Amino acid dipepetide frequency for Mytilus galloprovincialis (Mediterranean mussel)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.207AlaAla: 3.207 ± 0.123	1.152AlaCys: 1.152 ± 0.049	2.803AlaAsp: 2.803 ± 0.064	3.038AlaGlu: 3.038 ± 0.069	2.192AlaPhe: 2.192 ± 0.056	3.025AlaGly: 3.025 ± 0.108	0.989AlaHis: 0.989 ± 0.042	3.355AlaIle: 3.355 ± 0.073	3.183AlaLys: 3.183 ± 0.078	4.282AlaLeu: 4.282 ± 0.086	1.214AlaMet: 1.214 ± 0.042	2.338AlaAsn: 2.338 ± 0.061	1.706AlaPro: 1.706 ± 0.052	1.623AlaGln: 1.623 ± 0.056	1.937AlaArg: 1.937 ± 0.058	3.705AlaSer: 3.705 ± 0.09	3.135AlaThr: 3.135 ± 0.078	3.759AlaVal: 3.759 ± 0.08	0.518AlaTrp: 0.518 ± 0.027	1.603AlaTyr: 1.603 ± 0.05	0.001AlaXaa: 0.001 ± 0.001
Cys	1.087CysAla: 1.087 ± 0.064	0.65CysCys: 0.65 ± 0.042	1.526CysAsp: 1.526 ± 0.067	1.376CysGlu: 1.376 ± 0.042	0.945CysPhe: 0.945 ± 0.039	1.583CysGly: 1.583 ± 0.054	0.615CysHis: 0.615 ± 0.036	1.477CysIle: 1.477 ± 0.045	1.744CysLys: 1.744 ± 0.072	1.995CysLeu: 1.995 ± 0.05	0.514CysMet: 0.514 ± 0.031	1.284CysAsn: 1.284 ± 0.05	1.19CysPro: 1.19 ± 0.056	1.054CysGln: 1.054 ± 0.048	1.272CysArg: 1.272 ± 0.061	2.102CysSer: 2.102 ± 0.067	1.508CysThr: 1.508 ± 0.054	1.419CysVal: 1.419 ± 0.049	0.193CysTrp: 0.193 ± 0.015	0.895CysTyr: 0.895 ± 0.034	0.0CysXaa: 0.0 ± 0.0
Asp	2.682AspAla: 2.682 ± 0.055	1.395AspCys: 1.395 ± 0.05	4.34AspAsp: 4.34 ± 0.126	4.42AspGlu: 4.42 ± 0.082	2.623AspPhe: 2.623 ± 0.068	3.596AspGly: 3.596 ± 0.091	1.407AspHis: 1.407 ± 0.04	4.935AspIle: 4.935 ± 0.112	4.248AspLys: 4.248 ± 0.096	4.949AspLeu: 4.949 ± 0.101	1.519AspMet: 1.519 ± 0.048	3.57AspAsn: 3.57 ± 0.084	2.198AspPro: 2.198 ± 0.062	2.264AspGln: 2.264 ± 0.076	2.54AspArg: 2.54 ± 0.071	4.416AspSer: 4.416 ± 0.083	3.439AspThr: 3.439 ± 0.07	4.185AspVal: 4.185 ± 0.089	0.665AspTrp: 0.665 ± 0.032	2.029AspTyr: 2.029 ± 0.051	0.004AspXaa: 0.004 ± 0.002
Glu	3.164GluAla: 3.164 ± 0.08	1.44GluCys: 1.44 ± 0.059	4.548GluAsp: 4.548 ± 0.09	5.594GluGlu: 5.594 ± 0.12	2.322GluPhe: 2.322 ± 0.063	2.905GluGly: 2.905 ± 0.064	1.494GluHis: 1.494 ± 0.041	4.684GluIle: 4.684 ± 0.098	5.406GluLys: 5.406 ± 0.123	5.117GluLeu: 5.117 ± 0.097	1.861GluMet: 1.861 ± 0.065	4.317GluAsn: 4.317 ± 0.07	2.012GluPro: 2.012 ± 0.071	2.736GluGln: 2.736 ± 0.09	2.897GluArg: 2.897 ± 0.077	4.56GluSer: 4.56 ± 0.083	4.16GluThr: 4.16 ± 0.086	3.702GluVal: 3.702 ± 0.081	0.696GluTrp: 0.696 ± 0.033	2.129GluTyr: 2.129 ± 0.051	0.003GluXaa: 0.003 ± 0.002
Phe	1.7PheAla: 1.7 ± 0.049	1.042PheCys: 1.042 ± 0.037	2.468PheAsp: 2.468 ± 0.06	2.414PheGlu: 2.414 ± 0.056	1.406PhePhe: 1.406 ± 0.053	2.355PheGly: 2.355 ± 0.063	0.967PheHis: 0.967 ± 0.036	2.558PheIle: 2.558 ± 0.067	2.549PheLys: 2.549 ± 0.06	3.508PheLeu: 3.508 ± 0.085	0.859PheMet: 0.859 ± 0.036	1.95PheAsn: 1.95 ± 0.058	1.508PhePro: 1.508 ± 0.04	1.636PheGln: 1.636 ± 0.046	1.675PheArg: 1.675 ± 0.043	3.109PheSer: 3.109 ± 0.059	2.569PheThr: 2.569 ± 0.06	2.632PheVal: 2.632 ± 0.102	0.442PheTrp: 0.442 ± 0.025	1.431PheTyr: 1.431 ± 0.047	0.004PheXaa: 0.004 ± 0.002
Gly	2.637GlyAla: 2.637 ± 0.102	1.226GlyCys: 1.226 ± 0.049	3.248GlyAsp: 3.248 ± 0.078	2.97GlyGlu: 2.97 ± 0.064	2.388GlyPhe: 2.388 ± 0.089	4.196GlyGly: 4.196 ± 0.311	1.664GlyHis: 1.664 ± 0.141	3.595GlyIle: 3.595 ± 0.069	4.068GlyLys: 4.068 ± 0.093	4.117GlyLeu: 4.117 ± 0.092	1.293GlyMet: 1.293 ± 0.051	3.525GlyAsn: 3.525 ± 0.091	1.85GlyPro: 1.85 ± 0.064	2.522GlyGln: 2.522 ± 0.181	2.719GlyArg: 2.719 ± 0.084	4.414GlySer: 4.414 ± 0.096	3.575GlyThr: 3.575 ± 0.079	3.158GlyVal: 3.158 ± 0.069	0.728GlyTrp: 0.728 ± 0.032	2.345GlyTyr: 2.345 ± 0.06	0.003GlyXaa: 0.003 ± 0.002
His	1.079HisAla: 1.079 ± 0.039	0.635HisCys: 0.635 ± 0.032	1.307HisAsp: 1.307 ± 0.038	1.361HisGlu: 1.361 ± 0.04	1.064HisPhe: 1.064 ± 0.038	1.516HisGly: 1.516 ± 0.13	0.733HisHis: 0.733 ± 0.033	1.643HisIle: 1.643 ± 0.042	1.51HisLys: 1.51 ± 0.043	2.345HisLeu: 2.345 ± 0.073	0.558HisMet: 0.558 ± 0.027	1.234HisAsn: 1.234 ± 0.044	1.004HisPro: 1.004 ± 0.039	1.03HisGln: 1.03 ± 0.033	1.204HisArg: 1.204 ± 0.037	1.841HisSer: 1.841 ± 0.058	1.414HisThr: 1.414 ± 0.042	1.531HisVal: 1.531 ± 0.052	0.26HisTrp: 0.26 ± 0.02	0.899HisTyr: 0.899 ± 0.042	0.003HisXaa: 0.003 ± 0.002
Ile	3.223IleAla: 3.223 ± 0.074	1.698IleCys: 1.698 ± 0.056	4.16IleAsp: 4.16 ± 0.096	4.109IleGlu: 4.109 ± 0.106	2.38IlePhe: 2.38 ± 0.063	3.514IleGly: 3.514 ± 0.087	1.506IleHis: 1.506 ± 0.043	3.887IleIle: 3.887 ± 0.085	4.544IleLys: 4.544 ± 0.071	5.556IleLeu: 5.556 ± 0.101	1.435IleMet: 1.435 ± 0.038	3.518IleAsn: 3.518 ± 0.083	3.033IlePro: 3.033 ± 0.072	2.767IleGln: 2.767 ± 0.062	2.83IleArg: 2.83 ± 0.065	5.101IleSer: 5.101 ± 0.082	4.083IleThr: 4.083 ± 0.087	4.24IleVal: 4.24 ± 0.092	0.671IleTrp: 0.671 ± 0.03	2.162IleTyr: 2.162 ± 0.058	0.003IleXaa: 0.003 ± 0.002
Lys	3.457LysAla: 3.457 ± 0.082	1.821LysCys: 1.821 ± 0.075	4.631LysAsp: 4.631 ± 0.08	5.592LysGlu: 5.592 ± 0.118	2.393LysPhe: 2.393 ± 0.061	3.713LysGly: 3.713 ± 0.099	1.863LysHis: 1.863 ± 0.054	4.433LysIle: 4.433 ± 0.086	5.849LysLys: 5.849 ± 0.155	5.849LysLeu: 5.849 ± 0.088	1.903LysMet: 1.903 ± 0.048	3.799LysAsn: 3.799 ± 0.075	2.742LysPro: 2.742 ± 0.082	3.292LysGln: 3.292 ± 0.073	3.73LysArg: 3.73 ± 0.094	5.42LysSer: 5.42 ± 0.12	4.974LysThr: 4.974 ± 0.103	3.933LysVal: 3.933 ± 0.086	0.832LysTrp: 0.832 ± 0.036	2.552LysTyr: 2.552 ± 0.067	0.003LysXaa: 0.003 ± 0.002
Leu	3.925LeuAla: 3.925 ± 0.081	1.79LeuCys: 1.79 ± 0.063	4.801LeuAsp: 4.801 ± 0.095	5.448LeuGlu: 5.448 ± 0.096	3.31LeuPhe: 3.31 ± 0.075	3.712LeuGly: 3.712 ± 0.082	2.219LeuHis: 2.219 ± 0.053	4.737LeuIle: 4.737 ± 0.111	6.549LeuLys: 6.549 ± 0.107	7.399LeuLeu: 7.399 ± 0.142	2.033LeuMet: 2.033 ± 0.056	4.269LeuAsn: 4.269 ± 0.088	4.0LeuPro: 4.0 ± 0.094	4.098LeuGln: 4.098 ± 0.081	3.703LeuArg: 3.703 ± 0.08	6.499LeuSer: 6.499 ± 0.103	5.478LeuThr: 5.478 ± 0.092	4.855LeuVal: 4.855 ± 0.094	0.736LeuTrp: 0.736 ± 0.028	2.773LeuTyr: 2.773 ± 0.069	0.005LeuXaa: 0.005 ± 0.003
Met	1.367MetAla: 1.367 ± 0.048	0.519MetCys: 0.519 ± 0.027	1.448MetAsp: 1.448 ± 0.047	1.763MetGlu: 1.763 ± 0.049	0.987MetPhe: 0.987 ± 0.038	1.074MetGly: 1.074 ± 0.041	0.448MetHis: 0.448 ± 0.027	1.578MetIle: 1.578 ± 0.045	2.006MetLys: 2.006 ± 0.047	1.803MetLeu: 1.803 ± 0.052	0.844MetMet: 0.844 ± 0.043	1.36MetAsn: 1.36 ± 0.044	0.959MetPro: 0.959 ± 0.033	0.851MetGln: 0.851 ± 0.032	0.946MetArg: 0.946 ± 0.033	1.97MetSer: 1.97 ± 0.054	1.688MetThr: 1.688 ± 0.06	1.494MetVal: 1.494 ± 0.048	0.189MetTrp: 0.189 ± 0.016	0.828MetTyr: 0.828 ± 0.032	0.003MetXaa: 0.003 ± 0.002
Asn	2.616AsnAla: 2.616 ± 0.07	1.363AsnCys: 1.363 ± 0.051	3.284AsnAsp: 3.284 ± 0.077	3.599AsnGlu: 3.599 ± 0.078	2.029AsnPhe: 2.029 ± 0.055	3.732AsnGly: 3.732 ± 0.131	1.314AsnHis: 1.314 ± 0.043	4.158AsnIle: 4.158 ± 0.079	4.042AsnLys: 4.042 ± 0.079	4.196AsnLeu: 4.196 ± 0.08	1.272AsnMet: 1.272 ± 0.04	3.211AsnAsn: 3.211 ± 0.073	2.282AsnPro: 2.282 ± 0.06	2.285AsnGln: 2.285 ± 0.067	2.515AsnArg: 2.515 ± 0.062	3.958AsnSer: 3.958 ± 0.072	3.669AsnThr: 3.669 ± 0.086	3.596AsnVal: 3.596 ± 0.077	0.573AsnTrp: 0.573 ± 0.029	1.813AsnTyr: 1.813 ± 0.05	0.001AsnXaa: 0.001 ± 0.001
Pro	2.215ProAla: 2.215 ± 0.079	0.938ProCys: 0.938 ± 0.039	2.766ProAsp: 2.766 ± 0.067	2.69ProGlu: 2.69 ± 0.061	1.457ProPhe: 1.457 ± 0.048	2.423ProGly: 2.423 ± 0.198	0.832ProHis: 0.832 ± 0.032	2.175ProIle: 2.175 ± 0.071	2.679ProLys: 2.679 ± 0.088	3.201ProLeu: 3.201 ± 0.088	0.792ProMet: 0.792 ± 0.037	2.071ProAsn: 2.071 ± 0.06	2.557ProPro: 2.557 ± 0.085	1.648ProGln: 1.648 ± 0.053	1.721ProArg: 1.721 ± 0.059	3.456ProSer: 3.456 ± 0.086	2.96ProThr: 2.96 ± 0.098	3.059ProVal: 3.059 ± 0.074	0.468ProTrp: 0.468 ± 0.024	1.34ProTyr: 1.34 ± 0.042	0.003ProXaa: 0.003 ± 0.002
Gln	1.926GlnAla: 1.926 ± 0.046	1.053GlnCys: 1.053 ± 0.037	2.063GlnAsp: 2.063 ± 0.057	2.696GlnGlu: 2.696 ± 0.072	1.464GlnPhe: 1.464 ± 0.043	1.951GlnGly: 1.951 ± 0.08	1.12GlnHis: 1.12 ± 0.038	2.707GlnIle: 2.707 ± 0.064	3.177GlnLys: 3.177 ± 0.069	3.598GlnLeu: 3.598 ± 0.077	1.085GlnMet: 1.085 ± 0.04	2.649GlnAsn: 2.649 ± 0.066	1.915GlnPro: 1.915 ± 0.157	2.298GlnGln: 2.298 ± 0.147	1.933GlnArg: 1.933 ± 0.057	3.081GlnSer: 3.081 ± 0.083	3.058GlnThr: 3.058 ± 0.123	2.101GlnVal: 2.101 ± 0.058	0.481GlnTrp: 0.481 ± 0.027	1.506GlnTyr: 1.506 ± 0.041	0.003GlnXaa: 0.003 ± 0.002
Arg	1.821ArgAla: 1.821 ± 0.052	1.175ArgCys: 1.175 ± 0.052	2.361ArgAsp: 2.361 ± 0.054	2.821ArgGlu: 2.821 ± 0.067	1.725ArgPhe: 1.725 ± 0.051	2.474ArgGly: 2.474 ± 0.08	1.251ArgHis: 1.251 ± 0.038	2.627ArgIle: 2.627 ± 0.068	3.853ArgLys: 3.853 ± 0.072	3.922ArgLeu: 3.922 ± 0.083	1.172ArgMet: 1.172 ± 0.038	2.711ArgAsn: 2.711 ± 0.069	1.845ArgPro: 1.845 ± 0.056	2.091ArgGln: 2.091 ± 0.059	2.914ArgArg: 2.914 ± 0.073	3.185ArgSer: 3.185 ± 0.079	2.695ArgThr: 2.695 ± 0.074	2.185ArgVal: 2.185 ± 0.064	0.612ArgTrp: 0.612 ± 0.027	1.712ArgTyr: 1.712 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.93SerAla: 3.93 ± 0.075	1.883SerCys: 1.883 ± 0.056	4.887SerAsp: 4.887 ± 0.096	4.751SerGlu: 4.751 ± 0.103	2.984SerPhe: 2.984 ± 0.072	4.754SerGly: 4.754 ± 0.08	1.738SerHis: 1.738 ± 0.046	4.603SerIle: 4.603 ± 0.084	5.327SerLys: 5.327 ± 0.099	6.293SerLeu: 6.293 ± 0.102	1.777SerMet: 1.777 ± 0.053	4.269SerAsn: 4.269 ± 0.084	3.437SerPro: 3.437 ± 0.123	2.888SerGln: 2.888 ± 0.066	3.278SerArg: 3.278 ± 0.068	7.443SerSer: 7.443 ± 0.148	5.518SerThr: 5.518 ± 0.118	4.839SerVal: 4.839 ± 0.082	0.834SerTrp: 0.834 ± 0.036	2.428SerTyr: 2.428 ± 0.061	0.003SerXaa: 0.003 ± 0.002
Thr	3.616ThrAla: 3.616 ± 0.076	1.773ThrCys: 1.773 ± 0.061	4.251ThrAsp: 4.251 ± 0.088	4.692ThrGlu: 4.692 ± 0.136	2.565ThrPhe: 2.565 ± 0.064	4.058ThrGly: 4.058 ± 0.086	1.288ThrHis: 1.288 ± 0.041	4.134ThrIle: 4.134 ± 0.088	4.366ThrLys: 4.366 ± 0.089	5.114ThrLeu: 5.114 ± 0.086	1.419ThrMet: 1.419 ± 0.044	3.449ThrAsn: 3.449 ± 0.074	2.942ThrPro: 2.942 ± 0.106	2.29ThrGln: 2.29 ± 0.06	2.46ThrArg: 2.46 ± 0.064	5.585ThrSer: 5.585 ± 0.144	5.899ThrThr: 5.899 ± 0.415	4.821ThrVal: 4.821 ± 0.127	0.646ThrTrp: 0.646 ± 0.028	2.012ThrTyr: 2.012 ± 0.056	0.005ThrXaa: 0.005 ± 0.003
Val	3.016ValAla: 3.016 ± 0.072	1.595ValCys: 1.595 ± 0.077	3.932ValAsp: 3.932 ± 0.109	3.695ValGlu: 3.695 ± 0.083	2.587ValPhe: 2.587 ± 0.058	3.087ValGly: 3.087 ± 0.072	1.537ValHis: 1.537 ± 0.045	4.123ValIle: 4.123 ± 0.081	4.451ValLys: 4.451 ± 0.087	5.427ValLeu: 5.427 ± 0.101	1.462ValMet: 1.462 ± 0.049	3.276ValAsn: 3.276 ± 0.079	2.632ValPro: 2.632 ± 0.071	2.631ValGln: 2.631 ± 0.073	2.624ValArg: 2.624 ± 0.066	4.634ValSer: 4.634 ± 0.085	4.504ValThr: 4.504 ± 0.122	4.217ValVal: 4.217 ± 0.097	0.608ValTrp: 0.608 ± 0.031	2.227ValTyr: 2.227 ± 0.061	0.004ValXaa: 0.004 ± 0.002
Trp	0.461TrpAla: 0.461 ± 0.027	0.225TrpCys: 0.225 ± 0.016	0.558TrpAsp: 0.558 ± 0.03	0.632TrpGlu: 0.632 ± 0.029	0.431TrpPhe: 0.431 ± 0.022	0.533TrpGly: 0.533 ± 0.029	0.28TrpHis: 0.28 ± 0.019	0.711TrpIle: 0.711 ± 0.035	0.865TrpLys: 0.865 ± 0.035	0.823TrpLeu: 0.823 ± 0.035	0.288TrpMet: 0.288 ± 0.02	0.731TrpAsn: 0.731 ± 0.039	0.435TrpPro: 0.435 ± 0.024	0.426TrpGln: 0.426 ± 0.025	0.61TrpArg: 0.61 ± 0.029	0.808TrpSer: 0.808 ± 0.032	0.837TrpThr: 0.837 ± 0.034	0.526TrpVal: 0.526 ± 0.025	0.179TrpTrp: 0.179 ± 0.018	0.428TrpTyr: 0.428 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.632TyrAla: 1.632 ± 0.05	1.056TyrCys: 1.056 ± 0.05	2.045TyrAsp: 2.045 ± 0.063	2.08TyrGlu: 2.08 ± 0.063	1.528TyrPhe: 1.528 ± 0.046	2.037TyrGly: 2.037 ± 0.056	0.904TyrHis: 0.904 ± 0.037	2.297TyrIle: 2.297 ± 0.062	2.361TyrLys: 2.361 ± 0.062	2.845TyrLeu: 2.845 ± 0.062	0.819TyrMet: 0.819 ± 0.037	1.975TyrAsn: 1.975 ± 0.054	1.202TyrPro: 1.202 ± 0.05	1.432TyrGln: 1.432 ± 0.048	1.639TyrArg: 1.639 ± 0.046	2.573TyrSer: 2.573 ± 0.065	2.218TyrThr: 2.218 ± 0.065	2.016TyrVal: 2.016 ± 0.05	0.453TyrTrp: 0.453 ± 0.027	1.335TyrTyr: 1.335 ± 0.045	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.003XaaGlu: 0.003 ± 0.002	0.004XaaPhe: 0.004 ± 0.002	0.003XaaGly: 0.003 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.004XaaLys: 0.004 ± 0.002	0.003XaaLeu: 0.003 ± 0.002	0.005XaaMet: 0.005 ± 0.002	0.003XaaAsn: 0.003 ± 0.002	0.001XaaPro: 0.001 ± 0.001	0.003XaaGln: 0.003 ± 0.002	0.005XaaArg: 0.005 ± 0.003	0.005XaaSer: 0.005 ± 0.002	0.004XaaThr: 0.004 ± 0.003	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3147 proteins (761033 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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