Amino acid dipepetide frequency for Faecalibacterium prausnitzii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.989AlaAla: 13.989 ± 0.222
1.425AlaCys: 1.425 ± 0.04
5.846AlaAsp: 5.846 ± 0.085
7.494AlaGlu: 7.494 ± 0.129
3.562AlaPhe: 3.562 ± 0.072
7.523AlaGly: 7.523 ± 0.111
1.713AlaHis: 1.713 ± 0.048
4.779AlaIle: 4.779 ± 0.086
5.427AlaLys: 5.427 ± 0.093
10.742AlaLeu: 10.742 ± 0.125
2.744AlaMet: 2.744 ± 0.055
2.859AlaAsn: 2.859 ± 0.06
3.601AlaPro: 3.601 ± 0.094
3.907AlaGln: 3.907 ± 0.079
4.541AlaArg: 4.541 ± 0.095
4.822AlaSer: 4.822 ± 0.089
3.796AlaThr: 3.796 ± 0.074
7.91AlaVal: 7.91 ± 0.11
0.871AlaTrp: 0.871 ± 0.03
2.882AlaTyr: 2.882 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
1.617CysAla: 1.617 ± 0.049
0.358CysCys: 0.358 ± 0.02
0.887CysAsp: 0.887 ± 0.03
1.06CysGlu: 1.06 ± 0.033
0.645CysPhe: 0.645 ± 0.03
1.857CysGly: 1.857 ± 0.048
0.313CysHis: 0.313 ± 0.02
0.983CysIle: 0.983 ± 0.036
0.846CysLys: 0.846 ± 0.03
1.249CysLeu: 1.249 ± 0.044
0.424CysMet: 0.424 ± 0.021
0.528CysAsn: 0.528 ± 0.025
0.812CysPro: 0.812 ± 0.033
0.456CysGln: 0.456 ± 0.023
0.937CysArg: 0.937 ± 0.038
1.001CysSer: 1.001 ± 0.036
1.013CysThr: 1.013 ± 0.042
1.225CysVal: 1.225 ± 0.038
0.173CysTrp: 0.173 ± 0.016
0.61CysTyr: 0.61 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
5.893AspAla: 5.893 ± 0.1
0.948AspCys: 0.948 ± 0.038
2.963AspAsp: 2.963 ± 0.069
4.396AspGlu: 4.396 ± 0.077
2.452AspPhe: 2.452 ± 0.054
4.662AspGly: 4.662 ± 0.081
1.014AspHis: 1.014 ± 0.038
3.129AspIle: 3.129 ± 0.065
2.703AspLys: 2.703 ± 0.062
5.033AspLeu: 5.033 ± 0.086
1.311AspMet: 1.311 ± 0.04
1.79AspAsn: 1.79 ± 0.045
2.648AspPro: 2.648 ± 0.052
1.353AspGln: 1.353 ± 0.044
2.641AspArg: 2.641 ± 0.068
2.752AspSer: 2.752 ± 0.058
3.187AspThr: 3.187 ± 0.06
3.739AspVal: 3.739 ± 0.069
0.712AspTrp: 0.712 ± 0.032
2.34AspTyr: 2.34 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
6.548GluAla: 6.548 ± 0.102
0.824GluCys: 0.824 ± 0.03
3.668GluAsp: 3.668 ± 0.074
5.17GluGlu: 5.17 ± 0.104
2.086GluPhe: 2.086 ± 0.046
4.307GluGly: 4.307 ± 0.074
1.42GluHis: 1.42 ± 0.047
3.659GluIle: 3.659 ± 0.063
4.738GluLys: 4.738 ± 0.084
6.812GluLeu: 6.812 ± 0.086
2.182GluMet: 2.182 ± 0.056
3.296GluAsn: 3.296 ± 0.066
2.395GluPro: 2.395 ± 0.066
3.295GluGln: 3.295 ± 0.072
3.653GluArg: 3.653 ± 0.074
2.985GluSer: 2.985 ± 0.065
3.55GluThr: 3.55 ± 0.073
4.112GluVal: 4.112 ± 0.078
0.639GluTrp: 0.639 ± 0.029
2.357GluTyr: 2.357 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.698PheAla: 3.698 ± 0.071
0.844PheCys: 0.844 ± 0.037
2.566PheAsp: 2.566 ± 0.052
2.288PheGlu: 2.288 ± 0.058
1.542PhePhe: 1.542 ± 0.054
3.095PheGly: 3.095 ± 0.076
0.752PheHis: 0.752 ± 0.032
1.865PheIle: 1.865 ± 0.051
1.546PheLys: 1.546 ± 0.047
3.655PheLeu: 3.655 ± 0.071
0.862PheMet: 0.862 ± 0.032
1.353PheAsn: 1.353 ± 0.046
1.363PhePro: 1.363 ± 0.041
1.062PheGln: 1.062 ± 0.037
1.939PheArg: 1.939 ± 0.056
2.542PheSer: 2.542 ± 0.06
2.34PheThr: 2.34 ± 0.062
2.771PheVal: 2.771 ± 0.063
0.461PheTrp: 0.461 ± 0.028
1.492PheTyr: 1.492 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
6.488GlyAla: 6.488 ± 0.116
1.515GlyCys: 1.515 ± 0.041
3.641GlyAsp: 3.641 ± 0.069
4.676GlyGlu: 4.676 ± 0.076
3.018GlyPhe: 3.018 ± 0.061
5.764GlyGly: 5.764 ± 0.107
1.413GlyHis: 1.413 ± 0.047
4.908GlyIle: 4.908 ± 0.081
4.844GlyLys: 4.844 ± 0.085
6.763GlyLeu: 6.763 ± 0.091
2.435GlyMet: 2.435 ± 0.057
2.395GlyAsn: 2.395 ± 0.06
1.737GlyPro: 1.737 ± 0.05
2.387GlyGln: 2.387 ± 0.051
3.832GlyArg: 3.832 ± 0.074
4.425GlySer: 4.425 ± 0.08
4.558GlyThr: 4.558 ± 0.087
5.656GlyVal: 5.656 ± 0.097
0.986GlyTrp: 0.986 ± 0.04
3.004GlyTyr: 3.004 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.555HisAla: 1.555 ± 0.041
0.404HisCys: 0.404 ± 0.021
1.049HisAsp: 1.049 ± 0.039
1.066HisGlu: 1.066 ± 0.042
0.865HisPhe: 0.865 ± 0.035
1.492HisGly: 1.492 ± 0.049
0.511HisHis: 0.511 ± 0.038
1.178HisIle: 1.178 ± 0.044
0.921HisLys: 0.921 ± 0.032
1.737HisLeu: 1.737 ± 0.047
0.422HisMet: 0.422 ± 0.023
0.669HisAsn: 0.669 ± 0.027
1.141HisPro: 1.141 ± 0.035
0.583HisGln: 0.583 ± 0.026
0.986HisArg: 0.986 ± 0.037
1.011HisSer: 1.011 ± 0.034
1.161HisThr: 1.161 ± 0.035
1.076HisVal: 1.076 ± 0.04
0.236HisTrp: 0.236 ± 0.017
0.806HisTyr: 0.806 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.181IleAla: 5.181 ± 0.092
1.028IleCys: 1.028 ± 0.035
3.189IleAsp: 3.189 ± 0.067
3.481IleGlu: 3.481 ± 0.075
2.086IlePhe: 2.086 ± 0.056
4.039IleGly: 4.039 ± 0.081
1.064IleHis: 1.064 ± 0.042
2.765IleIle: 2.765 ± 0.074
2.44IleLys: 2.44 ± 0.058
5.421IleLeu: 5.421 ± 0.095
1.216IleMet: 1.216 ± 0.042
1.771IleAsn: 1.771 ± 0.053
2.544IlePro: 2.544 ± 0.056
1.823IleGln: 1.823 ± 0.049
3.093IleArg: 3.093 ± 0.06
3.41IleSer: 3.41 ± 0.063
3.31IleThr: 3.31 ± 0.06
3.983IleVal: 3.983 ± 0.074
0.535IleTrp: 0.535 ± 0.023
1.886IleTyr: 1.886 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.533LysAla: 5.533 ± 0.092
0.589LysCys: 0.589 ± 0.03
2.836LysAsp: 2.836 ± 0.063
3.888LysGlu: 3.888 ± 0.076
1.59LysPhe: 1.59 ± 0.043
3.578LysGly: 3.578 ± 0.07
0.994LysHis: 0.994 ± 0.035
3.06LysIle: 3.06 ± 0.064
3.941LysLys: 3.941 ± 0.078
5.15LysLeu: 5.15 ± 0.073
1.684LysMet: 1.684 ± 0.049
2.504LysAsn: 2.504 ± 0.061
2.225LysPro: 2.225 ± 0.059
2.153LysGln: 2.153 ± 0.051
2.755LysArg: 2.755 ± 0.055
2.565LysSer: 2.565 ± 0.059
3.277LysThr: 3.277 ± 0.064
3.488LysVal: 3.488 ± 0.063
0.493LysTrp: 0.493 ± 0.027
1.962LysTyr: 1.962 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
9.896LeuAla: 9.896 ± 0.116
2.157LeuCys: 2.157 ± 0.058
5.782LeuAsp: 5.782 ± 0.102
5.875LeuGlu: 5.875 ± 0.107
3.768LeuPhe: 3.768 ± 0.074
6.694LeuGly: 6.694 ± 0.102
1.939LeuHis: 1.939 ± 0.05
4.514LeuIle: 4.514 ± 0.084
4.886LeuLys: 4.886 ± 0.077
10.267LeuLeu: 10.267 ± 0.16
2.627LeuMet: 2.627 ± 0.061
3.744LeuAsn: 3.744 ± 0.067
4.935LeuPro: 4.935 ± 0.096
3.105LeuGln: 3.105 ± 0.06
5.511LeuArg: 5.511 ± 0.073
6.007LeuSer: 6.007 ± 0.094
6.26LeuThr: 6.26 ± 0.087
6.271LeuVal: 6.271 ± 0.097
1.028LeuTrp: 1.028 ± 0.035
3.353LeuTyr: 3.353 ± 0.069
0.0LeuXaa: 0.0 ± 0.0
Met
2.798MetAla: 2.798 ± 0.063
0.3MetCys: 0.3 ± 0.019
1.698MetAsp: 1.698 ± 0.043
2.007MetGlu: 2.007 ± 0.049
0.83MetPhe: 0.83 ± 0.032
1.964MetGly: 1.964 ± 0.051
0.404MetHis: 0.404 ± 0.023
1.38MetIle: 1.38 ± 0.043
1.829MetLys: 1.829 ± 0.049
2.676MetLeu: 2.676 ± 0.049
0.824MetMet: 0.824 ± 0.036
1.329MetAsn: 1.329 ± 0.039
1.275MetPro: 1.275 ± 0.042
1.163MetGln: 1.163 ± 0.039
1.278MetArg: 1.278 ± 0.035
1.586MetSer: 1.586 ± 0.049
1.705MetThr: 1.705 ± 0.042
1.793MetVal: 1.793 ± 0.053
0.192MetTrp: 0.192 ± 0.015
0.655MetTyr: 0.655 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.606AsnAla: 3.606 ± 0.065
0.615AsnCys: 0.615 ± 0.029
1.923AsnAsp: 1.923 ± 0.054
2.176AsnGlu: 2.176 ± 0.063
1.368AsnPhe: 1.368 ± 0.04
3.303AsnGly: 3.303 ± 0.07
0.721AsnHis: 0.721 ± 0.03
2.285AsnIle: 2.285 ± 0.057
1.697AsnLys: 1.697 ± 0.046
3.347AsnLeu: 3.347 ± 0.067
0.982AsnMet: 0.982 ± 0.04
1.283AsnAsn: 1.283 ± 0.043
1.804AsnPro: 1.804 ± 0.055
1.18AsnGln: 1.18 ± 0.034
1.969AsnArg: 1.969 ± 0.051
1.801AsnSer: 1.801 ± 0.05
2.124AsnThr: 2.124 ± 0.056
2.51AsnVal: 2.51 ± 0.051
0.408AsnTrp: 0.408 ± 0.024
1.495AsnTyr: 1.495 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
4.449ProAla: 4.449 ± 0.1
0.626ProCys: 0.626 ± 0.035
2.8ProAsp: 2.8 ± 0.059
3.929ProGlu: 3.929 ± 0.076
1.564ProPhe: 1.564 ± 0.047
3.021ProGly: 3.021 ± 0.064
0.749ProHis: 0.749 ± 0.031
2.102ProIle: 2.102 ± 0.059
2.025ProLys: 2.025 ± 0.049
3.635ProLeu: 3.635 ± 0.063
1.011ProMet: 1.011 ± 0.033
1.362ProAsn: 1.362 ± 0.037
1.215ProPro: 1.215 ± 0.043
1.56ProGln: 1.56 ± 0.046
1.588ProArg: 1.588 ± 0.044
1.98ProSer: 1.98 ± 0.049
2.061ProThr: 2.061 ± 0.052
3.363ProVal: 3.363 ± 0.064
0.405ProTrp: 0.405 ± 0.023
1.444ProTyr: 1.444 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.859GlnAla: 2.859 ± 0.064
0.495GlnCys: 0.495 ± 0.025
1.515GlnAsp: 1.515 ± 0.044
2.316GlnGlu: 2.316 ± 0.057
1.283GlnPhe: 1.283 ± 0.039
2.1GlnGly: 2.1 ± 0.055
0.685GlnHis: 0.685 ± 0.031
2.081GlnIle: 2.081 ± 0.052
2.631GlnLys: 2.631 ± 0.062
3.674GlnLeu: 3.674 ± 0.064
1.27GlnMet: 1.27 ± 0.041
1.662GlnAsn: 1.662 ± 0.045
1.492GlnPro: 1.492 ± 0.042
1.847GlnGln: 1.847 ± 0.052
2.084GlnArg: 2.084 ± 0.063
1.853GlnSer: 1.853 ± 0.051
2.084GlnThr: 2.084 ± 0.06
2.146GlnVal: 2.146 ± 0.052
0.424GlnTrp: 0.424 ± 0.021
1.335GlnTyr: 1.335 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
4.667ArgAla: 4.667 ± 0.091
0.89ArgCys: 0.89 ± 0.032
2.476ArgAsp: 2.476 ± 0.051
3.592ArgGlu: 3.592 ± 0.081
2.11ArgPhe: 2.11 ± 0.048
2.982ArgGly: 2.982 ± 0.066
0.914ArgHis: 0.914 ± 0.034
3.055ArgIle: 3.055 ± 0.063
3.042ArgLys: 3.042 ± 0.058
4.998ArgLeu: 4.998 ± 0.086
1.647ArgMet: 1.647 ± 0.048
1.883ArgAsn: 1.883 ± 0.052
2.032ArgPro: 2.032 ± 0.052
2.201ArgGln: 2.201 ± 0.064
3.407ArgArg: 3.407 ± 0.085
2.697ArgSer: 2.697 ± 0.06
3.049ArgThr: 3.049 ± 0.065
3.392ArgVal: 3.392 ± 0.062
0.649ArgTrp: 0.649 ± 0.026
2.086ArgTyr: 2.086 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.488SerAla: 5.488 ± 0.077
0.917SerCys: 0.917 ± 0.04
2.909SerAsp: 2.909 ± 0.073
3.174SerGlu: 3.174 ± 0.069
2.347SerPhe: 2.347 ± 0.053
4.936SerGly: 4.936 ± 0.091
1.002SerHis: 1.002 ± 0.036
3.191SerIle: 3.191 ± 0.06
2.415SerLys: 2.415 ± 0.056
4.986SerLeu: 4.986 ± 0.087
1.594SerMet: 1.594 ± 0.047
1.881SerAsn: 1.881 ± 0.054
2.036SerPro: 2.036 ± 0.053
1.719SerGln: 1.719 ± 0.05
2.842SerArg: 2.842 ± 0.059
3.45SerSer: 3.45 ± 0.103
3.027SerThr: 3.027 ± 0.057
4.025SerVal: 4.025 ± 0.075
0.537SerTrp: 0.537 ± 0.027
2.056SerTyr: 2.056 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
6.224ThrAla: 6.224 ± 0.086
0.778ThrCys: 0.778 ± 0.036
3.141ThrAsp: 3.141 ± 0.068
3.574ThrGlu: 3.574 ± 0.073
2.094ThrPhe: 2.094 ± 0.053
4.744ThrGly: 4.744 ± 0.072
1.025ThrHis: 1.025 ± 0.037
3.264ThrIle: 3.264 ± 0.066
2.588ThrLys: 2.588 ± 0.057
5.907ThrLeu: 5.907 ± 0.084
1.433ThrMet: 1.433 ± 0.042
1.81ThrAsn: 1.81 ± 0.051
2.84ThrPro: 2.84 ± 0.052
1.716ThrGln: 1.716 ± 0.049
2.491ThrArg: 2.491 ± 0.05
2.812ThrSer: 2.812 ± 0.062
3.141ThrThr: 3.141 ± 0.071
4.911ThrVal: 4.911 ± 0.091
0.487ThrTrp: 0.487 ± 0.025
1.778ThrTyr: 1.778 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.89ValAla: 5.89 ± 0.1
1.439ValCys: 1.439 ± 0.046
3.894ValAsp: 3.894 ± 0.07
4.689ValGlu: 4.689 ± 0.085
2.843ValPhe: 2.843 ± 0.064
4.791ValGly: 4.791 ± 0.085
1.233ValHis: 1.233 ± 0.04
3.722ValIle: 3.722 ± 0.072
3.44ValLys: 3.44 ± 0.069
7.793ValLeu: 7.793 ± 0.109
1.898ValMet: 1.898 ± 0.054
2.473ValAsn: 2.473 ± 0.061
3.045ValPro: 3.045 ± 0.06
2.426ValGln: 2.426 ± 0.057
3.751ValArg: 3.751 ± 0.077
4.407ValSer: 4.407 ± 0.087
4.256ValThr: 4.256 ± 0.069
5.182ValVal: 5.182 ± 0.103
0.763ValTrp: 0.763 ± 0.032
2.403ValTyr: 2.403 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.852TrpAla: 0.852 ± 0.036
0.206TrpCys: 0.206 ± 0.019
0.569TrpAsp: 0.569 ± 0.029
0.712TrpGlu: 0.712 ± 0.032
0.449TrpPhe: 0.449 ± 0.024
0.767TrpGly: 0.767 ± 0.035
0.22TrpHis: 0.22 ± 0.016
0.43TrpIle: 0.43 ± 0.019
0.643TrpLys: 0.643 ± 0.029
1.261TrpLeu: 1.261 ± 0.046
0.335TrpMet: 0.335 ± 0.025
0.511TrpAsn: 0.511 ± 0.023
0.333TrpPro: 0.333 ± 0.023
0.519TrpGln: 0.519 ± 0.028
0.499TrpArg: 0.499 ± 0.024
0.5TrpSer: 0.5 ± 0.028
0.488TrpThr: 0.488 ± 0.029
0.706TrpVal: 0.706 ± 0.032
0.126TrpTrp: 0.126 ± 0.013
0.375TrpTyr: 0.375 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.202TyrAla: 3.202 ± 0.06
0.637TyrCys: 0.637 ± 0.025
2.314TyrAsp: 2.314 ± 0.061
2.133TyrGlu: 2.133 ± 0.053
1.532TyrPhe: 1.532 ± 0.046
2.826TyrGly: 2.826 ± 0.068
0.786TyrHis: 0.786 ± 0.032
1.916TyrIle: 1.916 ± 0.053
1.663TyrLys: 1.663 ± 0.054
3.513TyrLeu: 3.513 ± 0.071
0.786TyrMet: 0.786 ± 0.031
1.495TyrAsn: 1.495 ± 0.043
1.416TyrPro: 1.416 ± 0.043
1.381TyrGln: 1.381 ± 0.037
1.971TyrArg: 1.971 ± 0.054
1.926TyrSer: 1.926 ± 0.048
2.369TyrThr: 2.369 ± 0.063
2.079TyrVal: 2.079 ± 0.052
0.375TyrTrp: 0.375 ± 0.023
1.483TyrTyr: 1.483 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2653 proteins (826170 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski