± 0.094
6.412LeuThr: 6.412 ± 0.101
6.381LeuVal: 6.381 ± 0.084
1.245LeuTrp: 1.245 ± 0.039
2.769LeuTyr: 2.769 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.571MetAla: 2.571 ± 0.055
0.182MetCys: 0.182 ± 0.011
1.102MetAsp: 1.102 ± 0.031
1.314MetGlu: 1.314 ± 0.036
0.814MetPhe: 0.814 ± 0.027
1.732MetGly: 1.732 ± 0.041
0.409MetHis: 0.409 ± 0.02
1.526MetIle: 1.526 ± 0.037
1.43MetLys: 1.43 ± 0.041
2.882MetLeu: 2.882 ± 0.046
0.837MetMet: 0.837 ± 0.03
1.124MetAsn: 1.124 ± 0.032
1.205MetPro: 1.205 ± 0.034
1.105MetGln: 1.105 ± 0.031
1.249MetArg: 1.249 ± 0.033
1.747MetSer: 1.747 ± 0.043
1.658MetThr: 1.658 ± 0.039
1.699MetVal: 1.699 ± 0.038
0.22MetTrp: 0.22 ± 0.014
0.53MetTyr: 0.53 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.354AsnAla: 3.354 ± 0.061
0.394AsnCys: 0.394 ± 0.019
2.173AsnAsp: 2.173 ± 0.05
2.356AsnGlu: 2.356 ± 0.047
1.52AsnPhe: 1.52 ± 0.036
3.125AsnGly: 3.125 ± 0.066
1.193AsnHis: 1.193 ± 0.031
3.295AsnIle: 3.295 ± 0.061
2.314AsnLys: 2.314 ± 0.057
4.117AsnLeu: 4.117 ± 0.069
1.072AsnMet: 1.072 ± 0.032
2.117AsnAsn: 2.117 ± 0.047
2.249AsnPro: 2.249 ± 0.046
2.163AsnGln: 2.163 ± 0.06
2.356AsnArg: 2.356 ± 0.049
2.476AsnSer: 2.476 ± 0.053
2.4AsnThr: 2.4 ± 0.051
2.505AsnVal: 2.505 ± 0.049
0.554AsnTrp: 0.554 ± 0.024
1.433AsnTyr: 1.433 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
4.033ProAla: 4.033 ± 0.093
0.382ProCys: 0.382 ± 0.019
2.963ProAsp: 2.963 ± 0.075
3.525ProGlu: 3.525 ± 0.062
1.839ProPhe: 1.839 ± 0.044
2.435ProGly: 2.435 ± 0.045
1.034ProHis: 1.034 ± 0.034
2.6ProIle: 2.6 ± 0.054
1.862ProLys: 1.862 ± 0.043
4.854ProLeu: 4.854 ± 0.1
0.986ProMet: 0.986 ± 0.03
1.675ProAsn: 1.675 ± 0.04
1.594ProPro: 1.594 ± 0.046
1.985ProGln: 1.985 ± 0.044
1.682ProArg: 1.682 ± 0.034
2.309ProSer: 2.309 ± 0.053
2.144ProThr: 2.144 ± 0.042
3.551ProVal: 3.551 ± 0.068
0.605ProTrp: 0.605 ± 0.025
1.351ProTyr: 1.351 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
4.456GlnAla: 4.456 ± 0.092
0.444GlnCys: 0.444 ± 0.022
1.991GlnAsp: 1.991 ± 0.049
2.553GlnGlu: 2.553 ± 0.054
1.703GlnPhe: 1.703 ± 0.037
3.261GlnGly: 3.261 ± 0.079
1.428GlnHis: 1.428 ± 0.041
2.723GlnIle: 2.723 ± 0.044
2.38GlnLys: 2.38 ± 0.056
5.441GlnLeu: 5.441 ± 0.086
1.094GlnMet: 1.094 ± 0.031
1.737GlnAsn: 1.737 ± 0.044
2.204GlnPro: 2.204 ± 0.066
3.48GlnGln: 3.48 ± 0.076
2.91GlnArg: 2.91 ± 0.063
2.636GlnSer: 2.636 ± 0.049
2.279GlnThr: 2.279 ± 0.052
3.016GlnVal: 3.016 ± 0.058
0.743GlnTrp: 0.743 ± 0.027
1.442GlnTyr: 1.442 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
3.696ArgAla: 3.696 ± 0.064
0.539ArgCys: 0.539 ± 0.022
2.618ArgAsp: 2.618 ± 0.047
3.438ArgGlu: 3.438 ± 0.056
2.351ArgPhe: 2.351 ± 0.046
2.941ArgGly: 2.941 ± 0.056
1.726ArgHis: 1.726 ± 0.051
3.563ArgIle: 3.563 ± 0.055
2.528ArgLys: 2.528 ± 0.056
6.088ArgLeu: 6.088 ± 0.082
1.311ArgMet: 1.311 ± 0.035
2.196ArgAsn: 2.196 ± 0.044
2.11ArgPro: 2.11 ± 0.05
3.149ArgGln: 3.149 ± 0.07
2.983ArgArg: 2.983 ± 0.062
2.628ArgSer: 2.628 ± 0.049
2.385ArgThr: 2.385 ± 0.046
3.193ArgVal: 3.193 ± 0.05
0.866ArgTrp: 0.866 ± 0.034
2.153ArgTyr: 2.153 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.172SerAla: 5.172 ± 0.074
0.598SerCys: 0.598 ± 0.021
3.201SerAsp: 3.201 ± 0.054
3.459SerGlu: 3.459 ± 0.061
2.464SerPhe: 2.464 ± 0.055
4.989SerGly: 4.989 ± 0.071
1.747SerHis: 1.747 ± 0.037
3.836SerIle: 3.836 ± 0.066
2.471SerLys: 2.471 ± 0.055
7.205SerLeu: 7.205 ± 0.082
1.472SerMet: 1.472 ± 0.037
2.179SerAsn: 2.179 ± 0.061
2.912SerPro: 2.912 ± 0.056
2.986SerGln: 2.986 ± 0.054
3.232SerArg: 3.232 ± 0.05
3.836SerSer: 3.836 ± 0.077
2.912SerThr: 2.912 ± 0.058
4.128SerVal: 4.128 ± 0.06
0.862SerTrp: 0.862 ± 0.028
1.924SerTyr: 1.924 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.68ThrAla: 4.68 ± 0.082
0.511ThrCys: 0.511 ± 0.02
2.705ThrAsp: 2.705 ± 0.047
3.082ThrGlu: 3.082 ± 0.045
1.972ThrPhe: 1.972 ± 0.043
4.247ThrGly: 4.247 ± 0.064
1.348ThrHis: 1.348 ± 0.037
3.163ThrIle: 3.163 ± 0.06
2.012ThrLys: 2.012 ± 0.05
6.975ThrLeu: 6.975 ± 0.1
0.948ThrMet: 0.948 ± 0.03
1.761ThrAsn: 1.761 ± 0.043
3.031ThrPro: 3.031 ± 0.065
2.482ThrGln: 2.482 ± 0.055
2.649ThrArg: 2.649 ± 0.053
2.973ThrSer: 2.973 ± 0.054
2.843ThrThr: 2.843 ± 0.053
3.663ThrVal: 3.663 ± 0.053
0.602ThrTrp: 0.602 ± 0.02
1.447ThrTyr: 1.447 ± 0.037
0.0ThrXaa: 0.0 ± 0.0
Val
5.42ValAla: 5.42 ± 0.08
0.726ValCys: 0.726 ± 0.027
3.4ValAsp: 3.4 ± 0.061
3.701ValGlu: 3.701 ± 0.063
2.583ValPhe: 2.583 ± 0.055
4.343ValGly: 4.343 ± 0.077
1.21ValHis: 1.21 ± 0.029
4.754ValIle: 4.754 ± 0.065
3.162ValLys: 3.162 ± 0.062
6.441ValLeu: 6.441 ± 0.096
1.958ValMet: 1.958 ± 0.041
2.825ValAsn: 2.825 ± 0.059
2.637ValPro: 2.637 ± 0.062
2.26ValGln: 2.26 ± 0.051
3.102ValArg: 3.102 ± 0.055
4.394ValSer: 4.394 ± 0.067
3.861ValThr: 3.861 ± 0.06
4.497ValVal: 4.497 ± 0.069
0.799ValTrp: 0.799 ± 0.026
1.706ValTyr: 1.706 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.839TrpAla: 0.839 ± 0.029
0.174TrpCys: 0.174 ± 0.011
0.61TrpAsp: 0.61 ± 0.024
0.668TrpGlu: 0.668 ± 0.024
0.567TrpPhe: 0.567 ± 0.022
0.8TrpGly: 0.8 ± 0.03
0.455TrpHis: 0.455 ± 0.019
0.723TrpIle: 0.723 ± 0.027
0.569TrpLys: 0.569 ± 0.024
2.097TrpLeu: 2.097 ± 0.054
0.362TrpMet: 0.362 ± 0.017
0.482TrpAsn: 0.482 ± 0.023
0.546TrpPro: 0.546 ± 0.023
1.207TrpGln: 1.207 ± 0.039
0.873TrpArg: 0.873 ± 0.028
0.788TrpSer: 0.788 ± 0.026
0.432TrpThr: 0.432 ± 0.018
0.84TrpVal: 0.84 ± 0.028
0.197TrpTrp: 0.197 ± 0.015
0.34TrpTyr: 0.34 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.336TyrAla: 2.336 ± 0.044
0.427TyrCys: 0.427 ± 0.019
1.672TyrAsp: 1.672 ± 0.054
1.381TyrGlu: 1.381 ± 0.038
1.438TyrPhe: 1.438 ± 0.036
2.239TyrGly: 2.239 ± 0.038
1.002TyrHis: 1.002 ± 0.031
1.833TyrIle: 1.833 ± 0.042
1.245TyrLys: 1.245 ± 0.037
3.761TyrLeu: 3.761 ± 0.062
0.678TyrMet: 0.678 ± 0.028
1.108TyrAsn: 1.108 ± 0.037
1.582TyrPro: 1.582 ± 0.04
1.938TyrGln: 1.938 ± 0.045
2.081TyrArg: 2.081 ± 0.043
1.965TyrSer: 1.965 ± 0.042
1.55TyrThr: 1.55 ± 0.036
1.725TyrVal: 1.725 ± 0.039
0.48TyrTrp: 0.48 ± 0.021
1.04TyrTyr: 1.04 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3749 proteins (1174667 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski