Amino acid dipepetide frequency for Erinaceus europaeus (Western European hedgehog)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.911AlaAla: 6.911 ± 0.032	1.41AlaCys: 1.41 ± 0.011	2.954AlaAsp: 2.954 ± 0.015	4.769AlaGlu: 4.769 ± 0.032	2.682AlaPhe: 2.682 ± 0.019	4.79AlaGly: 4.79 ± 0.03	1.597AlaHis: 1.597 ± 0.012	2.817AlaIle: 2.817 ± 0.016	3.294AlaLys: 3.294 ± 0.019	7.34AlaLeu: 7.34 ± 0.034	1.546AlaMet: 1.546 ± 0.013	1.984AlaAsn: 1.984 ± 0.012	4.354AlaPro: 4.354 ± 0.031	3.341AlaGln: 3.341 ± 0.025	3.782AlaArg: 3.782 ± 0.019	5.788AlaSer: 5.788 ± 0.023	3.587AlaThr: 3.587 ± 0.02	4.754AlaVal: 4.754 ± 0.024	0.81AlaTrp: 0.81 ± 0.009	1.562AlaTyr: 1.562 ± 0.011	0.004AlaXaa: 0.004 ± 0.001
Cys	1.286CysAla: 1.286 ± 0.013	0.62CysCys: 0.62 ± 0.011	1.022CysAsp: 1.022 ± 0.012	1.239CysGlu: 1.239 ± 0.012	0.847CysPhe: 0.847 ± 0.008	1.672CysGly: 1.672 ± 0.02	0.665CysHis: 0.665 ± 0.008	0.937CysIle: 0.937 ± 0.009	1.149CysLys: 1.149 ± 0.014	2.148CysLeu: 2.148 ± 0.013	0.411CysMet: 0.411 ± 0.006	0.765CysAsn: 0.765 ± 0.009	1.361CysPro: 1.361 ± 0.017	1.066CysGln: 1.066 ± 0.013	1.287CysArg: 1.287 ± 0.012	2.023CysSer: 2.023 ± 0.017	1.094CysThr: 1.094 ± 0.011	1.316CysVal: 1.316 ± 0.011	0.284CysTrp: 0.284 ± 0.005	0.587CysTyr: 0.587 ± 0.007	0.002CysXaa: 0.002 ± 0.0
Asp	2.881AspAla: 2.881 ± 0.014	1.029AspCys: 1.029 ± 0.012	2.598AspAsp: 2.598 ± 0.019	3.322AspGlu: 3.322 ± 0.018	2.123AspPhe: 2.123 ± 0.014	3.302AspGly: 3.302 ± 0.021	1.141AspHis: 1.141 ± 0.009	2.552AspIle: 2.552 ± 0.015	2.487AspLys: 2.487 ± 0.015	4.95AspLeu: 4.95 ± 0.022	1.137AspMet: 1.137 ± 0.009	1.676AspAsn: 1.676 ± 0.013	2.989AspPro: 2.989 ± 0.013	1.841AspGln: 1.841 ± 0.013	2.498AspArg: 2.498 ± 0.017	4.237AspSer: 4.237 ± 0.022	2.552AspThr: 2.552 ± 0.017	2.95AspVal: 2.95 ± 0.017	0.63AspTrp: 0.63 ± 0.007	1.459AspTyr: 1.459 ± 0.012	0.003AspXaa: 0.003 ± 0.0
Glu	5.264GluAla: 5.264 ± 0.036	1.347GluCys: 1.347 ± 0.022	4.372GluAsp: 4.372 ± 0.024	7.695GluGlu: 7.695 ± 0.052	2.024GluPhe: 2.024 ± 0.014	4.076GluGly: 4.076 ± 0.021	1.494GluHis: 1.494 ± 0.011	2.981GluIle: 2.981 ± 0.018	5.113GluLys: 5.113 ± 0.036	6.44GluLeu: 6.44 ± 0.038	1.629GluMet: 1.629 ± 0.012	2.918GluAsn: 2.918 ± 0.017	3.324GluPro: 3.324 ± 0.023	3.14GluGln: 3.14 ± 0.024	4.012GluArg: 4.012 ± 0.028	4.308GluSer: 4.308 ± 0.02	3.265GluThr: 3.265 ± 0.018	4.121GluVal: 4.121 ± 0.02	0.672GluTrp: 0.672 ± 0.007	1.542GluTyr: 1.542 ± 0.012	0.003GluXaa: 0.003 ± 0.0
Phe	1.995PheAla: 1.995 ± 0.013	0.982PheCys: 0.982 ± 0.009	1.675PheAsp: 1.675 ± 0.012	1.955PheGlu: 1.955 ± 0.013	1.683PhePhe: 1.683 ± 0.013	2.227PheGly: 2.227 ± 0.016	1.032PheHis: 1.032 ± 0.009	1.904PheIle: 1.904 ± 0.016	1.715PheLys: 1.715 ± 0.011	4.231PheLeu: 4.231 ± 0.025	0.792PheMet: 0.792 ± 0.008	1.298PheAsn: 1.298 ± 0.012	2.013PhePro: 2.013 ± 0.014	1.787PheGln: 1.787 ± 0.011	1.967PheArg: 1.967 ± 0.013	3.473PheSer: 3.473 ± 0.019	2.043PheThr: 2.043 ± 0.013	2.189PheVal: 2.189 ± 0.013	0.496PheTrp: 0.496 ± 0.006	1.203PheTyr: 1.203 ± 0.011	0.003PheXaa: 0.003 ± 0.0
Gly	4.621GlyAla: 4.621 ± 0.027	1.288GlyCys: 1.288 ± 0.014	3.19GlyAsp: 3.19 ± 0.021	4.035GlyGlu: 4.035 ± 0.03	2.422GlyPhe: 2.422 ± 0.015	5.135GlyGly: 5.135 ± 0.041	1.698GlyHis: 1.698 ± 0.012	2.665GlyIle: 2.665 ± 0.016	3.528GlyLys: 3.528 ± 0.021	6.124GlyLeu: 6.124 ± 0.028	1.301GlyMet: 1.301 ± 0.013	2.344GlyAsn: 2.344 ± 0.015	4.427GlyPro: 4.427 ± 0.055	2.794GlyGln: 2.794 ± 0.018	3.832GlyArg: 3.832 ± 0.019	5.872GlySer: 5.872 ± 0.028	3.637GlyThr: 3.637 ± 0.019	3.605GlyVal: 3.605 ± 0.02	0.776GlyTrp: 0.776 ± 0.011	1.731GlyTyr: 1.731 ± 0.014	0.005GlyXaa: 0.005 ± 0.001
His	1.319HisAla: 1.319 ± 0.01	0.713HisCys: 0.713 ± 0.009	0.884HisAsp: 0.884 ± 0.008	1.316HisGlu: 1.316 ± 0.014	1.116HisPhe: 1.116 ± 0.009	1.542HisGly: 1.542 ± 0.013	0.924HisHis: 0.924 ± 0.012	1.239HisIle: 1.239 ± 0.01	1.245HisLys: 1.245 ± 0.01	2.978HisLeu: 2.978 ± 0.017	0.609HisMet: 0.609 ± 0.007	0.867HisAsn: 0.867 ± 0.008	1.695HisPro: 1.695 ± 0.014	1.299HisGln: 1.299 ± 0.016	1.608HisArg: 1.608 ± 0.01	2.378HisSer: 2.378 ± 0.017	1.508HisThr: 1.508 ± 0.015	1.481HisVal: 1.481 ± 0.011	0.346HisTrp: 0.346 ± 0.005	0.844HisTyr: 0.844 ± 0.008	0.002HisXaa: 0.002 ± 0.0
Ile	2.526IleAla: 2.526 ± 0.013	1.086IleCys: 1.086 ± 0.01	1.949IleAsp: 1.949 ± 0.014	2.45IleGlu: 2.45 ± 0.016	1.924IlePhe: 1.924 ± 0.016	2.165IleGly: 2.165 ± 0.014	1.313IleHis: 1.313 ± 0.015	2.37IleIle: 2.37 ± 0.018	2.488IleLys: 2.488 ± 0.018	4.619IleLeu: 4.619 ± 0.023	1.008IleMet: 1.008 ± 0.009	1.765IleAsn: 1.765 ± 0.012	2.586IlePro: 2.586 ± 0.016	2.199IleGln: 2.199 ± 0.014	2.321IleArg: 2.321 ± 0.013	3.681IleSer: 3.681 ± 0.019	2.552IleThr: 2.552 ± 0.022	2.49IleVal: 2.49 ± 0.016	0.494IleTrp: 0.494 ± 0.006	1.396IleTyr: 1.396 ± 0.011	0.002IleXaa: 0.002 ± 0.0
Lys	3.924LysAla: 3.924 ± 0.022	1.078LysCys: 1.078 ± 0.012	3.079LysAsp: 3.079 ± 0.019	4.814LysGlu: 4.814 ± 0.03	1.686LysPhe: 1.686 ± 0.012	3.11LysGly: 3.11 ± 0.026	1.364LysHis: 1.364 ± 0.011	2.615LysIle: 2.615 ± 0.016	4.506LysLys: 4.506 ± 0.031	5.028LysLeu: 5.028 ± 0.026	1.418LysMet: 1.418 ± 0.01	2.284LysAsn: 2.284 ± 0.016	3.019LysPro: 3.019 ± 0.023	2.556LysGln: 2.556 ± 0.018	3.221LysArg: 3.221 ± 0.017	3.743LysSer: 3.743 ± 0.021	3.036LysThr: 3.036 ± 0.019	3.393LysVal: 3.393 ± 0.02	0.567LysTrp: 0.567 ± 0.007	1.507LysTyr: 1.507 ± 0.013	0.003LysXaa: 0.003 ± 0.0
Leu	7.061LeuAla: 7.061 ± 0.032	2.209LeuCys: 2.209 ± 0.015	4.778LeuAsp: 4.778 ± 0.021	7.083LeuGlu: 7.083 ± 0.043	3.457LeuPhe: 3.457 ± 0.021	6.123LeuGly: 6.123 ± 0.026	2.802LeuHis: 2.802 ± 0.017	3.832LeuIle: 3.832 ± 0.02	5.64LeuLys: 5.64 ± 0.029	11.205LeuLeu: 11.205 ± 0.053	2.026LeuMet: 2.026 ± 0.012	3.489LeuAsn: 3.489 ± 0.018	6.096LeuPro: 6.096 ± 0.029	5.838LeuGln: 5.838 ± 0.034	6.167LeuArg: 6.167 ± 0.027	8.202LeuSer: 8.202 ± 0.029	5.173LeuThr: 5.173 ± 0.021	5.722LeuVal: 5.722 ± 0.025	1.156LeuTrp: 1.156 ± 0.011	2.549LeuTyr: 2.549 ± 0.016	0.007LeuXaa: 0.007 ± 0.001
Met	2.0MetAla: 2.0 ± 0.011	0.388MetCys: 0.388 ± 0.005	1.274MetAsp: 1.274 ± 0.009	1.83MetGlu: 1.83 ± 0.013	0.751MetPhe: 0.751 ± 0.008	1.323MetGly: 1.323 ± 0.012	0.461MetHis: 0.461 ± 0.006	0.865MetIle: 0.865 ± 0.008	1.412MetLys: 1.412 ± 0.011	2.043MetLeu: 2.043 ± 0.014	0.586MetMet: 0.586 ± 0.008	0.899MetAsn: 0.899 ± 0.009	1.099MetPro: 1.099 ± 0.01	0.939MetGln: 0.939 ± 0.009	1.063MetArg: 1.063 ± 0.01	1.62MetSer: 1.62 ± 0.012	1.125MetThr: 1.125 ± 0.008	1.405MetVal: 1.405 ± 0.012	0.235MetTrp: 0.235 ± 0.004	0.636MetTyr: 0.636 ± 0.008	0.001MetXaa: 0.001 ± 0.0
Asn	1.981AsnAla: 1.981 ± 0.012	0.82AsnCys: 0.82 ± 0.008	1.444AsnAsp: 1.444 ± 0.013	2.072AsnGlu: 2.072 ± 0.013	1.47AsnPhe: 1.47 ± 0.011	2.364AsnGly: 2.364 ± 0.018	0.937AsnHis: 0.937 ± 0.01	2.029AsnIle: 2.029 ± 0.016	2.132AsnLys: 2.132 ± 0.012	3.651AsnLeu: 3.651 ± 0.019	0.909AsnMet: 0.909 ± 0.008	1.462AsnAsn: 1.462 ± 0.012	2.218AsnPro: 2.218 ± 0.013	1.643AsnGln: 1.643 ± 0.013	1.789AsnArg: 1.789 ± 0.012	3.108AsnSer: 3.108 ± 0.017	1.959AsnThr: 1.959 ± 0.014	2.112AsnVal: 2.112 ± 0.013	0.442AsnTrp: 0.442 ± 0.006	1.09AsnTyr: 1.09 ± 0.009	0.002AsnXaa: 0.002 ± 0.0
Pro	5.009ProAla: 5.009 ± 0.036	1.132ProCys: 1.132 ± 0.015	2.801ProAsp: 2.801 ± 0.015	4.506ProGlu: 4.506 ± 0.023	1.933ProPhe: 1.933 ± 0.015	5.488ProGly: 5.488 ± 0.073	1.509ProHis: 1.509 ± 0.012	1.862ProIle: 1.862 ± 0.013	2.745ProLys: 2.745 ± 0.02	5.437ProLeu: 5.437 ± 0.022	1.157ProMet: 1.157 ± 0.01	1.822ProAsn: 1.822 ± 0.014	6.426ProPro: 6.426 ± 0.057	2.98ProGln: 2.98 ± 0.022	3.484ProArg: 3.484 ± 0.024	5.753ProSer: 5.753 ± 0.029	3.221ProThr: 3.221 ± 0.02	3.84ProVal: 3.84 ± 0.021	0.683ProTrp: 0.683 ± 0.007	1.544ProTyr: 1.544 ± 0.017	0.005ProXaa: 0.005 ± 0.001
Gln	3.633GlnAla: 3.633 ± 0.023	0.952GlnCys: 0.952 ± 0.012	2.343GlnAsp: 2.343 ± 0.014	3.852GlnGlu: 3.852 ± 0.028	1.356GlnPhe: 1.356 ± 0.011	2.894GlnGly: 2.894 ± 0.021	1.314GlnHis: 1.314 ± 0.011	1.924GlnIle: 1.924 ± 0.011	2.844GlnLys: 2.844 ± 0.016	4.857GlnLeu: 4.857 ± 0.031	1.148GlnMet: 1.148 ± 0.011	1.787GlnAsn: 1.787 ± 0.015	2.863GlnPro: 2.863 ± 0.021	3.137GlnGln: 3.137 ± 0.036	2.981GlnArg: 2.981 ± 0.021	3.141GlnSer: 3.141 ± 0.017	2.313GlnThr: 2.313 ± 0.015	2.866GlnVal: 2.866 ± 0.018	0.531GlnTrp: 0.531 ± 0.007	1.147GlnTyr: 1.147 ± 0.01	0.003GlnXaa: 0.003 ± 0.0
Arg	3.982ArgAla: 3.982 ± 0.021	1.185ArgCys: 1.185 ± 0.014	2.813ArgAsp: 2.813 ± 0.014	3.992ArgGlu: 3.992 ± 0.027	1.886ArgPhe: 1.886 ± 0.014	3.715ArgGly: 3.715 ± 0.027	1.549ArgHis: 1.549 ± 0.012	2.37ArgIle: 2.37 ± 0.015	3.629ArgLys: 3.629 ± 0.019	5.562ArgLeu: 5.562 ± 0.031	1.192ArgMet: 1.192 ± 0.009	2.111ArgAsn: 2.111 ± 0.013	3.376ArgPro: 3.376 ± 0.021	2.635ArgGln: 2.635 ± 0.02	4.45ArgArg: 4.45 ± 0.025	4.308ArgSer: 4.308 ± 0.028	2.886ArgThr: 2.886 ± 0.017	3.205ArgVal: 3.205 ± 0.019	0.68ArgTrp: 0.68 ± 0.007	1.468ArgTyr: 1.468 ± 0.011	0.004ArgXaa: 0.004 ± 0.001
Ser	5.353SerAla: 5.353 ± 0.023	1.833SerCys: 1.833 ± 0.016	3.864SerAsp: 3.864 ± 0.023	5.081SerGlu: 5.081 ± 0.025	3.0SerPhe: 3.0 ± 0.015	5.725SerGly: 5.725 ± 0.029	2.155SerHis: 2.155 ± 0.014	3.18SerIle: 3.18 ± 0.018	4.02SerLys: 4.02 ± 0.022	8.308SerLeu: 8.308 ± 0.029	1.665SerMet: 1.665 ± 0.012	2.652SerAsn: 2.652 ± 0.019	6.148SerPro: 6.148 ± 0.04	3.874SerGln: 3.874 ± 0.02	4.674SerArg: 4.674 ± 0.031	9.507SerSer: 9.507 ± 0.061	4.564SerThr: 4.564 ± 0.029	4.903SerVal: 4.903 ± 0.022	1.071SerTrp: 1.071 ± 0.01	2.133SerTyr: 2.133 ± 0.017	0.005SerXaa: 0.005 ± 0.001
Thr	3.764ThrAla: 3.764 ± 0.019	1.326ThrCys: 1.326 ± 0.016	2.448ThrAsp: 2.448 ± 0.014	3.493ThrGlu: 3.493 ± 0.018	2.171ThrPhe: 2.171 ± 0.016	3.519ThrGly: 3.519 ± 0.023	1.355ThrHis: 1.355 ± 0.014	2.418ThrIle: 2.418 ± 0.024	2.573ThrLys: 2.573 ± 0.018	5.413ThrLeu: 5.413 ± 0.024	1.149ThrMet: 1.149 ± 0.01	1.674ThrAsn: 1.674 ± 0.011	3.793ThrPro: 3.793 ± 0.027	2.313ThrGln: 2.313 ± 0.015	2.46ThrArg: 2.46 ± 0.012	4.634ThrSer: 4.634 ± 0.03	3.078ThrThr: 3.078 ± 0.055	3.919ThrVal: 3.919 ± 0.022	0.676ThrTrp: 0.676 ± 0.008	1.47ThrTyr: 1.47 ± 0.011	0.003ThrXaa: 0.003 ± 0.0
Val	4.335ValAla: 4.335 ± 0.021	1.443ValCys: 1.443 ± 0.012	2.934ValAsp: 2.934 ± 0.017	3.75ValGlu: 3.75 ± 0.024	2.435ValPhe: 2.435 ± 0.017	3.422ValGly: 3.422 ± 0.019	1.553ValHis: 1.553 ± 0.012	2.918ValIle: 2.918 ± 0.017	3.282ValLys: 3.282 ± 0.023	6.38ValLeu: 6.38 ± 0.027	1.344ValMet: 1.344 ± 0.01	2.205ValAsn: 2.205 ± 0.015	3.708ValPro: 3.708 ± 0.024	2.737ValGln: 2.737 ± 0.016	3.084ValArg: 3.084 ± 0.019	4.86ValSer: 4.86 ± 0.02	3.852ValThr: 3.852 ± 0.026	4.065ValVal: 4.065 ± 0.02	0.714ValTrp: 0.714 ± 0.008	1.628ValTyr: 1.628 ± 0.013	0.003ValXaa: 0.003 ± 0.0
Trp	0.82TrpAla: 0.82 ± 0.008	0.245TrpCys: 0.245 ± 0.004	0.646TrpAsp: 0.646 ± 0.009	0.787TrpGlu: 0.787 ± 0.008	0.438TrpPhe: 0.438 ± 0.005	0.73TrpGly: 0.73 ± 0.01	0.298TrpHis: 0.298 ± 0.005	0.524TrpIle: 0.524 ± 0.006	0.769TrpLys: 0.769 ± 0.008	1.221TrpLeu: 1.221 ± 0.011	0.306TrpMet: 0.306 ± 0.004	0.538TrpAsn: 0.538 ± 0.006	0.515TrpPro: 0.515 ± 0.006	0.524TrpGln: 0.524 ± 0.006	0.72TrpArg: 0.72 ± 0.009	0.836TrpSer: 0.836 ± 0.008	0.672TrpThr: 0.672 ± 0.008	0.704TrpVal: 0.704 ± 0.008	0.192TrpTrp: 0.192 ± 0.004	0.324TrpTyr: 0.324 ± 0.006	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.405TyrAla: 1.405 ± 0.01	0.694TyrCys: 0.694 ± 0.007	1.287TyrAsp: 1.287 ± 0.01	1.694TyrGlu: 1.694 ± 0.015	1.257TyrPhe: 1.257 ± 0.011	1.703TyrGly: 1.703 ± 0.013	0.752TyrHis: 0.752 ± 0.007	1.378TyrIle: 1.378 ± 0.011	1.375TyrLys: 1.375 ± 0.014	2.674TyrLeu: 2.674 ± 0.014	0.621TyrMet: 0.621 ± 0.007	1.09TyrAsn: 1.09 ± 0.009	1.322TyrPro: 1.322 ± 0.012	1.24TyrGln: 1.24 ± 0.01	1.595TyrArg: 1.595 ± 0.012	2.239TyrSer: 2.239 ± 0.014	1.533TyrThr: 1.533 ± 0.014	1.609TyrVal: 1.609 ± 0.014	0.354TyrTrp: 0.354 ± 0.007	0.942TyrTyr: 0.942 ± 0.009	0.002TyrXaa: 0.002 ± 0.0
Xaa	0.004XaaAla: 0.004 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.004XaaGlu: 0.004 ± 0.001	0.002XaaPhe: 0.002 ± 0.0	0.005XaaGly: 0.005 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.003XaaIle: 0.003 ± 0.0	0.004XaaLys: 0.004 ± 0.001	0.005XaaLeu: 0.005 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.005XaaPro: 0.005 ± 0.001	0.002XaaGln: 0.002 ± 0.0	0.004XaaArg: 0.004 ± 0.0	0.005XaaSer: 0.005 ± 0.0	0.003XaaThr: 0.003 ± 0.0	0.005XaaVal: 0.005 ± 0.001	0.001XaaTrp: 0.001 ± 0.0	0.002XaaTyr: 0.002 ± 0.0	0.016XaaXaa: 0.016 ± 0.003

Statistics based on 27628 proteins (16097671 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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