Amino acid dipepetide frequency for Apis mellifera associated microvirus 14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.206AlaAla: 13.206 ± 2.547
0.734AlaCys: 0.734 ± 0.68
5.869AlaAsp: 5.869 ± 1.454
6.603AlaGlu: 6.603 ± 2.054
2.201AlaPhe: 2.201 ± 0.796
8.07AlaGly: 8.07 ± 2.931
3.668AlaHis: 3.668 ± 2.206
2.201AlaIle: 2.201 ± 1.571
8.804AlaLys: 8.804 ± 3.915
3.668AlaLeu: 3.668 ± 1.528
3.668AlaMet: 3.668 ± 1.308
7.337AlaAsn: 7.337 ± 2.658
2.201AlaPro: 2.201 ± 0.544
7.337AlaGln: 7.337 ± 3.494
8.07AlaArg: 8.07 ± 0.657
2.201AlaSer: 2.201 ± 0.898
7.337AlaThr: 7.337 ± 3.188
7.337AlaVal: 7.337 ± 1.121
1.467AlaTrp: 1.467 ± 1.009
4.402AlaTyr: 4.402 ± 0.732
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.734CysAsp: 0.734 ± 0.441
0.0CysGlu: 0.0 ± 0.0
0.734CysPhe: 0.734 ± 0.68
1.467CysGly: 1.467 ± 1.36
0.0CysHis: 0.0 ± 0.0
0.734CysIle: 0.734 ± 0.68
0.0CysLys: 0.0 ± 0.0
0.734CysLeu: 0.734 ± 0.68
0.734CysMet: 0.734 ± 0.68
0.0CysAsn: 0.0 ± 0.0
0.734CysPro: 0.734 ± 0.833
0.734CysGln: 0.734 ± 0.441
0.734CysArg: 0.734 ± 0.68
0.0CysSer: 0.0 ± 0.0
0.734CysThr: 0.734 ± 0.68
0.734CysVal: 0.734 ± 0.441
0.0CysTrp: 0.0 ± 0.0
0.734CysTyr: 0.734 ± 0.68
0.0CysXaa: 0.0 ± 0.0
Asp
8.804AspAla: 8.804 ± 2.162
0.0AspCys: 0.0 ± 0.0
0.0AspAsp: 0.0 ± 0.0
2.201AspGlu: 2.201 ± 0.94
2.201AspPhe: 2.201 ± 0.94
0.734AspGly: 0.734 ± 0.441
2.201AspHis: 2.201 ± 1.252
4.402AspIle: 4.402 ± 2.054
2.935AspLys: 2.935 ± 1.919
1.467AspLeu: 1.467 ± 0.676
1.467AspMet: 1.467 ± 0.676
2.201AspAsn: 2.201 ± 0.94
0.734AspPro: 0.734 ± 0.441
2.201AspGln: 2.201 ± 1.296
2.935AspArg: 2.935 ± 1.029
2.935AspSer: 2.935 ± 0.83
2.201AspThr: 2.201 ± 1.309
1.467AspVal: 1.467 ± 0.757
0.734AspTrp: 0.734 ± 0.68
5.136AspTyr: 5.136 ± 2.16
0.0AspXaa: 0.0 ± 0.0
Glu
4.402GluAla: 4.402 ± 3.129
0.0GluCys: 0.0 ± 0.0
1.467GluAsp: 1.467 ± 1.666
6.603GluGlu: 6.603 ± 4.564
2.201GluPhe: 2.201 ± 1.721
0.734GluGly: 0.734 ± 0.68
2.935GluHis: 2.935 ± 1.454
5.869GluIle: 5.869 ± 2.174
3.668GluLys: 3.668 ± 1.505
5.136GluLeu: 5.136 ± 2.307
0.734GluMet: 0.734 ± 0.441
2.935GluAsn: 2.935 ± 1.991
0.734GluPro: 0.734 ± 0.68
3.668GluGln: 3.668 ± 0.965
12.472GluArg: 12.472 ± 4.714
5.136GluSer: 5.136 ± 1.897
5.869GluThr: 5.869 ± 3.203
2.935GluVal: 2.935 ± 1.467
1.467GluTrp: 1.467 ± 0.676
2.935GluTyr: 2.935 ± 1.294
0.0GluXaa: 0.0 ± 0.0
Phe
3.668PheAla: 3.668 ± 1.473
0.0PheCys: 0.0 ± 0.0
2.201PheAsp: 2.201 ± 0.952
0.734PheGlu: 0.734 ± 0.68
2.935PhePhe: 2.935 ± 1.224
6.603PheGly: 6.603 ± 1.498
0.734PheHis: 0.734 ± 0.68
4.402PheIle: 4.402 ± 1.132
2.201PheLys: 2.201 ± 0.94
1.467PheLeu: 1.467 ± 0.676
2.201PheMet: 2.201 ± 0.86
2.201PheAsn: 2.201 ± 0.898
2.201PhePro: 2.201 ± 1.323
2.201PheGln: 2.201 ± 0.544
2.201PheArg: 2.201 ± 0.874
0.734PheSer: 0.734 ± 0.705
2.201PheThr: 2.201 ± 0.94
0.734PheVal: 0.734 ± 0.441
0.0PheTrp: 0.0 ± 0.0
1.467PheTyr: 1.467 ± 0.647
0.0PheXaa: 0.0 ± 0.0
Gly
5.136GlyAla: 5.136 ± 1.404
0.734GlyCys: 0.734 ± 0.68
5.136GlyAsp: 5.136 ± 1.566
10.271GlyGlu: 10.271 ± 2.151
2.201GlyPhe: 2.201 ± 0.544
5.869GlyGly: 5.869 ± 2.414
2.201GlyHis: 2.201 ± 1.252
2.201GlyIle: 2.201 ± 0.824
1.467GlyLys: 1.467 ± 0.882
5.869GlyLeu: 5.869 ± 2.143
2.935GlyMet: 2.935 ± 0.638
1.467GlyAsn: 1.467 ± 1.009
2.201GlyPro: 2.201 ± 0.874
3.668GlyGln: 3.668 ± 1.27
2.201GlyArg: 2.201 ± 1.309
2.935GlySer: 2.935 ± 0.638
5.869GlyThr: 5.869 ± 2.178
2.935GlyVal: 2.935 ± 1.243
0.0GlyTrp: 0.0 ± 0.0
3.668GlyTyr: 3.668 ± 1.619
0.0GlyXaa: 0.0 ± 0.0
His
2.201HisAla: 2.201 ± 0.874
0.0HisCys: 0.0 ± 0.0
1.467HisAsp: 1.467 ± 0.882
2.201HisGlu: 2.201 ± 1.505
0.734HisPhe: 0.734 ± 0.441
1.467HisGly: 1.467 ± 0.882
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
1.467HisLys: 1.467 ± 0.882
2.201HisLeu: 2.201 ± 0.898
0.734HisMet: 0.734 ± 0.68
2.201HisAsn: 2.201 ± 1.037
0.734HisPro: 0.734 ± 1.019
0.0HisGln: 0.0 ± 0.0
0.734HisArg: 0.734 ± 0.68
0.0HisSer: 0.0 ± 0.0
1.467HisThr: 1.467 ± 0.647
2.201HisVal: 2.201 ± 1.252
0.0HisTrp: 0.0 ± 0.0
1.467HisTyr: 1.467 ± 1.36
0.0HisXaa: 0.0 ± 0.0
Ile
3.668IleAla: 3.668 ± 2.894
0.734IleCys: 0.734 ± 0.441
2.935IleAsp: 2.935 ± 1.405
2.935IleGlu: 2.935 ± 1.483
2.201IlePhe: 2.201 ± 1.309
7.337IleGly: 7.337 ± 2.044
0.734IleHis: 0.734 ± 0.441
0.734IleIle: 0.734 ± 0.833
0.734IleLys: 0.734 ± 0.68
2.201IleLeu: 2.201 ± 0.544
1.467IleMet: 1.467 ± 0.98
2.935IleAsn: 2.935 ± 1.291
3.668IlePro: 3.668 ± 1.635
2.201IleGln: 2.201 ± 0.544
2.935IleArg: 2.935 ± 2.12
1.467IleSer: 1.467 ± 0.984
5.136IleThr: 5.136 ± 1.55
1.467IleVal: 1.467 ± 0.771
0.734IleTrp: 0.734 ± 0.441
2.201IleTyr: 2.201 ± 1.128
0.0IleXaa: 0.0 ± 0.0
Lys
4.402LysAla: 4.402 ± 1.62
0.0LysCys: 0.0 ± 0.0
1.467LysAsp: 1.467 ± 1.009
2.201LysGlu: 2.201 ± 1.595
2.201LysPhe: 2.201 ± 1.252
1.467LysGly: 1.467 ± 0.676
1.467LysHis: 1.467 ± 1.18
2.935LysIle: 2.935 ± 1.33
2.201LysLys: 2.201 ± 0.544
5.136LysLeu: 5.136 ± 1.912
0.734LysMet: 0.734 ± 0.441
1.467LysAsn: 1.467 ± 0.676
2.935LysPro: 2.935 ± 2.017
2.935LysGln: 2.935 ± 0.83
5.869LysArg: 5.869 ± 3.815
0.0LysSer: 0.0 ± 0.0
4.402LysThr: 4.402 ± 0.933
0.734LysVal: 0.734 ± 0.833
0.0LysTrp: 0.0 ± 0.0
2.935LysTyr: 2.935 ± 1.294
0.0LysXaa: 0.0 ± 0.0
Leu
7.337LeuAla: 7.337 ± 1.742
0.0LeuCys: 0.0 ± 0.0
0.734LeuAsp: 0.734 ± 0.68
3.668LeuGlu: 3.668 ± 1.885
2.201LeuPhe: 2.201 ± 0.874
4.402LeuGly: 4.402 ± 1.88
0.0LeuHis: 0.0 ± 0.0
1.467LeuIle: 1.467 ± 0.676
5.869LeuLys: 5.869 ± 2.837
1.467LeuLeu: 1.467 ± 0.984
2.935LeuMet: 2.935 ± 1.096
6.603LeuAsn: 6.603 ± 4.675
5.869LeuPro: 5.869 ± 1.922
2.935LeuGln: 2.935 ± 0.83
4.402LeuArg: 4.402 ± 0.732
2.201LeuSer: 2.201 ± 1.323
7.337LeuThr: 7.337 ± 2.366
2.935LeuVal: 2.935 ± 1.25
1.467LeuTrp: 1.467 ± 1.18
2.935LeuTyr: 2.935 ± 0.821
0.0LeuXaa: 0.0 ± 0.0
Met
1.467MetAla: 1.467 ± 1.41
1.467MetCys: 1.467 ± 0.647
1.467MetAsp: 1.467 ± 0.771
2.935MetGlu: 2.935 ± 1.39
0.734MetPhe: 0.734 ± 0.705
4.402MetGly: 4.402 ± 1.797
1.467MetHis: 1.467 ± 0.647
0.734MetIle: 0.734 ± 0.441
1.467MetLys: 1.467 ± 0.757
2.201MetLeu: 2.201 ± 0.972
0.734MetMet: 0.734 ± 0.705
1.467MetAsn: 1.467 ± 1.526
3.668MetPro: 3.668 ± 1.082
2.201MetGln: 2.201 ± 0.972
1.467MetArg: 1.467 ± 1.41
1.467MetSer: 1.467 ± 0.757
0.0MetThr: 0.0 ± 0.0
1.467MetVal: 1.467 ± 0.882
0.734MetTrp: 0.734 ± 0.441
2.201MetTyr: 2.201 ± 0.874
0.0MetXaa: 0.0 ± 0.0
Asn
5.136AsnAla: 5.136 ± 3.239
0.734AsnCys: 0.734 ± 0.68
2.935AsnAsp: 2.935 ± 1.819
2.935AsnGlu: 2.935 ± 1.991
0.0AsnPhe: 0.0 ± 0.0
1.467AsnGly: 1.467 ± 0.647
0.0AsnHis: 0.0 ± 0.0
2.935AsnIle: 2.935 ± 1.765
0.734AsnLys: 0.734 ± 0.833
6.603AsnLeu: 6.603 ± 2.146
2.935AsnMet: 2.935 ± 0.922
1.467AsnAsn: 1.467 ± 0.676
5.869AsnPro: 5.869 ± 1.699
1.467AsnGln: 1.467 ± 0.882
3.668AsnArg: 3.668 ± 2.806
2.935AsnSer: 2.935 ± 1.765
2.935AsnThr: 2.935 ± 1.08
2.201AsnVal: 2.201 ± 0.544
0.734AsnTrp: 0.734 ± 0.441
0.734AsnTyr: 0.734 ± 0.833
0.0AsnXaa: 0.0 ± 0.0
Pro
5.136ProAla: 5.136 ± 1.628
1.467ProCys: 1.467 ± 1.36
3.668ProAsp: 3.668 ± 1.873
3.668ProGlu: 3.668 ± 1.903
2.201ProPhe: 2.201 ± 0.952
2.935ProGly: 2.935 ± 1.224
0.734ProHis: 0.734 ± 0.68
5.136ProIle: 5.136 ± 2.168
2.935ProLys: 2.935 ± 1.294
3.668ProLeu: 3.668 ± 1.619
2.201ProMet: 2.201 ± 0.898
0.0ProAsn: 0.0 ± 0.0
3.668ProPro: 3.668 ± 2.316
2.935ProGln: 2.935 ± 2.083
2.201ProArg: 2.201 ± 0.898
2.935ProSer: 2.935 ± 1.353
4.402ProThr: 4.402 ± 1.341
1.467ProVal: 1.467 ± 0.882
1.467ProTrp: 1.467 ± 0.882
0.734ProTyr: 0.734 ± 0.68
0.0ProXaa: 0.0 ± 0.0
Gln
6.603GlnAla: 6.603 ± 4.663
0.734GlnCys: 0.734 ± 0.68
2.935GlnAsp: 2.935 ± 1.072
6.603GlnGlu: 6.603 ± 1.377
2.201GlnPhe: 2.201 ± 0.972
2.201GlnGly: 2.201 ± 1.309
0.0GlnHis: 0.0 ± 0.0
1.467GlnIle: 1.467 ± 0.676
2.935GlnLys: 2.935 ± 0.638
2.935GlnLeu: 2.935 ± 2.207
0.734GlnMet: 0.734 ± 0.705
3.668GlnAsn: 3.668 ± 0.388
0.734GlnPro: 0.734 ± 0.833
2.201GlnGln: 2.201 ± 0.972
3.668GlnArg: 3.668 ± 0.953
2.935GlnSer: 2.935 ± 1.353
1.467GlnThr: 1.467 ± 0.647
2.935GlnVal: 2.935 ± 0.821
1.467GlnTrp: 1.467 ± 1.36
0.734GlnTyr: 0.734 ± 0.441
0.0GlnXaa: 0.0 ± 0.0
Arg
8.804ArgAla: 8.804 ± 3.278
0.734ArgCys: 0.734 ± 0.68
4.402ArgAsp: 4.402 ± 2.029
5.136ArgGlu: 5.136 ± 2.94
5.136ArgPhe: 5.136 ± 1.621
4.402ArgGly: 4.402 ± 1.088
1.467ArgHis: 1.467 ± 0.882
2.935ArgIle: 2.935 ± 2.162
1.467ArgLys: 1.467 ± 1.009
8.804ArgLeu: 8.804 ± 1.468
2.201ArgMet: 2.201 ± 1.273
2.935ArgAsn: 2.935 ± 1.08
2.201ArgPro: 2.201 ± 0.874
5.869ArgGln: 5.869 ± 1.881
0.734ArgArg: 0.734 ± 0.441
2.935ArgSer: 2.935 ± 1.029
5.869ArgThr: 5.869 ± 1.643
2.935ArgVal: 2.935 ± 0.821
0.0ArgTrp: 0.0 ± 0.0
2.201ArgTyr: 2.201 ± 0.874
0.0ArgXaa: 0.0 ± 0.0
Ser
8.07SerAla: 8.07 ± 2.613
0.0SerCys: 0.0 ± 0.0
0.0SerAsp: 0.0 ± 0.0
2.935SerGlu: 2.935 ± 1.337
2.201SerPhe: 2.201 ± 0.898
3.668SerGly: 3.668 ± 1.225
0.0SerHis: 0.0 ± 0.0
1.467SerIle: 1.467 ± 0.676
0.0SerLys: 0.0 ± 0.0
3.668SerLeu: 3.668 ± 0.965
2.201SerMet: 2.201 ± 1.524
0.734SerAsn: 0.734 ± 0.441
2.935SerPro: 2.935 ± 1.353
0.734SerGln: 0.734 ± 0.705
4.402SerArg: 4.402 ± 0.732
1.467SerSer: 1.467 ± 0.676
7.337SerThr: 7.337 ± 3.762
1.467SerVal: 1.467 ± 0.647
0.0SerTrp: 0.0 ± 0.0
1.467SerTyr: 1.467 ± 0.676
0.0SerXaa: 0.0 ± 0.0
Thr
8.804ThrAla: 8.804 ± 1.839
0.734ThrCys: 0.734 ± 0.833
4.402ThrAsp: 4.402 ± 1.145
4.402ThrGlu: 4.402 ± 0.933
4.402ThrPhe: 4.402 ± 1.748
7.337ThrGly: 7.337 ± 3.577
0.734ThrHis: 0.734 ± 0.441
4.402ThrIle: 4.402 ± 2.647
2.935ThrLys: 2.935 ± 1.3
5.136ThrLeu: 5.136 ± 2.18
1.467ThrMet: 1.467 ± 0.676
2.935ThrAsn: 2.935 ± 1.294
5.869ThrPro: 5.869 ± 0.547
1.467ThrGln: 1.467 ± 0.676
5.136ThrArg: 5.136 ± 0.948
5.136ThrSer: 5.136 ± 2.124
6.603ThrThr: 6.603 ± 2.077
0.734ThrVal: 0.734 ± 0.441
1.467ThrTrp: 1.467 ± 0.676
2.935ThrTyr: 2.935 ± 0.821
0.0ThrXaa: 0.0 ± 0.0
Val
2.201ValAla: 2.201 ± 1.037
0.0ValCys: 0.0 ± 0.0
1.467ValAsp: 1.467 ± 0.882
2.935ValGlu: 2.935 ± 2.12
2.201ValPhe: 2.201 ± 0.874
0.734ValGly: 0.734 ± 0.441
0.734ValHis: 0.734 ± 0.705
3.668ValIle: 3.668 ± 1.9
1.467ValLys: 1.467 ± 1.18
2.935ValLeu: 2.935 ± 1.25
0.734ValMet: 0.734 ± 0.705
2.201ValAsn: 2.201 ± 1.323
3.668ValPro: 3.668 ± 1.619
0.734ValGln: 0.734 ± 0.68
4.402ValArg: 4.402 ± 1.498
4.402ValSer: 4.402 ± 1.403
4.402ValThr: 4.402 ± 1.341
1.467ValVal: 1.467 ± 0.98
1.467ValTrp: 1.467 ± 0.647
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
2.935TrpAla: 2.935 ± 1.3
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.0TrpGlu: 0.0 ± 0.0
0.734TrpPhe: 0.734 ± 0.441
0.734TrpGly: 0.734 ± 0.705
0.734TrpHis: 0.734 ± 0.441
0.0TrpIle: 0.0 ± 0.0
1.467TrpLys: 1.467 ± 0.676
0.734TrpLeu: 0.734 ± 0.68
0.0TrpMet: 0.0 ± 0.0
0.734TrpAsn: 0.734 ± 0.441
2.935TrpPro: 2.935 ± 1.908
0.0TrpGln: 0.0 ± 0.0
0.734TrpArg: 0.734 ± 1.019
0.0TrpSer: 0.0 ± 0.0
0.734TrpThr: 0.734 ± 0.441
0.734TrpVal: 0.734 ± 0.441
0.734TrpTrp: 0.734 ± 0.705
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.402TyrAla: 4.402 ± 1.95
1.467TyrCys: 1.467 ± 0.647
3.668TyrAsp: 3.668 ± 1.396
2.935TyrGlu: 2.935 ± 1.454
1.467TyrPhe: 1.467 ± 0.882
2.935TyrGly: 2.935 ± 1.908
1.467TyrHis: 1.467 ± 1.009
0.734TyrIle: 0.734 ± 0.441
0.734TyrLys: 0.734 ± 0.68
0.734TyrLeu: 0.734 ± 0.441
2.201TyrMet: 2.201 ± 0.874
2.935TyrAsn: 2.935 ± 0.855
0.0TyrPro: 0.0 ± 0.0
3.668TyrGln: 3.668 ± 0.716
2.935TyrArg: 2.935 ± 0.638
2.935TyrSer: 2.935 ± 0.578
0.734TyrThr: 0.734 ± 0.441
2.935TyrVal: 2.935 ± 1.224
0.0TyrTrp: 0.0 ± 0.0
0.734TyrTyr: 0.734 ± 0.68
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski