Amino acid dipepetide frequency for Vicingus serpentipes

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.831AlaAla: 3.831 ± 0.093
0.58AlaCys: 0.58 ± 0.029
3.313AlaAsp: 3.313 ± 0.07
4.001AlaGlu: 4.001 ± 0.146
3.028AlaPhe: 3.028 ± 0.07
4.196AlaGly: 4.196 ± 0.097
0.965AlaHis: 0.965 ± 0.037
5.517AlaIle: 5.517 ± 0.095
4.827AlaLys: 4.827 ± 0.117
5.522AlaLeu: 5.522 ± 0.102
1.261AlaMet: 1.261 ± 0.045
3.729AlaAsn: 3.729 ± 0.076
1.809AlaPro: 1.809 ± 0.052
2.36AlaGln: 2.36 ± 0.068
1.665AlaArg: 1.665 ± 0.042
3.861AlaSer: 3.861 ± 0.073
3.618AlaThr: 3.618 ± 0.1
3.426AlaVal: 3.426 ± 0.07
0.536AlaTrp: 0.536 ± 0.024
2.41AlaTyr: 2.41 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.496CysAla: 0.496 ± 0.031
0.097CysCys: 0.097 ± 0.011
0.588CysAsp: 0.588 ± 0.035
0.496CysGlu: 0.496 ± 0.026
0.531CysPhe: 0.531 ± 0.024
0.772CysGly: 0.772 ± 0.042
0.17CysHis: 0.17 ± 0.024
0.658CysIle: 0.658 ± 0.028
0.589CysLys: 0.589 ± 0.026
0.734CysLeu: 0.734 ± 0.029
0.15CysMet: 0.15 ± 0.014
0.678CysAsn: 0.678 ± 0.044
0.401CysPro: 0.401 ± 0.029
0.26CysGln: 0.26 ± 0.018
0.205CysArg: 0.205 ± 0.015
0.774CysSer: 0.774 ± 0.036
0.498CysThr: 0.498 ± 0.03
0.57CysVal: 0.57 ± 0.028
0.102CysTrp: 0.102 ± 0.01
0.328CysTyr: 0.328 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.437AspAla: 3.437 ± 0.064
0.551AspCys: 0.551 ± 0.029
2.878AspAsp: 2.878 ± 0.064
3.85AspGlu: 3.85 ± 0.075
3.563AspPhe: 3.563 ± 0.071
3.917AspGly: 3.917 ± 0.093
0.693AspHis: 0.693 ± 0.026
4.539AspIle: 4.539 ± 0.075
4.315AspLys: 4.315 ± 0.082
5.074AspLeu: 5.074 ± 0.082
1.087AspMet: 1.087 ± 0.037
3.453AspAsn: 3.453 ± 0.07
1.512AspPro: 1.512 ± 0.051
1.274AspGln: 1.274 ± 0.034
1.523AspArg: 1.523 ± 0.04
3.59AspSer: 3.59 ± 0.082
2.813AspThr: 2.813 ± 0.09
3.757AspVal: 3.757 ± 0.058
0.691AspTrp: 0.691 ± 0.026
2.835AspTyr: 2.835 ± 0.06
0.0AspXaa: 0.0 ± 0.0
Glu
4.129GluAla: 4.129 ± 0.143
0.385GluCys: 0.385 ± 0.023
3.314GluAsp: 3.314 ± 0.062
5.255GluGlu: 5.255 ± 0.134
3.008GluPhe: 3.008 ± 0.06
3.724GluGly: 3.724 ± 0.069
1.033GluHis: 1.033 ± 0.033
6.064GluIle: 6.064 ± 0.093
6.063GluLys: 6.063 ± 0.115
6.602GluLeu: 6.602 ± 0.089
1.569GluMet: 1.569 ± 0.048
4.865GluAsn: 4.865 ± 0.082
1.535GluPro: 1.535 ± 0.045
2.3GluGln: 2.3 ± 0.06
2.034GluArg: 2.034 ± 0.055
3.329GluSer: 3.329 ± 0.075
3.332GluThr: 3.332 ± 0.06
4.277GluVal: 4.277 ± 0.072
0.646GluTrp: 0.646 ± 0.027
2.469GluTyr: 2.469 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
2.785PheAla: 2.785 ± 0.059
0.503PheCys: 0.503 ± 0.022
3.184PheAsp: 3.184 ± 0.067
3.238PheGlu: 3.238 ± 0.062
2.632PhePhe: 2.632 ± 0.078
3.493PheGly: 3.493 ± 0.072
0.785PheHis: 0.785 ± 0.029
4.484PheIle: 4.484 ± 0.09
3.878PheLys: 3.878 ± 0.078
4.324PheLeu: 4.324 ± 0.085
0.984PheMet: 0.984 ± 0.042
3.883PheAsn: 3.883 ± 0.077
1.547PhePro: 1.547 ± 0.043
1.321PheGln: 1.321 ± 0.044
1.335PheArg: 1.335 ± 0.043
4.177PheSer: 4.177 ± 0.09
3.27PheThr: 3.27 ± 0.08
2.948PheVal: 2.948 ± 0.061
0.511PheTrp: 0.511 ± 0.024
2.399PheTyr: 2.399 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
4.189GlyAla: 4.189 ± 0.087
0.85GlyCys: 0.85 ± 0.055
3.59GlyAsp: 3.59 ± 0.077
3.754GlyGlu: 3.754 ± 0.068
3.531GlyPhe: 3.531 ± 0.071
5.099GlyGly: 5.099 ± 0.125
1.083GlyHis: 1.083 ± 0.038
5.308GlyIle: 5.308 ± 0.081
4.741GlyLys: 4.741 ± 0.086
5.794GlyLeu: 5.794 ± 0.09
1.562GlyMet: 1.562 ± 0.041
4.06GlyAsn: 4.06 ± 0.104
1.303GlyPro: 1.303 ± 0.048
1.797GlyGln: 1.797 ± 0.052
1.814GlyArg: 1.814 ± 0.053
4.236GlySer: 4.236 ± 0.105
4.148GlyThr: 4.148 ± 0.15
4.696GlyVal: 4.696 ± 0.071
0.666GlyTrp: 0.666 ± 0.028
2.779GlyTyr: 2.779 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
0.792HisAla: 0.792 ± 0.03
0.181HisCys: 0.181 ± 0.014
0.737HisAsp: 0.737 ± 0.032
0.896HisGlu: 0.896 ± 0.033
1.011HisPhe: 1.011 ± 0.036
1.011HisGly: 1.011 ± 0.04
0.438HisHis: 0.438 ± 0.02
1.329HisIle: 1.329 ± 0.037
1.109HisLys: 1.109 ± 0.041
1.614HisLeu: 1.614 ± 0.042
0.277HisMet: 0.277 ± 0.02
0.96HisAsn: 0.96 ± 0.035
0.858HisPro: 0.858 ± 0.034
0.713HisGln: 0.713 ± 0.031
0.549HisArg: 0.549 ± 0.023
0.92HisSer: 0.92 ± 0.037
0.849HisThr: 0.849 ± 0.03
0.769HisVal: 0.769 ± 0.033
0.189HisTrp: 0.189 ± 0.013
0.803HisTyr: 0.803 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.741IleAla: 5.741 ± 0.089
0.824IleCys: 0.824 ± 0.039
5.513IleAsp: 5.513 ± 0.088
6.33IleGlu: 6.33 ± 0.091
3.634IlePhe: 3.634 ± 0.081
5.405IleGly: 5.405 ± 0.079
1.313IleHis: 1.313 ± 0.036
7.014IleIle: 7.014 ± 0.12
6.59IleLys: 6.59 ± 0.109
7.073IleLeu: 7.073 ± 0.1
1.426IleMet: 1.426 ± 0.046
6.041IleAsn: 6.041 ± 0.094
3.192IlePro: 3.192 ± 0.063
2.489IleGln: 2.489 ± 0.064
2.259IleArg: 2.259 ± 0.052
6.193IleSer: 6.193 ± 0.091
5.092IleThr: 5.092 ± 0.1
5.11IleVal: 5.11 ± 0.083
0.68IleTrp: 0.68 ± 0.032
3.291IleTyr: 3.291 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.827LysAla: 4.827 ± 0.134
0.447LysCys: 0.447 ± 0.024
4.407LysAsp: 4.407 ± 0.087
6.331LysGlu: 6.331 ± 0.113
3.014LysPhe: 3.014 ± 0.06
4.639LysGly: 4.639 ± 0.08
1.388LysHis: 1.388 ± 0.043
6.857LysIle: 6.857 ± 0.101
7.006LysLys: 7.006 ± 0.12
6.796LysLeu: 6.796 ± 0.111
2.034LysMet: 2.034 ± 0.053
5.655LysAsn: 5.655 ± 0.088
2.287LysPro: 2.287 ± 0.06
2.873LysGln: 2.873 ± 0.077
2.475LysArg: 2.475 ± 0.06
4.769LysSer: 4.769 ± 0.095
4.491LysThr: 4.491 ± 0.075
4.839LysVal: 4.839 ± 0.09
0.752LysTrp: 0.752 ± 0.028
3.332LysTyr: 3.332 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
5.595LeuAla: 5.595 ± 0.086
0.757LeuCys: 0.757 ± 0.053
4.6LeuAsp: 4.6 ± 0.079
5.363LeuGlu: 5.363 ± 0.096
4.911LeuPhe: 4.911 ± 0.1
5.588LeuGly: 5.588 ± 0.085
1.33LeuHis: 1.33 ± 0.048
7.95LeuIle: 7.95 ± 0.13
7.884LeuLys: 7.884 ± 0.129
8.271LeuLeu: 8.271 ± 0.139
1.956LeuMet: 1.956 ± 0.051
6.439LeuAsn: 6.439 ± 0.106
3.38LeuPro: 3.38 ± 0.061
2.573LeuGln: 2.573 ± 0.057
2.553LeuArg: 2.553 ± 0.06
6.844LeuSer: 6.844 ± 0.099
5.405LeuThr: 5.405 ± 0.083
5.119LeuVal: 5.119 ± 0.083
0.809LeuTrp: 0.809 ± 0.034
3.059LeuTyr: 3.059 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
1.42MetAla: 1.42 ± 0.044
0.155MetCys: 0.155 ± 0.012
1.109MetAsp: 1.109 ± 0.039
1.282MetGlu: 1.282 ± 0.041
0.929MetPhe: 0.929 ± 0.039
1.37MetGly: 1.37 ± 0.041
0.373MetHis: 0.373 ± 0.02
1.478MetIle: 1.478 ± 0.042
2.001MetLys: 2.001 ± 0.046
1.87MetLeu: 1.87 ± 0.05
0.547MetMet: 0.547 ± 0.029
1.271MetAsn: 1.271 ± 0.037
0.786MetPro: 0.786 ± 0.03
0.668MetGln: 0.668 ± 0.03
0.669MetArg: 0.669 ± 0.025
1.411MetSer: 1.411 ± 0.031
1.003MetThr: 1.003 ± 0.033
1.252MetVal: 1.252 ± 0.038
0.15MetTrp: 0.15 ± 0.013
0.711MetTyr: 0.711 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.6AsnAla: 3.6 ± 0.061
0.718AsnCys: 0.718 ± 0.038
3.635AsnAsp: 3.635 ± 0.07
4.422AsnGlu: 4.422 ± 0.091
3.278AsnPhe: 3.278 ± 0.071
4.565AsnGly: 4.565 ± 0.137
1.11AsnHis: 1.11 ± 0.033
5.625AsnIle: 5.625 ± 0.079
5.303AsnLys: 5.303 ± 0.09
5.969AsnLeu: 5.969 ± 0.086
1.252AsnMet: 1.252 ± 0.043
5.315AsnAsn: 5.315 ± 0.109
3.019AsnPro: 3.019 ± 0.068
2.512AsnGln: 2.512 ± 0.06
1.917AsnArg: 1.917 ± 0.046
4.61AsnSer: 4.61 ± 0.098
3.829AsnThr: 3.829 ± 0.086
3.945AsnVal: 3.945 ± 0.073
0.793AsnTrp: 0.793 ± 0.035
3.435AsnTyr: 3.435 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
1.831ProAla: 1.831 ± 0.053
0.265ProCys: 0.265 ± 0.02
1.82ProAsp: 1.82 ± 0.041
2.43ProGlu: 2.43 ± 0.05
1.893ProPhe: 1.893 ± 0.047
1.907ProGly: 1.907 ± 0.057
0.524ProHis: 0.524 ± 0.022
2.871ProIle: 2.871 ± 0.06
2.413ProLys: 2.413 ± 0.054
2.785ProLeu: 2.785 ± 0.049
0.608ProMet: 0.608 ± 0.027
2.46ProAsn: 2.46 ± 0.057
0.849ProPro: 0.849 ± 0.038
1.063ProGln: 1.063 ± 0.037
0.741ProArg: 0.741 ± 0.028
2.282ProSer: 2.282 ± 0.055
2.185ProThr: 2.185 ± 0.079
2.111ProVal: 2.111 ± 0.053
0.248ProTrp: 0.248 ± 0.017
1.488ProTyr: 1.488 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
1.836GlnAla: 1.836 ± 0.052
0.214GlnCys: 0.214 ± 0.016
1.527GlnAsp: 1.527 ± 0.038
2.152GlnGlu: 2.152 ± 0.064
1.717GlnPhe: 1.717 ± 0.048
1.656GlnGly: 1.656 ± 0.047
0.511GlnHis: 0.511 ± 0.023
2.652GlnIle: 2.652 ± 0.056
2.833GlnLys: 2.833 ± 0.057
3.288GlnLeu: 3.288 ± 0.07
0.726GlnMet: 0.726 ± 0.03
2.217GlnAsn: 2.217 ± 0.055
1.006GlnPro: 1.006 ± 0.035
1.279GlnGln: 1.279 ± 0.045
0.911GlnArg: 0.911 ± 0.038
1.772GlnSer: 1.772 ± 0.045
1.839GlnThr: 1.839 ± 0.055
1.871GlnVal: 1.871 ± 0.048
0.299GlnTrp: 0.299 ± 0.02
1.217GlnTyr: 1.217 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
1.701ArgAla: 1.701 ± 0.052
0.201ArgCys: 0.201 ± 0.015
1.499ArgAsp: 1.499 ± 0.046
1.945ArgGlu: 1.945 ± 0.05
1.459ArgPhe: 1.459 ± 0.041
1.695ArgGly: 1.695 ± 0.05
0.44ArgHis: 0.44 ± 0.022
2.539ArgIle: 2.539 ± 0.057
2.362ArgLys: 2.362 ± 0.058
2.79ArgLeu: 2.79 ± 0.069
0.695ArgMet: 0.695 ± 0.031
1.701ArgAsn: 1.701 ± 0.044
0.873ArgPro: 0.873 ± 0.038
0.795ArgGln: 0.795 ± 0.031
1.033ArgArg: 1.033 ± 0.041
1.534ArgSer: 1.534 ± 0.044
1.574ArgThr: 1.574 ± 0.045
1.838ArgVal: 1.838 ± 0.045
0.303ArgTrp: 0.303 ± 0.019
1.169ArgTyr: 1.169 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
3.845SerAla: 3.845 ± 0.065
0.762SerCys: 0.762 ± 0.04
3.484SerAsp: 3.484 ± 0.073
3.832SerGlu: 3.832 ± 0.066
4.181SerPhe: 4.181 ± 0.071
4.699SerGly: 4.699 ± 0.103
1.005SerHis: 1.005 ± 0.037
6.138SerIle: 6.138 ± 0.083
4.889SerLys: 4.889 ± 0.088
6.378SerLeu: 6.378 ± 0.092
1.201SerMet: 1.201 ± 0.042
4.487SerAsn: 4.487 ± 0.084
2.26SerPro: 2.26 ± 0.057
1.984SerGln: 1.984 ± 0.05
1.705SerArg: 1.705 ± 0.048
5.063SerSer: 5.063 ± 0.104
4.028SerThr: 4.028 ± 0.092
4.172SerVal: 4.172 ± 0.076
0.671SerTrp: 0.671 ± 0.027
2.954SerTyr: 2.954 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
3.629ThrAla: 3.629 ± 0.096
0.442ThrCys: 0.442 ± 0.029
3.349ThrAsp: 3.349 ± 0.086
3.403ThrGlu: 3.403 ± 0.073
2.949ThrPhe: 2.949 ± 0.069
4.128ThrGly: 4.128 ± 0.128
0.971ThrHis: 0.971 ± 0.038
5.397ThrIle: 5.397 ± 0.104
3.835ThrLys: 3.835 ± 0.074
5.097ThrLeu: 5.097 ± 0.08
0.859ThrMet: 0.859 ± 0.037
3.723ThrAsn: 3.723 ± 0.091
2.553ThrPro: 2.553 ± 0.076
1.798ThrGln: 1.798 ± 0.046
1.355ThrArg: 1.355 ± 0.042
4.084ThrSer: 4.084 ± 0.097
3.865ThrThr: 3.865 ± 0.114
3.825ThrVal: 3.825 ± 0.115
0.613ThrTrp: 0.613 ± 0.03
2.562ThrTyr: 2.562 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
3.867ValAla: 3.867 ± 0.072
0.688ValCys: 0.688 ± 0.029
3.667ValAsp: 3.667 ± 0.071
4.009ValGlu: 4.009 ± 0.083
3.351ValPhe: 3.351 ± 0.063
3.915ValGly: 3.915 ± 0.073
0.851ValHis: 0.851 ± 0.032
5.045ValIle: 5.045 ± 0.071
4.674ValLys: 4.674 ± 0.098
5.51ValLeu: 5.51 ± 0.089
1.319ValMet: 1.319 ± 0.037
4.004ValAsn: 4.004 ± 0.077
1.89ValPro: 1.89 ± 0.048
1.529ValGln: 1.529 ± 0.047
1.754ValArg: 1.754 ± 0.049
4.442ValSer: 4.442 ± 0.065
3.596ValThr: 3.596 ± 0.118
4.29ValVal: 4.29 ± 0.085
0.622ValTrp: 0.622 ± 0.03
2.531ValTyr: 2.531 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.565TrpAla: 0.565 ± 0.025
0.086TrpCys: 0.086 ± 0.009
0.726TrpAsp: 0.726 ± 0.038
0.585TrpGlu: 0.585 ± 0.026
0.555TrpPhe: 0.555 ± 0.028
0.683TrpGly: 0.683 ± 0.026
0.194TrpHis: 0.194 ± 0.015
0.754TrpIle: 0.754 ± 0.029
0.658TrpLys: 0.658 ± 0.029
0.889TrpLeu: 0.889 ± 0.033
0.253TrpMet: 0.253 ± 0.018
0.69TrpAsn: 0.69 ± 0.03
0.218TrpPro: 0.218 ± 0.021
0.349TrpGln: 0.349 ± 0.02
0.319TrpArg: 0.319 ± 0.019
0.692TrpSer: 0.692 ± 0.04
0.511TrpThr: 0.511 ± 0.025
0.594TrpVal: 0.594 ± 0.029
0.122TrpTrp: 0.122 ± 0.012
0.43TrpTyr: 0.43 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.339TyrAla: 2.339 ± 0.05
0.392TyrCys: 0.392 ± 0.021
2.413TyrAsp: 2.413 ± 0.068
2.361TyrGlu: 2.361 ± 0.074
2.508TyrPhe: 2.508 ± 0.063
2.535TyrGly: 2.535 ± 0.065
0.827TyrHis: 0.827 ± 0.033
2.992TyrIle: 2.992 ± 0.055
3.252TyrLys: 3.252 ± 0.067
4.007TyrLeu: 4.007 ± 0.076
0.688TyrMet: 0.688 ± 0.029
3.222TyrAsn: 3.222 ± 0.081
1.496TyrPro: 1.496 ± 0.043
1.585TyrGln: 1.585 ± 0.045
1.328TyrArg: 1.328 ± 0.049
3.152TyrSer: 3.152 ± 0.074
2.492TyrThr: 2.492 ± 0.071
2.143TyrVal: 2.143 ± 0.052
0.472TyrTrp: 0.472 ± 0.022
2.109TyrTyr: 2.109 ± 0.065
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2518 proteins (911875 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski